| Compound ID |
Compound Name |
Compound Formula |
|
CP0357692
|
1,2-bis(3-fluorobenzylidene)hydrazine
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|
C14H10F2N2
|
1
|
| 1 |
EC50 = 2.36 nM
|
|
|
|
CP0088840
|
3-Cyano-N-(2,5-diphenyl-2H-pyrazol-3-yl)-benzamide
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|
C23H16N4O
|
2
|
| 1 |
EC50 = 10 nM
|
|
|
| 2 |
EC50 = 27 nM
|
|
|
|
CP0269821
|
N-(2,5-diphenylpyrazol-3-yl)-3,4-difluorobenzamide
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|
C22H15F2N3O
|
1
|
| 1 |
EC50 = 10 nM
|
|
|
|
CP0159187
|
N-(2,5-diphenylpyrazol-3-yl)-4-(trifluoromethyl)benzamide
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|
C23H16F3N3O
|
1
|
| 1 |
EC50 = 19 nM
|
|
|
|
CP0273701
|
N-(2,5-diphenylpyrazol-3-yl)-3-fluorobenzamide
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|
C22H16FN3O
|
1
|
| 1 |
EC50 = 20 nM
|
|
|
|
CP0278839
|
4-Chloro-N-(2,5-diphenyl-2H-pyrazol-3-yl)-benzamide
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|
C22H16ClN3O
|
1
|
| 1 |
EC50 = 20 nM
|
|
|
|
CP0159176
|
N-(2,5-diphenylpyrazol-3-yl)-4-methylbenzamide
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|
C23H19N3O
|
1
|
| 1 |
EC50 = 30 nM
|
|
|
|
CP0254837
|
N-(2,5-diphenylpyrazol-3-yl)-4-fluorobenzamide
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|
C22H16FN3O
|
1
|
| 1 |
EC50 = 30 nM
|
|
|
|
CP0525617
|
3-(2-phenylethynyl)-7,8-dihydro-6H-quinolin-5-one
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|
C17H13NO
|
1
|
| 1 |
EC50 = 30.7 nM
|
|
|
|
CP0049482
|
N-(2,5-diphenylpyrazol-3-yl)benzamide
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|
C22H17N3O
|
1
|
| 1 |
EC50 = 40 nM
|
|
|
|
CP0279418
|
3-Chloro-N-(2,5-diphenyl-2H-pyrazol-3-yl)-benzamide
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|
C22H16ClN3O
|
1
|
| 1 |
EC50 = 40 nM
|
|
|
|
CP0155799
|
2-phenylethynyl-7,8-dihydro-6H-quinolin-5-one
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|
C17H13NO
|
1
|
| 1 |
EC50 = 50 nM
|
|
|
|
CP0257798
|
N-(2,5-diphenylpyrazol-3-yl)-2-fluorobenzamide
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|
C22H16FN3O
|
1
|
| 1 |
EC50 = 75 nM
|
|
|
|
CP0303943
|
N-(2,5-diphenylpyrazol-3-yl)-3-methylbenzamide
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|
C23H19N3O
|
1
|
| 1 |
EC50 = 90 nM
|
|
|
|
CP0159185
|
N-(2,5-diphenylpyrazol-3-yl)thiophene-2-carboxamide
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|
C20H15N3OS
|
1
|
| 1 |
EC50 = 200 nM
|
|
|
|
CP0318828
|
N-(2,5-diphenylpyrazol-3-yl)pyrazine-2-carboxamide
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|
C20H15N5O
|
1
|
| 1 |
EC50 = 200 nM
|
|
|
|
CP0435679
|
N-[4-chloro-2-[(1,3-dioxoisoindol-2-yl)methyl]phenyl]pyridine-2-carboxamide
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|
C21H14ClN3O3
|
2
|
| 1 |
EC50 = 245 nM
|
|
|
| 2 |
EC50 = 250 nM
|
|
|
|
CP0360030
|
N-[4-chloro-2-[(1,3-dioxoisoindol-2-yl)methyl]phenyl]-2-hydroxybenzamide
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|
C22H15ClN2O4
|
2
|
| 1 |
EC50 = 250 nM
|
|
|
| 2 |
EC50 = 300 nM
|
|
|
|
CP0893450
|
N-(4-chloro-2-((1,3-dioxoisoindolin-2-yl)methyl)phenyl)picolinamide
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|
C21H15Cl2N3O3
|
1
|
| 1 |
EC50 = 250 nM
|
|
|
|
CP0458661
|
N-[4-chloro-2-[(1,3-dioxoisoindol-2-yl)methyl]phenyl]-3-hydroxypyridine-2-carboxamide
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|
C21H14ClN3O4
|
1
|
| 1 |
EC50 = 260 nM
|
|
|
|
CP0457978
|
N-[4-chloro-2-[(4-ethoxy-1,3-dioxoisoindol-2-yl)methyl]phenyl]pyridine-2-carboxamide
Show/Hide
|
C23H18ClN3O4
|
1
|
| 1 |
EC50 = 280 nM
|
|
|
|
CP0102364
|
N-(2,5-diphenylpyrazol-3-yl)pyridine-2-carboxamide
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|
C21H16N4O
|
1
|
| 1 |
EC50 = 290 nM
|
|
|
|
CP0458583
|
N-[4-chloro-2-[(5-fluoro-1,3-dioxoisoindol-2-yl)methyl]phenyl]pyridine-2-carboxamide
Show/Hide
|
C21H13ClFN3O3
|
1
|
| 1 |
EC50 = 330 nM
|
|
|
|
CP0397662
|
6,6-dimethyl-2-(3-methylanilino)-7,8-dihydroquinazolin-5-one
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|
C17H19N3O
|
1
|
| 1 |
EC50 = 694 nM
|
|
|
|
CP0421879
|
N-[4-bromo-2-[(4-ethoxy-1,3-dioxoisoindol-2-yl)methyl]phenyl]pyridine-2-carboxamide
Show/Hide
|
C23H18BrN3O4
|
1
|
| 1 |
EC50 = 720 nM
|
|
|
|
CP0372146
|
N-[4-bromo-2-[(1,3-dioxoisoindol-2-yl)methyl]phenyl]pyridine-2-carboxamide
Show/Hide
|
C21H14BrN3O3
|
2
|
| 1 |
EC50 = 740 nM
|
|
|
| 2 |
EC50 = 750 nM
|
|
|
|
CP0457980
|
N-[4-bromo-2-[(5-fluoro-1,3-dioxoisoindol-2-yl)methyl]phenyl]pyridine-2-carboxamide
Show/Hide
|
C21H13BrFN3O3
|
1
|
| 1 |
EC50 = 930 nM
|
|
|
|
CP0467231
|
N-[2-[(1,3-dioxoisoindol-2-yl)methyl]-4-methoxyphenyl]pyridine-2-carboxamide
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|
C22H17N3O4
|
1
|
| 1 |
EC50 = 1400 nM
|
|
|
|
CP0372139
|
N-[2-[(1,3-dioxoisoindol-2-yl)methyl]-4-fluorophenyl]pyridine-2-carboxamide
Show/Hide
|
C21H14FN3O3
|
1
|
| 1 |
EC50 = 1500 nM
|
|
|
|
CP0457981
|
N-[4-chloro-2-[(1,3-dioxoisoindol-2-yl)methyl]phenyl]cyclohexanecarboxamide
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|
C22H21ClN2O3
|
1
|
| 1 |
EC50 = 1500 nM
|
|
|
|
CP0458585
|
N-[4-chloro-2-[(1,3-dioxoisoindol-2-yl)methyl]phenyl]-3-methoxybenzamide
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|
C23H17ClN2O4
|
1
|
| 1 |
EC50 = 1500 nM
|
|
|
|
CP0458631
|
(E)-N-(4-chloro-2-(3-oxo-3-phenylprop-1-enyl)phenyl)picolinamide
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|
C21H15ClN2O2
|
1
|
| 1 |
EC50 = 1700 nM
|
|
|
|
CP0083196
|
N-(2,5-diphenylpyrazol-3-yl)thiophene-3-carboxamide
Show/Hide
|
C20H15N3OS
|
1
|
| 1 |
EC50 = 1800 nM
|
|
|
|
CP0458630
|
N-[4-chloro-2-[(1,3-dioxoisoindol-2-yl)methyl]phenyl]-1,3-thiazole-5-carboxamide
Show/Hide
|
C19H12ClN3O3S
|
1
|
| 1 |
EC50 = 1900 nM
|
|
|
|
CP0458511
|
N-[4-chloro-2-[(1,3-dioxoisoindol-2-yl)methyl]phenyl]pyrimidine-2-carboxamide
Show/Hide
|
C20H13ClN4O3
|
1
|
| 1 |
EC50 = 2100 nM
|
|
|
|
CP0461714
|
N-[4-chloro-2-[(4,5-dimethyl-1,3-dioxoisoindol-2-yl)methyl]phenyl]pyridine-2-carboxamide
Show/Hide
|
C23H18ClN3O3
|
1
|
| 1 |
EC50 = 2200 nM
|
|
|
|
CP0500560
|
N-[4-chloro-2-[(1,3-dioxoisoindol-2-yl)methyl]phenyl]furan-2-carboxamide
Show/Hide
|
C20H13ClN2O4
|
1
|
| 1 |
EC50 = 2300 nM
|
|
|
|
CP0221648
|
2-Chloro-N-(2,5-diphenyl-2H-pyrazol-3-yl)-benzamide
Show/Hide
|
C22H16ClN3O
|
1
|
| 1 |
EC50 = 2500 nM
|
|
|
|
CP0501268
|
N-[4-chloro-2-(3-oxo-3-phenylpropyl)phenyl]pyridine-2-carboxamide
Show/Hide
|
C21H17ClN2O2
|
1
|
| 1 |
EC50 = 4500 nM
|
|
|
|
CP0372144
|
N-[4-chloro-2-[(1,3-dioxoisoindol-2-yl)methyl]phenyl]-2-nitrobenzamide
Show/Hide
|
C22H14ClN3O5
|
1
|
| 1 |
EC50 = 5700 nM
|
|
|
|
CP0560221
|
N-[4-chloro-2-[(1,3-dioxoisoindol-2-yl)methyl]phenyl]-2-(trifluoromethyl)benzamide
Show/Hide
|
C23H14ClF3N2O3
|
1
|
| 1 |
EC50 = 5700 nM
|
|
|
|
CP0272651
|
N-(2,5-diphenylpyrazol-3-yl)-2-methylbenzamide
Show/Hide
|
C23H19N3O
|
1
|
| 1 |
EC50 > 10000 nM
|
|
|
|
CP0278834
|
N-(2,5-diphenylpyrazol-3-yl)-2-hydroxybenzamide
Show/Hide
|
C22H17N3O2
|
1
|
| 1 |
EC50 > 10000 nM
|
|
|
|
CP0504956
|
N-[2-[(1,3-dioxoisoindol-2-yl)methyl]phenyl]pyridine-2-carboxamide
Show/Hide
|
C21H15N3O3
|
1
|
| 1 |
EC50 = 13900 nM
|
|
|
|
CP0382134
|
N-[4-chloro-2-[(1,3-dioxoisoindol-2-yl)methyl]phenyl]pyridine-3-carboxamide
Show/Hide
|
C21H14ClN3O3
|
1
|
| 1 |
EC50 = 35000 nM
|
|
|
|
CP0372143
|
N-[4-bromo-2-[(4,5-dimethyl-1,3-dioxoisoindol-2-yl)methyl]phenyl]pyridine-2-carboxamide
Show/Hide
|
C23H18BrN3O3
|
1
|
| 1 |
EC50 > 100000 nM
|
|
|
|
CP0457977
|
N-[2-[(1,3-dioxoisoindol-2-yl)methyl]-3-fluorophenyl]pyridine-2-carboxamide
Show/Hide
|
C21H14FN3O3
|
1
|
| 1 |
EC50 > 100000 nM
|
|
|
|
CP0458426
|
N-[4-bromo-2-[(4,5-dimethoxy-1,3-dioxoisoindol-2-yl)methyl]phenyl]pyridine-2-carboxamide
