General Information of the Compound
Compound ID
CP0402272
Compound Name
methyl N-[(2S)-1-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2S)-2-(methoxycarbonylamino)pentanoyl]pyrrolidin-2-yl]-1,3-thiazol-5-yl]phenyl]phenyl]-1,3-thiazol-2-yl]pyrrolidin-1-yl]-1-oxopentan-2-yl]carbamate
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Structure
Formula
C40H48N6O6S2
Molecular Weight
772.994
Canonical SMILES
CCC[C@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1ncc(s1)-c1ccc(cc1)-c1ccc(cc1)-c1cnc(s1)[C@@H]1CCCN1C(=O)[C@H](CCC)NC(=O)OC
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InChI
InChI=1S/C40H48N6O6S2/c1-5-9-29(43-39(49)51-3)37(47)45-21-7-11-31(45)35-41-23-33(53-35)27-17-13-25(14-18-27)26-15-19-28(20-16-26)34-24-42-36(54-34)32-12-8-22-46(32)38(48)30(10-6-2)44-40(50)52-4/h13-20,23-24,29-32H,5-12,21-22H2,1-4H3,(H,43,49)(H,44,50)/t29-,30-,31-,32-/m0/s1
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InChIKey
ZMIYSCUDFZMZGL-YDPTYEFTSA-N
Physicochemical Property
logP
7.977
Rotatable Bonds
13
Heavy Atom Count
54
Polar Areas
143.06
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
10
Complexity
54

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 53246423
SID: 124362729
ChEMBL ID
CHEMBL4517969
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00149, Nonstructural protein 5A
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000148 Huh-7 Homo sapiens (Human)  1
1
EC50 = 123.1 nM
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Cell Viability or Cytotoxicity Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000148 Huh-7 Homo sapiens (Human)  1
1
CC50 > 50000 nM
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   TS