| Compound ID |
Compound Name |
Compound Formula |
|
CP0295729
|
(3S)-3-[1-(4-fluorophenyl)indazol-5-yl]-2,2-dimethyl-3-phenyl-N-(1,3-thiazol-2-yl)propanamide
Show/Hide
|
C27H23FN4OS
|
2
|
| 1 |
EC50 = 0.5 nM
|
|
|
| 2 |
EC50 = 1.4 nM
|
|
|
|
CP0258751
|
N-carbamoyl-2-[(5S)-9-fluoro-2-[4-[(3S)-3-fluoropyrrolidine-1-carbonyl]phenyl]-5H-chromeno[2,3-b]pyridin-5-yl]-2-methylpropanamide
Show/Hide
|
C28H26F2N4O4
|
2
|
| 1 |
EC50 = 0.6 nM
|
|
|
| 2 |
EC50 = 0.8 nM
|
|
|
|
CP0395793
|
2,2,2-trifluoro-N-[(3S)-3-[1-(4-fluorophenyl)indazol-5-yl]-2-methyl-3-phenylpropyl]ethanesulfonamide
Show/Hide
|
C25H23F4N3O2S
|
2
|
| 1 |
EC50 = 0.66 nM
|
|
|
| 2 |
EC50 = 5.2 nM
|
|
|
|
CP0039833
|
(1S)-1-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4H,4aH,5H,6H,7H,8H-cyclohexa[f]indazol-5-yl]-1-(thiophen-3-yl)ethan-1-ol
Show/Hide
|
C24H25FN2OS
|
2
|
| 1 |
EC50 = 0.96 nM
|
|
|
| 2 |
EC50 = 1 nM
|
|
|
|
CP0419139
|
(R)-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4H,4aH,5H,6H,7H,8H-cyclohexa[f]indazol-5-yl](thiophen-3-yl)methanol
Show/Hide
|
C23H23FN2OS
|
1
|
| 1 |
EC50 = 1 nM
|
|
|
|
CP0008077
|
(1R,2S,10S,11S,13R,14R,15S,17S)-1-fluoro-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,13,15-trimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-dien-5-one
Show/Hide
|
C22H29FO5
|
9
|
| 1 |
EC50 = 1.1 nM
|
|
|
| 2 |
EC50 = 2.5 nM
|
|
|
| 3 |
EC50 = 5.012 nM
|
|
|
| 4 |
EC50 = 5.37 nM
|
|
|
| 5 |
IC50 = 1 nM
|
|
|
| 6 |
IC50 = 1.175 nM
|
|
|
| 7 |
IC50 = 3.981 nM
|
|
|
| 8 |
IC50 > 10000 nM
|
|
|
| 9 |
IC50 < 1000 nM
|
|
|
|
CP0053814
|
N-carbamoyl-2-[(5S)-9-fluoro-2-[4-(morpholine-4-carbonyl)phenyl]-5H-chromeno[2,3-b]pyridin-5-yl]-2-methylpropanamide
Show/Hide
|
C28H27FN4O5
|
2
|
| 1 |
EC50 = 1.2 nM
|
|
|
| 2 |
EC50 = 2.1 nM
|
|
|
|
CP0335641
|
8,15-dimethyl-N-(1,3-thiazol-2-yl)tetracyclo[6.6.2.0^{2,7}.0^{9,14}]hexadeca-2,4,6,9(14),10,12-hexaene-15-carboxamide
Show/Hide
|
C22H20N2OS
|
2
|
| 1 |
EC50 = 1.4 nM
|
|
|
| 2 |
EC50 = 5.3 nM
|
|
|
|
CP0178242
|
N-[(3S)-3-[1-(4-fluorophenyl)indazol-5-yl]-2-methyl-3-phenylpropyl]methanesulfonamide
Show/Hide
|
C24H24FN3O2S
|
2
|
| 1 |
EC50 = 1.4 nM
|
|
|
| 2 |
EC50 = 8.4 nM
|
|
|
|
CP0123605
|
N-carbamoyl-2-[(5S)-9-fluoro-2-[4-(pyrrolidine-1-carbonyl)phenyl]-5H-chromeno[2,3-b]pyridin-5-yl]-2-methylpropanamide
Show/Hide
|
C28H27FN4O4
|
2
|
| 1 |
EC50 = 1.4 nM
|
|
|
| 2 |
EC50 = 1.6 nM
|
|
|
|
CP0778182
|
(1R)-benzo[b]thiophen-3-yl((4aR)-1-(4-fluorophenyl)-4a-methyl-4,4a,5,6,7,8-hexahydro-1H-benzo[f]indazol-5-yl)methanol
Show/Hide
|
C27H25FN2OS
|
1
|
| 1 |
EC50 = 1.8 nM
|
|
|
|
CP0318783
|
N-[(3S)-3-[1-(4-fluorophenyl)indazol-5-yl]-2-methyl-3-phenylpropyl]ethanesulfonamide
Show/Hide
|
C25H26FN3O2S
|
2
|
| 1 |
EC50 = 1.8 nM
|
|
|
| 2 |
EC50 = 4.3 nM
|
|
|
|
CP0041631
|
(R)-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4H,4aH,5H,6H,7H,8H-cyclohexa[f]indazol-5-yl](4-chlorophenyl)methanol
Show/Hide
|
C25H24ClFN2O
|
1
|
| 1 |
EC50 = 1.9 nM
|
|
|
|
CP0138750
|
5-amino-N-(2-((2,6-dichloro-N-ethylbenzamido)methyl)-3,3,3-trifluoro-2-hydroxypropyl)-1-(4-fluorophenyl)-1H-pyrazole-4-carboxamide
Show/Hide
|
C23H21Cl2F4N5O3
|
1
|
| 1 |
EC50 = 1.995 nM
|
|
|
|
CP0039830
|
(R)-1-Cyclohexyl-1-((5aR,6S)-1-(4-fluorophenyl)-5a-methyl-5,5a,6,7,8,9-hexahydroimidazo[1,5-b]isoquinolin-6-yl)ethanol
Show/Hide
|
C26H33FN2O
|
2
|
| 1 |
EC50 = 2 nM
|
|
|
| 2 |
EC50 = 33 nM
|
|
|
|
CP0424335
|
(S)-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4H,4aH,5H,6H,7H-cyclopenta[f]indazol-5-yl](thiophen-3-yl)methanol
Show/Hide
|
C22H21FN2OS
|
1
|
| 1 |
EC50 = 2.1 nM
|
|
|
|
CP0052880
|
2-[(5S)-9-fluoro-2-[4-(morpholine-4-carbonyl)phenyl]-5H-chromeno[2,3-b]pyridin-5-yl]-2-methyl-N-(1,3,4-thiadiazol-2-yl)propanamide
Show/Hide
|
C29H26FN5O4S
|
1
|
| 1 |
EC50 = 2.1 nM
|
|
|
|
CP0039831
|
(1S)-1-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4H,4aH,5H,6H,7H,8H-cyclohexa[f]indazol-5-yl]-1-(4-fluorophenyl)ethan-1-ol
Show/Hide
|
C26H26F2N2O
|
1
|
| 1 |
EC50 = 2.2 nM
|
|
|
|
CP0054319
|
(3S)-3-[1-(4-fluorophenyl)indazol-5-yl]-2,2-dimethyl-3-phenyl-N-(1,3,4-thiadiazol-2-yl)propanamide
Show/Hide
|
C26H22FN5OS
|
2
|
| 1 |
EC50 = 2.4 nM
|
|
|
| 2 |
EC50 = 4 nM
|
|
|
|
CP0263964
|
(R)-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4H,4aH,5H,6H,7H,8H-cyclohexa[f]indazol-5-yl](2-fluorophenyl)methanol
Show/Hide
|
C25H24F2N2O
|
1
|
| 1 |
EC50 = 2.7 nM
|
|
|
|
CP0348242
|
(R)-[(4aR,5S)-1-(4-Fluoro-phenyl)-4a-methyl-4,4a,5,6,7,8-hexahydro-1H-benzo[f]indazol-5-yl]-furan-3-yl-methanol
Show/Hide
|
C23H23FN2O2
|
1
|
| 1 |
EC50 = 2.7 nM
|
|
|
|
CP0101543
|
(R)-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4H,4aH,5H,6H,7H,8H-cyclohexa[f]indazol-5-yl](phenyl)methanol
Show/Hide
|
C25H25FN2O
|
1
|
| 1 |
EC50 = 2.9 nM
|
|
|
|
CP0273275
|
2-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4H,4aH,5H,6H,7H,8H-cyclohexa[f]indazol-5-yl]propan-2-ol
Show/Hide
|
C21H25FN2O
|
1
|
| 1 |
EC50 = 3 nM
|
|
|
|
CP0424336
|
(R)-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4H,4aH,5H,6H,7H-cyclopenta[f]indazol-5-yl](1-benzofuran-3-yl)methanol
Show/Hide
|
C26H23FN2O2
|
1
|
| 1 |
EC50 = 3 nM
|
|
|
|
CP0138755
|
N-[2-[[[5-amino-1-(4-fluorophenyl)pyrazole-4-carbonyl]amino]methyl]-3,3,3-trifluoro-2-hydroxypropyl]-N-ethyl-1H-indole-5-carboxamide
Show/Hide
|
C25H24F4N6O3
|
1
|
| 1 |
EC50 = 3.162 nM
|
|
|
|
CP0135024
|
(1S)-1-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4H,4aH,5H,6H,7H,8H-cyclohexa[f]indazol-5-yl]-2-(4-fluorophenyl)ethan-1-ol
Show/Hide
|
C26H26F2N2O
|
1
|
| 1 |
EC50 = 3.2 nM
|
|
|
|
CP0053820
|
N-acetyl-2-[(5S)-9-fluoro-2-[4-(morpholine-4-carbonyl)phenyl]-5H-chromeno[2,3-b]pyridin-5-yl]-2-methylpropanamide
Show/Hide
|
C29H28FN3O5
|
2
|
| 1 |
EC50 = 3.2 nM
|
|
|
| 2 |
EC50 = 5 nM
|
|
|
|
CP0074372
|
2-[(9S)-3-hydroxy-9H-xanthen-9-yl]-2-methyl-N-(1,3,4-thiadiazol-2-yl)propanamide
Show/Hide
|
C19H17N3O3S
|
2
|
| 1 |
EC50 = 3.5 nM
|
|
|
| 2 |
EC50 = 7.8 nM
|
|
|
|
CP0053818
|
N-acetyl-2-[(5S)-9-fluoro-2-[4-(pyrrolidine-1-carbonyl)phenyl]-5H-chromeno[2,3-b]pyridin-5-yl]-2-methylpropanamide
Show/Hide
|
C29H28FN3O4
|
2
|
| 1 |
EC50 = 3.6 nM
|
|
|
| 2 |
EC50 = 5.1 nM
|
|
|
|
CP0123518
|
N-carbamoyl-2-[(5S)-9-fluoro-2-(6-propan-2-yloxypyridin-3-yl)-5H-chromeno[2,3-b]pyridin-5-yl]-2-methylpropanamide
Show/Hide
|
C25H25FN4O4
|
2
|
| 1 |
EC50 = 3.8 nM
|
|
|
| 2 |
EC50 = 6.7 nM
|
|
|
|
CP0680149
|
rac-3-(1-(4-fluorophenyl)-1H-indazol-5-yl)-2,2-dimethyl-3-phenyl-N-(thiazol-2-yl)propanamide
Show/Hide
|
C27H23FN4OS
|
1
|
| 1 |
EC50 = 4.1 nM
|
|
|
|
CP0094961
|
(1S)-1-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4H,4aH,5H,6H,7H,8H-cyclohexa[f]indazol-5-yl]pent-4-en-1-ol
Show/Hide
|
C23H27FN2O
|
1
|
| 1 |
EC50 = 4.4 nM
|
|
|
|
CP0047174
|
(1S,2R,10S,11S,14R,15S,17S)-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-dien-5-one
Show/Hide
|
C21H28O5
|
8
|
| 1 |
EC50 = 4.5 nM
|
|
|
| 2 |
EC50 = 13.6 nM
|
|
|
| 3 |
EC50 = 14.4 nM
|
|
|
| 4 |
EC50 = 15.8 nM
|
|
|
| 5 |
EC50 = 16.1 nM
|
|
|
| 6 |
EC50 = 31.62 nM
|
|
|
| 7 |
EC50 = 50.12 nM
|
|
|
| 8 |
IC50 = 8.511 nM
|
|
|
|
CP0083140
|
N,N-dimethyl-4-[(5S)-5-[2-methyl-1-oxo-1-(1,3,4-thiadiazol-2-ylamino)propan-2-yl]-5H-chromeno[2,3-b]pyridin-2-yl]benzamide
Show/Hide
|
C27H25N5O3S
|
4
|
| 1 |
EC50 = 4.6 nM
|
|
|
| 2 |
EC50 = 12.2 nM
|
|
|
| 3 |
EC50 = 33.2 nM
|
|
|
| 4 |
EC50 = 33.8 nM
|
|
|
|
CP0123603
|
N-carbamoyl-2-methyl-2-[(5S)-2-[4-(morpholine-4-carbonyl)phenyl]-5H-chromeno[2,3-b]pyridin-5-yl]propanamide
Show/Hide
|
C28H28N4O5
|
2
|
| 1 |
EC50 = 4.8 nM
|
|
|
| 2 |
EC50 = 6.2 nM
|
|
|
|
CP0461955
|
(S)-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4H,4aH,5H,6H,7H-cyclopenta[f]indazol-5-yl](1-benzofuran-3-yl)methanol
Show/Hide
|
C26H23FN2O2
|
1
|
| 1 |
EC50 = 5 nM
|
|
|
|
CP0467973
|
(R)-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4H,4aH,5H,6H,7H-cyclopenta[f]indazol-5-yl](1-benzothiophen-3-yl)methanol
Show/Hide
|
C26H23FN2OS
|
1
|
| 1 |
EC50 = 5 nM
|
|
|
|
CP0303088
|
(S)-1-((5aR,6S)-1-(4-Fluorophenyl)-5a-methyl-5,5a,6,7,8,9-hexahydroimidazo[1,5-b]isoquinolin-6-yl)-1-(thiophen-3-yl)ethanol
Show/Hide
|
C24H25FN2OS
|
2
|
| 1 |
EC50 = 5 nM
|
|
|
| 2 |
EC50 = 37 nM
|
|
|
|
CP0415425
|
N-carbamoyl-2-methyl-2-[(5S)-2-[4-(pyrrolidine-1-carbonyl)phenyl]-5H-chromeno[2,3-b]pyridin-5-yl]propanamide
Show/Hide
|
C28H28N4O4
|
2
|
| 1 |
EC50 = 5 nM
|
|
|
| 2 |
EC50 = 8.7 nM
|
|
|
|
CP0217373
|
5-amino-N-[2-[(1-ethyl-3,4-dihydro-2H-naphthalen-1-yl)methyl]-3,3,3-trifluoro-2-hydroxypropyl]-1-phenylpyrazole-4-carboxamide
Show/Hide
|
C26H29F3N4O2
|
3
|
| 1 |
EC50 = 5.623 nM
|
|
|
| 2 |
IC50 = 1.585 nM
|
|
|
| 3 |
IC50 = 1.66 nM
|
|
|
|
CP0151699
|
(S)-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4H,4aH,5H,6H,7H,8H-cyclohexa[f]indazol-5-yl](1-benzothiophen-3-yl)methanol
Show/Hide
|
C27H25FN2OS
|
1
|
| 1 |
EC50 = 6 nM
|
|
|
|
CP0425703
|
(S)-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4H,4aH,5H,6H,7H-cyclopenta[f]indazol-5-yl](4-fluorophenyl)methanol
Show/Hide
|
C24H22F2N2O
|
1
|
| 1 |
EC50 = 6 nM
|
|
|
|
CP0306287
|
(3S)-3-(3-bromo-4-hydroxyphenyl)-2,2-dimethyl-3-phenyl-N-(1,3,4-thiadiazol-2-yl)propanamide
Show/Hide
|
C19H18BrN3O2S
|
2
|
| 1 |
EC50 = 6.2 nM
|
|
|
| 2 |
EC50 = 12.7 nM
|
|
|
|
CP0237984
|
2-[(5S)-2-(4-acetylphenyl)-5H-chromeno[2,3-b]pyridin-5-yl]-2-methyl-N-(1,3,4-thiadiazol-2-yl)propanamide
Show/Hide
|
C26H22N4O3S
|
2
|
| 1 |
EC50 = 6.2 nM
|
|
|
| 2 |
EC50 = 10.2 nM
|
|
|
|
CP0145729
|
2-methyl-2-[(5S)-2-[4-(morpholine-4-carbonyl)phenyl]-5H-chromeno[2,3-b]pyridin-5-yl]-N-(1,3,4-thiadiazol-2-yl)propanamide
Show/Hide
|
C29H27N5O4S
|
2
|
| 1 |
EC50 = 6.3 nM
|
|
|
| 2 |
EC50 = 12.4 nM
|
|
|
|
CP0261726
|
3,3,3-trifluoro-2-hydroxy-N-(4-methyl-1-oxo-2,3-benzoxazin-6-yl)-2-[(1-pentan-3-yl-3,4-dihydro-2H-naphthalen-1-yl)methyl]propanamide
Show/Hide
|
C28H31F3N2O4
|
3
|
| 1 |
EC50 = 6.31 nM
|
|
|
| 2 |
IC50 = 1.202 nM
|
|
|
| 3 |
IC50 = 66.07 nM
|
|
|
|
CP0313985
|
3,3,3-trifluoro-N-[(3S)-3-[1-(4-fluorophenyl)indazol-5-yl]-2,2-dimethyl-3-phenylpropyl]propanamide
Show/Hide
|
C27H25F4N3O
|
2
|
| 1 |
EC50 = 6.85 nM
|
|
|
| 2 |
EC50 = 12.4 nM
|
|
|
|
CP0716109
|
[(5S)-2-[4-[(Ethylmethylamino)carbonyl]-3-fluorophenyl]-alpha,alpha-dimethyl-N-1,3,4-thiadiazol-2-yl-5H-[1]benzopyrano-[2,3-b]pyridin-5-acetamide
Show/Hide
|
C28H26FN5O3S
|
2
|
| 1 |
EC50 = 6.89 nM
|
|
|
| 2 |
EC50 = 17.7 nM
|
|
|
|
CP0258764
|
N-ethyl-N-methyl-4-[(5S)-5-[2-methyl-1-oxo-1-(1,3,4-thiadiazol-2-ylamino)propan-2-yl]-5H-chromeno[2,3-b]pyridin-2-yl]benzamide
Show/Hide
|
C28H27N5O3S
|
2
|
| 1 |
EC50 = 6.89 nM
|
|
|
| 2 |
EC50 = 17.7 nM
|
|
|
|
CP0244757
|
(S)-1-(4-Chlorophenyl)-1-((5aR,6S)-1-(4-fluorophenyl)-5a-methyl-5,5a,6,7,8,9-hexahydroimidazo[1,5-b]isoquinolin-6-yl)ethanol
Show/Hide
|
C26H26ClFN2O
|
2
|
| 1 |
EC50 = 7.5 nM
|
|
|
| 2 |
EC50 = 19 nM
|
|
|
|
CP0258531
|
2,2,2-trifluoro-N-[(3S)-3-[1-(4-fluorophenyl)indazol-5-yl]-2,2-dimethyl-3-phenylpropyl]ethanesulfonamide
Show/Hide
|
C26H25F4N3O2S
|
2
|
| 1 |
EC50 = 7.6 nM
|
|
|
| 2 |
EC50 = 20.4 nM
|
|
|
|
CP0297988
|
N-ethyl-N-methyl-4-[(5R)-5-[2-methyl-1-oxo-1-(1,3,4-thiadiazol-2-ylamino)propan-2-yl]-5H-chromeno[2,3-b]pyridin-2-yl]benzamide
