General Information of the Compound
Compound ID
CP0931253
Compound Name
methyl N-[(2S)-1-[(2S,5S)-2-[17-[2-[(2S,5S)-1-[(2S)-2-(methoxycarbonylamino)-3-methylbutanoyl]-5-methylpyrrolidin-2-yl]-1H-imidazol-5-yl]-21-oxa-5,7-diazapentacyclo[11.8.0.03,11.04,8.014,19]henicosa-1(13),2,4(8),5,9,11,14(19),15,17-nonaen-6-yl]-5-methylpyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]carbamate
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Structure
Formula
C45H54N8O7
Molecular Weight
818.976
Canonical SMILES
COC(=O)N[C@H](C(=O)N1[C@@H](C)CC[C@H]1c1ncc(-c2ccc3c(c2)COc2cc4c(ccc5nc([C@@H]6CC[C@H](C)N6C(=O)[C@@H](NC(=O)OC)C(C)C)[nH]c54)cc2-3)[nH]1)C(C)C
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InChI
InChI=1S/C45H54N8O7/c1-22(2)37(50-44(56)58-7)42(54)52-24(5)9-15-34(52)40-46-20-33(48-40)27-11-13-29-28(17-27)21-60-36-19-30-26(18-31(29)36)12-14-32-39(30)49-41(47-32)35-16-10-25(6)53(35)43(55)38(23(3)4)51-45(57)59-8/h11-14,17-20,22-25,34-35,37-38H,9-10,15-16,21H2,1-8H3,(H,46,48)(H,47,49)(H,50,56)(H,51,57)/t24-,25-,34-,35-,37-,38-/m0/s1
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InChIKey
DJVIVJVKYOMANY-GEWDOAPNSA-N
Physicochemical Property
logP
7.5308
Rotatable Bonds
9
Heavy Atom Count
60
Polar Areas
183.87
Hydrogen Bond Donor Count
4
Hydrogen Bond Acceptor Count
9
Complexity
60

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 67683162
ChEMBL ID
CHEMBL4449384
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00149, Nonstructural protein 5A
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000148 Huh-7 Homo sapiens (Human)  4
1
EC50 = 0.012 nM
   TI
   LI
   LO
   TS
2
EC50 = 0.014 nM
   TI
   LI
   LO
   TS
3
EC50 = 0.063 nM
   TI
   LI
   LO
   TS
4
EC50 = 0.28 nM
   TI
   LI
   LO
   TS