General Information of the Compound
Compound ID
CP0575366
Compound Name
N-[(2R)-1-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2R)-2-(cyclopropanecarbonylamino)propanoyl]pyrrolidin-2-yl]-1,3-thiazol-5-yl]phenyl]phenyl]-1,3-thiazol-2-yl]pyrrolidin-1-yl]-1-oxopropan-2-yl]cyclopropanecarboxamide
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Structure
Formula
C40H44N6O4S2
Molecular Weight
736.964
Canonical SMILES
C[C@@H](NC(=O)C1CC1)C(=O)N1CCC[C@H]1c1ncc(s1)-c1ccc(cc1)-c1ccc(cc1)-c1cnc(s1)[C@@H]1CCCN1C(=O)[C@@H](C)NC(=O)C1CC1
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InChI
InChI=1S/C40H44N6O4S2/c1-23(43-35(47)29-15-16-29)39(49)45-19-3-5-31(45)37-41-21-33(51-37)27-11-7-25(8-12-27)26-9-13-28(14-10-26)34-22-42-38(52-34)32-6-4-20-46(32)40(50)24(2)44-36(48)30-17-18-30/h7-14,21-24,29-32H,3-6,15-20H2,1-2H3,(H,43,47)(H,44,48)/t23-,24-,31+,32+/m1/s1
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InChIKey
DFWGZRQPMXCTRU-DDADIKCBSA-N
Physicochemical Property
logP
6.757
Rotatable Bonds
11
Heavy Atom Count
52
Polar Areas
124.6
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
8
Complexity
52

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 53246068
SID: 124362375
ChEMBL ID
CHEMBL4437392
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00149, Nonstructural protein 5A
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000148 Huh-7 Homo sapiens (Human)  1
1
EC50 = 115.4 nM
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