Brief Information of the Compound and Protein
Compound Name
 Compound Info 
[2-[6-(3-chlorophenyl)-4-methylpyridin-3-yl]-4-fluoropyrrolidin-1-yl]-cyclobutylmethanone
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 PubChem ID
CID: 56673929
Canonical SMILES
Cc1cc(ncc1C1CC(F)CN1C(=O)C1CCC1)-c1cccc(Cl)c1
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Compound Formula C21H22ClFN2O
Compound Structure
Protein Name
 Protein Info 
Metabotropic glutamate receptor 5
Protein Classification
Membrane receptor
>
Family C G protein-coupled receptor
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Small molecule receptor (family C GPCR)
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Neurotransmitter receptor (family C GPCR)
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Metabotropic glutamate receptor
Uniprot ID
P41594
Gene Name
GRM5
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  1
1
Ki = 130 nM
   TI
   LI
   LO
   TS
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 140 nM
   TI
   LI
   LO
   TS