Show/Hide
|
C28H27N5O3S
|
2
|
| 1 |
EC50 = 7.8 nM
|
|
|
| 2 |
EC50 = 17.4 nM
|
|
|
|
CP0256573
|
(3S)-3-(3-fluoro-4-hydroxyphenyl)-2,2-dimethyl-3-phenyl-N-(1,3,4-thiadiazol-2-yl)propanamide
Show/Hide
|
C19H18FN3O2S
|
2
|
| 1 |
EC50 = 7.9 nM
|
|
|
| 2 |
EC50 = 21.2 nM
|
|
|
|
CP0234134
|
5-amino-N-(2-((N-ethyl-2,6-difluorobenzamido)methyl)-3,3,3-trifluoro-2-hydroxypropyl)-1-(4-fluorophenyl)-1H-pyrazole-4-carboxamide
Show/Hide
|
C23H21F6N5O3
|
1
|
| 1 |
EC50 = 7.943 nM
|
|
|
|
CP0169235
|
2-[(5R)-2-(4-ethylphenyl)-5H-chromeno[2,3-b]pyridin-5-yl]-2-methyl-N-(1,3,4-thiadiazol-2-yl)propanamide
Show/Hide
|
C26H24N4O2S
|
2
|
| 1 |
EC50 = 8.3 nM
|
|
|
| 2 |
EC50 = 17.7 nM
|
|
|
|
CP0332035
|
(1S)-1-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4H,4aH,5H,6H,7H,8H-cyclohexa[f]indazol-5-yl]-3-cyclopropylpropan-1-ol
Show/Hide
|
C24H29FN2O
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1
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| 1 |
EC50 = 8.6 nM
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CP0073120
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(3S)-3-(3-bromo-4-hydroxyphenyl)-2,2-dimethyl-3-phenyl-N-(1,3-thiazol-2-yl)propanamide
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C20H19BrN2O2S
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2
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| 1 |
EC50 = 8.6 nM
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| 2 |
EC50 = 40.1 nM
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CP0256572
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(3S)-3-(3-fluoro-4-hydroxyphenyl)-2,2-dimethyl-3-phenyl-N-(1,3-thiazol-2-yl)propanamide
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C20H19FN2O2S
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2
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| 1 |
EC50 = 8.6 nM
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| 2 |
EC50 = 15.9 nM
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CP0283289
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2-[(1-ethyl-3,4-dihydro-2H-naphthalen-1-yl)methyl]-3,3,3-trifluoro-2-hydroxy-N-(4-methyl-1-oxo-2,3-benzoxazin-6-yl)propanamide
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C25H25F3N2O4
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3
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| 1 |
EC50 = 9.12 nM
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| 2 |
IC50 = 5.012 nM
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| 3 |
IC50 = 199.53 nM
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CP0207747
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(1S)-1-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4H,4aH,5H,6H,7H,8H-cyclohexa[f]indazol-5-yl]but-3-en-1-ol
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C22H25FN2O
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1
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| 1 |
EC50 = 9.3 nM
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CP0740766
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(1S)-1-((4aR)-1-(4-fluorophenyl)-4a-methyl-4,4a,5,6,7,8-hexahydro-1H-benzo[f]indazol-5-yl)but-3-en-1-ol
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C22H25FN2O
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1
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| 1 |
EC50 = 9.3 nM
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CP0087252
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2-[(9S)-3-hydroxy-9H-xanthen-9-yl]-2-methyl-N-(1,3-thiazol-2-yl)propanamide
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C20H18N2O3S
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2
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| 1 |
EC50 = 9.3 nM
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| 2 |
EC50 = 17.5 nM
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CP0244756
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(S)-1-((5aR,6S)-1-(4-Fluorophenyl)-5a-methyl-5,5a,6,7,8,9-hexahydroimidazo[1,5-b]isoquinolin-6-yl)-1-m-tolylethanol
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C27H29FN2O
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2
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| 1 |
EC50 = 9.5 nM
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| 2 |
EC50 = 99 nM
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CP0043529
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(R)-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4H,4aH,5H,6H,7H,8H-cyclohexa[f]indazol-5-yl](4-fluorophenyl)methanol
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C25H24F2N2O
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1
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| 1 |
EC50 = 9.7 nM
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CP0375417
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8-bromo-15-methyl-N-(1,3-thiazol-2-yl)tetracyclo[6.6.2.0^{2,7}.0^{9,14}]hexadeca-2,4,6,9(14),10,12-hexaene-15-carboxamide
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C21H17BrN2OS
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2
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| 1 |
EC50 = 9.9 nM
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| 2 |
EC50 = 118.8 nM
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CP0041416
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(6alpha)-17-(Acetyloxy)-6-methylpreg-4-ene-3,20-dione
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C24H34O4
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1
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| 1 |
EC50 = 10 nM
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CP0424208
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(S)-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4H,4aH,5H,6H,7H-cyclopenta[f]indazol-5-yl](1-benzothiophen-3-yl)methanol
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C26H23FN2OS
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1
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| 1 |
EC50 = 10 nM
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CP0072483
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3-[1-(4-chlorophenyl)indazol-5-yl]-2,2-dimethyl-3-phenyl-N-(1,3,4-thiadiazol-2-yl)propanamide
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C26H22ClN5OS
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2
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| 1 |
EC50 = 10 nM
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| 2 |
EC50 = 23 nM
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CP0267416
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(R)-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4H,4aH,5H,6H,7H,8H-cyclohexa[f]indazol-5-yl](4-fluoro-3-methylphenyl)methanol
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C26H26F2N2O
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1
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| 1 |
EC50 = 10.2 nM
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CP0116163
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2-[(5S)-9-fluoro-2-[4-(morpholine-4-carbonyl)phenyl]-5H-chromeno[2,3-b]pyridin-5-yl]-2-methyl-N-(methylcarbamoyl)propanamide
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C29H29FN4O5
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2
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| 1 |
EC50 = 10.7 nM
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| 2 |
EC50 = 16.1 nM
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CP0103974
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(S)-1-(5-Chlorothiophen-2-yl)-1-((5aR,6S)-1-(4-fluorophenyl)-5a-methyl-5,5a,6,7,8,9-hexahydroimidazo[1,5-b]isoquinolin-6-yl)-ethanol
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C24H24ClFN2OS
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1
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| 1 |
EC50 = 11 nM
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CP0395797
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1-tert-butyl-3-[(3S)-3-[1-(4-fluorophenyl)indazol-5-yl]-2,2,5-trimethylhexyl]urea
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C27H37FN4O
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2
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| 1 |
EC50 = 11.3 nM
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| 2 |
EC50 = 25 nM
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CP0273293
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(1S)-1-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4H,4aH,5H,6H,7H,8H-cyclohexa[f]indazol-5-yl]-2-(4-methylphenyl)ethan-1-ol
Show/Hide
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C27H29FN2O
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1
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| 1 |
EC50 = 11.4 nM
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CP0323511
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2-[(5S)-2-[3-fluoro-4-(morpholine-4-carbonyl)phenyl]-5H-chromeno[2,3-b]pyridin-5-yl]-2-methyl-N-(1,3,4-thiadiazol-2-yl)propanamide
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C29H26FN5O4S
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1
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| 1 |
EC50 = 11.7 nM
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CP0123606
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N-carbamoyl-2-[(5S)-9-fluoro-2-[6-(pyrrolidine-1-carbonyl)pyridin-3-yl]-5H-chromeno[2,3-b]pyridin-5-yl]-2-methylpropanamide
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C27H26FN5O4
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2
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| 1 |
EC50 = 12.2 nM
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| 2 |
EC50 = 16.5 nM
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CP0452478
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8-chloro-15-methyl-N-(1,3-thiazol-2-yl)tetracyclo[6.6.2.0^{2,7}.0^{9,14}]hexadeca-2,4,6,9(14),10,12-hexaene-15-carboxamide
Show/Hide
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C21H17ClN2OS
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2
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| 1 |
EC50 = 12.3 nM
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| 2 |
EC50 = 229.4 nM
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CP0269534
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(R)-[(4aR,5S)-1-(4-Fluoro-phenyl)-4a-methyl-4,4a,5,6,7,8-hexahydro-1H-benzo[f]indazol-5-yl]-(6-fluoro-pyridin-3-yl)-methanol
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C24H23F2N3O
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1
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| 1 |
EC50 = 13 nM
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CP0289638
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(R)-(5-Chloro-thiophen-2-yl)-[(4aR,5S)-1-(4-fluoro-phenyl)-4a-methyl-4,4a,5,6,7,8-hexahydro-1H-benzo[f]indazol-5-yl]-methanol