Show/Hide
|
C23H18BrN3O5
|
1
|
| 1 |
EC50 > 100000 nM
|
|
|
|
CP0458660
|
N-[4-chloro-2-[(1,3-dioxoisoindol-2-yl)methyl]phenyl]pyridazine-3-carboxamide
Show/Hide
|
C20H13ClN4O3
|
1
|
| 1 |
EC50 > 100000 nM
|
|
|
|
CP0464781
|
N-[4-chloro-2-[(1,3-dioxoisoindol-2-yl)methyl]phenyl]-2-methoxybenzamide
Show/Hide
|
C23H17ClN2O4
|
1
|
| 1 |
EC50 > 100000 nM
|
|
|
|
CP0500559
|
N-[4-chloro-2-[(4,5-dimethoxy-1,3-dioxoisoindol-2-yl)methyl]phenyl]pyridine-2-carboxamide
Show/Hide
|
C23H18ClN3O5
|
1
|
| 1 |
EC50 > 100000 nM
|
|
|
|
CP0501267
|
N-[4-chloro-2-[(1,3-dioxoisoindol-2-yl)methyl]phenyl]benzamide
Show/Hide
|
C22H15ClN2O3
|
1
|
| 1 |
EC50 > 100000 nM
|
|
|
|
CP0433158
|
3-methyl-1-(2-thiophen-3-ylethynyl)pyrrolo[1,2-a]pyrazine-7-carbonitrile
Show/Hide
|
C15H9N3S
|
1
|
| 1 |
IC50 = 0.3981 nM
|
|
|
|
CP0477864
|
3-methyl-1-[2-(3-methylphenyl)ethynyl]pyrrolo[1,2-a]pyrazine
Show/Hide
|
C17H14N2
|
1
|
| 1 |
IC50 = 0.3981 nM
|
|
|
|
CP0433160
|
1-[2-(3-fluorophenyl)ethynyl]-3-methylpyrrolo[1,2-a]pyrazine-7-carbonitrile
Show/Hide
|
C17H10FN3
|
1
|
| 1 |
IC50 = 0.7943 nM
|
|
|
|
CP0432623
|
3-[(2-methyl-4-thiazolyl)ethynyl]benzonitrile
Show/Hide
|
C13H8N2S
|
1
|
| 1 |
IC50 = 0.94 nM
|
|
|
|
CP0516478
|
3-methyl-1-(2-phenylethynyl)pyrrolo[1,2-a]pyrazine-7-carbonitrile
Show/Hide
|
C17H11N3
|
1
|
| 1 |
IC50 = 1.259 nM
|
|
|
|
CP0500672
|
3-[(2-methyl-4-thiazolyl)ethynyl]-5-vinylpyridine
Show/Hide
|
C13H10N2S
|
1
|
| 1 |
IC50 = 2.01 nM
|
|
|
|
CP0422668
|
3-methyl-1-(2-phenylethynyl)pyrrolo[1,2-a]pyrazine
Show/Hide
|
C16H12N2
|
1
|
| 1 |
IC50 = 2.512 nM
|
|
|
|
CP0433161
|
1-[2-(2-fluorophenyl)ethynyl]-3-methylpyrrolo[1,2-a]pyrazine-7-carbonitrile
Show/Hide
|
C17H10FN3
|
1
|
| 1 |
IC50 = 3.162 nM
|
|
|
|
CP0464878
|
ethyl 1-[2-(3-cyanophenyl)ethynyl]-3-methylpyrrolo[1,2-a]pyrazine-7-carboxylate
Show/Hide
|
C20H15N3O2
|
1
|
| 1 |
IC50 = 3.162 nM
|
|
|
|
CP0516477
|
3-methyl-5-[3-methyl-1-(2-phenylethynyl)pyrrolo[1,2-a]pyrazin-7-yl]-1,2,4-oxadiazole
Show/Hide
|
C19H14N4O
|
1
|
| 1 |
IC50 = 6.31 nM
|
|
|
|
CP0408029
|
ethyl 3-methyl-1-(2-thiophen-3-ylethynyl)pyrrolo[1,2-a]pyrazine-7-carboxylate
Show/Hide
|
C17H14N2O2S
|
1
|
| 1 |
IC50 = 7.943 nM
|
|
|
|
CP0439319
|
1-(6-methyl-2-thiophen-2-yl-[1,3]oxazolo[3,2-b][1,2,4]triazol-5-yl)ethyl N-phenylcarbamate
Show/Hide
|
C18H16N4O3S
|
1
|
| 1 |
IC50 = 7.943 nM
|
|
|
|
CP0191235
|
2-Methyl-6-(phenylethynyl)pyridine
Show/Hide
|
C14H11N
|
3
|
| 1 |
IC50 = 10 nM
|
|
|
| 2 |
IC50 = 31 nM
|
|
|
| 3 |
IC50 = 39 nM
|
|
|
|
CP0457594
|
3-methyl-1-(2-thiophen-3-ylethynyl)-7-(trifluoromethyl)pyrrolo[1,2-a]pyrazine
Show/Hide
|
C15H9F3N2S
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0477856
|
[3-methyl-1-(2-thiophen-3-ylethynyl)pyrrolo[1,2-a]pyrazin-7-yl]-morpholin-4-ylmethanone
Show/Hide
|
C19H17N3O2S
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0505132
|
ethyl 3-methyl-1-(2-phenylethynyl)pyrrolo[1,2-a]pyrazine-7-carboxylate
Show/Hide
|
C19H16N2O2
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0500027
|
1-[2-(4-fluorophenyl)-6-methyl-[1,3]oxazolo[3,2-b][1,2,4]triazol-5-yl]ethyl N-phenylcarbamate
Show/Hide
|
C20H17FN4O3
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0544135
|
1-(2-chloro-6-methyl-[1,3]oxazolo[3,2-b][1,2,4]triazol-5-yl)ethyl N-phenylcarbamate
Show/Hide
|
C14H13ClN4O3
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0428300
|
2-(4-fluorophenyl)-5-[(2-methyl-4-thiazolyl)ethynyl]pyridine
Show/Hide
|
C17H11FN2S
|
1
|
| 1 |
IC50 = 10.2 nM
|
|
|
|
CP0546271
|
3-(3,5-difluorophenyl)sulfonyl-8-fluoro-4-(4-fluorophenyl)quinoline
Show/Hide
|
C21H11F4NO2S
|
1
|
| 1 |
IC50 = 12 nM
|
|
|
|
CP0394913
|
3-[2-[3-methyl-7-(trifluoromethyl)pyrrolo[1,2-a]pyrazin-1-yl]ethynyl]benzonitrile
Show/Hide
|
C18H10F3N3
|
1
|
| 1 |
IC50 = 12.59 nM
|
|
|
|
CP0536929
|
[3-methyl-1-[2-[3-(trifluoromethyl)phenyl]ethynyl]pyrrolo[1,2-a]pyrazin-7-yl]-morpholin-4-ylmethanone
Show/Hide
|
C22H18F3N3O2
|
1
|
| 1 |
IC50 = 12.59 nM
|
|
|
|
CP0503505
|
1-(3-methylimidazo[2,1-b][1,3]thiazol-2-yl)ethyl N-phenylcarbamate
Show/Hide
|
C15H15N3O2S
|
1
|
| 1 |
IC50 = 12.59 nM
|
|
|
|
CP0505477
|
1-(2-cyclopropyl-6-methyl-[1,3]oxazolo[3,2-b][1,2,4]triazol-5-yl)ethyl N-phenylcarbamate
Show/Hide
|
C17H18N4O3
|
1
|
| 1 |
IC50 = 12.59 nM
|
|
|
|
CP0548764
|
4-(4-chlorophenyl)-3-(3,4-difluorophenyl)sulfonyl-8-fluoroquinoline
Show/Hide
|
C21H11ClF3NO2S
|
1
|
| 1 |
IC50 = 13 nM
|
|
|
|
CP0422665
|
1-[2-(3-fluorophenyl)ethynyl]-3-methyl-7-(trifluoromethyl)pyrrolo[1,2-a]pyrazine
Show/Hide
|
C17H10F4N2
|
1
|
| 1 |
IC50 = 15.85 nM
|
|
|
|
CP0433159
|
3-methyl-1-[2-[3-(trifluoromethyl)phenyl]ethynyl]pyrrolo[1,2-a]pyrazine-7-carbonitrile
Show/Hide
|
C18H10F3N3
|
1
|
| 1 |
IC50 = 15.85 nM
|
|
|
|
CP0505133
|
1-[2-(4-fluorophenyl)ethynyl]-3-methylpyrrolo[1,2-a]pyrazine
Show/Hide
|
C16H11FN2
|
1
|
| 1 |
IC50 = 15.85 nM
|
|
|
|
CP0551985
|
[3-methyl-1-(2-phenylethynyl)pyrrolo[1,2-a]pyrazin-7-yl]-morpholin-4-ylmethanone
Show/Hide
|
C21H19N3O2
|
1
|
| 1 |
IC50 = 15.85 nM
|
|
|
|
CP0300950
|
3-Fluoro-5-(2-(pyridin-2-yl)-7,8-dihydro-4H-oxazolo[4,5-c]azepin-5(6H)-yl)benzonitrile
Show/Hide
|
C19H15FN4O
|
1
|
| 1 |
IC50 = 16 nM
|
|
|
|
CP0562438
|
3-ethynyl-5-[(2-methyl-4-thiazolyl)ethynyl]pyridine
Show/Hide
|
C13H8N2S
|
1
|
| 1 |
IC50 = 19.2 nM
|
|
|
|
CP0372870
|
[1-[2-(3-fluorophenyl)ethynyl]-3-methylpyrrolo[1,2-a]pyrazin-7-yl]-morpholin-4-ylmethanone
Show/Hide
|
C21H18FN3O2
|
1
|
| 1 |
IC50 = 19.95 nM
|
|
|
|
CP0408030
|
ethyl 1-[2-(3-chlorophenyl)ethynyl]-3-methylpyrrolo[1,2-a]pyrazine-7-carboxylate
Show/Hide
|
C19H15ClN2O2
|
1
|
| 1 |
IC50 = 19.95 nM
|
|
|
|
CP0412889
|
[3-methyl-1-(2-thiophen-3-ylethynyl)pyrrolo[1,2-a]pyrazin-7-yl]-pyrrolidin-1-ylmethanone
Show/Hide
|
C19H17N3OS
|
1
|
| 1 |
IC50 = 19.95 nM
|
|
|
|
CP0477951
|
[1-[2-(3-fluorophenyl)ethynyl]-3-methylpyrrolo[1,2-a]pyrazin-7-yl]-pyrrolidin-1-ylmethanone
Show/Hide
|
C21H18FN3O
|
1
|
| 1 |
IC50 = 19.95 nM
|
|
|
|
CP0551975
|
3-[7-fluoro-4-(4-fluorophenyl)quinolin-3-yl]sulfonylbenzonitrile
Show/Hide
|
C22H12F2N2O2S
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0547065
|
3-(3-chloro-4-fluorophenyl)sulfonyl-7-fluoro-4-(4-fluorophenyl)quinoline
Show/Hide
|
C21H11ClF3NO2S
|
1
|
| 1 |
IC50 = 21 nM
|
|
|
|
CP0423228
|
4-(4-chlorophenyl)-3-(3,4-difluorophenyl)sulfonyl-7-fluoroquinoline
Show/Hide
|
C21H11ClF3NO2S
|
1
|
| 1 |
IC50 = 22 nM
|
|
|
|
CP0554307
|
4-(2-(3-fluorophenyl)ethynyl)-2-methylthiazole
Show/Hide
|
C12H8FNS
|
1
|
| 1 |
IC50 = 23 nM
|
|
|
|
CP0208917
|
6,6-dimethyl-2-phenylethynyl-7,8-dihydro-6H-quinolin-5-one
Show/Hide
|
C19H17NO
|
1
|
| 1 |
IC50 = 23.2 nM
|
|
|
|
CP0521084
|
3-(3,5-difluorophenyl)sulfonyl-7-fluoro-4-(4-fluorophenyl)quinoline
Show/Hide
|
C21H11F4NO2S
|
1
|
| 1 |
IC50 = 25 nM
|
|
|
|
CP0546268
|
3-(3,5-dichlorophenyl)sulfonyl-8-fluoro-4-(4-fluorophenyl)quinoline
Show/Hide
|
C21H11Cl2F2NO2S
|
1
|
| 1 |
IC50 = 25 nM
|
|
|
|
CP0546269
|
3-(3,5-dichlorophenyl)sulfonyl-7-fluoro-4-(4-fluorophenyl)quinoline
Show/Hide
|
C21H11Cl2F2NO2S
|
1
|
| 1 |
IC50 = 25 nM
|
|
|
|
CP0505131
|
1-[2-(3-bromophenyl)ethynyl]-3-methyl-7-(trifluoromethyl)pyrrolo[1,2-a]pyrazine
Show/Hide
|
C17H10BrF3N2
|
1
|
| 1 |
IC50 = 25.12 nM
|
|
|
|
CP0449613
|
4-(3,5-difluorophenylethynyl)-2-methylthiazole
Show/Hide
|
C12H7F2NS
|
1
|
| 1 |
IC50 = 25.3 nM
|
|
|
|
CP0548763
|
3-(3-chloro-4-fluorophenyl)sulfonyl-4-(4-chlorophenyl)-7-fluoroquinoline
Show/Hide
|
C21H11Cl2F2NO2S
|
1
|
| 1 |
IC50 = 27 nM
|
|
|
|
CP0405958
|
methyl (1R,5S)-3-[2-(3-chlorophenyl)ethynyl]-3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate
Show/Hide
|
C17H18ClNO3
|
1
|
| 1 |
IC50 = 27.4 nM
|
|
|
|
CP0489744
|
7-methyl-3-(2-phenylethynyl)-7,8-dihydro-6H-quinolin-5-one
