General Information of the Compound
Compound ID
CP0575365
Compound Name
methyl N-[(2S)-1-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2S)-2-(methoxycarbonylamino)-3,3-dimethylbutanoyl]pyrrolidin-2-yl]-1,3-thiazol-5-yl]phenyl]phenyl]-1,3-thiazol-2-yl]pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]carbamate
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Structure
Formula
C42H52N6O6S2
Molecular Weight
801.048
Canonical SMILES
COC(=O)N[C@H](C(=O)N1CCC[C@H]1c1ncc(s1)-c1ccc(cc1)-c1ccc(cc1)-c1cnc(s1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C(C)(C)C)C(C)(C)C
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InChI
InChI=1S/C42H52N6O6S2/c1-41(2,3)33(45-39(51)53-7)37(49)47-21-9-11-29(47)35-43-23-31(55-35)27-17-13-25(14-18-27)26-15-19-28(20-16-26)32-24-44-36(56-32)30-12-10-22-48(30)38(50)34(42(4,5)6)46-40(52)54-8/h13-20,23-24,29-30,33-34H,9-12,21-22H2,1-8H3,(H,45,51)(H,46,52)/t29-,30-,33+,34+/m0/s1
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InChIKey
VMGHAXDIIIPZHM-XITCCLNHSA-N
Physicochemical Property
logP
8.469
Rotatable Bonds
9
Heavy Atom Count
56
Polar Areas
143.06
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
10
Complexity
56

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 53246542
SID: 124362848
ChEMBL ID
CHEMBL4533285
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00149, Nonstructural protein 5A
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000148 Huh-7 Homo sapiens (Human)  1
1
EC50 = 470.8 nM
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