Show/Hide
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C23H22ClFN2OS
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1
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| 1 |
EC50 = 13 nM
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CP0261713
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1,1,1-trifluoro-2-[(1-methyl-3,4-dihydro-2H-naphthalen-1-yl)methyl]-3-(quinolin-5-ylamino)propan-2-ol
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C24H25F3N2O
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2
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| 1 |
EC50 = 13.49 nM
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| 2 |
IC50 = 3.09 nM
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CP0210728
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2-[(5S)-2-[4-(dimethylamino)phenyl]-5H-chromeno[2,3-b]pyridin-5-yl]-2-methyl-N-(1,3,4-thiadiazol-2-yl)propanamide
Show/Hide
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C26H25N5O2S
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2
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| 1 |
EC50 = 13.6 nM
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| 2 |
EC50 = 20 nM
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CP0208099
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(1S)-1-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4H,4aH,5H,6H,7H,8H-cyclohexa[f]indazol-5-yl]-2-phenylethan-1-ol
Show/Hide
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C26H27FN2O
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1
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| 1 |
EC50 = 13.9 nM
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CP0238440
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3-[1-(2,4-difluorophenyl)imidazo[1,5-a]pyridin-6-yl]-2,2-dimethyl-3-phenyl-N-(1,3-thiazol-2-yl)propanamide
Show/Hide
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C27H22F2N4OS
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1
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| 1 |
EC50 = 14 nM
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CP0297207
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(1S)-1-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4H,4aH,5H,6H,7H,8H-cyclohexa[f]indazol-5-yl]ethan-1-ol
Show/Hide
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C20H23FN2O
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1
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| 1 |
EC50 = 14.3 nM
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CP0043410
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(R)-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4H,4aH,5H,6H,7H,8H-cyclohexa[f]indazol-5-yl](3,4-difluoro-5-methoxyphenyl)methanol
Show/Hide
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C26H25F3N2O2
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1
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| 1 |
EC50 = 14.4 nM
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CP0053816
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N-carbamoyl-2-[(5S)-9-fluoro-2-[6-(2-hydroxypropan-2-yl)pyridin-3-yl]-5H-chromeno[2,3-b]pyridin-5-yl]-2-methylpropanamide
Show/Hide
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C25H25FN4O4
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2
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| 1 |
EC50 = 14.7 nM
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| 2 |
EC50 = 21.9 nM
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CP0338226
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(3S)-3-(1H-indazol-5-yl)-2,2-dimethyl-3-phenyl-N-(1,3,4-thiadiazol-2-yl)propanamide
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C20H19N5OS
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2
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| 1 |
EC50 = 15 nM
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| 2 |
EC50 = 24 nM
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CP0294968
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3-[1-(2,4-difluorophenyl)imidazo[1,5-a]pyridin-6-yl]-2,2-dimethyl-3-phenyl-N-(1,3,4-thiadiazol-2-yl)propanamide
Show/Hide
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C26H21F2N5OS
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1
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| 1 |
EC50 = 15 nM
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CP0093346
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2-methyl-2-[(5R)-2-(4-propylphenyl)-5H-chromeno[2,3-b]pyridin-5-yl]-N-(1,3,4-thiadiazol-2-yl)propanamide
Show/Hide
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C27H26N4O2S
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2
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| 1 |
EC50 = 15.1 nM
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| 2 |
EC50 = 29.7 nM
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CP0117928
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(S)-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4H,4aH,5H,6H,7H,8H-cyclohexa[f]indazol-5-yl](4-fluorophenyl)methanol
Show/Hide
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C25H24F2N2O
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2
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| 1 |
EC50 = 15.5 nM
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| 2 |
EC50 = 16.5 nM
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CP0379760
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N-[(3S)-3-[1-(4-fluorophenyl)indazol-5-yl]-2,2-dimethyl-3-phenylpropyl]ethanesulfonamide
Show/Hide
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C26H28FN3O2S
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2
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| 1 |
EC50 = 15.6 nM
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| 2 |
EC50 = 28.8 nM
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CP0335636
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2-methyl-2-[(5S)-2-[4-(piperidine-1-carbonyl)phenyl]-5H-chromeno[2,3-b]pyridin-5-yl]-N-(1,3,4-thiadiazol-2-yl)propanamide
Show/Hide
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C30H29N5O3S
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2
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| 1 |
EC50 = 15.7 nM
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| 2 |
EC50 = 28.6 nM
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CP0039826
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(S)-1-((5aR,6S)-1-(4-fluorophenyl)-5a-methyl-5,5a,6,7,8,9-hexahydroimidazo[1,5-b]isoquinolin-6-yl)-1-phenylethanol
Show/Hide
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C26H27FN2O
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2
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| 1 |
EC50 = 16 nM
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| 2 |
EC50 = 61 nM
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CP0132626
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N-carbamoyl-2-[(5S)-9-fluoro-2-[6-(morpholine-4-carbonyl)pyridin-3-yl]-5H-chromeno[2,3-b]pyridin-5-yl]-2-methylpropanamide
Show/Hide
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C27H26FN5O5
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2
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| 1 |
EC50 = 16.3 nM
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| 2 |
EC50 = 20.3 nM
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CP0308385
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3-[1-(4-fluorophenyl)indazol-5-yl]-2,2-dimethyl-3-phenyl-N-(triazol-2-yl)propanamide
Show/Hide
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C26H23FN6O
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1
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| 1 |
EC50 = 17 nM
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CP0283198
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2-[(1-cyclobutyl-3,4-dihydro-2H-naphthalen-1-yl)methyl]-3,3,3-trifluoro-2-hydroxy-N-(4-methyl-1-oxo-2,3-benzoxazin-6-yl)propanamide
Show/Hide
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C27H27F3N2O4
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3
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| 1 |
EC50 = 17.38 nM
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| 2 |
IC50 = 4.898 nM
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| 3 |
IC50 = 165.96 nM
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CP0053822
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N-[2-[(5S)-9-fluoro-2-[4-(morpholine-4-carbonyl)phenyl]-5H-chromeno[2,3-b]pyridin-5-yl]-2-methylpropanoyl]cyclobutanecarboxamide
Show/Hide
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C32H32FN3O5
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2
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| 1 |
EC50 = 17.5 nM
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| 2 |
EC50 = 32.8 nM
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CP0371593
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N-(cyclobutylcarbamoyl)-2-[(5S)-9-fluoro-2-[4-(morpholine-4-carbonyl)phenyl]-5H-chromeno[2,3-b]pyridin-5-yl]-2-methylpropanamide
Show/Hide
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C32H33FN4O5
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2
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| 1 |
EC50 = 17.5 nM
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| 2 |
EC50 = 32.8 nM
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CP0122728
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N-[2-[(5S)-9-fluoro-2-[4-(morpholine-4-carbonyl)phenyl]-5H-chromeno[2,3-b]pyridin-5-yl]-2-methylpropanoyl]cyclopropanecarboxamide
Show/Hide
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C31H30FN3O5
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2
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| 1 |
EC50 = 17.6 nM
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| 2 |
EC50 = 18.4 nM
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CP0770597
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2-((1-cyclopentyl-1,2,3,4-tetrahydronaphthalen-1-yl)methyl)-3,3,3-trifluoro-2-hydroxy-N-(4-methyl-1-oxo-1H-benzo[d][1,2]oxazin-6-yl)propanamide
Show/Hide
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C28H29F3N2O4
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3
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| 1 |
EC50 = 17.78 nM
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| 2 |
IC50 = 2.042 nM
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| 3 |
IC50 = 53.7 nM
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CP0045383
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(2R)-2-[[(1R)-1-cyclopentyl-3,4-dihydro-2H-naphthalen-1-yl]methyl]-3,3,3-trifluoro-2-hydroxy-N-(4-methyl-1-oxo-2,3-benzoxazin-6-yl)propanamide
Show/Hide
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C28H29F3N2O4
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3