Show/Hide
|
C18H15NO
|
1
|
| 1 |
IC50 = 27.8 nM
|
|
|
|
CP0342238
|
3-Fluoro-5-(2-(pyridin-2-yl)-6,7-dihydrooxazolo[4,5-c]pyridin-5(4H)-yl)benzonitrile
Show/Hide
|
C18H13FN4O
|
1
|
| 1 |
IC50 = 28 nM
|
|
|
|
CP0394922
|
2-[2-(3-fluorophenyl)ethynyl]-6-methylpyridin-3-amine
Show/Hide
|
C14H11FN2
|
1
|
| 1 |
IC50 = 31.62 nM
|
|
|
|
CP0387780
|
2-(4-chloroanilino)-7-methyl-7,8-dihydro-6H-quinazolin-5-one
Show/Hide
|
C15H14ClN3O
|
1
|
| 1 |
IC50 = 34.3 nM
|
|
|
|
CP0571826
|
3-(3,5-dichlorophenyl)sulfonyl-7-fluoro-4-(3-fluorophenyl)quinoline
Show/Hide
|
C21H11Cl2F2NO2S
|
1
|
| 1 |
IC50 = 35 nM
|
|
|
|
CP0509551
|
4-(2-methoxyphenylethynyl)-2-methylthiazole
Show/Hide
|
C13H11NOS
|
1
|
| 1 |
IC50 = 36.3 nM
|
|
|
|
CP0461897
|
methyl 8-hydroxy-8-[2-(3-methylphenyl)ethynyl]-3-azabicyclo[4.2.0]octane-3-carboxylate
Show/Hide
|
C18H21NO3
|
1
|
| 1 |
IC50 = 36.5 nM
|
|
|
|
CP0457598
|
3-methyl-1-(2-phenylethynyl)-7-(trifluoromethyl)pyrrolo[1,2-a]pyrazine
Show/Hide
|
C17H11F3N2
|
1
|
| 1 |
IC50 = 39.81 nM
|
|
|
|
CP0477950
|
(2-methylpyrrolidin-1-yl)-[3-methyl-1-(2-thiophen-3-ylethynyl)pyrrolo[1,2-a]pyrazin-7-yl]methanone
Show/Hide
|
C20H19N3OS
|
1
|
| 1 |
IC50 = 39.81 nM
|
|
|
|
CP0377510
|
1-(2,6-dimethyl-[1,3]oxazolo[3,2-b][1,2,4]triazol-5-yl)ethyl N-phenylcarbamate
Show/Hide
|
C15H16N4O3
|
1
|
| 1 |
IC50 = 39.81 nM
|
|
|
|
CP0377511
|
[(1R)-1-(5-methyl-[1,3]thiazolo[2,3-c][1,2,4]triazol-6-yl)ethyl] N-(3-fluorophenyl)carbamate
Show/Hide
|
C14H13FN4O2S
|
1
|
| 1 |
IC50 = 39.81 nM
|
|
|
|
CP0377745
|
[(1R)-1-(6-methyl-[1,3]thiazolo[3,2-b][1,2,4]triazol-5-yl)ethyl] N-phenylcarbamate
Show/Hide
|
C14H14N4O2S
|
1
|
| 1 |
IC50 = 39.81 nM
|
|
|
|
CP0398845
|
1-[6-methyl-2-(trifluoromethyl)-[1,3]oxazolo[3,2-b][1,2,4]triazol-5-yl]ethyl N-phenylcarbamate
Show/Hide
|
C15H13F3N4O3
|
1
|
| 1 |
IC50 = 39.81 nM
|
|
|
|
CP0518387
|
1-(6-methyl-[1,3]oxazolo[3,2-b][1,2,4]triazol-5-yl)ethyl N-(3-chlorophenyl)carbamate
Show/Hide
|
C14H13ClN4O3
|
1
|
| 1 |
IC50 = 39.81 nM
|
|
|
|
CP0496067
|
propan-2-yl 4-[1-(2-fluoropyridin-3-yl)-5-methyltriazol-4-yl]-3,6-dihydro-2H-pyridine-1-carboxylate
Show/Hide
|
C17H20FN5O2
|
1
|
| 1 |
IC50 = 40 nM
|
|
|
|
CP0574458
|
3-(3,4-difluorophenyl)sulfonyl-7-fluoro-4-(4-fluorophenyl)quinoline
Show/Hide
|
C21H11F4NO2S
|
1
|
| 1 |
IC50 = 43 nM
|
|
|
|
CP0486441
|
2-[(6-chloropyridin-3-yl)amino]-7-methyl-7,8-dihydro-6H-quinazolin-5-one
Show/Hide
|
C14H13ClN4O
|
1
|
| 1 |
IC50 = 43.2 nM
|
|
|
|
CP0436587
|
2-chloro-3-[(2-methyl-4-thiazolyl)ethynyl]pyridine
Show/Hide
|
C11H7ClN2S
|
1
|
| 1 |
IC50 = 45.5 nM
|
|
|
|
CP0467456
|
methyl (1S,5R)-3-hydroxy-3-[2-(3-methylphenyl)ethynyl]-8-azabicyclo[3.2.1]octane-8-carboxylate
Show/Hide
|
C18H21NO3
|
1
|
| 1 |
IC50 = 46.6 nM
|
|
|
|
CP0469206
|
ethyl (1R,5S)-3-hydroxy-3-[2-(3-methylphenyl)ethynyl]-8-azabicyclo[3.2.1]octane-8-carboxylate
Show/Hide
|
C19H23NO3
|
1
|
| 1 |
IC50 = 47.8 nM
|
|
|
|
CP0449611
|
4-(3-methoxyphenylethynyl)-2-methylthiazole
Show/Hide
|
C13H11NOS
|
1
|
| 1 |
IC50 = 49 nM
|
|
|
|
CP0408028
|
N,3-dimethyl-1-(2-thiophen-3-ylethynyl)pyrrolo[1,2-a]pyrazine-7-carboxamide
Show/Hide
|
C16H13N3OS
|
1
|
| 1 |
IC50 = 50.12 nM
|
|
|
|
CP0433157
|
3-methyl-1-(2-thiophen-3-ylethynyl)pyrrolo[1,2-a]pyrazine-7-carboxamide
Show/Hide
|
C15H11N3OS
|
1
|
| 1 |
IC50 = 50.12 nM
|
|
|
|
CP0457595
|
3,7-dimethyl-1-(2-phenylethynyl)pyrrolo[1,2-a]pyrazine
Show/Hide
|
C17H14N2
|
1
|
| 1 |
IC50 = 50.12 nM
|
|
|
|
CP0516473
|
3-methyl-1-(2-pyridin-2-ylethynyl)-7-(trifluoromethyl)pyrrolo[1,2-a]pyrazine
Show/Hide
|
C16H10F3N3
|
1
|
| 1 |
IC50 = 50.12 nM
|
|
|
|
CP0551980
|
1-[2-(furan-3-yl)ethynyl]-3-methyl-7-(trifluoromethyl)pyrrolo[1,2-a]pyrazine
Show/Hide
|
C15H9F3N2O
|
1
|
| 1 |
IC50 = 50.12 nM
|
|
|
|
CP0500026
|
1-(6-methyl-[1,3]oxazolo[3,2-b][1,2,4]triazol-5-yl)ethyl N-(3-fluorophenyl)carbamate
Show/Hide
|
C14H13FN4O3
|
1
|
| 1 |
IC50 = 50.12 nM
|
|
|
|
CP0938224
|
Methyl 3-endo-hydroxy-3-(m-tolylethynyl)-8-azabicyclo[3.2.1]octane-8-carboxylate
Show/Hide
|
C18H21NO3
|
1
|
| 1 |
IC50 = 50.7 nM
|
|
|
|
CP0372668
|
3-Fluoro-5-(2-(pyridin-2-yl)-6,7-dihydrooxazolo[5,4-c]pyridin-5(4H)-yl)benzonitrile
Show/Hide
|
C18H13FN4O
|
1
|
| 1 |
IC50 = 54 nM
|
|
|
|
CP0504487
|
3-(2-(Pyridin-2-yl)-7,8-dihydro-4H-oxazolo[4,5-c]azepin-5(6H)-yl)benzonitril
Show/Hide
|
C19H16N4O
|
1
|
| 1 |
IC50 = 57 nM
|
|
|
|
CP0460173
|
3-bromo-5-[(2-methyl-4-thiazolyl)ethynyl]pyridine
Show/Hide
|
C11H7BrN2S
|
1
|
| 1 |
IC50 = 60 nM
|
|
|
|
CP0504484
|
3-(2-(Pyridin-2-yl)-6,7-dihydrooxazolo[4,5-c]pyridin-5(4H)-yl)-benzonitrile
Show/Hide
|
C18H14N4O
|
1
|
| 1 |
IC50 = 60 nM
|
|
|
|
CP0524910
|
methyl (1R,5S)-3-[2-(3-fluorophenyl)ethynyl]-3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate
Show/Hide
|
C17H18FNO3
|
1
|
| 1 |
IC50 = 61.3 nM
|
|
|
|
CP0412643
|
3,7-dimethyl-1-(2-thiophen-3-ylethynyl)pyrrolo[1,2-a]pyrazine
Show/Hide
|
C15H12N2S
|
1
|
| 1 |
IC50 = 63.1 nM
|
|
|
|
CP0428102
|
3-methyl-1-(2-thiophen-2-ylethynyl)-7-(trifluoromethyl)pyrrolo[1,2-a]pyrazine
Show/Hide
|
C15H9F3N2S
|
1
|
| 1 |
IC50 = 63.1 nM
|
|
|
|
CP0377512
|
1-(6-methyl-[1,3]oxazolo[3,2-b][1,2,4]triazol-5-yl)ethyl N-phenylcarbamate
Show/Hide
|
C14H14N4O3
|
1
|
| 1 |
IC50 = 63.1 nM
|
|
|
|
CP0498365
|
1-(5-methyl-[1,3]thiazolo[2,3-c][1,2,4]triazol-6-yl)ethyl N-(3-fluorophenyl)carbamate
Show/Hide
|
C14H13FN4O2S
|
1
|
| 1 |
IC50 = 63.1 nM
|
|
|
|
CP0473430
|
methyl (1S,5R)-3-[2-(3-methylphenyl)ethynyl]-8-azabicyclo[3.2.1]octane-8-carboxylate
Show/Hide
|
C18H21NO2
|
1
|
| 1 |
IC50 = 64.8 nM
|
|
|
|
CP0411355
|
7,7-dimethyl-3-(2-phenylethynyl)-6,8-dihydroquinolin-5-one
Show/Hide
|
C19H17NO
|
1
|
| 1 |
IC50 = 68.4 nM
|
|
|
|
CP0436588
|
3-[5-[(2-methyl-4-thiazolyl)ethynyl]-3-pyridyl]-2-propyn-1-ol
Show/Hide
|
C14H10N2OS
|
1
|
| 1 |
IC50 = 68.6 nM
|
|
|
|
CP0511761
|
8-fluoro-4-(4-fluorophenyl)-3-(3-fluorophenyl)sulfonylquinoline
Show/Hide
|
C21H12F3NO2S
|
1
|
| 1 |
IC50 = 69 nM
|
|
|
|
CP0394974
|
AFQ056
Show/Hide
|
C19H23NO3
|
1
|
| 1 |
IC50 = 71.6 nM
|
|
|
|
CP0461895
|
methyl (1R,5S)-3-[2-[3-(difluoromethoxy)phenyl]ethynyl]-3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate
Show/Hide
|
C18H19F2NO4
|
1
|
| 1 |
IC50 = 72.2 nM
|
|
|
|
CP0546270
|
3-(3,5-difluorophenyl)sulfonyl-7-fluoro-4-(3-fluorophenyl)quinoline
Show/Hide
|
C21H11F4NO2S
|
1
|
| 1 |
IC50 = 74 nM
|
|
|
|
CP0469205
|
methyl (1R,5S)-3-hydroxy-3-[2-(3-methoxyphenyl)ethynyl]-8-azabicyclo[3.2.1]octane-8-carboxylate
Show/Hide
|
C18H21NO4
|
1
|
| 1 |
IC50 = 76.3 nM
|
|
|
|
CP0509547
|
4-(3-fluorophenylethynyl)-2-thiazolylamine
Show/Hide
|
C11H7FN2S
|
1
|
| 1 |
IC50 = 78.6 nM
|
|
|
|
CP0422667
|
[3-methyl-1-(2-phenylethynyl)pyrrolo[1,2-a]pyrazin-7-yl]-pyrrolidin-1-ylmethanone
Show/Hide
|
C21H19N3O
|
1
|
| 1 |
IC50 = 79.43 nM
|
|
|
|
CP0428104
|
3-methyl-1-(2-pyridin-4-ylethynyl)-7-(trifluoromethyl)pyrrolo[1,2-a]pyrazine
Show/Hide
|
C16H10F3N3
|
1
|
| 1 |
IC50 = 79.43 nM
|
|
|
|
CP0505128
|
3-methyl-1-[2-[3-(trifluoromethyl)phenyl]ethynyl]pyrrolo[1,2-a]pyrazine-7-carboxamide
Show/Hide
|
C18H12F3N3O
|
1
|
| 1 |
IC50 = 79.43 nM
|
|
|
|
CP0551983
|
1-[2-(3-methoxyphenyl)ethynyl]-3-methyl-7-(trifluoromethyl)pyrrolo[1,2-a]pyrazine
Show/Hide
|
C18H13F3N2O
|
1
|
| 1 |
IC50 = 79.43 nM
|
|
|
|
CP0460208
|
2-Methyl-4-m-tolylethynyl-thiazole
Show/Hide
|
C13H11NS
|
1
|
| 1 |
IC50 = 82.6 nM
|
|
|
|
CP0484313
|
4-[(7-methyl-5-oxo-7,8-dihydro-6H-quinazolin-2-yl)amino]benzonitrile
Show/Hide
|
C16H14N4O
|
1
|
| 1 |
IC50 = 83.1 nM
|
|
|
|
CP0525639
|
methyl (1S,4S,5S)-5-hydroxy-5-[2-(3-methylphenyl)ethynyl]-2-azabicyclo[2.2.2]octane-2-carboxylate
Show/Hide
|
C18H21NO3
|
1
|
| 1 |
IC50 = 85 nM
|
|
|
|
CP0387974
|
methyl 10-hydroxy-10-[2-(3-methylphenyl)ethynyl]-1-azaspiro[5.5]undecane-1-carboxylate
