Brief Information of the Compound and Protein
Compound Name
[(1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl]-[3-methyl-1-(2-thiophen-3-ylethynyl)pyrrolo[1,2-a]pyrazin-7-yl]methanone
    Show/Hide
PubChem ID
CID: 44452913
Canonical SMILES
CN1C[C@@H]2C[C@H]1CN2C(=O)c1cc2c(nc(C)cn2c1)C#Cc1ccsc1
    Show/Hide
Compound Formula C21H20N4OS
Compound Structure
Protein Name
Metabotropic glutamate receptor 5
Protein Classification
Membrane receptor
>
Family C G protein-coupled receptor
>
Small molecule receptor (family C GPCR)
>
Neurotransmitter receptor (family C GPCR)
>
Metabotropic glutamate receptor
Uniprot ID
P41594
Gene Name
GRM5
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 3981.07 nM
   TI
   LI
   LO
   TS