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| 1 |
EC50 = 17.78 nM
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| 2 |
IC50 = 2.042 nM
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| 3 |
IC50 = 53.7 nM
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CP0293164
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(R)-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4H,4aH,5H,6H,7H,8H-cyclohexa[f]indazol-5-yl](1-benzothiophen-3-yl)methanol
Show/Hide
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C27H25FN2OS
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1
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| 1 |
EC50 = 18 nM
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CP0039828
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(S)-1-((5aR,6S)-1-(4-Fluorophenyl)-5a-methyl-5,5a,6,7,8,9-hexahydroimidazo[1,5-b]isoquinolin-6-yl)-1-(5-methylthiophen-2-yl)-ethanol
Show/Hide
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C25H27FN2OS
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2
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| 1 |
EC50 = 18 nM
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| 2 |
EC50 = 28 nM
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CP0189072
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3-((S)-1-((5aR,6S)-1-(4-fluorophenyl)-5a-methyl-5,5a,6,7,8,9-hexahydroimidazo[1,5-b]isoquinolin-6-yl)-1-hydroxyethyl)benzonitrile
Show/Hide
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C27H26FN3O
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2
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| 1 |
EC50 = 18 nM
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| 2 |
EC50 = 31 nM
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CP0054317
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3-[1-(4-fluorophenyl)indazol-5-yl]-2,2-dimethyl-N-(1,3,4-thiadiazol-2-yl)hexanamide
Show/Hide
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C23H24FN5OS
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1
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| 1 |
EC50 = 18 nM
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CP0132652
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2-methyl-2-[(5R)-2-(4-propan-2-yloxyphenyl)-5H-chromeno[2,3-b]pyridin-5-yl]-N-(1,3,4-thiadiazol-2-yl)propanamide
Show/Hide
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C27H26N4O3S
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1
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| 1 |
EC50 = 18.1 nM
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CP0330406
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3,3,3-trifluoro-2-hydroxy-N-(4-methyl-1-oxo-2,3-benzoxazin-6-yl)-2-[(1-propan-2-yl-3,4-dihydro-2H-naphthalen-1-yl)methyl]propanamide
Show/Hide
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C26H27F3N2O4
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3
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| 1 |
EC50 = 18.62 nM
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| 2 |
IC50 = 2.951 nM
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| 3 |
IC50 = 128.82 nM
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CP0059549
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(R)-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4H,4aH,5H,6H,7H,8H-cyclohexa[f]indazol-5-yl](1-benzothiophen-2-yl)methanol
Show/Hide
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C27H25FN2OS
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1
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| 1 |
EC50 = 19 nM
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CP0338373
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(3S)-2,2-dimethyl-3-phenyl-3-(1-pyridin-3-ylindazol-5-yl)-N-(1,3,4-thiadiazol-2-yl)propanamide
Show/Hide
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C25H22N6OS
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1
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| 1 |
EC50 = 19 nM
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CP0085232
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N-[(3S)-3-[1-(4-fluorophenyl)indazol-5-yl]-2,2-dimethyl-3-phenylpropyl]methanesulfonamide
Show/Hide
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C25H26FN3O2S
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2
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| 1 |
EC50 = 19.1 nM
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| 2 |
EC50 = 20.5 nM
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CP0178005
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(15R)-8-cyano-15-methyl-N-(1,3-thiazol-2-yl)tetracyclo[6.6.2.0^{2,7}.0^{9,14}]hexadeca-2,4,6,9(14),10,12-hexaene-15-carboxamide
Show/Hide
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C22H17N3OS
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2
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| 1 |
EC50 = 19.4 nM
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| 2 |
EC50 = 243.1 nM
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CP0246071
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4-[(R)-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4H,4aH,5H,6H,7H,8H-cyclohexa[f]indazol-5-yl](hydroxy)methyl]phenol
Show/Hide
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C25H25FN2O2
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1
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| 1 |
EC50 = 19.5 nM
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CP0334432
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3,3,3-trifluoro-2-hydroxy-N-(4-methyl-1-oxo-2,3-benzoxazin-6-yl)-2-[(1-propyl-3,4-dihydro-2H-naphthalen-1-yl)methyl]propanamide
Show/Hide
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C26H27F3N2O4
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3
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| 1 |
EC50 = 19.95 nM
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| 2 |
IC50 = 4.677 nM
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| 3 |
IC50 = 25.12 nM
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CP0117595
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5-amino-N-[2-[[ethyl-(2-fluorobenzoyl)amino]methyl]-3,3,3-trifluoro-2-hydroxypropyl]-1-(4-fluorophenyl)pyrazole-4-carboxamide
Show/Hide
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C23H22F5N5O3
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1
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| 1 |
EC50 = 19.95 nM
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CP0125784
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N-[4-[1-(4-fluorophenyl)indazol-5-yl]-3-(trifluoromethyl)phenyl]-1-phenylmethanesulfonamide
Show/Hide
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C27H19F4N3O2S
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2
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| 1 |
EC50 = 19.95 nM
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|
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| 2 |
IC50 = 10 nM
|
|
|
|
CP0086647
|
(S)-1-(4-Fluorophenyl)-1-((5aR,6S)-1-(4-fluorophenyl)-5a-methyl-5,5a,6,7,8,9-hexahydroimidazo[1,5-b]-isoquinolin-6-yl)ethanol
Show/Hide
|
C26H26F2N2O
|
2
|
| 1 |
EC50 = 20 nM
|
|
|
| 2 |
EC50 = 44 nM
|
|
|
|
CP0100809
|
2,2-dimethyl-3-phenyl-3-(1-phenylindazol-5-yl)-N-(1,3,4-thiadiazol-2-yl)propanamide
Show/Hide
|
C26H23N5OS
|
1
|
| 1 |
EC50 = 20 nM
|
|
|
|
CP0210725
|
(3S)-3-(4-hydroxyphenyl)-2,2-dimethyl-3-phenyl-N-(1,3,4-thiadiazol-2-yl)propanamide
Show/Hide
|
C19H19N3O2S
|
3
|
| 1 |
EC50 = 20.3 nM
|
|
|
| 2 |
EC50 = 21 nM
|
|
|
| 3 |
EC50 = 27.5 nM
|
|
|
|
CP0335635
|
2-[(5S)-2-[4-(3,3-difluoropyrrolidine-1-carbonyl)-3-fluorophenyl]-5H-chromeno[2,3-b]pyridin-5-yl]-2-methyl-N-(1,3,4-thiadiazol-2-yl)propanamide
Show/Hide
|
C29H24F3N5O3S
|
2
|
| 1 |
EC50 = 20.6 nM
|
|
|
| 2 |
EC50 = 37.9 nM
|
|
|
|
CP0200282
|
2-[(1-cyclohexyl-3,4-dihydro-2H-naphthalen-1-yl)methyl]-3,3,3-trifluoro-2-hydroxy-N-(4-methyl-1-oxo-2,3-benzoxazin-6-yl)propanamide
Show/Hide
|
C29H31F3N2O4
|
3
|
| 1 |
EC50 = 20.89 nM
|
|
|
| 2 |
IC50 = 3.311 nM
|
|
|
| 3 |
IC50 = 199.53 nM
|
|
|
|
CP0493195
|
(S)-[(4aR,5S)-1-(4-Fluoro-phenyl)-4a-methyl-4,4a,5,6,7,8-hexahydro-1H-benzo[f]indazol-5-yl]-(6-fluoro-pyridin-3-yl)-methanol
Show/Hide
|
C24H23F2N3O
|
1
|
| 1 |
EC50 = 21 nM
|
|
|
|
CP0426986
|
(R)-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4H,4aH,5H,6H,7H-cyclopenta[f]indazol-5-yl](thiophen-3-yl)methanol
Show/Hide
|
C22H21FN2OS
|
1
|
| 1 |
EC50 = 21 nM
|
|
|
|
CP0338372
|
3-(1-cycloheptylindazol-5-yl)-2,2-dimethyl-3-phenyl-N-(1,3,4-thiadiazol-2-yl)propanamide
Show/Hide
|
C27H31N5OS
|
2
|
| 1 |
EC50 = 21 nM
|
|
|
| 2 |
EC50 = 29 nM
|
|
|
|
CP0213090
|
2-[(5S)-2-(4-methoxyphenyl)-5H-chromeno[2,3-b]pyridin-5-yl]-2-methyl-N-(1,3,4-thiadiazol-2-yl)propanamide
Show/Hide
|
C25H22N4O3S
|
2
|
| 1 |
EC50 = 21.3 nM
|
|
|
| 2 |
EC50 = 28.3 nM
|
|
|
|
CP0093349
|
2-[(5S)-2-(4-ethylsulfonylphenyl)-5H-chromeno[2,3-b]pyridin-5-yl]-2-methyl-N-(1,3,4-thiadiazol-2-yl)propanamide
Show/Hide
|
C26H24N4O4S2
|
2
|
| 1 |
EC50 = 22.8 nM
|
|
|
| 2 |
EC50 = 28.6 nM
|
|
|
|
CP0271637
|
N-[(3S)-3-[1-(4-fluorophenyl)indazol-5-yl]-2,2-dimethyl-3-phenylpropyl]-2,2-dimethylpropanamide
Show/Hide
|
C29H32FN3O
|
2
|
| 1 |
EC50 = 23 nM
|
|
|
| 2 |
EC50 = 78 nM
|
|
|
|
CP0690740
|
rac-3-(1-(4-fluorophenyl)-1H-indazol-5-yl)-2,2-dimethyl-3-phenyl-N-(1,3,4-thiadiazol-2-yl)propanamide
Show/Hide
|
C26H22FN5OS
|
1
|
| 1 |
EC50 = 23 nM
|
|
|
|
CP0115414
|
2-[(5S)-9-fluoro-2-[4-(morpholine-4-carbonyl)phenyl]-5H-chromeno[2,3-b]pyridin-5-yl]-2-methyl-N-(2-methylpropanoyl)propanamide
Show/Hide
|
C31H32FN3O5
|
2
|
| 1 |
EC50 = 23.7 nM
|
|
|
| 2 |
EC50 = 74.8 nM
|
|
|
|
CP0101307
|
(1S)-1-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4H,4aH,5H,6H,7H,8H-cyclohexa[f]indazol-5-yl]-2-(4-tert-butylphenyl)ethan-1-ol
Show/Hide
|
C30H35FN2O
|
1
|
| 1 |
EC50 = 24.2 nM
|
|
|
|
CP0039827
|
(S)-1-((5aR,6S)-1-(4-Fluorophenyl)-5a-methyl-5,5a,6,7,8,9-hexahydroimidazo[1,5-b]isoquinolin-6-yl)-1-o-tolylethanol
Show/Hide
|
C27H29FN2O
|
2
|
| 1 |
EC50 = 25 nM
|
|
|
| 2 |
EC50 = 31 nM
|
|
|
|
CP0213088
|
2-[(5S)-2-[3-fluoro-4-(pyrrolidine-1-carbonyl)phenyl]-5H-chromeno[2,3-b]pyridin-5-yl]-2-methyl-N-(1,3,4-thiadiazol-2-yl)propanamide
Show/Hide
|
C29H26FN5O3S
|
2
|
| 1 |
EC50 = 25 nM
|
|
|
| 2 |
EC50 = 29.2 nM
|
|
|
|
CP0098794
|
5-amino-N-[2-[[ethyl-(2-fluoro-6-methylsulfonylbenzoyl)amino]methyl]-3,3,3-trifluoro-2-hydroxypropyl]-1-(4-fluorophenyl)pyrazole-4-carboxamide
Show/Hide
|
C24H24F5N5O5S
|
1
|
| 1 |
EC50 = 25.12 nM
|
|
|
|
CP0205887
|
5-amino-N-[2-[[(2,6-difluorobenzoyl)-propylamino]methyl]-3,3,3-trifluoro-2-hydroxypropyl]-1-(4-fluorophenyl)pyrazole-4-carboxamide
Show/Hide
|
C24H23F6N5O3
|
1
|
| 1 |
EC50 = 25.12 nM
|
|
|
|
CP0323512
|
2-[(5S)-2-[3-fluoro-4-(piperidine-1-carbonyl)phenyl]-5H-chromeno[2,3-b]pyridin-5-yl]-2-methyl-N-(1,3,4-thiadiazol-2-yl)propanamide
Show/Hide
|
C30H28FN5O3S
|
2
|
| 1 |
EC50 = 25.6 nM
|
|
|
| 2 |
EC50 = 27.5 nM
|
|
|
|
CP0083148