Show/Hide
|
C21H27NO3
|
1
|
| 1 |
IC50 = 86.3 nM
|
|
|
|
CP0511762
|
4-(4-chlorophenyl)-3-(3,5-dichlorophenyl)sulfonyl-7-fluoroquinoline
Show/Hide
|
C21H11Cl3FNO2S
|
1
|
| 1 |
IC50 = 94 nM
|
|
|
|
CP0433155
|
(2-methylpiperidin-1-yl)-[3-methyl-1-(2-thiophen-3-ylethynyl)pyrrolo[1,2-a]pyrazin-7-yl]methanone
Show/Hide
|
C21H21N3OS
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0457591
|
1-[2-(3-fluorophenyl)ethynyl]-N,3-dimethylpyrrolo[1,2-a]pyrazine-7-carboxamide
Show/Hide
|
C18H14FN3O
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0457596
|
[3-methyl-1-(2-phenylethynyl)pyrrolo[1,2-a]pyrazin-7-yl]-(4-methylpiperazin-1-yl)methanone
Show/Hide
|
C22H22N4O
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0515060
|
1-[2-(3-chlorophenyl)ethynyl]-3-methyl-7-(trifluoromethyl)pyrrolo[1,2-a]pyrazine
Show/Hide
|
C17H10ClF3N2
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0537125
|
1-[2-(4-fluorophenyl)ethynyl]-3-methyl-7-(trifluoromethyl)pyrrolo[1,2-a]pyrazine
Show/Hide
|
C17H10F4N2
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0505988
|
2-(2-(Pyridin-2-yl)-6,7-dihydrooxazolo[4,5-c]pyridin-5(4H)-yl)-nicotinonitrile
Show/Hide
|
C17H13N5O
|
1
|
| 1 |
IC50 = 110 nM
|
|
|
|
CP0486440
|
7-methyl-2-[(6-methylpyridin-3-yl)amino]-7,8-dihydro-6H-quinazolin-5-one
Show/Hide
|
C15H16N4O
|
1
|
| 1 |
IC50 = 111 nM
|
|
|
|
CP0491782
|
2-(3-chloroanilino)-7,8-dihydro-6H-quinazolin-5-one
Show/Hide
|
C14H12ClN3O
|
1
|
| 1 |
IC50 = 120 nM
|
|
|
|
CP0411356
|
2-[4-(difluoromethoxy)anilino]-7-methyl-7,8-dihydro-6H-quinazolin-5-one
Show/Hide
|
C16H15F2N3O2
|
1
|
| 1 |
IC50 = 125 nM
|
|
|
|
CP0405054
|
1-[2-(2-fluorophenyl)ethynyl]-3-methyl-7-(trifluoromethyl)pyrrolo[1,2-a]pyrazine
Show/Hide
|
C17H10F4N2
|
1
|
| 1 |
IC50 = 125.89 nM
|
|
|
|
CP0433156
|
[1-[2-(2-fluorophenyl)ethynyl]-3-methylpyrrolo[1,2-a]pyrazin-7-yl]-morpholin-4-ylmethanone
Show/Hide
|
C21H18FN3O2
|
1
|
| 1 |
IC50 = 125.89 nM
|
|
|
|
CP0464876
|
(3,3-difluoropyrrolidin-1-yl)-[3-methyl-1-(2-thiophen-3-ylethynyl)pyrrolo[1,2-a]pyrazin-7-yl]methanone
Show/Hide
|
C19H15F2N3OS
|
1
|
| 1 |
IC50 = 125.89 nM
|
|
|
|
CP0471204
|
N,3-dimethyl-1-(2-phenylethynyl)pyrrolo[1,2-a]pyrazine-7-carboxamide
Show/Hide
|
C18H15N3O
|
1
|
| 1 |
IC50 = 125.89 nM
|
|
|
|
CP0505190
|
1-(5-methyl-[1,3]thiazolo[2,3-c][1,2,4]triazol-6-yl)ethyl N-phenylcarbamate
Show/Hide
|
C14H14N4O2S
|
1
|
| 1 |
IC50 = 125.89 nM
|
|
|
|
CP0515847
|
4-(3-chlorophenylethynyl)-2-methylthiazole
Show/Hide
|
C12H8ClNS
|
1
|
| 1 |
IC50 = 129 nM
|
|
|
|
CP0504486
|
3-(2-(pyridin-2-yl)-3aH-pyrrolo[3,4-d]oxazol-5(4H,6H,6aH)-yl)benzonitrile
Show/Hide
|
C17H14N4O
|
1
|
| 1 |
IC50 = 129 nM
|
|
|
|
CP0387843
|
(1R,5S)-3-hydroxy-N,N-dimethyl-3-[2-(3-methylphenyl)ethynyl]-8-azabicyclo[3.2.1]octane-8-carboxamide
Show/Hide
|
C19H24N2O2
|
1
|
| 1 |
IC50 = 132 nM
|
|
|
|
CP0072660
|
3-[4-(4-chlorophenyl)-7-fluoroquinolin-3-yl]sulfonylbenzonitrile
Show/Hide
|
C22H12ClFN2O2S
|
1
|
| 1 |
IC50 = 133 nM
|
|
|
|
CP0525634
|
methyl (1R,5S)-3-methoxy-3-[2-(3-methylphenyl)ethynyl]-8-azabicyclo[3.2.1]octane-8-carboxylate
Show/Hide
|
C19H23NO3
|
1
|
| 1 |
IC50 = 137 nM
|
|
|
|
CP0514222
|
4-(2-fluorophenylethynyl)-2-methylthiazole
Show/Hide
|
C12H8FNS
|
1
|
| 1 |
IC50 = 140 nM
|
|
|
|
CP0504485
|
3-fluoro-5-(2-(pyridin-2-yl)-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)benzonitrile
Show/Hide
|
C18H14FN5
|
1
|
| 1 |
IC50 = 153 nM
|
|
|
|
CP0403907
|
2-fluoro-4-[(7-methyl-5-oxo-7,8-dihydro-6H-quinazolin-2-yl)amino]benzonitrile
Show/Hide
|
C16H13FN4O
|
1
|
| 1 |
IC50 = 157 nM
|
|
|
|
CP0412887
|
(4-methylpiperazin-1-yl)-[3-methyl-1-(2-thiophen-3-ylethynyl)pyrrolo[1,2-a]pyrazin-7-yl]methanone
Show/Hide
|
C20H20N4OS
|
1
|
| 1 |
IC50 = 158.49 nM
|
|
|
|
CP0513762
|
3-methyl-1-(2-phenylethynyl)-7-(piperidin-1-ylmethyl)pyrrolo[1,2-a]pyrazine
Show/Hide
|
C22H23N3
|
1
|
| 1 |
IC50 = 158.49 nM
|
|
|
|
CP0525660
|
1-(2-phenylethynyl)-7-(trifluoromethyl)pyrrolo[1,2-a]pyrazine
Show/Hide
|
C16H9F3N2
|
1
|
| 1 |
IC50 = 158.49 nM
|
|
|
|
CP0530011
|
[3-methyl-1-[2-[3-(trifluoromethyl)phenyl]ethynyl]pyrrolo[1,2-a]pyrazin-7-yl]-pyrrolidin-1-ylmethanone
Show/Hide
|
C22H18F3N3O
|
1
|
| 1 |
IC50 = 158.49 nM
|
|
|
|
CP0537126
|
3,7-dimethyl-1-[2-[3-(trifluoromethyl)phenyl]ethynyl]pyrrolo[1,2-a]pyrazine
Show/Hide
|
C18H13F3N2
|
1
|
| 1 |
IC50 = 158.49 nM
|
|
|
|
CP0419607
|
3-(4-fluorophenyl)-5-[(2-methyl-4-thiazolyl)ethynyl]pyridine
Show/Hide
|
C17H11FN2S
|
1
|
| 1 |
IC50 = 162 nM
|
|
|
|
CP0473429
|
(1R,5S)-N'-cyano-3-hydroxy-N,N-dimethyl-3-[2-(3-methylphenyl)ethynyl]-8-azabicyclo[3.2.1]octane-8-carboximidamide
Show/Hide
|
C20H24N4O
|
1
|
| 1 |
IC50 = 168 nM
|
|
|
|
CP0424385
|
tert-butyl 4-[1-(3-fluoropyridin-2-yl)-5-methyltriazol-4-yl]-3,6-dihydro-2H-pyridine-1-carboxylate
Show/Hide
|
C18H22FN5O2
|
1
|
| 1 |
IC50 = 170 nM
|
|
|
|
CP0405968
|
2-[(1S,5R)-3-hydroxy-3-[2-(3-methylphenyl)ethynyl]-8-azabicyclo[3.2.1]octan-8-yl]pyridine-3-carbonitrile
Show/Hide
|
C22H21N3O
|
1
|
| 1 |
IC50 = 170 nM
|
|
|
|
CP0473211
|
methyl (4aR,7aS)-3,3-difluoro-4-hydroxy-4-[2-(3-methylphenyl)ethynyl]-2,4a,5,6,7,7a-hexahydrocyclopenta[b]pyridine-1-carboxylate
Show/Hide
|
C19H21F2NO3
|
1
|
| 1 |
IC50 = 180 nM
|
|
|
|
CP0388001
|
methyl (1R,5S)-3-[2-(3-cyanophenyl)ethynyl]-3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate
Show/Hide
|
C18H18N2O3
|
1
|
| 1 |
IC50 = 187 nM
|
|
|
|
CP0406007
|
methyl (4aS,7aR)-4-hydroxy-4-[2-(3-methylphenyl)ethynyl]-3,4a,5,6,7,7a-hexahydro-2H-cyclopenta[b]pyridine-1-carboxylate
Show/Hide
|
C19H23NO3
|
1
|
| 1 |
IC50 = 189 nM
|
|
|
|
CP0497427
|
2-ethynyl-3-[(2-methyl-4-thiazolyl)ethynyl]pyridine
Show/Hide
|
C13H8N2S
|
1
|
| 1 |
IC50 = 192 nM
|
|
|
|
CP0412646
|
4-[[3-methyl-1-(2-phenylethynyl)pyrrolo[1,2-a]pyrazin-7-yl]methyl]piperazin-2-one
Show/Hide
|
C21H20N4O
|
1
|
| 1 |
IC50 = 199.53 nM
|
|
|
|
CP0471201
|
ethyl 3-methyl-1-[2-[3-(trifluoromethyl)phenyl]ethynyl]pyrrolo[1,2-a]pyrazine-7-carboxylate
Show/Hide
|
C20H15F3N2O2
|
1
|
| 1 |
IC50 = 199.53 nM
|
|
|
|
CP0516471
|
[1-[2-(3-fluorophenyl)ethynyl]-3-methylpyrrolo[1,2-a]pyrazin-7-yl]-(4-methylpiperazin-1-yl)methanone
Show/Hide
|
C22H21FN4O
|
1
|
| 1 |
IC50 = 199.53 nM
|
|
|
|
CP0516472
|
N,3-dimethyl-1-[2-[3-(trifluoromethyl)phenyl]ethynyl]pyrrolo[1,2-a]pyrazine-7-carboxamide
Show/Hide
|
C19H14F3N3O
|
1
|
| 1 |
IC50 = 199.53 nM
|
|
|
|
CP0487770
|
azetidin-1-yl-[(1R,5S)-3-hydroxy-3-[2-(3-methylphenyl)ethynyl]-8-azabicyclo[3.2.1]octan-8-yl]methanone
Show/Hide
|
C20H24N2O2
|
1
|
| 1 |
IC50 = 210 nM
|
|
|
|
CP0449606
|
3-(4-methoxyphenyl)-5-[(2-methyl-4-thiazolyl)ethynyl]pyridine
Show/Hide
|
C18H14N2OS
|
1
|
| 1 |
IC50 = 225 nM
|
|
|
|
CP0447746
|
methyl 4-hydroxy-4-[2-(3-methylphenyl)ethynyl]-2,3,4a,5,6,7,8,8a-octahydroquinoline-1-carboxylate
Show/Hide
|
C20H25NO3
|
1
|
| 1 |
IC50 = 227 nM
|
|
|
|
CP0497187
|
2-methoxy-3-[(2-methyl-4-thiazolyl)ethynyl]pyridine
Show/Hide
|
C12H10N2OS
|
1
|
| 1 |
IC50 = 228 nM
|
|
|
|
CP0397665
|
2-(4-chloroanilino)-7,7-dimethyl-6,8-dihydroquinazolin-5-one
Show/Hide
|
C16H16ClN3O
|
1
|
| 1 |
IC50 = 245 nM
|
|
|
|
CP0412888
|
(4-methylpiperazin-1-yl)-[3-methyl-1-[2-[3-(trifluoromethyl)phenyl]ethynyl]pyrrolo[1,2-a]pyrazin-7-yl]methanone
Show/Hide
|
C23H21F3N4O
|
1
|
| 1 |
IC50 = 251.19 nM
|
|
|
|
CP0505127
|
[1-[2-(2-fluorophenyl)ethynyl]-3-methylpyrrolo[1,2-a]pyrazin-7-yl]-pyrrolidin-1-ylmethanone
Show/Hide
|
C21H18FN3O
|
1
|
| 1 |
IC50 = 251.19 nM
|
|
|
|
CP0514221
|
2-methyl-4-[[3-(trifluoromethoxy)phenyl]ethynyl]thiazole
Show/Hide
|
C13H8F3NOS
|
1
|
| 1 |
IC50 = 266 nM
|
|
|
|
CP0397661
|
3-[(5-oxo-7,8-dihydro-6H-quinazolin-2-yl)amino]benzonitrile
Show/Hide
|
C15H12N4O
|
1
|
| 1 |
IC50 = 272 nM
|
|
|
|
CP0454225
|
