General Information of the Compound
Compound ID
CP0948415
Compound Name
methyl N-[(2S)-1-[(2S,5S)-2-[5-[6-[(2S,4S)-1-[(2S)-2-(methoxycarbonylamino)-3-methylbutanoyl]-4-(methoxymethyl)pyrrolidin-2-yl]-21-oxa-5,7-diazapentacyclo[11.8.0.03,11.04,8.014,19]henicosa-1(13),2,4(8),5,9,11,14(19),15,17-nonaen-17-yl]-1H-imidazol-2-yl]-5-methylpyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]carbamate
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Structure
Formula
C46H56N8O8
Molecular Weight
849.002
Canonical SMILES
COC[C@H]1C[C@@H](c2nc3ccc4cc5c(cc4c3[nH]2)OCc2cc(-c3cnc([C@@H]4CC[C@H](C)N4C(=O)[C@@H](NC(=O)OC)C(C)C)[nH]3)ccc2-5)N(C(=O)[C@@H](NC(=O)OC)C(C)C)C1
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InChI
InChI=1S/C46H56N8O8/c1-23(2)38(51-45(57)60-7)43(55)53-20-26(21-59-6)15-36(53)42-48-33-13-11-27-17-32-30-12-10-28(16-29(30)22-62-37(32)18-31(27)40(33)50-42)34-19-47-41(49-34)35-14-9-25(5)54(35)44(56)39(24(3)4)52-46(58)61-8/h10-13,16-19,23-26,35-36,38-39H,9,14-15,20-22H2,1-8H3,(H,47,49)(H,48,50)(H,51,57)(H,52,58)/t25-,26-,35-,36-,38-,39-/m0/s1
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InChIKey
SVIMHPLJLPQHHH-SORRNWNHSA-N
Physicochemical Property
logP
7.0148
Rotatable Bonds
11
Heavy Atom Count
62
Polar Areas
193.1
Hydrogen Bond Donor Count
4
Hydrogen Bond Acceptor Count
10
Complexity
62

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 71571821
SID: 163615352
ChEMBL ID
CHEMBL4583723
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00149, Nonstructural protein 5A
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000148 Huh-7 Homo sapiens (Human)  5
1
EC50 = 0.011 nM
   TI
   LI
   LO
   TS
2
EC50 = 0.012 nM
   TI
   LI
   LO
   TS
3
EC50 = 0.017 nM
   TI
   LI
   LO
   TS
4
EC50 = 0.067 nM
   TI
   LI
   LO
   TS
5
EC50 = 0.157 nM
   TI
   LI
   LO
   TS