|
2-methyl-2-[(5S)-2-(4-methylphenyl)-5H-chromeno[2,3-b]pyridin-5-yl]-N-(1,3,4-thiadiazol-2-yl)propanamide
Show/Hide
|
C25H22N4O2S
|
2
|
| 1 |
EC50 = 26.6 nM
|
|
|
| 2 |
EC50 = 46.8 nM
|
|
|
|
CP0313988
|
N-[(3S)-3-[1-(4-fluorophenyl)indazol-5-yl]-2,2-dimethyl-3-phenylpropyl]cyclopropanesulfonamide
Show/Hide
|
C27H28FN3O2S
|
2
|
| 1 |
EC50 = 26.8 nM
|
|
|
| 2 |
EC50 = 29.3 nM
|
|
|
|
CP0295884
|
(3S)-3-(4-hydroxy-3-methylphenyl)-2,2-dimethyl-3-phenyl-N-(1,3,4-thiadiazol-2-yl)propanamide
Show/Hide
|
C20H21N3O2S
|
2
|
| 1 |
EC50 = 28.6 nM
|
|
|
| 2 |
EC50 = 119.3 nM
|
|
|
|
CP0209790
|
(S)-1-((5aR,6S)-1-(4-Fluorophenyl)-5a-methyl-5,5a,6,7,8,9-hexahydroimidazo[1,5-b]isoquinolin-6-yl)-1-(3-methylthiophen-2-yl)-ethanol
Show/Hide
|
C25H27FN2OS
|
2
|
| 1 |
EC50 = 29 nM
|
|
|
| 2 |
EC50 = 30 nM
|
|
|
|
CP0303983
|
3-[1-(4-fluorophenyl)indazol-5-yl]-2,2-dimethyl-N-(4-methyl-1,3-thiazol-2-yl)-3-phenylpropanamide
Show/Hide
|
C28H25FN4OS
|
1
|
| 1 |
EC50 = 29 nM
|
|
|
|
CP0336445
|
3-[1-(4-fluorophenyl)indazol-5-yl]-2,2,5-trimethyl-N-(1,3,4-thiadiazol-2-yl)hexanamide
Show/Hide
|
C24H26FN5OS
|
1
|
| 1 |
EC50 = 29 nM
|
|
|
|
CP0087253
|
(3S)-3-(4-hydroxyphenyl)-2,2-dimethyl-3-phenyl-N-(1,3-thiazol-2-yl)propanamide
Show/Hide
|
C20H20N2O2S
|
2
|
| 1 |
EC50 = 29.5 nM
|
|
|
| 2 |
EC50 = 40.9 nM
|
|
|
|
CP0480488
|
15-methyl-N-(1,3-thiazol-2-yl)tetracyclo[6.6.2.0^{2,7}.0^{9,14}]hexadeca-2,4,6,9(14),10,12-hexaene-15-carboxamide
Show/Hide
|
C21H18N2OS
|
2
|
| 1 |
EC50 = 30.7 nM
|
|
|
| 2 |
EC50 = 268 nM
|
|
|
|
CP0319027
|
(R)-(2,5-Dichloro-thiophen-3-yl)-[(4aR,5S)-1-(4-fluoro-phenyl)-4a-methyl-4,4a,5,6,7,8-hexahydro-1H-benzo[f]indazol-5-yl]-methanol
Show/Hide
|
C23H21Cl2FN2OS
|
1
|
| 1 |
EC50 = 31 nM
|
|
|
|
CP0277119
|
(S)-1,1,1-Trifluoro-2-((5aR,6S)-1-(4-fluorophenyl)-5a-methyl-5,5a,6,7,8,9-hexahydroimidazo[1,5-b]isoquinolin-6-yl)propan-2-ol
Show/Hide
|
C21H22F4N2O
|
1
|
| 1 |
EC50 = 31 nM
|
|
|
|
CP0088590
|
(R)-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4H,4aH,5H,6H,7H,8H-cyclohexa[f]indazol-5-yl](4-fluoro-3-methoxyphenyl)methanol
Show/Hide
|
C26H26F2N2O2
|
1
|
| 1 |
EC50 = 31.3 nM
|
|
|
|
CP0464253
|
(S)-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4H,4aH,5H,6H,7H-cyclopenta[f]indazol-5-yl](naphthalen-1-yl)methanol
Show/Hide
|
C28H25FN2O
|
1
|
| 1 |
EC50 = 33 nM
|
|
|
|
CP0078261
|
2-fluoro-N,N-dimethyl-4-[(5R)-5-[2-methyl-1-oxo-1-(1,3,4-thiadiazol-2-ylamino)propan-2-yl]-5H-chromeno[2,3-b]pyridin-2-yl]benzamide
Show/Hide
|
C27H24FN5O3S
|
2
|
| 1 |
EC50 = 33.2 nM
|
|
|
| 2 |
EC50 = 33.8 nM
|
|
|
|
CP0145661
|
2-[(5S)-2-[3-chloro-4-(3,3-difluoropyrrolidine-1-carbonyl)phenyl]-5H-chromeno[2,3-b]pyridin-5-yl]-2-methyl-N-(1,3,4-thiadiazol-2-yl)propanamide
Show/Hide
|
C29H24ClF2N5O3S
|
2
|
| 1 |
EC50 = 33.8 nM
|
|
|
| 2 |
EC50 = 50 nM
|
|
|
|
CP0244758
|
(R)-2-((5aR,6S)-1-(4-Fluorophenyl)-5a-methyl-5,5a,6,7,8,9-hexahydroimidazo[1,5-b]isoquinolin-6-yl)hexan-2-ol
Show/Hide
|
C24H31FN2O
|
2
|
| 1 |
EC50 = 34 nM
|
|
|
| 2 |
EC50 = 130 nM
|
|
|
|
CP0304453
|
2-fluoro-N-methyl-4-[(5S)-5-[2-methyl-1-oxo-1-(1,3,4-thiadiazol-2-ylamino)propan-2-yl]-5H-chromeno[2,3-b]pyridin-2-yl]benzamide
Show/Hide
|
C26H22FN5O3S
|
2
|
| 1 |
EC50 = 34.1 nM
|
|
|
| 2 |
EC50 = 157 nM
|
|
|
|
CP0115416
|
N-(ethylcarbamoyl)-2-[(5S)-9-fluoro-2-[4-(morpholine-4-carbonyl)phenyl]-5H-chromeno[2,3-b]pyridin-5-yl]-2-methylpropanamide
Show/Hide
|
C30H31FN4O5
|
2
|
| 1 |
EC50 = 34.2 nM
|
|
|
| 2 |
EC50 = 36.4 nM
|
|
|
|
CP0319026
|
(R)-[(4aR,5S)-1-(4-Fluoro-phenyl)-4a-methyl-4,4a,5,6,7,8-hexahydro-1H-benzo[f]indazol-5-yl]-thiophen-2-yl-methanol
Show/Hide
|
C23H23FN2OS
|
1
|
| 1 |
EC50 = 37 nM
|
|
|
|
CP0278261
|
(R)-1-Cyclopropyl-1-((5aR,6S)-1-(4-fluorophenyl)-5a-methyl-5,5a,6,7,8,9-hexahydroimidazo[1,5-b]isoquinolin-6-yl)ethanol
Show/Hide
|
C23H27FN2O
|
2
|
| 1 |
EC50 = 37 nM
|
|
|
| 2 |
EC50 = 49 nM
|
|
|
|
CP0280531
|
3-(3-fluoro-4-hydroxyphenyl)-2,2-dimethyl-3-phenyl-N-(1,3-thiazol-2-yl)propanamide
Show/Hide
|
C20H19FN2O2S
|
2
|
| 1 |
EC50 = 37.7 nM
|
|
|
| 2 |
EC50 = 51.1 nM
|
|
|
|
CP0076842
|
(R)-[(4aR,5S)-1-(4-Fluoro-phenyl)-4a-methyl-4,4a,5,6,7,8-hexahydro-1H-benzo[f]indazol-5-yl]-pyridin-4-yl-methanol
Show/Hide
|
C24H24FN3O
|
1
|
| 1 |
EC50 = 38 nM
|
|
|
|
CP0318784
|
3,3,3-trifluoro-N-[(3S)-3-[1-(4-fluorophenyl)indazol-5-yl]-2,2,5-trimethylhexyl]propanamide
Show/Hide
|
C25H29F4N3O
|
2
|
| 1 |
EC50 = 38 nM
|
|
|
| 2 |
EC50 = 61 nM
|
|
|
|
CP0496701
|
2-[(1-cyclopropyl-3,4-dihydro-2H-naphthalen-1-yl)methyl]-3,3,3-trifluoro-2-hydroxy-N-(4-methyl-1-oxo-2,3-benzoxazin-6-yl)propanamide
Show/Hide
|
C26H25F3N2O4
|
3
|
| 1 |
EC50 = 39.81 nM
|
|
|
| 2 |
IC50 = 9.55 nM
|
|
|
| 3 |
IC50 = 204.17 nM
|
|
|
|
CP0071198
|
(+/-)-N-(2-((5-amino-1-(4-fluorophenyl)-1H-pyrazole-4-carboxamido)methyl)-3,3,3-trifluoro-2-hydroxypropyl)-3-chloro-N-ethylpicolinamide
Show/Hide
|
C22H21ClF4N6O3
|
1
|
| 1 |
EC50 = 39.81 nM
|
|
|
|
CP0086667
|
(S)-1-((5aR,6S)-1-(4-Fluorophenyl)-5a-methyl-5,5a,6,7,8,9-hexahydroimidazo[1,5-b]isoquinolin-6-yl)-1-(thiophen-2-yl)ethanol
Show/Hide
|
C24H25FN2OS
|
2
|
| 1 |
EC50 = 41 nM
|
|
|
| 2 |
EC50 = 52 nM
|
|
|
|
CP0278812
|
1,1,1-trifluoro-2-(1H-indol-2-ylmethyl)-3-(1-methyl-3,4-dihydro-2H-naphthalen-1-yl)propan-2-ol
Show/Hide
|
C23H24F3NO
|
3
|
| 1 |
EC50 = 41.69 nM
|
|
|
| 2 |
IC50 = 42.66 nM
|
|
|
| 3 |
IC50 = 446.68 nM
|
|
|
|
CP0093348
|
2-[(5S)-2-(4-acetyl-3-fluorophenyl)-5H-chromeno[2,3-b]pyridin-5-yl]-2-methyl-N-(1,3,4-thiadiazol-2-yl)propanamide
Show/Hide
|
C26H21FN4O3S
|
1
|
| 1 |
EC50 = 42 nM
|
|
|
|
CP0335471
|
2,2-dimethyl-3-[1-(3-methylbutyl)indazol-5-yl]-3-phenyl-N-(1,3,4-thiadiazol-2-yl)propanamide
Show/Hide
|
C25H29N5OS
|
2
|
| 1 |
EC50 = 45 nM
|
|
|
| 2 |
EC50 = 49 nM
|
|
|
|
CP0132651
|
2-[(5S)-2-(3-fluoro-4-propan-2-yloxyphenyl)-5H-chromeno[2,3-b]pyridin-5-yl]-2-methyl-N-(1,3,4-thiadiazol-2-yl)propanamide
Show/Hide
|
C27H25FN4O3S
|
2
|
| 1 |
EC50 = 47 nM
|
|
|
| 2 |
EC50 = 73 nM
|
|
|
|
CP0434459
|
(R)-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4H,4aH,5H,6H,7H-cyclopenta[f]indazol-5-yl](naphthalen-1-yl)methanol
Show/Hide
|
C28H25FN2O
|
1
|
| 1 |
EC50 = 48 nM
|
|
|
|
CP0254851
|
(R)-1-((5aR,6S)-1-(4-Fluorophenyl)-5a-methyl-5,5a,6,7,8,9-hexahydroimidazo[1,5-b]isoquinolin-6-yl)-1-(tetrahydro-2H-pyran-4-yl)-ethanol
Show/Hide
|
C25H31FN2O2
|
2
|
| 1 |
EC50 = 48 nM
|
|
|
| 2 |
EC50 = 57 nM
|
|
|
|
CP0218061
|
3-[1-(4-fluorophenyl)indazol-5-yl]-2,2-dimethyl-N-(5-methyl-1,3-thiazol-2-yl)-3-phenylpropanamide
Show/Hide
|
C28H25FN4OS
|
1
|
| 1 |
EC50 = 49 nM
|
|
|
|
CP0071189
|
5-amino-N-(2-((2,6-difluoro-N-(2-hydroxyethyl)benzamido)methyl)-3,3,3-trifluoro-2-hydroxypropyl)-1-(4-fluorophenyl)-1H-pyrazole-4-carboxamide
Show/Hide
|
C23H21F6N5O4
|
1
|
| 1 |
EC50 = 50.12 nM
|
|
|
|
CP0071192
|
(+/-)-5-amino-N-(2-((2,6-difluoro-N-(2-fluoroethyl)benzamido)methyl)-3,3,3-trifluoro-2-hydroxypropyl)-1-(4-fluorophenyl)-1H-pyrazole-4-carboxamide
Show/Hide
|
C23H20F7N5O3
|
1
|
| 1 |
EC50 = 50.12 nM
|
|
|
|
CP0138752
|
5-amino-N-[2-[[(2-chloro-3-fluorobenzoyl)-ethylamino]methyl]-3,3,3-trifluoro-2-hydroxypropyl]-1-(4-fluorophenyl)pyrazole-4-carboxamide
Show/Hide
|
C23H21ClF5N5O3
|
1
|
| 1 |
EC50 = 50.12 nM
|
|
|
|
CP0291235
|
5-amino-N-[2-[[ethyl-(2,4,6-trichlorobenzoyl)amino]methyl]-3,3,3-trifluoro-2-hydroxypropyl]-1-(4-fluorophenyl)pyrazole-4-carboxamide
Show/Hide
|
C23H20Cl3F4N5O3
|
1
|
| 1 |
EC50 = 50.12 nM
|
|
|
|
CP0287672
|
2-[(2-chloroquinolin-4-yl)methyl]-3-(1-ethyl-3,4-dihydro-2H-naphthalen-1-yl)-1,1,1-trifluoropropan-2-ol
Show/Hide
|
C25H25ClF3NO
|
2
|
| 1 |
EC50 = 51.29 nM
|
|
|
| 2 |
IC50 = 30.2 nM
|
|
|
|
CP0263935
|
3-[(R)-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4H,4aH,5H,6H,7H,8H-cyclohexa[f]indazol-5-yl](hydroxy)methyl]phenol
Show/Hide
|
C25H25FN2O2
|
1
|
| 1 |
EC50 = 54.2 nM
|
|
|
|
CP0100808
|
3-[1-(4-methoxyphenyl)indazol-5-yl]-2,2-dimethyl-3-phenyl-N-(1,3,4-thiadiazol-2-yl)propanamide
Show/Hide
|
C27H25N5O2S
|
2
|
| 1 |
EC50 = 56 nM
|
|
|
| 2 |
EC50 = 143 nM
|
|
|
|
CP0254606
|
(R)-2-((5aR,6S)-1-(4-Fluorophenyl)-5a-methyl-5,5a,6,7,8,9-hexahydroimidazo[1,5-b]isoquinolin-6-yl)pent-4-en-2-ol
Show/Hide
|
C23H27FN2O
|
2
|
| 1 |
EC50 = 57 nM
|
|
|
| 2 |
EC50 = 79 nM
|
|
|
|
CP0143500
|
1-tert-butyl-3-[(3S)-3-[1-(4-fluorophenyl)indazol-5-yl]-2,2-dimethyl-3-phenylpropyl]urea
Show/Hide
|
C29H33FN4O
|
2
|
| 1 |
EC50 = 57 nM
|
|
|
| 2 |
EC50 = 58 nM
|
|
|
|
CP0083142
|
N,N-dimethyl-6-[9-[2-methyl-1-oxo-1-(1,3,4-thiadiazol-2-ylamino)propan-2-yl]-9H-xanthen-3-yl]pyridine-3-carboxamide
Show/Hide
|
C27H25N5O3S
|
1
|
| 1 |
EC50 = 58 nM
|
|
|
|
CP0072484
|
(3R)-3-[1-(4-fluorophenyl)indazol-5-yl]-2,2-dimethyl-3-phenyl-N-(1,3-thiazol-2-yl)propanamide
Show/Hide
|
C27H23FN4OS
|
2
|
| 1 |
EC50 = 58 nM
|
|
|
| 2 |
EC50 = 400 nM
|
|
|
|
CP0278380
|
4-((S)-1-((5aR,6S)-1-(4-fluorophenyl)-5a-methyl-5,5a,6,7,8,9-hexahydroimidazo[1,5-b]isoquinolin-6-yl)-1-hydroxyethyl)benzonitrile
Show/Hide
|
C27H26FN3O
|
2
|
| 1 |
EC50 = 59 nM
|
|
|
| 2 |
EC50 = 105 nM
|
|
|
|
CP0280530
|
3-(4-hydroxyphenyl)-2,2-dimethyl-3-phenyl-N-(1,3-thiazol-2-yl)propanamide
Show/Hide
|
C20H20N2O2S
|
2
|
| 1 |
EC50 = 61.4 nM
|
|
|
| 2 |
EC50 = 125.2 nM
|
|
|
|
CP0210668
|
2-chloro-N-ethyl-N-methyl-4-[(5R)-5-[2-methyl-1-oxo-1-(1,3,4-thiadiazol-2-ylamino)propan-2-yl]-5H-chromeno[2,3-b]pyridin-2-yl]benzamide
Show/Hide
|
C28H26ClN5O3S
|
2
|
| 1 |
EC50 = 64.9 nM
|
|
|
| 2 |
EC50 = 124 nM
|
|
|
|
CP0072478
|
3-cyclohexyl-3-[1-(4-fluorophenyl)indazol-5-yl]-2,2-dimethyl-N-(1,3-thiazol-2-yl)propanamide
Show/Hide
|
C27H29FN4OS
|
1
|
| 1 |
EC50 = 66 nM
|
|
|
|
CP0295753
|
3-[1-(4-fluorophenyl)indazol-5-yl]-2,2-dimethyl-3-phenyl-N-thiophen-3-ylpropanamide
Show/Hide
|
C28H24FN3OS
|
1
|
| 1 |
EC50 = 73 nM
|
|
|
|
CP0314580
|
N,N-dimethyl-4-[9-[2-methyl-1-oxo-1-(1,3,4-thiadiazol-2-ylamino)propan-2-yl]-9H-xanthen-3-yl]benzamide
Show/Hide
|
C28H26N4O3S
|
2
|
| 1 |
EC50 = 74.9 nM
|
|
|
| 2 |
EC50 = 77.9 nM
|
|
|
|
CP0218085
|
2,2-dimethyl-3-phenyl-3-(1-pyridin-4-ylindazol-5-yl)-N-(1,3,4-thiadiazol-2-yl)propanamide
Show/Hide
|
C25H22N6OS
|
2
|
| 1 |
EC50 = 78 nM
|
|
|
| 2 |
EC50 = 106 nM
|
|
|
|
CP0180713
|
3-[1-(4-fluorophenyl)indazol-5-yl]-2,2,4-trimethyl-N-(1,3,4-thiadiazol-2-yl)pentanamide
Show/Hide
|
C23H24FN5OS
|
1
|
| 1 |
EC50 = 81 nM
|
|
|
|
CP0218062
|
3-cyclopentyl-3-[1-(4-fluorophenyl)indazol-5-yl]-2,2-dimethyl-N-(1,3-thiazol-2-yl)propanamide
Show/Hide
|
C26H27FN4OS
|
1
|
| 1 |
EC50 = 82 nM
|
|
|
|
CP0395792
|
N-[(3S)-3-[1-(4-fluorophenyl)indazol-5-yl]-2,2-dimethyl-3-phenylpropyl]propane-1-sulfonamide
Show/Hide
|
C27H30FN3O2S
|
2
|
| 1 |
EC50 = 86 nM
|
|
|
| 2 |
EC50 = 143 nM
|
|
|
|
CP0101013
|
1-[(3S)-3-[1-(4-fluorophenyl)indazol-5-yl]-2,2,5-trimethylhexyl]-3-(2,2,2-trifluoroethyl)urea
Show/Hide
|
C25H30F4N4O
|
2
|
| 1 |
EC50 = 87 nM
|
|
|
| 2 |
EC50 = 118 nM
|
|
|
|
CP0072479
|
3-[1-(4-fluorophenyl)indazol-5-yl]-2,2-dimethyl-N-(1,3-thiazol-2-yl)pentanamide
Show/Hide
|
C23H23FN4OS
|
1
|
| 1 |
EC50 = 87 nM
|
|
|
|
CP0176416
|
3-[1-(4-cyanophenyl)imidazo[1,5-a]pyridin-6-yl]-2,2-dimethyl-3-phenyl-N-(1,3-thiazol-2-yl)propanamide
Show/Hide
|
C28H23N5OS
|
1