3-(2-(Pyridin-2-yl)-6,7-dihydrooxazolo[5,4-c]pyridin-5(4H)-yl)-benzonitrile
Show/Hide
|
C18H14N4O
|
1
|
| 1 |
IC50 = 290 nM
|
|
|
|
CP0388002
|
methyl (1S,5R)-3-hydroxy-3-(2-phenylethynyl)-8-azabicyclo[3.2.1]octane-8-carboxylate
Show/Hide
|
C17H19NO3
|
1
|
| 1 |
IC50 = 298 nM
|
|
|
|
CP0524129
|
methyl 2-hydroxy-2-[2-(3-methylphenyl)ethynyl]-7-azaspiro[3.5]nonane-7-carboxylate
Show/Hide
|
C19H23NO3
|
1
|
| 1 |
IC50 = 306 nM
|
|
|
|
CP0405969
|
1-[(1S,5R)-3-hydroxy-3-[2-(3-methylphenyl)ethynyl]-8-azabicyclo[3.2.1]octan-8-yl]-2,2-dimethylpropan-1-one
Show/Hide
|
C21H27NO2
|
1
|
| 1 |
IC50 = 308 nM
|
|
|
|
CP0373023
|
[(2S,6R)-2,6-dimethylmorpholin-4-yl]-[3-methyl-1-(2-thiophen-3-ylethynyl)pyrrolo[1,2-a]pyrazin-7-yl]methanone
Show/Hide
|
C21H21N3O2S
|
1
|
| 1 |
IC50 = 316.23 nM
|
|
|
|
CP0394920
|
1-[4-[[3-methyl-1-(2-phenylethynyl)pyrrolo[1,2-a]pyrazin-7-yl]methyl]piperazin-1-yl]ethanone
Show/Hide
|
C23H24N4O
|
1
|
| 1 |
IC50 = 316.23 nM
|
|
|
|
CP0516476
|
3-methyl-7-(trifluoromethyl)-1-[2-[3-(trifluoromethyl)phenyl]ethynyl]pyrrolo[1,2-a]pyrazine
Show/Hide
|
C18H10F6N2
|
1
|
| 1 |
IC50 = 316.23 nM
|
|
|
|
CP0530013
|
ethyl 1-[2-(2-fluorophenyl)ethynyl]-3-methylpyrrolo[1,2-a]pyrazine-7-carboxylate
Show/Hide
|
C19H15FN2O2
|
1
|
| 1 |
IC50 = 316.23 nM
|
|
|
|
CP0551986
|
3-[2-(3-methylpyrrolo[1,2-a]pyrazin-1-yl)ethynyl]phenol
Show/Hide
|
C16H12N2O
|
1
|
| 1 |
IC50 = 316.23 nM
|
|
|
|
CP0466753
|
1-(6-methyl-[1,3]thiazolo[3,2-b][1,2,4]triazol-5-yl)ethyl N-pyridin-3-ylcarbamate
Show/Hide
|
C13H13N5O2S
|
1
|
| 1 |
IC50 = 316.23 nM
|
|
|
|
CP0488870
|
5-Phenyl-2-(pyridin-2-yl)-4,5,6,7-tetrahydrooxazolo[4,5-c]pyridine
Show/Hide
|
C17H15N3O
|
1
|
| 1 |
IC50 = 330 nM
|
|
|
|
CP0491917
|
2-methyl-4-(3-thienylethynyl)thiazole
Show/Hide
|
C10H7NS2
|
1
|
| 1 |
IC50 = 337 nM
|
|
|
|
CP0473215
|
methyl 8-hydroxy-8-[2-(3-methylphenyl)ethynyl]-5-azaspiro[3.5]nonane-5-carboxylate
Show/Hide
|
C19H23NO3
|
1
|
| 1 |
IC50 = 340 nM
|
|
|
|
CP0527134
|
3-Fluoro-5-(2-(pyridin-2-yl)-5,6-dihydro-[1,2,4]triazolo[1,5-a]-pyrazin-7(8H)-yl)benzonitrile
Show/Hide
|
C17H13FN6
|
1
|
| 1 |
IC50 = 346 nM
|
|
|
|
CP0394918
|
1-[2-(4-fluorophenyl)ethynyl]-3,7-dimethylpyrrolo[1,2-a]pyrazine
Show/Hide
|
C17H13FN2
|
1
|
| 1 |
IC50 = 398.11 nM
|
|
|
|
CP0507789
|
ethyl 1-[2-(4-fluorophenyl)ethynyl]-3-methylpyrrolo[1,2-a]pyrazine-7-carboxylate
Show/Hide
|
C19H15FN2O2
|
1
|
| 1 |
IC50 = 398.11 nM
|
|
|
|
CP0516470
|
(2,5-dimethylpyrrolidin-1-yl)-[3-methyl-1-(2-thiophen-3-ylethynyl)pyrrolo[1,2-a]pyrazin-7-yl]methanone
Show/Hide
|
C21H21N3OS
|
1
|
| 1 |
IC50 = 398.11 nM
|
|
|
|
CP0509550
|
2-methyl-4-[[3-(trifluoromethyl)phenyl]ethynyl]thiazole
Show/Hide
|
C13H8F3NS
|
1
|
| 1 |
IC50 = 413 nM
|
|
|
|
CP0428301
|
2-methoxy-5-(2-(2-methylthiazol-4-yl)ethynyl)pyridine
Show/Hide
|
C12H10N2OS
|
1
|
| 1 |
IC50 = 426 nM
|
|
|
|
CP0482474
|
N-(3-chlorophenyl)-5,6,7,8-tetrahydroquinazolin-2-amine
Show/Hide
|
C14H14ClN3
|
1
|
| 1 |
IC50 = 452 nM
|
|
|
|
CP0098719
|
2-methyl-4-(pyridin-3-ylethynyl)thiazole
Show/Hide
|
C11H8N2S
|
1
|
| 1 |
IC50 = 462 nM
|
|
|
|
CP0432621
|
2-methyl-4-(2-thienylethynyl)thiazole
Show/Hide
|
C10H7NS2
|
1
|
| 1 |
IC50 = 475 nM
|
|
|
|
CP0470416
|
7,7-dimethyl-2-(4-methylanilino)-6,8-dihydroquinazolin-5-one
Show/Hide
|
C17H19N3O
|
1
|
| 1 |
IC50 = 492 nM
|
|
|
|
CP0486443
|
4-[(7,7-dimethyl-5-oxo-6,8-dihydroquinazolin-2-yl)amino]benzonitrile
Show/Hide
|
C17H16N4O
|
1
|
| 1 |
IC50 = 493 nM
|
|
|
|
CP0429194
|
2-(3-methylanilino)-7,8-dihydro-6H-quinazolin-5-one
Show/Hide
|
C15H15N3O
|
1
|
| 1 |
IC50 = 496 nM
|
|
|
|
CP0505129
|
1-[2-(2-fluorophenyl)ethynyl]-3-methylpyrrolo[1,2-a]pyrazine-7-carboxamide
Show/Hide
|
C17H12FN3O
|
1
|
| 1 |
IC50 = 501.19 nM
|
|
|
|
CP0510652
|
3-methyl-1-(2-pyridin-3-ylethynyl)-7-(trifluoromethyl)pyrrolo[1,2-a]pyrazine
Show/Hide
|
C16H10F3N3
|
1
|
| 1 |
IC50 = 501.19 nM
|
|
|
|
CP0537127
|
3-methyl-7-[(4-methylpiperazin-1-yl)methyl]-1-(2-phenylethynyl)pyrrolo[1,2-a]pyrazine
Show/Hide
|
C22H24N4
|
1
|
| 1 |
IC50 = 501.19 nM
|
|
|
|
CP0439318
|
1-(6-methyl-[1,3]oxazolo[3,2-b][1,2,4]triazol-5-yl)ethyl N-(2-chlorophenyl)carbamate
Show/Hide
|
C14H13ClN4O3
|
1
|
| 1 |
IC50 = 501.19 nM
|
|
|
|
CP0514218
|
2-bromo-4-(3-fluorophenylethynyl)thiazole
Show/Hide
|
C11H5BrFNS
|
1
|
| 1 |
IC50 = 526 nM
|
|
|
|
CP0405970
|
1-[(1S,5R)-3-hydroxy-3-[2-(3-methylphenyl)ethynyl]-8-azabicyclo[3.2.1]octan-8-yl]ethanone
Show/Hide
|
C18H21NO2
|
1
|
| 1 |
IC50 = 543 nM
|
|
|
|
CP0540410
|
(1R,5S)-3-[2-(3-methylphenyl)ethynyl]-8-methylsulfonyl-8-azabicyclo[3.2.1]octan-3-ol
Show/Hide
|
C17H21NO3S
|
1
|
| 1 |
IC50 = 575 nM
|
|
|
|
CP0397663
|
2-(4-methoxyanilino)-7-methyl-7,8-dihydro-6H-quinazolin-5-one
Show/Hide
|
C16H17N3O2
|
1
|
| 1 |
IC50 = 598 nM
|
|
|
|
CP0394911
|
[(1R,4S)-2-azabicyclo[2.2.1]heptan-2-yl]-[3-methyl-1-(2-thiophen-3-ylethynyl)pyrrolo[1,2-a]pyrazin-7-yl]methanone
Show/Hide
|
C21H19N3OS
|
1
|
| 1 |
IC50 = 630.96 nM
|
|
|
|
CP0537128
|
1-[2-(4-chlorophenyl)ethynyl]-3-methylpyrrolo[1,2-a]pyrazine
Show/Hide
|
C16H11ClN2
|
1
|
| 1 |
IC50 = 630.96 nM
|
|
|
|
CP0372667
|
2-(2-(Pyridin-2-yl)-6,7-dihydrooxazolo[5,4-c]pyridin-5(4H)-yl)-nicotinonitrile
Show/Hide
|
C17H13N5O
|
1
|
| 1 |
IC50 = 640 nM
|
|
|
|
CP0449610
|
3-[(2-methyl-4-thiazolyl)ethynyl]phenol
Show/Hide
|
C12H9NOS
|
1
|
| 1 |
IC50 = 654 nM
|
|
|
|
CP0449608
|
3-[(2,5-dimethyl-4-thiazolyl)ethynyl]pyridine
Show/Hide
|
C12H10N2S
|
1
|
| 1 |
IC50 = 698 nM
|
|
|
|
CP0554579
|
2-[(5-chloropyridin-2-yl)amino]-7-methyl-7,8-dihydro-6H-quinazolin-5-one
Show/Hide
|
C14H13ClN4O
|
1
|
| 1 |
IC50 = 721 nM
|
|
|
|
CP0554581
|
2-(4-chloroanilino)-7,8-dihydro-6H-quinazolin-5-one
Show/Hide
|
C14H12ClN3O
|
1
|
| 1 |
IC50 = 722 nM
|
|
|
|
CP0462913
|
4-(3-pyridylethynyl)-2-thiazolylamine
Show/Hide
|
C10H7N3S
|
1
|
| 1 |
IC50 = 789 nM
|
|
|
|
CP0433162
|
4-[3-[2-[3-methyl-7-(trifluoromethyl)pyrrolo[1,2-a]pyrazin-1-yl]ethynyl]phenyl]-1,2-oxazole
Show/Hide
|
C20H12F3N3O
|
1
|
| 1 |
IC50 = 794.33 nM
|
|
|
|
CP0516475
|
N-[3-[2-[3-methyl-7-(trifluoromethyl)pyrrolo[1,2-a]pyrazin-1-yl]ethynyl]phenyl]acetamide
Show/Hide
|
C19H14F3N3O
|
1
|
| 1 |
IC50 = 794.33 nM
|
|
|
|
CP0524128
|
methyl 3-hydroxy-3-[2-(3-methylphenyl)ethynyl]-1-oxa-8-azaspiro[4.5]decane-8-carboxylate
Show/Hide
|
C19H23NO4
|
1
|
| 1 |
IC50 = 813 nM
|
|
|
|
CP0530997
|
methyl (1R,5S)-3-hydroxy-3-[2-(6-methylpyridin-2-yl)ethynyl]-8-azabicyclo[3.2.1]octane-8-carboxylate
Show/Hide
|
C17H20N2O3
|
1
|
| 1 |
IC50 = 818 nM
|
|
|
|
CP0432397
|
tert-butyl 4-(1-phenyltriazol-4-yl)-3,6-dihydro-2H-pyridine-1-carboxylate
Show/Hide
|
C18H22N4O2
|
1
|
| 1 |
IC50 = 820 nM
|
|
|
|
CP0501123
|
2-fluoro-5-[(2-methyl-4-thiazolyl)ethynyl]pyridine
Show/Hide
|
C11H7FN2S
|
1
|
| 1 |
IC50 = 833 nM
|
|
|
|
CP0375350
|
tert-butyl 4-[1-(2-methylphenyl)triazol-4-yl]-3,6-dihydro-2H-pyridine-1-carboxylate
Show/Hide
|
C19H24N4O2
|
1
|
| 1 |
IC50 = 880 nM
|
|
|
|
CP0473214
|
methyl 6-hydroxy-6-[2-(3-methylphenyl)ethynyl]-3,3a,4,5,7,7a-hexahydro-1H-isoindole-2-carboxylate
Show/Hide
|
C19H23NO3
|
1
|
| 1 |
IC50 = 930 nM
|
|
|
|
CP0462915
|
5-[(2-methyl-4-thiazolyl)ethynyl]pyrimidine
Show/Hide
|
C10H7N3S
|
1
|
| 1 |
IC50 = 946 nM
|
|
|
|
CP0485591
|
tert-butyl 4-[1-(2-fluorophenyl)triazol-4-yl]-3,6-dihydro-2H-pyridine-1-carboxylate
Show/Hide
|
C18H21FN4O2
|
1
|
| 1 |
IC50 = 1000 nM
|
|
|
|
CP0491918
|
3-[(2-methyl-4-thiazolyl)ethynyl]benzamide
Show/Hide
|
C13H10N2OS
|
1
|
| 1 |
IC50 = 1000 nM
|
|
|
|
CP0524130
|
methyl (3aR,7aS)-7-hydroxy-7-[2-(3-methylphenyl)ethynyl]-3,3a,4,5,6,7a-hexahydro-1H-isoindole-2-carboxylate
Show/Hide
|
C19H23NO3
|
1
|
| 1 |
IC50 = 1010 nM
|
|
|
|
CP0851945
|
endo-Methyl 3-hydroxy-3-(m-tolylethynyl)-9-azabicyclo[3.3.1]nonane-9-carboxylate
Show/Hide
|
C19H23NO3