|
| 1 |
EC50 = 89 nM
|
|
|
|
CP0335639
|
2-[(5R)-2-(4-hydroxyphenyl)-5H-chromeno[2,3-b]pyridin-5-yl]-2-methyl-N-(1,3,4-thiadiazol-2-yl)propanamide
Show/Hide
|
C24H20N4O3S
|
2
|
| 1 |
EC50 = 90.8 nM
|
|
|
| 2 |
EC50 = 108 nM
|
|
|
|
CP0039829
|
(S)-1-((5aR,6S)-1-(4-Fluorophenyl)-5a-methyl-5,5a,6,7,8,9-hexahydroimidazo[,5-b]isoquinolin-6-yl)-1-(thiazol-2-yl)ethanol
Show/Hide
|
C23H24FN3OS
|
2
|
| 1 |
EC50 = 92 nM
|
|
|
| 2 |
EC50 = 110 nM
|
|
|
|
CP0054318
|
(3R)-3-[1-(4-fluorophenyl)indazol-5-yl]-2,2-dimethyl-3-phenyl-N-(1,3,4-thiadiazol-2-yl)propanamide
Show/Hide
|
C26H22FN5OS
|
1
|
| 1 |
EC50 = 92 nM
|
|
|
|
CP0115415
|
4-[(5S)-5-(1-acetamido-2-methyl-1-oxopropan-2-yl)-9-fluoro-5H-chromeno[2,3-b]pyridin-2-yl]-N,N-dimethylbenzamide
Show/Hide
|
C27H26FN3O4
|
2
|
| 1 |
EC50 = 109.1 nM
|
|
|
| 2 |
EC50 = 212.6 nM
|
|
|
|
CP0055330
|
3-[1-(3-chloro-4-fluorophenyl)imidazo[1,5-a]pyridin-6-yl]-2,2-dimethyl-3-phenyl-N-(1,3,4-thiadiazol-2-yl)propanamide
Show/Hide
|
C26H21ClFN5OS
|
1
|
| 1 |
EC50 = 111 nM
|
|
|
|
CP0338931
|
2,2-dimethyl-3-[1-(2-methylpropyl)indazol-5-yl]-3-phenyl-N-(1,3,4-thiadiazol-2-yl)propanamide
Show/Hide
|
C24H27N5OS
|
2
|
| 1 |
EC50 = 114 nM
|
|
|
| 2 |
EC50 = 1823 nM
|
|
|
|
CP0341682
|
3-[1-(3-chloro-4-fluorophenyl)imidazo[1,5-a]pyridin-6-yl]-2,2-dimethyl-3-phenyl-N-(1,3-thiazol-2-yl)propanamide
Show/Hide
|
C27H22ClFN4OS
|
1
|
| 1 |
EC50 = 114 nM
|
|
|
|
CP0043125
|
(15R)-15-methyl-N-(1,3-thiazol-2-yl)tetracyclo[6.6.2.0^{2,7}.0^{9,14}]hexadeca-2,4,6,9(14),10,12-hexaene-15-carboxamide
Show/Hide
|
C21H18N2OS
|
1
|
| 1 |
EC50 = 114.9 nM
|
|
|
|
CP0189106
|
(R)-1-(4-Fluorophenyl)-2-((5aR,6S)-1-(4-fluorophenyl)-5a-methyl-5,5a,6,7,8,9-hexahydroimidazo[1,5-b]isoquinolin-6-yl)propan-2-ol
Show/Hide
|
C27H28F2N2O
|
2
|
| 1 |
EC50 = 121 nM
|
|
|
| 2 |
EC50 = 227 nM
|
|
|
|
CP0335640
|
2-methyl-2-[(5S)-2-(2-methylphenyl)-5H-chromeno[2,3-b]pyridin-5-yl]-N-(1,3,4-thiadiazol-2-yl)propanamide
Show/Hide
|
C25H22N4O2S
|
2
|
| 1 |
EC50 = 122 nM
|
|
|
| 2 |
EC50 > 5000 nM
|
|
|
|
CP0101014
|
2,2,2-trifluoro-N-[(3S)-3-[1-(4-fluorophenyl)indazol-5-yl]-2,2-dimethyl-3-phenylpropyl]acetamide
Show/Hide
|
C26H23F4N3O
|
2
|
| 1 |
EC50 = 124 nM
|
|
|
| 2 |
EC50 = 725 nM
|
|
|
|
CP0294379
|
4-[1-(4-fluorophenyl)indazol-5-yl]-N-phenyl-N-propan-2-yl-3-(trifluoromethyl)benzenesulfonamide
Show/Hide
|
C29H23F4N3O2S
|
2
|
| 1 |
EC50 = 125.89 nM
|
|
|
| 2 |
IC50 = 50.12 nM
|
|
|
|
CP0338932
|
2,2-dimethyl-3-phenyl-3-(1-pyridin-2-ylindazol-5-yl)-N-(1,3,4-thiadiazol-2-yl)propanamide
Show/Hide
|
C25H22N6OS
|
1
|
| 1 |
EC50 = 127 nM
|
|
|
|
CP0254850
|
(R)-2-((5aR,6S)-1-(4-Fluorophenyl)-5a-methyl-5,5a,6,7,8,9-hexahydroimidazo[1,5-b]isoquinolin-6-yl)-4-methylpentan-2-ol
Show/Hide
|
C24H31FN2O
|
2
|
| 1 |
EC50 = 132 nM
|
|
|
| 2 |
EC50 = 133 nM
|
|
|
|
CP0318785
|
N-[(3S)-3-[1-(4-fluorophenyl)indazol-5-yl]-2,2-dimethyl-3-phenylpropyl]-3,3-dimethylbutanamide
Show/Hide
|
C30H34FN3O
|
2
|
| 1 |
EC50 = 138 nM
|
|
|
| 2 |
EC50 = 215 nM
|
|
|
|
CP0055332
|
3-[1-(4-cyanophenyl)imidazo[1,5-a]pyridin-6-yl]-2,2-dimethyl-3-phenyl-N-(1,3,4-thiadiazol-2-yl)propanamide
Show/Hide
|
C27H22N6OS
|
1
|
| 1 |
EC50 = 140 nM
|
|
|
|
CP0154191
|
3-[1-(4-fluorophenyl)indazol-5-yl]-2,2-dimethyl-N-(5-methyl-1,3,4-thiadiazol-2-yl)-3-phenylpropanamide
Show/Hide
|
C27H24FN5OS
|
1
|
| 1 |
EC50 = 141 nM
|
|
|
|
CP0245699
|
2-[(5S)-9-fluoro-2-[4-(morpholine-4-carbonyl)phenyl]-5H-chromeno[2,3-b]pyridin-5-yl]-N-[(4-methoxyphenyl)methylcarbamoyl]-2-methylpropanamide
Show/Hide
|
C36H35FN4O6
|
2
|
| 1 |
EC50 = 148.8 nM
|
|
|
| 2 |
EC50 = 243.6 nM
|
|
|
|
CP0206108
|
(+/-)-5-amino-N-(2-((N-ethyl-2-(methylsulfonyl)benzamido)methyl)-3,3,3-trifluoro-2-hydroxypropyl)-1-(4-fluorophenyl)-1H-pyrazole-4-carboxamide
Show/Hide
|
C24H25F4N5O5S
|
1
|
| 1 |
EC50 = 158.49 nM
|
|
|
|
CP0039328
|
N-[4-[1-(4-fluorophenyl)indazol-5-yl]-3-(trifluoromethyl)phenyl]propane-2-sulfonamide
Show/Hide
|
C23H19F4N3O2S
|
2
|
| 1 |
EC50 = 158.49 nM
|
|
|
| 2 |
IC50 = 50.12 nM
|
|
|
|
CP0335638
|
N-methyl-4-[(5S)-5-[2-methyl-1-oxo-1-(1,3,4-thiadiazol-2-ylamino)propan-2-yl]-5H-chromeno[2,3-b]pyridin-2-yl]benzamide
Show/Hide
|
C26H23N5O3S
|
2
|
| 1 |
EC50 = 167 nM
|
|
|
| 2 |
EC50 = 216 nM
|
|
|
|
CP0335634
|
N,N-dimethyl-2-[9-[2-methyl-1-oxo-1-(1,3,4-thiadiazol-2-ylamino)propan-2-yl]-9H-xanthen-3-yl]pyrimidine-5-carboxamide
Show/Hide
|
C26H24N6O3S
|
1
|
| 1 |
EC50 = 183 nM
|
|
|
|
CP0218086
|
(3R)-2,2-dimethyl-3-phenyl-3-(1-pyridin-3-ylindazol-5-yl)-N-(1,3,4-thiadiazol-2-yl)propanamide
Show/Hide
|
C25H22N6OS
|
2
|
| 1 |
EC50 = 185 nM
|
|
|
| 2 |
EC50 = 349 nM
|
|
|
|
CP0073919
|
2,2-dimethyl-3-phenyl-3-(1-propan-2-ylindazol-5-yl)-N-(1,3,4-thiadiazol-2-yl)propanamide
Show/Hide
|
C23H25N5OS
|
2
|
| 1 |
EC50 = 195 nM
|
|
|
| 2 |
EC50 = 301 nM
|
|
|
|
CP0095577
|
N-[4-[1-(4-fluorophenyl)indazol-5-yl]-3-(trifluoromethyl)phenyl]-3-(trifluoromethyl)benzenesulfonamide
Show/Hide
|
C27H16F7N3O2S
|
2
|
| 1 |
EC50 = 199.53 nM
|
|
|
| 2 |
IC50 = 63.1 nM
|
|
|
|
CP0128350
|
N-ethyl-4-[1-(4-fluorophenyl)indazol-5-yl]-N-phenyl-3-(trifluoromethyl)benzenesulfonamide
Show/Hide
|
C28H21F4N3O2S
|
2
|
| 1 |
EC50 = 199.53 nM
|
|
|
| 2 |
IC50 = 125.89 nM
|
|
|
|
CP0237547
|
N-(dimethylcarbamoyl)-2-[(5S)-9-fluoro-2-[4-(morpholine-4-carbonyl)phenyl]-5H-chromeno[2,3-b]pyridin-5-yl]-2-methylpropanamide
Show/Hide
|
C30H31FN4O5
|
2
|
| 1 |
EC50 = 203.2 nM
|
|
|
| 2 |
EC50 = 907 nM
|
|
|
|
CP0047028
|
(3S)-3-(3-cyano-4-hydroxyphenyl)-2,2-dimethyl-3-phenyl-N-(1,3-thiazol-2-yl)propanamide
Show/Hide
|
C21H19N3O2S
|
2
|
| 1 |
EC50 = 205.9 nM
|
|
|
| 2 |
EC50 = 506 nM
|
|
|
|
CP0295668
|
3-[1-(4-fluorophenyl)indol-5-yl]-2,2-dimethyl-3-phenyl-N-(1,3-thiazol-2-yl)propanamide
Show/Hide
|
C28H24FN3OS
|
1
|
| 1 |
EC50 = 220 nM
|
|
|
|
CP0336511
|
3-[1-(3-cyanophenyl)imidazo[1,5-a]pyridin-6-yl]-2,2-dimethyl-3-phenyl-N-(1,3-thiazol-2-yl)propanamide
Show/Hide
|
C28H23N5OS
|
1
|
| 1 |
EC50 = 225 nM
|
|
|
|
CP0336510
|
3-(1H-indol-5-yl)-2,2-dimethyl-3-phenyl-N-(1,3-thiazol-2-yl)propanamide
Show/Hide
|
C22H21N3OS
|
1
|
| 1 |
EC50 = 230 nM
|
|
|
|
CP0138798
|
(+/-)-5-amino-N-(2-((2,6-difluoro-N-methylbenzamido)methyl)-3,3,3-trifluoro-2-hydroxypropyl)-1-(4-fluorophenyl)-1H-pyrazole-4-carboxamide
Show/Hide
|
C22H19F6N5O3
|
1
|
| 1 |
EC50 = 251.19 nM
|
|
|
|
CP0347086
|
5-amino-N-[2-[[(3-chlorobenzoyl)-ethylamino]methyl]-3,3,3-trifluoro-2-hydroxypropyl]-1-(4-fluorophenyl)pyrazole-4-carboxamide
Show/Hide
|
C23H22ClF4N5O3
|
1
|
| 1 |
EC50 = 251.19 nM
|
|
|
|
CP0070885
|
N-[4-[1-(4-fluorophenyl)indazol-5-yl]-3-(trifluoromethyl)phenyl]-3-(trifluoromethoxy)benzenesulfonamide
Show/Hide
|
C27H16F7N3O3S
|
2
|
| 1 |
EC50 = 251.19 nM
|
|
|
| 2 |
IC50 = 79.43 nM
|
|
|
|
CP0293479
|
N-[4-[1-(4-fluorophenyl)indazol-5-yl]-3-(trifluoromethyl)phenyl]-3-methoxybenzenesulfonamide
Show/Hide
|
C27H19F4N3O3S
|
2
|
| 1 |
EC50 = 251.19 nM
|
|
|
| 2 |
IC50 = 79.43 nM
|
|
|
|
CP0293480
|
N-[4-[1-(4-fluorophenyl)indazol-5-yl]-3-(trifluoromethyl)phenyl]thiophene-3-sulfonamide
Show/Hide
|
C24H15F4N3O2S2
|
2
|
| 1 |
EC50 = 251.19 nM
|
|
|
| 2 |
IC50 = 100 nM
|
|
|
|
CP0178244
|
1-[(3S)-3-[1-(4-fluorophenyl)indazol-5-yl]-2,2-dimethyl-3-phenylpropyl]-3-(2,2,2-trifluoroethyl)urea
Show/Hide
|
C27H26F4N4O
|
2
|
| 1 |
EC50 = 252 nM
|
|
|
| 2 |
EC50 = 393 nM
|
|
|
|
CP0100807
|
3-[1-(4-hydroxyphenyl)indazol-5-yl]-2,2-dimethyl-3-phenyl-N-(1,3,4-thiadiazol-2-yl)propanamide
Show/Hide
|
C26H23N5O2S
|
2
|
| 1 |
EC50 = 271 nM
|
|
|
| 2 |
EC50 > 5000 nM
|
|
|
|
CP0214938
|
(4-fluorophenyl)-((5aR,6S)-1-(4-fluorophenyl)-5a-methyl-5,5a,6,7,8,9-hexahydroimidazo[1,5-b]isoquinolin-6-yl)methanol
Show/Hide
|
C25H24F2N2O
|
1
|
| 1 |
EC50 = 272 nM
|
|
|
|
CP0197568
|
(S)-1-((5aR,6S)-1-(4-Fluorophenyl)-5a-methyl-5,5a,6,7,8,9-hexahydroimidazo[1,5-b]isoquinolin-6-yl)-1-(pyridin-2-yl)ethanol
Show/Hide
|
C25H26FN3O
|
2
|
| 1 |
EC50 = 280 nM
|
|
|
| 2 |
EC50 = 398 nM
|
|
|
|
CP0042215
|
15-methyl-N-(1,3,4-thiadiazol-2-yl)tetracyclo[6.6.2.0^{2,7}.0^{9,14}]hexadeca-2,4,6,9(14),10,12-hexaene-15-carboxamide
Show/Hide
|
C20H17N3OS
|
1
|
| 1 |
EC50 = 294.9 nM
|
|
|
|
CP0201628
|
5-amino-N-[2-[[(2-chloro-4-fluorobenzoyl)-ethylamino]methyl]-3,3,3-trifluoro-2-hydroxypropyl]-1-(4-fluorophenyl)pyrazole-4-carboxamide
Show/Hide
|
C23H21ClF5N5O3
|
1
|
| 1 |
EC50 = 316.23 nM
|
|
|
|
CP0125701
|
4-[1-(4-fluorophenyl)indazol-5-yl]-N-phenyl-N-propyl-3-(trifluoromethyl)benzenesulfonamide
Show/Hide
|
C29H23F4N3O2S
|
2
|
| 1 |
EC50 = 316.23 nM
|
|
|
| 2 |
IC50 = 316.23 nM
|
|
|
|
CP0277120
|
(S)-1-((5aR,6S)-1-(4-Fluorophenyl)-5a-methyl-5,5a,6,7,8,9-hexahydroimidazo[1,5-b]isoquinolin-6-yl)-1-(pyridin-4-yl)ethanol
Show/Hide
|
C25H26FN3O
|
2
|
| 1 |
EC50 = 324 nM
|
|
|
| 2 |
EC50 = 2750 nM
|
|
|
|
CP0504360
|
8-cyano-15-methyl-N-(1,3-thiazol-2-yl)tetracyclo[6.6.2.0^{2,7}.0^{9,14}]hexadeca-2,4,6,9(14),10,12-hexaene-15-carboxamide
Show/Hide
|
C22H17N3OS
|
2
|
| 1 |
EC50 = 330.6 nM
|
|
|
| 2 |
EC50 = 425.5 nM
|
|
|
|
CP0093350
|
2-[(5R)-2-(4-methoxyphenyl)-5H-chromeno[2,3-b]pyridin-5-yl]-2-methyl-N-(1,3,4-thiadiazol-2-yl)propanamide
Show/Hide
|
C25H22N4O3S
|
2
|
| 1 |
EC50 = 355 nM
|
|
|
| 2 |
EC50 > 10000 nM
|
|
|
|
CP0072477
|
3-[1-(4-fluorophenyl)indazol-5-yl]-2,2-dimethyl-3-pyridin-4-yl-N-(1,3-thiazol-2-yl)propanamide
Show/Hide
|
C26H22FN5OS
|
1
|
| 1 |
EC50 = 389 nM
|
|
|
|
CP0358730
|
(15S)-15-methyl-N-(1,3-thiazol-2-yl)tetracyclo[6.6.2.0^{2,7}.0^{9,14}]hexadeca-2,4,6,9(14),10,12-hexaene-15-carboxamide
Show/Hide
|
C21H18N2OS
|
1
|
| 1 |
EC50 = 543.5 nM
|
|
|
|
CP0213089
|
4-[(5S)-5-[2-methyl-1-oxo-1-(1,3,4-thiadiazol-2-ylamino)propan-2-yl]-5H-chromeno[2,3-b]pyridin-2-yl]benzoic acid
Show/Hide
|
C25H20N4O4S
|
2
|
| 1 |
EC50 = 544 nM
|
|
|
| 2 |
EC50 = 1086 nM
|
|
|
|
CP0085171
|
3-[1-(2-hydroxyethyl)indazol-5-yl]-2,2-dimethyl-3-phenyl-N-(1,3,4-thiadiazol-2-yl)propanamide
Show/Hide
|
C22H23N5O2S
|
2
|
| 1 |
EC50 = 550 nM
|
|
|
| 2 |
EC50 = 1047 nM
|
|
|
|
CP0209791
|
(S)-1-((5aR,6S)-1-(4-Fluorophenyl)-5a-methyl-5,5a,6,7,8,9-hexahydroimidazo[1,5-b]isoquinolin-6-yl)-1-(pyridin-3-yl)ethanol
Show/Hide
|
C25H26FN3O
|
2
|
| 1 |
EC50 = 573 nM
|
|
|
| 2 |
EC50 = 930 nM
|
|
|
|
CP0338225
|
(3R)-3-(1H-indazol-5-yl)-2,2-dimethyl-3-phenyl-N-(1,3,4-thiadiazol-2-yl)propanamide
Show/Hide
|
C20H19N5OS
|
2
|
| 1 |
EC50 = 617 nM
|
|
|
| 2 |
EC50 > 5000 nM
|
|
|
|
CP0092996
|
4-[1-(4-fluorophenyl)indazol-5-yl]-N-methyl-N-phenyl-3-(trifluoromethyl)benzenesulfonamide
Show/Hide
|
C27H19F4N3O2S
|
2
|
| 1 |
EC50 = 630.96 nM
|
|
|
| 2 |
IC50 = 398.11 nM
|
|
|
|
CP0338180
|
2-methyl-2-[(5S)-2-(3-methylphenyl)-5H-chromeno[2,3-b]pyridin-5-yl]-N-(1,3,4-thiadiazol-2-yl)propanamide
Show/Hide
|
C25H22N4O2S
|
2
|
| 1 |
EC50 = 654 nM
|
|
|
| 2 |
EC50 > 5000 nM
|
|
|
|
CP0423020
|
1-cyano-15-methyl-N-(1,3-thiazol-2-yl)tetracyclo[6.6.2.0^{2,7}.0^{9,14}]hexadeca-2,4,6,9(14),10,12-hexaene-15-carboxamide
Show/Hide
|
C22H17N3OS
|
2
|
| 1 |
EC50 = 678.1 nM
|
|
|
| 2 |
EC50 = 874.2 nM
|
|
|
|
CP0218084
|
3-[1-(4-fluorophenyl)indazol-5-yl]-2,2-dimethyl-4-phenyl-N-(1,3,4-thiadiazol-2-yl)butanamide
Show/Hide
|
C27H24FN5OS
|
1
|
| 1 |
EC50 = 705 nM
|
|
|
|
CP0217151
|