|
1
|
| 1 |
IC50 = 1020 nM
|
|
|
|
CP0478808
|
8,8-dimethyl-2-(3-methylanilino)-6,7-dihydroquinazolin-5-one
Show/Hide
|
C17H19N3O
|
1
|
| 1 |
IC50 = 1040 nM
|
|
|
|
CP0514220
|
5-fluoro-2-[(2-methyl-4-thiazolyl)ethynyl]pyridine
Show/Hide
|
C11H7FN2S
|
1
|
| 1 |
IC50 = 1093 nM
|
|
|
|
CP0375349
|
tert-butyl 4-[1-(4-fluorophenyl)triazol-4-yl]-3,6-dihydro-2H-pyridine-1-carboxylate
Show/Hide
|
C18H21FN4O2
|
1
|
| 1 |
IC50 = 1100 nM
|
|
|
|
CP0480578
|
tert-butyl 4-[1-(3-fluorophenyl)triazol-4-yl]-3,6-dihydro-2H-pyridine-1-carboxylate
Show/Hide
|
C18H21FN4O2
|
1
|
| 1 |
IC50 = 1100 nM
|
|
|
|
CP0447565
|
2-ethyl-5-(1-(2-fluoropyridin-3-yl)-5-methyl-1H-1,2,3-triazol-4-yl)isoindolin-1-one
Show/Hide
|
C18H16FN5O
|
1
|
| 1 |
IC50 = 1100 nM
|
|
|
|
CP0525618
|
2-(4-chloroanilino)-7-ethyl-7,8-dihydro-6H-quinazolin-5-one
Show/Hide
|
C16H16ClN3O
|
1
|
| 1 |
IC50 = 1120 nM
|
|
|
|
CP0554578
|
7-methyl-2-[(4-methylcyclohexyl)amino]-7,8-dihydro-6H-quinazolin-5-one
Show/Hide
|
C16H23N3O
|
1
|
| 1 |
IC50 = 1130 nM
|
|
|
|
CP0492160
|
2-(2-Phenyl-6,7-dihydrooxazolo[4,5-c]pyridin-5(4H)-yl)nicotinonitrile
Show/Hide
|
C18H14N4O
|
1
|
| 1 |
IC50 = 1200 nM
|
|
|
|
CP0509549
|
3-[(5-ethyl-2-methyl-4-thiazolyl)ethynyl]pyridine
Show/Hide
|
C13H12N2S
|
1
|
| 1 |
IC50 = 1243 nM
|
|
|
|
CP0372869
|
[1-[2-(2-fluorophenyl)ethynyl]-3-methylpyrrolo[1,2-a]pyrazin-7-yl]-(4-methylpiperazin-1-yl)methanone
Show/Hide
|
C22H21FN4O
|
1
|
| 1 |
IC50 = 1258.93 nM
|
|
|
|
CP0405169
|
(2,2-dimethylpyrrolidin-1-yl)-[3-methyl-1-(2-thiophen-3-ylethynyl)pyrrolo[1,2-a]pyrazin-7-yl]methanone
Show/Hide
|
C21H21N3OS
|
1
|
| 1 |
IC50 = 1258.93 nM
|
|
|
|
CP0477952
|
ethyl 3-methyl-1-(2-pyridin-3-ylethynyl)pyrrolo[1,2-a]pyrazine-7-carboxylate
Show/Hide
|
C18H15N3O2
|
1
|
| 1 |
IC50 = 1584.89 nM
|
|
|
|
CP0530012
|
1-[2-(2-fluorophenyl)ethynyl]-N,3-dimethylpyrrolo[1,2-a]pyrazine-7-carboxamide
Show/Hide
|
C18H14FN3O
|
1
|
| 1 |
IC50 = 1584.89 nM
|
|
|
|
CP0514219
|
2-[(2-methyl-4-thiazolyl)ethynyl]pyrazine
Show/Hide
|
C10H7N3S
|
1
|
| 1 |
IC50 = 1830 nM
|
|
|
|
CP0515844
|
N-[4-(2-pyridin-3-ylethynyl)-1,3-thiazol-2-yl]acetamide
Show/Hide
|
C12H9N3OS
|
1
|
| 1 |
IC50 = 1920 nM
|
|
|
|
CP0394916
|
3,7-dimethyl-1-(2-pyridin-3-ylethynyl)pyrrolo[1,2-a]pyrazine
Show/Hide
|
C16H13N3
|
1
|
| 1 |
IC50 = 1995.26 nM
|
|
|
|
CP0394921
|
3-methyl-1-(2-pyrimidin-5-ylethynyl)pyrrolo[1,2-a]pyrazine
Show/Hide
|
C14H10N4
|
1
|
| 1 |
IC50 = 1995.26 nM
|
|
|
|
CP0551982
|
1-[2-(4-chlorophenyl)ethynyl]-3-methyl-7-(trifluoromethyl)pyrrolo[1,2-a]pyrazine
Show/Hide
|
C17H10ClF3N2
|
1
|
| 1 |
IC50 = 1995.26 nM
|
|
|
|
CP0394688
|
N-[3-[2-(2-methyl-1,3-thiazol-4-yl)ethynyl]phenyl]acetamide
Show/Hide
|
C14H12N2OS
|
1
|
| 1 |
IC50 = 2020 nM
|
|
|
|
CP0406003
|
methyl (1S,5R)-3-[2-(4-fluorophenyl)ethynyl]-3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate
Show/Hide
|
C17H18FNO3
|
1
|
| 1 |
IC50 = 2190 nM
|
|
|
|
CP0397667
|
2-(3-fluoroanilino)-7,8-dihydro-6H-quinazolin-5-one
Show/Hide
|
C14H12FN3O
|
1
|
| 1 |
IC50 = 2230 nM
|
|
|
|
CP0397153
|
5-(1-(2-fluoropyridin-3-yl)-5-methyl-1H-1,2,3-triazol-4-yl)-2-isopropylisoindolin-1-one
Show/Hide
|
C19H18FN5O
|
1
|
| 1 |
IC50 = 2300 nM
|
|
|
|
CP0486950
|
[5-[2-(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridin-2-yl] methanesulfonate
Show/Hide
|
C12H10N2O3S2
|
1
|
| 1 |
IC50 = 2340 nM
|
|
|
|
CP0527169
|
1-(6-methyl-[1,3]oxazolo[3,2-b][1,2,4]triazol-5-yl)ethyl N-(4-chlorophenyl)carbamate
Show/Hide
|
C14H13ClN4O3
|
1
|
| 1 |
IC50 = 2511.89 nM
|
|
|
|
CP0499666
|
N-(4-fluorophenyl)-4,5,6,7-tetrahydro-1,3-benzothiazol-2-amine
Show/Hide
|
C13H13FN2S
|
1
|
| 1 |
IC50 = 2570 nM
|
|
|
|
CP0527196
|
3-(2-(Pyridin-2-yl)-4,5,6,7-tetrahydrooxazolo[5,4-c]pyridine-5-carbonyl)benzonitrile
Show/Hide
|
C19H14N4O2
|
1
|
| 1 |
IC50 = 2600 nM
|
|
|
|
CP0485274
|
5-(1-(2-fluoropyridin-3-yl)-5-methyl-1H-1,2,3-triazol-4-yl)-2-propylisoindolin-1-one
Show/Hide
|
C19H18FN5O
|
1
|
| 1 |
IC50 = 2800 nM
|
|
|
|
CP0515841
|
2-ethynyl-4-(3-fluorophenylethynyl)thiazole
Show/Hide
|
C13H6FNS
|
1
|
| 1 |
IC50 = 2920 nM
|
|
|
|
CP0562437
|
3-ethynyl-5-[(2-methyl-4-thiazolyl)ethynyl]pyridine
Show/Hide
|
C13H8N2S
|
1
|
| 1 |
IC50 = 2950 nM
|
|
|
|
CP0392191
|
4-(2-(4-fluorophenyl)ethynyl)-2-methylthiazole
Show/Hide
|
C12H8FNS
|
1
|
| 1 |
IC50 = 2966 nM
|
|
|
|
CP0449605
|
(E)-3-[2-(2-methyl-4-thiazolyl)vinyl]pyridine
Show/Hide
|
C11H10N2S
|
1
|
| 1 |
IC50 = 3090 nM
|
|
|
|
CP0533182
|
1-(6-methyl-[1,3]oxazolo[3,2-b][1,2,4]triazol-5-yl)ethyl N-cyclohexylcarbamate
Show/Hide
|
C14H20N4O3
|
1
|
| 1 |
IC50 = 3162.28 nM
|
|
|
|
CP0523027
|
methyl (1S,5R)-9-hydroxy-9-[2-(3-methylphenyl)ethynyl]-3-oxa-7-azabicyclo[3.3.1]nonane-7-carboxylate
Show/Hide
|
C18H21NO4
|
1
|
| 1 |
IC50 = 3350 nM
|
|
|
|
CP0494547
|
propan-2-yl 4-[1-(2-fluoropyridin-3-yl)triazol-4-yl]-3,6-dihydro-2H-pyridine-1-carboxylate
Show/Hide
|
C16H18FN5O2
|
1
|
| 1 |
IC50 = 3900 nM
|
|
|
|
CP0372868
|
[(1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl]-[3-methyl-1-(2-thiophen-3-ylethynyl)pyrrolo[1,2-a]pyrazin-7-yl]methanone
Show/Hide
|
C21H20N4OS
|
1
|
| 1 |
IC50 = 3981.07 nM
|
|
|
|
CP0461398
|
tert-butyl 4-[1-(2-methoxyphenyl)triazol-4-yl]-3,6-dihydro-2H-pyridine-1-carboxylate
Show/Hide
|
C19H24N4O3
|
1
|
| 1 |
IC50 = 4000 nM
|
|
|
|
CP0461399
|
tert-butyl 4-[1-(3-fluoropyridin-2-yl)triazol-4-yl]-3,6-dihydro-2H-pyridine-1-carboxylate
Show/Hide
|
C17H20FN5O2
|
1
|
| 1 |
IC50 = 4300 nM
|
|
|
|
CP0489365
|
N-(4-chlorophenyl)-5,6,7,8-tetrahydroquinazolin-2-amine
Show/Hide
|
C14H14ClN3
|
1
|
| 1 |
IC50 = 4710 nM
|
|
|
|
CP0408031
|
3-methyl-1-[2-(3-thiophen-3-ylphenyl)ethynyl]-7-(trifluoromethyl)pyrrolo[1,2-a]pyrazine
Show/Hide
|
C21H13F3N2S
|
1
|
| 1 |
IC50 = 5011.87 nM
|
|
|
|
CP0471202
|
1-[2-(2-chlorophenyl)ethynyl]-3-methyl-7-(trifluoromethyl)pyrrolo[1,2-a]pyrazine
Show/Hide
|
C17H10ClF3N2
|
1
|
| 1 |
IC50 = 5011.87 nM
|
|
|
|
CP0500025
|
1-(6-methyl-[1,3]oxazolo[3,2-b][1,2,4]triazol-5-yl)ethyl N-(3,4-dichlorophenyl)carbamate
Show/Hide
|
C14H12Cl2N4O3
|
1
|
| 1 |
IC50 = 5011.87 nM
|
|
|
|
CP0377707
|
3-cyano-N-(6-methylpyridin-2-yl)benzamide
Show/Hide
|
C14H11N3O
|
1
|
| 1 |
IC50 = 5330 nM
|
|
|
|
CP0494285
|
2-cyclopropyl-5-(1-(2-fluoropyridin-3-yl)-5-methyl-1H-1,2,3-triazol-4-yl)isoindolin-1-one
Show/Hide
|
C19H16FN5O
|
1
|
| 1 |
IC50 = 5400 nM
|
|
|
|
CP0529102
|
3-bromo-N-(6-methylpyridin-2-yl)benzamide
Show/Hide
|
C13H11BrN2O
|
1
|
| 1 |
IC50 = 5480 nM
|
|
|
|
CP0528195
|
3-methyl-N-(6-methylpyridin-2-yl)benzamide
Show/Hide
|
C14H14N2O
|
1
|
| 1 |
IC50 = 5900 nM
|
|
|
|
CP0486442
|
2-(3-chloroanilino)-7-methyl-7,8-dihydro-6H-quinazolin-5-one
Show/Hide
|
C15H14ClN3O
|
1
|
| 1 |
IC50 = 6160 nM
|
|
|
|
CP0344016
|
4-(1-(2-fluoropyridin-3-yl)-5-methyl-1H-1,2,3-triazol-4-yl)-N-isopropyl-N-methyl-5,6-dihydropyridine-1(2H)-carboxamide
Show/Hide
|
C18H23FN6O
|
2
|
| 1 |
IC50 = 6200 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0495987
|
4-fluoro-N-methyl-N-(4-(pyrimidin-5-yl)thiazol-2-yl)benzamide
Show/Hide
|
C15H11FN4OS
|
1
|
| 1 |
IC50 = 6600 nM
|
|
|
|
CP0071075
|
4-fluoro-N-(4-(6-(isopropylamino)pyrimidin-4-yl)thiazol-2-yl)-N-methylbenzamide
Show/Hide
|
C18H18FN5OS
|
1
|
| 1 |
IC50 = 7000 nM
|
|
|
|
CP0054323
|
4-fluoro-N-methyl-N-(4-(6-(methylamino)pyrimidin-4-yl)thiazol-2-yl)benzamide
Show/Hide
|
C16H14FN5OS
|
1
|
| 1 |
IC50 = 7900 nM
|
|
|
|
CP0375446
|
tert-butyl 4-(1-pyridin-3-yltriazol-4-yl)-3,6-dihydro-2H-pyridine-1-carboxylate
Show/Hide
|
C17H21N5O2
|
1
|
| 1 |
IC50 = 8300 nM
|
|
|
|
CP0375445
|
N-tert-butyl-4-[1-(2-fluorophenyl)triazol-4-yl]-3,6-dihydro-2H-pyridine-1-carboxamide
Show/Hide
|
C18H22FN5O
|
1
|
| 1 |
IC50 = 8600 nM
|
|
|
|
CP0466996
|