N-[2-[[[5-amino-1-(4-fluorophenyl)pyrazole-4-carbonyl]amino]methyl]-3,3,3-trifluoro-2-hydroxypropyl]-2-chloro-N-ethylpyridine-3-carboxamide
Show/Hide
|
C22H21ClF4N6O3
|
1
|
| 1 |
EC50 = 794.33 nM
|
|
|
|
CP0358731
|
(15S)-8-cyano-15-methyl-N-(1,3-thiazol-2-yl)tetracyclo[6.6.2.0^{2,7}.0^{9,14}]hexadeca-2,4,6,9(14),10,12-hexaene-15-carboxamide
Show/Hide
|
C22H17N3OS
|
2
|
| 1 |
EC50 = 836.8 nM
|
|
|
| 2 |
EC50 > 5000 nM
|
|
|
|
CP0358727
|
N-(4,5-dimethyl-1,3-thiazol-2-yl)-15-methyltetracyclo[6.6.2.02,7.09,14]hexadeca-2,4,6,9,11,13-hexaene-15-carboxamide
Show/Hide
|
C23H22N2OS
|
1
|
| 1 |
EC50 = 922.6 nM
|
|
|
|
CP0308386
|
3-[1-(4-bromophenyl)indazol-5-yl]-2,2-dimethyl-3-phenyl-N-(1,3,4-thiadiazol-2-yl)propanamide
Show/Hide
|
C26H22BrN5OS
|
1
|
| 1 |
EC50 = 956 nM
|
|
|
|
CP0308557
|
3-[1-(3-hydroxypropyl)-1H-isoindol-5-yl]-2,2-dimethyl-3-phenyl-N-(1,3,4-thiadiazol-2-yl)propanamide
Show/Hide
|
C24H26N4O2S
|
1
|
| 1 |
EC50 = 1020 nM
|
|
|
|
CP0480486
|
15-methyl-8-nitro-N-(1,3-thiazol-2-yl)tetracyclo[6.6.2.0^{2,7}.0^{9,14}]hexadeca-2,4,6,9(14),10,12-hexaene-15-carboxamide
Show/Hide
|
C21H17N3O3S
|
2
|
| 1 |
EC50 = 1067.3 nM
|
|
|
| 2 |
EC50 > 5000 nM
|
|
|
|
CP0419806
|
N-[(3S)-3-[1-(4-fluorophenyl)indazol-5-yl]-2,2-dimethyl-3-phenylpropyl]acetamide
Show/Hide
|
C26H26FN3O
|
2
|
| 1 |
EC50 = 1152 nM
|
|
|
| 2 |
EC50 > 5000 nM
|
|
|
|
CP0375416
|
15-methyl-1-nitro-N-(1,3-thiazol-2-yl)tetracyclo[6.6.2.0^{2,7}.0^{9,14}]hexadeca-2,4,6,9(14),10,12-hexaene-15-carboxamide
Show/Hide
|
C21H17N3O3S
|
2
|
| 1 |
EC50 = 1159.6 nM
|
|
|
| 2 |
EC50 > 5000 nM
|
|
|
|
CP0121598
|
3-[1-(3-methoxyphenyl)indazol-5-yl]-2,2-dimethyl-3-phenyl-N-(1,3,4-thiadiazol-2-yl)propanamide
Show/Hide
|
C27H25N5O2S
|
1
|
| 1 |
EC50 = 1200 nM
|
|
|
|
CP0367982
|
3-imidazo[1,5-a]pyridin-7-yl-2,2-dimethyl-3-phenyl-N-(1,3-thiazol-2-yl)propanamide
Show/Hide
|
C21H20N4OS
|
1
|
| 1 |
EC50 = 1200 nM
|
|
|
|
CP0358729
|
N,15-dimethyl-N-(1,3-thiazol-2-yl)tetracyclo[6.6.2.02,7.09,14]hexadeca-2,4,6,9,11,13-hexaene-15-carboxamide
Show/Hide
|
C22H20N2OS
|
1
|
| 1 |
EC50 = 1236 nM
|
|
|
|
CP0218220
|
3-[1-(3-cyanophenyl)imidazo[1,5-a]pyridin-6-yl]-2,2-dimethyl-3-phenyl-N-(1,3,4-thiadiazol-2-yl)propanamide
Show/Hide
|
C27H22N6OS
|
1
|
| 1 |
EC50 = 1350 nM
|
|
|
|
CP0338930
|
3-(1-benzylindazol-5-yl)-2,2-dimethyl-3-phenyl-N-(1,3,4-thiadiazol-2-yl)propanamide
Show/Hide
|
C27H25N5OS
|
1
|
| 1 |
EC50 = 1932 nM
|
|
|
|
CP0108605
|
N-[(3S)-3-[1-(4-fluorophenyl)indazol-5-yl]-2,2-dimethyl-3-phenylpropyl]-2-phenylacetamide
Show/Hide
|
C32H30FN3O
|
1
|
| 1 |
EC50 = 2520 nM
|
|
|
|
CP0072480
|
3-[1-(4-fluorophenyl)indazol-5-yl]-2,2-dimethyl-N-(1,3,4-thiadiazol-2-yl)propanamide
Show/Hide
|
C20H18FN5OS
|
1
|
| 1 |
EC50 = 4322 nM
|
|
|
|
CP0038907
|
(S)-2-chloro-4-((1-methylpyrrolidin-3-yl)(2-(trifluoromethyl)benzyl)amino)benzonitrile
Show/Hide
|
C20H19ClF3N3
|
1
|
| 1 |
EC50 = 7900 nM
|
|
|
|
CP0378000
|
3-fluoro-5-(2'-thioxo-1',2'-dihydrospiro[cyclohexane-1,3'-indol]-5'-yl)benzonitrile
Show/Hide
|
C20H17FN2S
|
2
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 = 35 nM
|
|
|
|
CP0035184
|
2-[(1-cyclopentyl-3,4-dihydro-2H-naphthalen-1-yl)methyl]-1,1,1-trifluoro-3-quinolin-4-ylpropan-2-ol
Show/Hide
|
C28H30F3NO
|
2
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 = 741.31 nM
|
|
|
|
CP0276473
|
3,3,3-trifluoro-2-hydroxy-2-[(1-methyl-3,4-dihydro-2H-naphthalen-1-yl)methyl]-N-(4-methyl-1-oxo-2,3-benzoxazin-6-yl)propanamide
Show/Hide
|
C24H23F3N2O4
|
2
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 = 398.11 nM
|
|
|
|
CP0449380
|
2-[(5-ethyl-6,7,8,9-tetrahydrobenzo[7]annulen-5-yl)methyl]-3,3,3-trifluoro-2-hydroxy-N-(4-methyl-1-oxo-2,3-benzoxazin-6-yl)propanamide
Show/Hide
|
C26H27F3N2O4
|
2
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 = 7.943 nM
|
|
|
|
CP0165972
|
N-butyl-4-[1-(4-fluorophenyl)indazol-5-yl]-N-phenyl-3-(trifluoromethyl)benzenesulfonamide
Show/Hide
|
C30H25F4N3O2S
|
2
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0047027
|
(3R)-3-(3-fluoro-4-hydroxyphenyl)-2,2-dimethyl-3-phenyl-N-(1,3-thiazol-2-yl)propanamide
Show/Hide
|
C20H19FN2O2S
|
2
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
EC50 > 5000 nM
|
|
|
|
CP0234749
|
(3S)-3-(3-acetyl-4-hydroxyphenyl)-2,2-dimethyl-3-phenyl-N-(1,3-thiazol-2-yl)propanamide
Show/Hide
|
C22H22N2O3S
|
2
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
EC50 > 5000 nM
|
|
|
|
CP0286694
|
2,2-dimethyl-3,3-diphenyl-N-(1,3-thiazol-2-yl)propanamide
Show/Hide
|
C20H20N2OS
|
1
|
| 1 |
EC50 > 10000 nM
|
|
|
|
CP0286695
|
3-(4-methoxyphenyl)-2,2-dimethyl-3-phenyl-N-(1,3-thiazol-2-yl)propanamide
Show/Hide
|
C21H22N2O2S
|
1
|
| 1 |
EC50 > 10000 nM
|
|
|
|
CP0303488
|
(3R)-3-(4-hydroxyphenyl)-2,2-dimethyl-3-phenyl-N-(1,3-thiazol-2-yl)propanamide
Show/Hide
|
C20H20N2O2S
|
1
|
| 1 |
EC50 > 10000 nM
|
|
|
|
CP0306286
|
3-(2-fluoro-4-hydroxyphenyl)-2,2-dimethyl-3-phenyl-N-(1,3-thiazol-2-yl)propanamide
Show/Hide
|
C20H19FN2O2S
|
1
|
| 1 |
EC50 > 10000 nM
|
|
|
|
CP0236526
|
4-[(5S)-5-[2-methyl-1-oxo-1-(1,3,4-thiadiazol-2-ylamino)propan-2-yl]-5H-chromeno[2,3-b]pyridin-2-yl]benzamide
Show/Hide
|
C25H21N5O3S
|
1
|
| 1 |
EC50 > 10000 nM
|
|
|
|
CP0335637
|
N,N-dimethyl-4-[(5R)-5-[2-methyl-1-oxo-1-(1,3,4-thiadiazol-2-ylamino)propan-2-yl]-5H-chromeno[2,3-b]pyridin-2-yl]benzamide
Show/Hide
|
C27H25N5O3S
|
1
|
| 1 |
EC50 > 10000 nM
|
|
|
|
CP0295751
|
3-[1-(4-fluorophenyl)indazol-5-yl]-2,2-dimethyl-3-phenyl-N-(tetrazol-2-yl)propanamide
Show/Hide
|
C25H22FN7O
|
1
|
| 1 |
EC50 > 10000 nM
|
|
|
|
CP0338929
|
2,2-dimethyl-3-phenyl-3-[1-(2-phenylethyl)indazol-5-yl]-N-(1,3,4-thiadiazol-2-yl)propanamide
Show/Hide
|
C28H27N5OS
|
1
|
| 1 |
EC50 > 10000 nM
|
|
|
|
CP0055328
|
2,2-dimethyl-3-phenyl-N-(1,3-thiazol-2-yl)-3-([1,2,4]triazolo[4,3-a]pyridin-6-yl)propanamide
Show/Hide
|
C20H19N5OS
|
1
|
| 1 |
EC50 > 10000 nM
|
|
|
|
CP0295670
|
3-imidazo[1,5-a]pyridin-6-yl-2,2-dimethyl-3-phenyl-N-(1,3-thiazol-2-yl)propanamide
Show/Hide
|
C21H20N4OS
|
1
|
| 1 |
EC50 > 10000 nM
|
|
|
|
CP0336509
|
3-isoquinolin-6-yl-2,2-dimethyl-3-phenyl-N-(1,3-thiazol-2-yl)propanamide
Show/Hide
|
C23H21N3OS
|
1
|
| 1 |
EC50 > 10000 nM
|
|
|
|
CP0341681
|
2,2-dimethyl-3-phenyl-3-quinolin-6-yl-N-(1,3-thiazol-2-yl)propanamide
Show/Hide
|
C23H21N3OS
|
1
|
| 1 |
EC50 > 10000 nM
|
|
|
|
CP0367981
|
3-[8-(4-fluorophenyl)quinolin-6-yl]-2,2-dimethyl-3-phenyl-N-(1,3,4-thiadiazol-2-yl)propanamide
Show/Hide
|
C28H23FN4OS
|
1
|
| 1 |
EC50 > 10000 nM
|
|
|
|
CP0368866
|
3-[8-(4-fluorophenyl)quinolin-6-yl]-2,2-dimethyl-3-phenyl-N-(1,3-thiazol-2-yl)propanamide
Show/Hide
|
C29H24FN3OS
|
1
|
| 1 |
EC50 > 10000 nM
|
|
|
|
CP0035185
|
2-[(1-ethyl-3,4-dihydro-2H-naphthalen-1-yl)methyl]-1,1,1-trifluoro-3-(1H-pyrrolo[2,3-c]pyridin-2-yl)propan-2-ol
Show/Hide
|
C23H25F3N2O
|
2
|
| 1 |
EC50 > 1000 nM
|
|
|
| 2 |
IC50 = 741.31 nM
|
|
|
|
CP0075580
|
1-[3,3,3-trifluoro-2-hydroxy-2-[(1-methyl-3,4-dihydro-2H-naphthalen-1-yl)methyl]propyl]quinolin-4-one
Show/Hide
|
C24H24F3NO2
|
1
|
| 1 |
EC50 > 1000 nM
|
|
|
|
CP0157225
|
2-[2-[(1-ethyl-3,4-dihydro-2H-naphthalen-1-yl)methyl]-3,3,3-trifluoro-2-hydroxypropyl]-1H-indole-3-carbonitrile
Show/Hide
|
C25H25F3N2O
|
3
|
| 1 |
EC50 > 1000 nM
|
|
|
| 2 |
IC50 = 6.607 nM
|
|
|
| 3 |
IC50 = 57.54 nM
|
|
|
|
CP0315640
|
1-[2-[(1-ethyl-3,4-dihydro-2H-naphthalen-1-yl)methyl]-3,3,3-trifluoro-2-hydroxypropyl]quinolin-4-one
Show/Hide
|
C25H26F3NO2
|
2
|
| 1 |
EC50 > 1000 nM
|
|
|
| 2 |
IC50 = 8.128 nM
|
|
|
|
CP0421863
|
2-[(1-ethyl-3,4-dihydro-2H-naphthalen-1-yl)methyl]-1,1,1-trifluoro-3-(quinolin-5-ylamino)propan-2-ol
Show/Hide
|
C25H27F3N2O
|
2
|
| 1 |
EC50 > 1000 nM
|
|
|
| 2 |
IC50 = 12.3 nM
|
|
|
|
CP0280217
|
2-[(1-butyl-3,4-dihydro-2H-naphthalen-1-yl)methyl]-3,3,3-trifluoro-2-hydroxy-N-(4-methyl-1-oxo-2,3-benzoxazin-6-yl)propanamide
Show/Hide
|
C27H29F3N2O4
|
2
|
| 1 |
EC50 > 1000 nM
|
|
|
| 2 |
IC50 = 6.607 nM
|
|
|
|
CP0283199
|
3,3,3-trifluoro-2-hydroxy-N-(4-methyl-1-oxo-2,3-benzoxazin-6-yl)-2-[[1-(2-methylpropyl)-3,4-dihydro-2H-naphthalen-1-yl]methyl]propanamide
Show/Hide
|
C27H29F3N2O4
|
3
|
| 1 |
EC50 > 1000 nM
|
|
|
| 2 |
IC50 = 15.85 nM
|
|
|
| 3 |
IC50 = 512.86 nM
|
|
|
|
CP0035186
|
(10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]-14-hydroxy-15-methyl-14-(prop-1-yn-1-yl)tetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-1,6-dien-5-one
Show/Hide
|
C29H35NO2
|
10
|
| 1 |
EC50 < 1000 nM
|
|
|
| 2 |
IC50 = 1.6 nM
|
|
|
| 3 |
IC50 = 4.677 nM
|
|
|
| 4 |
IC50 = 6 nM
|
|
|
| 5 |
IC50 = 6.31 nM
|
|
|
| 6 |
IC50 = 11.48 nM
|
|
|
| 7 |
IC50 > 10000 nM
|
|
|
| 8 |
IC50 > 1000 nM
|
|
|
| 9 |
IC50 < 1000 nM
|
|
|
| 10 |
Ki = 1 nM
|
|
|
|
CP0162409
|
5-methyl-1-phenyl-N-[3,3,3-trifluoro-2-hydroxy-2-[(1-methyl-3,4-dihydro-2H-naphthalen-1-yl)methyl]propyl]pyrazole-4-sulfonamide
Show/Hide
|
C25H28F3N3O3S
|
3
|
| 1 |
EC50 < 1000 nM
|
|
|
| 2 |
IC50 = 309.03 nM
|
|
|
| 3 |
IC50 < 1000 nM
|
|
|
|
CP0305885
|
5-methyl-1-phenyl-N-[3,3,3-trifluoro-2-hydroxy-2-[(1-methyl-3,4-dihydro-2H-naphthalen-1-yl)methyl]propyl]pyrazole-4-carboxamide
Show/Hide
|
C26H28F3N3O2
|
1
|
| 1 |
EC50 < 1000 nM
|
|
|
|
CP0083149
|
2-methyl-2-[(5S)-2-phenyl-5H-chromeno[2,3-b]pyridin-5-yl]-N-(1,3,4-thiadiazol-2-yl)propanamide
Show/Hide
|
C24H20N4O2S
|
1
|
| 1 |
EC50 > 1500 nM
|
|
|
|
CP0336442
|
15-ethyl-N-(1,3-thiazol-2-yl)tetracyclo[6.6.2.0^{2,7}.0^{9,14}]hexadeca-2,4,6,9(14),10,12-hexaene-15-carboxamide
Show/Hide
|
C22H20N2OS
|
1
|
| 1 |
EC50 > 2500 nM
|
|
|
|
CP0197630
|
1-(1-(4-Fluorophenyl)-5a-methyl-5,5a,6,7,8,9-hexahydroimidazo-[1,5-b]isoquinolin-6-yl)but-3-en-1-ol
Show/Hide
|
C22H25FN2O
|
2
|
| 1 |
EC50 > 2500 nM
|
|
|
| 2 |
EC50 > 5000 nM
|
|
|
|
CP0092418
|
15-(2-hydroxyethyl)-N-(1,3-thiazol-2-yl)tetracyclo[6.6.2.0^{2,7}.0^{9,14}]hexadeca-2,4,6,9(14),10,12-hexaene-15-carboxamide
Show/Hide
|
C22H20N2O2S
|
1
|
| 1 |
EC50 > 5000 nM
|
|
|
|
CP0127659
|
15-methyl-N-(4-methyl-1,3-thiazol-2-yl)tetracyclo[6.6.2.0^{2,7}.0^{9,14}]hexadeca-2,4,6,9(14),10,12-hexaene-15-carboxamide
Show/Hide
|
C22H20N2OS
|
1
|
| 1 |
EC50 > 5000 nM
|
|
|
|
CP0167152
|
N-(1H-imidazol-2-yl)-15-methyltetracyclo[6.6.2.02,7.09,14]hexadeca-2,4,6,9,11,13-hexaene-15-carboxamide
Show/Hide
|
C21H19N3O
|
1
|
| 1 |
EC50 > 5000 nM
|
|
|
|
CP0178009
|
N-(2-hydroxy-4-nitrophenyl)-15-methyltetracyclo[6.6.2.02,7.09,14]hexadeca-2,4,6,9,11,13-hexaene-15-carboxamide
Show/Hide
|
C24H20N2O4
|
1
|
| 1 |
EC50 > 5000 nM
|
|
|
|
CP0189105
|
(R)-2-((5aR,6S)-1-(4-Fluorophenyl)-5a-methyl-5,5a,6,7,8,9-hexahydroimidazo[1,5-b]isoquinolin-6-yl)-4-phenylbutan-2-ol
Show/Hide
|
C28H31FN2O
|
1
|
| 1 |
EC50 > 5000 nM
|
|
|
|
CP0284175
|
(5aR,6S)-1-(4-Fluorophenyl)-6-((S)-1-methoxy-1-(thiophen-2-yl)-ethyl)-5a-methyl-5,5a,6,7,8,9-hexahydroimidazo[1,5-b]isoquinoline
Show/Hide
|
C25H27FN2OS
|
1
|
| 1 |
EC50 > 5000 nM
|
|
|
|
CP0245577
|
2-[(9R)-3-hydroxy-9H-xanthen-9-yl]-2-methyl-N-(1,3,4-thiadiazol-2-yl)propanamide
Show/Hide
|
C19H17N3O3S
|
1
|
| 1 |
EC50 > 5000 nM
|
|
|
|
CP0306288
|
2-methyl-N-(1,3,4-thiadiazol-2-yl)-2-(9H-xanthen-9-yl)propanamide
Show/Hide
|
C19H17N3O2S
|
1
|
| 1 |
EC50 > 5000 nM
|
|
|
|
CP0294967