methyl (3aS,6aR)-5-hydroxy-5-[2-(3-methylphenyl)ethynyl]-1,3,3a,4,6,6a-hexahydrocyclopenta[c]pyrrole-2-carboxylate
Show/Hide
|
C18H21NO3
|
1
|
| 1 |
IC50 = 8600 nM
|
|
|
|
CP0375353
|
tert-butyl 4-(1-pyridin-2-yltriazol-4-yl)-3,6-dihydro-2H-pyridine-1-carboxylate
Show/Hide
|
C17H21N5O2
|
1
|
| 1 |
IC50 = 8700 nM
|
|
|
|
CP0443608
|
N-[4-[6-(ethylamino)pyrimidin-4-yl]-1,3-thiazol-2-yl]-4-fluoro-N-methylbenzamide
Show/Hide
|
C17H16FN5OS
|
1
|
| 1 |
IC50 = 9200 nM
|
|
|
|
CP0424383
|
1-(3,3-Dimethylbutanolyl)-4-[1-(2-fluorophenyl)-1H-1,2,3-triazol-4-yl]-1,2,3,6-tetrahydorohydropyridine
Show/Hide
|
C19H23FN4O
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0424384
|
tert-butyl 4-(1-pyridin-4-yltriazol-4-yl)-3,6-dihydro-2H-pyridine-1-carboxylate
Show/Hide
|
C17H21N5O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0405053
|
1-[2-[3-(furan-3-yl)phenyl]ethynyl]-3-methyl-7-(trifluoromethyl)pyrrolo[1,2-a]pyrazine
Show/Hide
|
C21H13F3N2O
|
1
|
| 1 |
IC50 = 10000 nM
|
|
|
|
CP0394719
|
2-methylthiazole-4-carboxylic acid 3-fluorophenylamide
Show/Hide
|
C11H9FN2OS
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0436586
|
3-[(2-methyl-4-oxazolyl)ethynyl]pyridine
Show/Hide
|
C11H8N2O
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0460172
|
[3-[2-(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridin-2-yl] methanesulfonate
Show/Hide
|
C12H10N2O3S2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0462910
|
3-[4-(3-fluorophenylethynyl)-2-thiazolyl]-2-propyn-1-ol
Show/Hide
|
C14H8FNOS
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0462912
|
methyl N-[4-(2-pyridin-3-ylethynyl)-1,3-thiazol-2-yl]carbamate
Show/Hide
|
C12H9N3O2S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0486951
|
1-(2,4-difluorophenyl)-3-[4-(3-pyridylethynyl)-2-thiazolyl]-urea
Show/Hide
|
C17H10F2N4OS
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0491915
|
5-[(2-methyl-4-thiazolyl)ethynyl]-1H-indole
Show/Hide
|
C14H10N2S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0491916
|
6-[(2-methyl-4-thiazolyl)ethynyl]quinoxaline
Show/Hide
|
C14H9N3S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0496832
|
2-chloro-5-[(2-methyl-4-thiazolyl)ethynyl]pyridine
Show/Hide
|
C11H7ClN2S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0500673
|
2-(3,5-difluorophenyl)-4-(3-fluorophenylethynyl)thiazole
Show/Hide
|
C17H8F3NS
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0500674
|
N-benzyl-4-(2-pyridin-3-ylethynyl)-1,3-thiazol-2-amine
Show/Hide
|
C17H13N3S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0500675
|
3-[(2-methyl-4-thiazolyl)ethynyl]quinoline
Show/Hide
|
C15H10N2S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0509548
|
3-[(2-methyl-5-phenyl-4-thiazolyl)ethynyl]pyridine
Show/Hide
|
C17H12N2S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0514223
|
4-[(3-fluorophenyl)ethynyl]-2-methyloxazole
Show/Hide
|
C12H8FNO
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0515840
|
2-methylthiazole-4-carboxylic acid 3-pyridylamide
Show/Hide
|
C10H9N3OS
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0562436
|
5-[(2-methyl-4-thiazolyl)ethynyl]-2-vinylpyridine
Show/Hide
|
C13H10N2S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0452412
|
N-[4-(6-aminopyrimidin-4-yl)-1,3-thiazol-2-yl]-4-fluoro-N-methylbenzamide
Show/Hide
|
C15H12FN5OS
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
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CP0461231
|
4-fluoro-N-(4-(6-(isopropyl(methyl)amino)pyrimidin-4-yl)thiazol-2-yl)-N-methylbenzamide
Show/Hide
|
C19H20FN5OS
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0398847
|
[(1S)-1-(6-methyl-[1,3]thiazolo[3,2-b][1,2,4]triazol-5-yl)ethyl] N-phenylcarbamate
Show/Hide
|
C14H14N4O2S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0466793
|
1-([1,3]thiazolo[3,2-b][1,2,4]triazol-5-yl)ethyl N-phenylcarbamate
Show/Hide
|
C13H12N4O2S
|
1
|
| 1 |
IC50 = 10000 nM
|
|
|
|
CP0529731
|
3-iodo-N-(6-methylpyridin-2-yl)benzamide
Show/Hide
|
C13H11IN2O
|
1
|
| 1 |
IC50 = 10800 nM
|
|
|
|
CP0478809
|
3-fluoro-5-[(5-oxo-7,8-dihydro-6H-quinazolin-2-yl)amino]benzonitrile
Show/Hide
|
C15H11FN4O
|
1
|
| 1 |
IC50 = 11000 nM
|
|
|
|
CP0412648
|
4-[2-(3-methylpyrrolo[1,2-a]pyrazin-1-yl)ethynyl]isoquinoline
Show/Hide
|
C19H13N3
|
1
|
| 1 |
IC50 > 12589.25 nM
|
|
|
|
CP0433163
|
3-methyl-1-[2-[3-(1H-pyrazol-4-yl)phenyl]ethynyl]-7-(trifluoromethyl)pyrrolo[1,2-a]pyrazine
Show/Hide
|
C20H13F3N4
|
1
|
| 1 |
IC50 > 12589.25 nM
|
|
|
|
CP0433164
|
3-methyl-1-[2-(3-methylimidazol-4-yl)ethynyl]-7-(trifluoromethyl)pyrrolo[1,2-a]pyrazine
Show/Hide
|
C15H11F3N4
|
1
|
| 1 |
IC50 > 12589.25 nM
|
|
|
|
CP0433165
|
tert-butyl 3-[2-[3-methyl-7-(trifluoromethyl)pyrrolo[1,2-a]pyrazin-1-yl]ethynyl]benzoate
Show/Hide
|
C22H19F3N2O2
|
1
|
| 1 |
IC50 > 12589.25 nM
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|
|
|
CP0433166
|
3-[2-[3-methyl-7-(trifluoromethyl)pyrrolo[1,2-a]pyrazin-1-yl]ethynyl]benzoic acid
Show/Hide
|
C18H11F3N2O2
|
1
|
| 1 |
IC50 > 12589.25 nM
|
|
|
|
CP0457593
|
3-methyl-1-[2-[3-(1-methylpyrazol-4-yl)phenyl]ethynyl]-7-(trifluoromethyl)pyrrolo[1,2-a]pyrazine
Show/Hide
|
C21H15F3N4
|
1
|
| 1 |
IC50 > 12589.25 nM
|
|
|
|
CP0471203
|
N-[3-[2-[3-methyl-7-(trifluoromethyl)pyrrolo[1,2-a]pyrazin-1-yl]ethynyl]phenyl]methanesulfonamide
Show/Hide
|
C18H14F3N3O2S
|
1
|
| 1 |
IC50 > 12589.25 nM
|
|
|
|
CP0477863
|
1-[2-(4-bromophenyl)ethynyl]-3-methylpyrrolo[1,2-a]pyrazine
Show/Hide
|
C16H11BrN2
|
1
|
| 1 |
IC50 > 12589.25 nM
|
|
|
|
CP0515056
|
3,5-dimethyl-4-[3-[2-[3-methyl-7-(trifluoromethyl)pyrrolo[1,2-a]pyrazin-1-yl]ethynyl]phenyl]-1,2-oxazole
Show/Hide
|
C22H16F3N3O
|
1
|
| 1 |
IC50 > 12589.25 nM
|
|
|
|
CP0526607
|
3-chloro-N-(6-chloropyridin-2-yl)benzamide
Show/Hide
|
C12H8Cl2N2O
|
1
|
| 1 |
IC50 = 12700 nM
|
|
|
|
CP0270522
|
3-chloro-N-(4-methylthiazol-2-yl)benzamide
Show/Hide
|
C11H9ClN2OS
|
1
|
| 1 |
IC50 = 15000 nM
|
|
|
|
CP0394912
|
N,N-dimethyl-4-[2-[3-methyl-7-(trifluoromethyl)pyrrolo[1,2-a]pyrazin-1-yl]ethynyl]aniline
Show/Hide
|
C19H16F3N3
|
1
|
| 1 |
IC50 > 15848.93 nM
|
|
|
|
CP0422666
|
4-[2-(3,7-dimethylpyrrolo[1,2-a]pyrazin-1-yl)ethynyl]benzonitrile
Show/Hide
|
C18H13N3
|
1
|
| 1 |
IC50 > 15848.93 nM
|
|
|
|
CP0433167
|
3,7-dimethyl-1-[2-[4-(trifluoromethyl)phenyl]ethynyl]pyrrolo[1,2-a]pyrazine
Show/Hide
|
C18H13F3N2
|
1
|
| 1 |
IC50 > 15848.93 nM
|
|
|
|
CP0457592
|
ethyl 1-[2-(4-chlorophenyl)ethynyl]-3-methylpyrrolo[1,2-a]pyrazine-7-carboxylate
Show/Hide
|
C19H15ClN2O2
|
1
|
| 1 |
IC50 > 15848.93 nM
|
|
|
|
CP0477858
|
ethyl 1-[2-(4-cyanophenyl)ethynyl]-3-methylpyrrolo[1,2-a]pyrazine-7-carboxylate
Show/Hide
|
C20H15N3O2
|
1
|
| 1 |
IC50 > 15848.93 nM
|
|
|
|
CP0505130
|
ethyl 3-methyl-1-[2-[4-(trifluoromethyl)phenyl]ethynyl]pyrrolo[1,2-a]pyrazine-7-carboxylate
Show/Hide
|
C20H15F3N2O2
|
1
|
| 1 |
IC50 > 15848.93 nM
|
|
|
|
CP0513761
|
3-methyl-7-(trifluoromethyl)-1-[2-[2-(trifluoromethyl)phenyl]ethynyl]pyrrolo[1,2-a]pyrazine
Show/Hide
|
C18H10F6N2
|
1
|
| 1 |
IC50 > 15848.93 nM
|
|
|
|
CP0516474
|
1-[2-(2,4-difluorophenyl)ethynyl]-3-methyl-7-(trifluoromethyl)pyrrolo[1,2-a]pyrazine
Show/Hide
|
C17H9F5N2
|
1
|
| 1 |
IC50 > 15848.93 nM
|
|
|
|
CP0535452
|
4-[2-[3-methyl-7-(trifluoromethyl)pyrrolo[1,2-a]pyrazin-1-yl]ethynyl]benzonitrile
Show/Hide
|
C18H10F3N3
|
1
|
| 1 |
IC50 > 15848.93 nM
|
|
|
|
CP0537124
|
3-methyl-7-(trifluoromethyl)-1-[2-[4-(trifluoromethyl)phenyl]ethynyl]pyrrolo[1,2-a]pyrazine
Show/Hide
|
C18H10F6N2
|
1
|
| 1 |
IC50 > 15848.93 nM
|
|
|
|
CP0551981
|
N-[4-[2-[3-methyl-7-(trifluoromethyl)pyrrolo[1,2-a]pyrazin-1-yl]ethynyl]phenyl]methanesulfonamide
Show/Hide
|
C18H14F3N3O2S
|
1
|
| 1 |
IC50 > 15848.93 nM
|
|
|
|
CP0453859
|
N-(6-methylpyridin-2-yl)-3-phenylbenzamide
Show/Hide
|
C19H16N2O
|
1
|
| 1 |
IC50 = 18300 nM
|
|
|
|
CP0377513
|
1-(6-methyl-[1,3]thiazolo[3,2-b][1,2,4]triazol-5-yl)ethyl N-phenylcarbamate
Show/Hide
|
C14H14N4O2S
|
1
|
| 1 |
IC50 > 31622.78 nM
|
|
|
|
CP0404612
|
[1,3]thiazolo[3,2-b][1,2,4]triazol-5-ylmethyl N-phenylcarbamate
Show/Hide
|
C12H10N4O2S
|
1
|
| 1 |
IC50 > 31622.78 nM
|
|
|
|
CP0498364
|
1-(6-methyl-[1,3]thiazolo[3,2-b][1,2,4]triazol-5-yl)ethyl N-methyl-N-phenylcarbamate
Show/Hide
|
C15H16N4O2S
|
1
|
| 1 |
IC50 > 31622.78 nM
|
|
|
|
CP0503504
|
(6-methyl-[1,3]thiazolo[3,2-b][1,2,4]triazol-5-yl)methyl N-phenylcarbamate
Show/Hide
|
C13H12N4O2S
|
1
|
| 1 |
IC50 > 31622.78 nM
|
|
|
|
CP0496756
|
3-methoxy-N-(6-methylpyridin-2-yl)benzamide
Show/Hide
|
C14H14N2O2
|
1
|
| 1 |
IC50 = 46000 nM
|
|
|
|
CP0296718
|
2-(3,5-dimethylanilino)-7,8-dihydro-6H-quinazolin-5-one
Show/Hide
|
C16H17N3O
|
1
|
| 1 |
IC50 > 100000 nM
|
|
|
|
CP0403906
|
8,8-dimethyl-2-(4-methylanilino)-6,7-dihydroquinazolin-5-one
Show/Hide
|
C17H19N3O
|
1
|
| 1 |
IC50 > 100000 nM
|
|
|
|
CP0411357
|
2-(2-chloroanilino)-7,8-dihydro-6H-quinazolin-5-one
Show/Hide
|
C14H12ClN3O
|
1
|
| 1 |
IC50 > 100000 nM
|
|
|
|
CP0429192
|
6,6-dimethyl-2-(4-methylanilino)-7,8-dihydroquinazolin-5-one
Show/Hide
|
C17H19N3O
|
1
|
| 1 |
IC50 > 100000 nM
|
|
|
|
CP0491780
|
2-(4-chloroanilino)-7-propyl-7,8-dihydro-6H-quinazolin-5-one
Show/Hide
|
C17H18ClN3O
|
1
|
| 1 |
IC50 > 100000 nM
|
|
|
|
CP0554580
|
2-(2-chloroanilino)-7-methyl-7,8-dihydro-6H-quinazolin-5-one
Show/Hide
|
C15H14ClN3O
|
1
|
| 1 |
IC50 > 100000 nM
|
|
|
|
CP0484696
|
methyl (1S,5R)-3-hydroxy-3-(2-imidazo[1,2-a]pyridin-2-ylethynyl)-8-azabicyclo[3.2.1]octane-8-carboxylate
Show/Hide
|
C18H19N3O3
|
1
|
| 1 |
IC50 > 100000 nM
|
|
|
|
CP0412645
|
1-[2-(4-chlorophenyl)ethynyl]-3,7-dimethylpyrrolo[1,2-a]pyrazine
Show/Hide
|
C17H13ClN2
|
1
|
| 1 |
IC50 > 3981.07 nM
|
|
|
|
CP0428293
|
2-[[4-(2,3-dihydro-1H-inden-2-ylamino)-5,6,7,8-tetrahydroquinazolin-2-yl]sulfanyl]ethanol
Show/Hide
|
C19H23N3OS
|
1
|
| 1 |
IC50 > 9100 nM
|
|
|
|
CP0457396
|
[(2R)-2-[6-(3-chlorophenyl)-4-methylpyridin-3-yl]pyrrolidin-1-yl]-(1,3-thiazol-2-yl)methanone
Show/Hide
|
C20H18ClN3OS
|
1
|
| 1 |
Ki = 12 nM
|
|
|
|
CP0477470
|
[2-[6-(3-chlorophenyl)-4-methoxypyridin-3-yl]pyrrolidin-1-yl]-cyclobutylmethanone
Show/Hide
|
C21H23ClN2O2
|
1
|
| 1 |
Ki = 12 nM
|
|
|
|
CP0524933
|
[2-[6-(3-chlorophenyl)-4-methylpyridin-3-yl]pyrrolidin-1-yl]-cyclobutylmethanone
Show/Hide
|
C21H23ClN2O
|
1
|
| 1 |
Ki = 15 nM
|
|
|
|
CP0917299
|
rac-(2-(6-(3-chlorophenyl)-4-methylpyridin-3-yl)pyrrolidin-1-yl)(thiazol-2-yl)methanone
Show/Hide
|
C20H18ClN3OS
|
1
|
| 1 |
Ki = 19 nM
|
|
|
|
CP0428272
|
[2-[6-(3-chlorophenyl)-4-methoxypyridin-3-yl]pyrrolidin-1-yl]-(1,3-thiazol-5-yl)methanone
Show/Hide
|
C20H18ClN3O2S
|
1
|
| 1 |
Ki = 20 nM
|
|
|
|
CP0426646
|
[2-[6-(3-chlorophenyl)-4-methylpyridin-3-yl]pyrrolidin-1-yl]-(1,3-thiazol-5-yl)methanone
Show/Hide
|
C20H18ClN3OS
|
1
|
| 1 |
Ki = 30 nM
|
|
|
|
CP0468828
|
[2-[6-(3-chlorophenyl)pyridin-3-yl]pyrrolidin-1-yl]-thiophen-2-ylmethanone
Show/Hide
|
C20H17ClN2OS
|
1
|
| 1 |
Ki = 89 nM
|
|
|
|
CP0426181
|
[2-[6-(3-chlorophenyl)-4-methylpyridin-3-yl]-4-fluoropyrrolidin-1-yl]-(1,3-thiazol-5-yl)methanone
Show/Hide
|
C20H17ClFN3OS
|
1
|
| 1 |
Ki = 100 nM
|
|
|
|
CP0375556
|
[2-[6-(3-fluorophenyl)-4-methylpyridin-3-yl]pyrrolidin-1-yl]-(1,3-thiazol-5-yl)methanone
Show/Hide
|
C20H18FN3OS
|
1
|
| 1 |
Ki = 110 nM
|
|
|
|
CP0468826
|
[2-[6-(3-chlorophenyl)pyridin-3-yl]pyrrolidin-1-yl]-(1,3-thiazol-5-yl)methanone
Show/Hide
|
C19H16ClN3OS
|
1
|
| 1 |
Ki = 110 nM
|
|
|
|
CP0425122
|
[2-[6-(3-chlorophenyl)-4-methylpyridin-3-yl]pyrrolidin-1-yl]-pyrazin-2-ylmethanone
Show/Hide
|
C21H19ClN4O
|
1
|
| 1 |
Ki = 120 nM
|
|
|
|
CP0498811
|
[2-[6-(3-chlorophenyl)-4-methylpyridin-3-yl]-4-fluoropyrrolidin-1-yl]-cyclobutylmethanone
Show/Hide
|
C21H22ClFN2O
|
1
|
| 1 |
Ki = 130 nM
|
|
|
|
CP0468834
|
[2-[6-(3-chlorophenyl)pyridin-3-yl]pyrrolidin-1-yl]-(1,3-thiazol-2-yl)methanone
Show/Hide
|
C19H16ClN3OS
|
1
|
| 1 |
Ki = 140 nM
|
|
|
|
CP0425120
|
[2-[6-(3-chloro-5-fluorophenyl)-4-methylpyridin-3-yl]pyrrolidin-1-yl]-(1,3-thiazol-5-yl)methanone
Show/Hide
|
C20H17ClFN3OS
|
1
|
| 1 |
Ki = 150 nM
|
|
|
|
CP0477472
|
[2-[6-(3-chlorophenyl)-4-methylpyridin-3-yl]pyrrolidin-1-yl]-(5-methyl-1,2-oxazol-3-yl)methanone
Show/Hide
|
C21H20ClN3O2
|
1
|
| 1 |
Ki = 150 nM
|
|
|
|
CP0426104
|
[2-[6-(3-chlorophenyl)-4-methylpyridin-3-yl]pyrrolidin-1-yl]-pyridin-4-ylmethanone
Show/Hide
|
C22H20ClN3O
|
1
|
| 1 |
Ki = 180 nM
|
|
|
|
CP0426180
|
[2-[6-(3-chlorophenyl)-4-methylpyridin-3-yl]pyrrolidin-1-yl]-pyrimidin-4-ylmethanone
Show/Hide
|
C21H19ClN4O
|
1
|
| 1 |
Ki = 180 nM
|
|
|
|
CP0505323
|
[2-[6-(3-chlorophenyl)-4-methylpyridin-3-yl]-4-hydroxypyrrolidin-1-yl]-(1,3-thiazol-2-yl)methanone
Show/Hide
|
C20H18ClN3O2S
|
1
|
| 1 |
Ki = 230 nM
|
|
|
|
CP0498812
|
[2-[6-(3-chlorophenyl)-4-methylpyridin-3-yl]-4-fluoropyrrolidin-1-yl]-pyrazin-2-ylmethanone
Show/Hide
|
C21H18ClFN4O
|
1
|
| 1 |
Ki = 260 nM
|
|
|
|
CP0374977
|
[2-[6-(3-chlorophenyl)-4-methylpyridin-3-yl]pyrrolidin-1-yl]-pyrimidin-5-ylmethanone
Show/Hide
|
C21H19ClN4O
|
1
|
| 1 |
Ki = 290 nM
|
|
|
|
CP0494546
|
[2-[6-(3-chlorophenyl)pyridin-3-yl]pyrrolidin-1-yl]-cyclobutylmethanone
Show/Hide
|
C20H21ClN2O
|
1
|
| 1 |
Ki = 360 nM
|
|
|
|
CP0527172
|
[2-[6-(3,5-difluorophenyl)-4-methylpyridin-3-yl]pyrrolidin-1-yl]-(1,3-thiazol-5-yl)methanone
Show/Hide
|
C20H17F2N3OS
|
1
|
| 1 |
Ki = 360 nM
|
|
|
|
CP0468825
|
[2-[6-(3-chlorophenyl)-4-methylpyridin-3-yl]pyrrolidin-1-yl]-pyridin-2-ylmethanone
Show/Hide
|
C22H20ClN3O
|
1
|
| 1 |
Ki = 370 nM
|
|
|
|
CP0375104
|
[2-[6-(3-chlorophenyl)-4-methylpyridin-3-yl]pyrrolidin-1-yl]-pyridin-3-ylmethanone
Show/Hide
|
C22H20ClN3O
|
1
|
| 1 |
Ki = 540 nM
|
|
|
|
CP0498852
|
[2-[6-(3-chlorophenyl)pyridin-3-yl]pyrrolidin-1-yl]-(5-methyl-1,2-oxazol-3-yl)methanone
Show/Hide
|
C20H18ClN3O2
|
1
|
| 1 |
Ki = 540 nM
|
|
|
|
CP0527377
|
[2-[6-(3-chlorophenyl)pyridin-3-yl]pyrrolidin-1-yl]-pyrazin-2-ylmethanone
Show/Hide
|
C20H17ClN4O
|
1
|
| 1 |
Ki = 540 nM
|
|
|
|
CP0457398
|
[2-[6-(3-chlorophenyl)-4-methylpyridin-3-yl]-4-hydroxypyrrolidin-1-yl]-cyclobutylmethanone
Show/Hide
|
C21H23ClN2O2
|
1
|
| 1 |
Ki = 570 nM
|
|
|
|
CP0457391
|
[2-[6-(3-chloro-5-fluorophenyl)-4-methylpyridin-3-yl]pyrrolidin-1-yl]-pyrazin-2-ylmethanone
Show/Hide
|
C21H18ClFN4O
|
1
|
| 1 |
Ki = 800 nM
|
|
|
|
CP0468830
|
[2-[4-methyl-6-(2-methylpyridin-4-yl)pyridin-3-yl]pyrrolidin-1-yl]-(1,3-thiazol-5-yl)methanone
Show/Hide
|
C20H20N4OS
|
1
|
| 1 |
Ki = 840 nM
|
|
|
|
CP0425121
|
[2-[6-(3-fluorophenyl)-4-methylpyridin-3-yl]pyrrolidin-1-yl]-pyrazin-2-ylmethanone
Show/Hide
|
C21H19FN4O
|
1
|
| 1 |
Ki = 1100 nM
|
|
|
|
CP0426644
|
[2-[6-(3,5-difluorophenyl)-4-methylpyridin-3-yl]pyrrolidin-1-yl]-pyrazin-2-ylmethanone
Show/Hide
|
C21H18F2N4O
|
1
|
| 1 |
Ki = 2400 nM
|
|
|
|
CP0457392
|
[2-[6-(3-chlorophenyl)-4-methylpyridin-3-yl]-4-hydroxypyrrolidin-1-yl]-pyrazin-2-ylmethanone
Show/Hide
|
C21H19ClN4O2
|
1
|
| 1 |
Ki = 3000 nM
|
|
|
|
CP0457395
|
[2-[6-(3-chlorophenyl)-4-methylpyridin-3-yl]pyrrolidin-1-yl]-(1,1-dioxothiolan-3-yl)methanone
Show/Hide
|
C21H23ClN2O3S
|
1
|
| 1 |
Ki = 7000 nM
|
|
|
|
CP0429896
|
2-(3-chlorophenyl)-5-[1-(cyclobutanecarbonyl)pyrrolidin-2-yl]-1H-pyridin-4-one
Show/Hide
|
C20H21ClN2O2
|
1
|
| 1 |
Ki = 7800 nM
|
|
|
|
CP0375558
|
[2-[6-(3-chlorophenyl)-4-(2-hydroxy-2-methylpropyl)pyridin-3-yl]pyrrolidin-1-yl]-(1,3-thiazol-2-yl)methanone
Show/Hide
|
C23H24ClN3O2S
|
1
|
| 1 |
Ki = 13000 nM
|
|
|
|
CP0477471
|
4-[2-[6-(3-chlorophenyl)-4-methylpyridin-3-yl]pyrrolidine-1-carbonyl]-1-methylpyrrolidin-2-one
Show/Hide
|
C22H24ClN3O2
|
1
|
| 1 |
Ki = 16000 nM
|
|
|