|
3-[1-[3-(hydroxymethyl)phenyl]imidazo[1,5-a]pyridin-6-yl]-2,2-dimethyl-3-phenyl-N-(1,3,4-thiadiazol-2-yl)propanamide
Show/Hide
|
C27H25N5O2S
|
1
|
| 1 |
EC50 > 5000 nM
|
|
|
|
CP0145326
|
5-amino-N-[2-[[(4-chlorobenzoyl)-ethylamino]methyl]-3,3,3-trifluoro-2-hydroxypropyl]-1-(4-fluorophenyl)pyrazole-4-carboxamide
Show/Hide
|
C23H22ClF4N5O3
|
1
|
| 1 |
EC50 > 6309.57 nM
|
|
|
|
CP0310475
|
5-amino-N-[2-[[(2,6-difluorobenzoyl)amino]methyl]-3,3,3-trifluoro-2-hydroxypropyl]-1-(4-fluorophenyl)pyrazole-4-carboxamide
Show/Hide
|
C21H17F6N5O3
|
1
|
| 1 |
EC50 > 6309.57 nM
|
|
|
|
CP0244609
|
4-chloro-N-[[4-(3,5-dimethyl-1,2-oxazol-4-yl)phenyl]methyl]-1,3-dimethylpyrazolo[3,4-b]pyridine-5-carboxamide
Show/Hide
|
C21H20ClN5O2
|
2
|
| 1 |
EC50 > 6309.57 nM
|
|
|
| 2 |
IC50 = 100 nM
|
|
|
|
CP0294481
|
4-chloro-N-[[2-(3-methoxyphenyl)phenyl]methyl]-1,3-dimethylpyrazolo[3,4-b]pyridine-5-carboxamide
Show/Hide
|
C23H21ClN4O2
|
2
|
| 1 |
EC50 > 6309.57 nM
|
|
|
| 2 |
IC50 = 199.53 nM
|
|
|
|
CP0294482
|
4-chloro-N-[(2,4-dimethylphenyl)methyl]-1-ethylpyrazolo[3,4-b]pyridine-5-carboxamide
Show/Hide
|
C18H19ClN4O
|
2
|
| 1 |
EC50 > 6309.57 nM
|
|
|
| 2 |
IC50 = 199.53 nM
|
|
|
|
CP0301835
|
4-chloro-N-(2,3-dihydro-1H-inden-2-ylmethyl)-3-ethyl-1-methylpyrazolo[3,4-b]pyridine-5-carboxamide
Show/Hide
|
C20H21ClN4O
|
2
|
| 1 |
EC50 > 6309.57 nM
|
|
|
| 2 |
IC50 = 251.19 nM
|
|
|
|
CP0202195
|
FLUTICASONE FUROATE
Show/Hide
|
C27H29F3O6S
|
1
|
| 1 |
IC50 = 0.03981 nM
|
|
|
|
CP0321547
|
2,6-dichloro-N-ethyl-N-[(2R)-3,3,3-trifluoro-2-[[[1-(4-fluorophenyl)indazol-4-yl]amino]methyl]-2-hydroxypropyl]benzamide
Show/Hide
|
C26H22Cl2F4N4O2
|
2
|
| 1 |
IC50 = 0.07943 nM
|
|
|
| 2 |
IC50 = 0.3162 nM
|
|
|
|
CP0285177
|
2,4,6-trimethyl-N-[(2S)-1-[[6-methyl-1-[3-(propan-2-ylamino)phenyl]indazol-4-yl]amino]propan-2-yl]benzenesulfonamide
Show/Hide
|
C29H37N5O2S
|
2
|
| 1 |
IC50 = 0.1259 nM
|
|
|
| 2 |
IC50 = 0.5012 nM
|
|
|
|
CP0506145
|
N-ethyl-2-fluoro-N-[3,3,3-trifluoro-2-[[[1-(4-fluorophenyl)-6-methylindazol-4-yl]amino]methyl]-2-hydroxypropyl]benzamide
Show/Hide
|
C27H25F5N4O2
|
1
|
| 1 |
IC50 = 0.1995 nM
|
|
|
|
CP0128058
|
(2R)-2-[3-[6-methyl-4-[[(2S)-2-[(2,4,6-trimethylphenyl)sulfonylamino]propyl]amino]indazol-1-yl]anilino]propanamide
Show/Hide
|
C29H36N6O3S
|
2
|
| 1 |
IC50 = 0.1995 nM
|
|
|
| 2 |
IC50 = 1.995 nM
|
|
|
|
CP0496702
|
N-ethyl-2-fluoro-N-[3,3,3-trifluoro-2-hydroxy-2-[[(6-methyl-1-phenylindazol-4-yl)amino]methyl]propyl]benzamide
Show/Hide
|
C27H26F4N4O2
|
1
|
| 1 |
IC50 = 0.2512 nM
|
|
|
|
CP0506143
|
2-chloro-N-ethyl-N-[3,3,3-trifluoro-2-[[[1-(4-fluorophenyl)indazol-4-yl]amino]methyl]-2-hydroxypropyl]benzamide
Show/Hide
|
C26H23ClF4N4O2
|
1
|
| 1 |
IC50 = 0.2512 nM
|
|
|
|
CP0290103
|
2-[3-[6-methyl-4-[[(2S)-2-[(2,4,6-trimethylphenyl)sulfonylamino]propyl]amino]indazol-1-yl]anilino]acetamide
Show/Hide
|
C28H34N6O3S
|
2
|
| 1 |
IC50 = 0.2512 nM
|
|
|
| 2 |
IC50 = 2.512 nM
|
|
|
|
CP0439300
|
N-ethyl-2-fluoro-N-[3,3,3-trifluoro-2-hydroxy-2-[[(1-phenylindazol-4-yl)amino]methyl]propyl]benzamide
Show/Hide
|
C26H24F4N4O2
|
1
|
| 1 |
IC50 = 0.3162 nM
|
|
|
|
CP0502388
|
N-ethyl-2,6-difluoro-N-[3,3,3-trifluoro-2-[[[1-(4-fluorophenyl)indazol-4-yl]amino]methyl]-2-hydroxypropyl]benzamide
Show/Hide
|
C26H22F6N4O2
|
1
|
| 1 |
IC50 = 0.3162 nM
|
|
|
|
CP0506144
|
N-ethyl-2-methyl-N-[3,3,3-trifluoro-2-[[[1-(4-fluorophenyl)indazol-4-yl]amino]methyl]-2-hydroxypropyl]benzamide
Show/Hide
|
C27H26F4N4O2
|
1
|
| 1 |
IC50 = 0.3162 nM
|
|
|
|
CP0233163
|
N-[(2S)-1-[[1-[3-(cyclopropylamino)phenyl]-6-methylindazol-4-yl]amino]propan-2-yl]-2,4,6-trimethylbenzenesulfonamide
Show/Hide
|
C29H35N5O2S
|
2
|
| 1 |
IC50 = 0.3162 nM
|
|
|
| 2 |
IC50 = 1.259 nM
|
|
|
|
CP0506146
|
N-ethyl-N-[3,3,3-trifluoro-2-[[[1-(4-fluorophenyl)-6-methylindazol-4-yl]amino]methyl]-2-hydroxypropyl]benzamide
Show/Hide
|
C27H26F4N4O2
|
1
|
| 1 |
IC50 = 0.3981 nM
|
|
|
|
CP0507790
|
N-ethyl-N-[3,3,3-trifluoro-2-hydroxy-2-[[(6-methyl-1-phenylindazol-4-yl)amino]methyl]propyl]benzamide
Show/Hide
|
C27H27F3N4O2
|
1
|
| 1 |
IC50 = 0.3981 nM
|
|
|
|
CP0492147
|
N-ethyl-2,6-dimethyl-N-[3,3,3-trifluoro-2-[[[1-(4-fluorophenyl)indazol-4-yl]amino]methyl]-2-hydroxypropyl]benzamide
Show/Hide
|
C28H28F4N4O2
|
1
|
| 1 |
IC50 = 0.5012 nM
|
|
|
|
CP0285178
|
(2S)-2-[3-[6-methyl-4-[[(2S)-2-[(2,4,6-trimethylphenyl)sulfonylamino]propyl]amino]indazol-1-yl]anilino]propanamide
Show/Hide
|
C29H36N6O3S
|
2
|
| 1 |
IC50 = 0.5012 nM
|
|
|
| 2 |
IC50 = 1.585 nM
|
|
|
|
CP0480388
|
N-ethyl-N-[3,3,3-trifluoro-2-[[[1-(4-fluorophenyl)indazol-4-yl]amino]methyl]-2-hydroxypropyl]benzamide
Show/Hide
|
C26H24F4N4O2
|
1
|
| 1 |
IC50 = 0.7943 nM
|
|
|
|
CP0497365
|
N-ethyl-N-[3,3,3-trifluoro-2-hydroxy-2-[[(1-phenylindazol-4-yl)amino]methyl]propyl]benzamide
Show/Hide
|
C26H25F3N4O2
|
1
|
| 1 |
IC50 = 0.7943 nM
|
|
|
|
CP0232703
|
N-[(2S)-1-[[1-[4-(cyclopropylamino)phenyl]-6-methylindazol-4-yl]amino]propan-2-yl]-2,4,6-trimethylbenzenesulfonamide
Show/Hide
|
C29H35N5O2S
|
2
|
| 1 |
IC50 = 1.259 nM
|
|
|
| 2 |
IC50 = 7.943 nM
|
|
|
|
CP0290100
|
N-[(2S)-1-[[1-(4-fluorophenyl)-6-methylindazol-4-yl]amino]propan-2-yl]-2,4,6-trimethylbenzenesulfonamide
Show/Hide
|
C26H29FN4O2S
|
2
|
| 1 |
IC50 = 1.259 nM
|
|
|
| 2 |
IC50 = 3.981 nM
|
|
|
|
CP0232705
|
3-[4-[[(2S)-2-(cyclopropylsulfonylamino)propyl]amino]-6-methylindazol-1-yl]-N-propan-2-ylbenzamide
Show/Hide
|
C24H31N5O3S
|
2
|
| 1 |
IC50 = 1.995 nM
|
|
|
| 2 |
IC50 = 12.59 nM
|
|
|
|
CP0257951
|
2,4,6-trimethyl-N-[(2S)-1-[[6-methyl-1-[4-(propan-2-ylamino)phenyl]indazol-4-yl]amino]propan-2-yl]benzenesulfonamide
Show/Hide
|
C29H37N5O2S
|
2
|
| 1 |
IC50 = 1.995 nM
|
|
|
| 2 |
IC50 = 10 nM
|
|
|
|
CP0290102
|
N-[(2S)-1-[[1-(4-cyanophenyl)-6-methylindazol-4-yl]amino]propan-2-yl]-2,4,6-trimethylbenzenesulfonamide
Show/Hide
|
C27H29N5O2S
|
2
|
| 1 |
IC50 = 1.995 nM
|
|
|
| 2 |
IC50 = 5.012 nM
|
|
|
|
CP0474657
|
N-ethyl-N-[3,3,3-trifluoro-2-hydroxy-2-[[(1-phenylindazol-4-yl)amino]methyl]propyl]benzenesulfonamide
Show/Hide
|
C25H25F3N4O3S
|
1
|
| 1 |
IC50 = 2.512 nM
|
|
|
|
CP0321549
|
N-[(2R)-1-amino-1-oxopropan-2-yl]-3-[4-[[(2S)-2-(cyclopropylsulfonylamino)propyl]amino]-6-methylindazol-1-yl]-N-methylbenzamide
Show/Hide
|
C25H32N6O4S
|
2
|
| 1 |
IC50 = 2.512 nM
|
|
|
| 2 |
IC50 = 50.12 nM
|
|
|
|
CP0504013
|
N-propyl-N-[3,3,3-trifluoro-2-hydroxy-2-[[(1-phenylindazol-4-yl)amino]methyl]propyl]benzamide
Show/Hide
|
C27H27F3N4O2
|
1
|
| 1 |
IC50 = 3.162 nM
|
|
|
|
CP0226942
|
N-[(2R)-1-amino-1-oxopropan-2-yl]-3-[4-[[(2S)-2-(cyclopropylsulfonylamino)propyl]amino]-6-methylindazol-1-yl]benzamide
Show/Hide
|
C24H30N6O4S
|
2
|
| 1 |
IC50 = 3.162 nM
|
|
|
| 2 |
IC50 = 125.89 nM
|
|
|
|
CP0313041
|
2-[4-[6-methyl-4-[[(2S)-2-[(2,4,6-trimethylphenyl)sulfonylamino]propyl]amino]indazol-1-yl]anilino]acetamide
Show/Hide
|
C28H34N6O3S
|
2
|
| 1 |
IC50 = 3.162 nM
|
|
|
| 2 |
IC50 = 63.1 nM
|
|
|
|
CP0496704
|
N-methyl-N-[3,3,3-trifluoro-2-hydroxy-2-[[(1-phenylindazol-4-yl)amino]methyl]propyl]benzamide
Show/Hide
|
C25H23F3N4O2
|
1
|
| 1 |
IC50 = 5.012 nM
|
|
|
|
CP0128056
|
2,4,6-trimethyl-N-[(2S)-1-[[6-methyl-1-[4-(methylamino)phenyl]indazol-4-yl]amino]propan-2-yl]benzenesulfonamide
Show/Hide
|
C27H33N5O2S
|
2
|
| 1 |
IC50 = 5.012 nM
|
|
|
| 2 |
IC50 = 251.19 nM
|
|
|
|
CP0232706
|
N-(2-amino-2-oxoethyl)-3-[4-[[(2S)-2-(cyclopropylsulfonylamino)propyl]amino]-6-methylindazol-1-yl]benzamide
Show/Hide
|
C23H28N6O4S
|
2
|
| 1 |
IC50 = 5.012 nM
|
|
|
| 2 |
IC50 = 199.53 nM
|
|
|
|
CP0233165
|
N-[(2S)-1-amino-1-oxopropan-2-yl]-3-[4-[[(2S)-2-(cyclopropylsulfonylamino)propyl]amino]-6-methylindazol-1-yl]benzamide
Show/Hide
|
C24H30N6O4S
|
2
|
| 1 |
IC50 = 5.012 nM
|
|
|
| 2 |
IC50 = 199.53 nM
|
|
|
|
CP0313879
|
2,4,6-trimethyl-N-[(2S)-1-[[6-methyl-1-(4-methylsulfonylphenyl)indazol-4-yl]amino]propan-2-yl]benzenesulfonamide
Show/Hide
|
C27H32N4O4S2
|
2
|
| 1 |
IC50 = 5.012 nM
|
|
|
| 2 |
IC50 = 12.59 nM
|
|
|
|
CP0290101
|
N-[(2R)-2-[[1-(4-fluorophenyl)-6-methylindazol-4-yl]amino]propyl]-2,4,6-trimethylbenzenesulfonamide
Show/Hide
|
C26H29FN4O2S
|
2
|
| 1 |
IC50 = 6.31 nM
|
|
|
| 2 |
IC50 = 50.12 nM
|
|
|
|
CP0401201
|
(1S,3S,3aR,3bS,10R)-1-Hydroxy-12a-methyl-10-(4-methylsulfanyl-phenyl)-1-pentafluoroethyl-2,3,3a,3b,4,5,9,10,12,12a-decahydro-1H,8H-11-oxa-naphtho[2,1-e]azulen-7-one
Show/Hide
|
C27H29F5O3S
|
1
|
| 1 |
IC50 = 7 nM
|
|
|
|
CP0474658
|
N-ethyl-4-fluoro-N-[3,3,3-trifluoro-2-hydroxy-2-[[(1-phenylindazol-4-yl)amino]methyl]propyl]benzenesulfonamide
Show/Hide
|
C25H24F4N4O3S
|
1
|
| 1 |
IC50 = 7.943 nM
|
|
|
|
CP0282871
|
3-[6-methyl-4-[[(2S)-2-(propan-2-ylsulfonylamino)propyl]amino]indazol-1-yl]-N-propan-2-ylbenzamide
Show/Hide
|
C24H33N5O3S
|
2
|
| 1 |
IC50 = 7.943 nM
|
|
|
| 2 |
IC50 = 50.12 nM
|
|
|
|
CP0321548
|
(2R)-2-[4-[6-methyl-4-[[(2S)-2-[(2,4,6-trimethylphenyl)sulfonylamino]propyl]amino]indazol-1-yl]anilino]propanamide
Show/Hide
|
C29H36N6O3S
|
2
|
| 1 |
IC50 = 7.943 nM
|
|
|
| 2 |
IC50 = 158.49 nM
|
|
|
|
CP0322727
|
N-[(2S)-1-[[1-(3-fluorophenyl)-6-methylindazol-4-yl]amino]propan-2-yl]-2,4,6-trimethylbenzenesulfonamide
Show/Hide
|
C26H29FN4O2S
|
2
|
| 1 |
IC50 = 7.943 nM
|
|
|
| 2 |
IC50 = 25.12 nM
|
|
|
|
CP0336156
|
(2S)-2-[4-[6-methyl-4-[[(2S)-2-[(2,4,6-trimethylphenyl)sulfonylamino]propyl]amino]indazol-1-yl]anilino]propanamide
Show/Hide
|
C29H36N6O3S
|
2
|
| 1 |
IC50 = 7.943 nM
|
|
|
| 2 |
IC50 = 15.85 nM
|
|
|
|
CP0510938
|
(8S,11R,13S,14S,17S)-11-(4-(dimethylphosphoryl)phenyl)-17-hydroxy-13-methyl-17-(prop-1-ynyl)-1,2,7,8,11,12,13,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3(14H)-one
Show/Hide
|
C29H35O3P
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0264662
|
N-[(2S)-1-[[1-(4-methoxyphenyl)-6-methylindazol-4-yl]amino]propan-2-yl]-2,4,6-trimethylbenzenesulfonamide
Show/Hide
|
C27H32N4O3S
|
2
|
| 1 |
IC50 = 12.59 nM
|
|
|
| 2 |
IC50 = 50.12 nM
|
|
|
|
CP0513478
|
(8S,11R,13S,14S,17S)-11-(2-ethyl-1,3-benzoxazol-5-yl)-17-hydroxy-13-methyl-17-prop-1-ynyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one
Show/Hide
|
C30H33NO3
|
1
|
| 1 |
IC50 = 13 nM
|
|
|
|
CP0401202
|
(1R,3S,3aR,3bS,10R)-10-(4-Dimethylamino-phenyl)-1-hydroxy-12a-methyl-1-prop-1-ynyl-2,3,3a,3b,4,5,9,10,12,12a-decahydro-1H,8H-11-oxa-naphtho[2,1-e]azulen-7-one
Show/Hide
|
C29H35NO3
|
1
|
| 1 |
IC50 = 17 nM
|
|
|
|
CP0232704
|
3-[6-methyl-4-[[(2S)-2-(propylsulfonylamino)propyl]amino]indazol-1-yl]-N-propan-2-ylbenzamide
Show/Hide
|
C24H33N5O3S
|
2
|
| 1 |
IC50 = 19.95 nM
|
|
|
| 2 |
IC50 = 79.43 nM
|
|
|
|
CP0404924
|
(1S,3S,3aR,3bS,10R)-10-(4-Dimethylamino-phenyl)-1-hydroxy-12a-methyl-1-pentafluoroethyl-2,3,3a,3b,4,5,9,10,12,12a-decahydro-1H,8H-11-oxa-naphtho[2,1-e]azulen-7-one
Show/Hide
|
C28H32F5NO3
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0397052
|
(1R,3S,3aR,3bS,10R)-1-Hydroxy-10-(4-methoxy-phenyl)-12a-methyl-1-phenylethynyl-2,3,3a,3b,4,5,9,10,12,12a-decahydro-1H,8H-11-oxa-naphtho[2,1-e]azulen-7-one
Show/Hide
|
C33H34O4
|
1
|
| 1 |
IC50 = 21 nM
|
|
|
|
CP0458934
|
(8S,11R,13S,14R,17S)-11-(4-dimethylamino-phenyl)-17-hydroxy-13-methyl-17-p-tolylethynyl-1,2,8,11,12,13,14,15,16,17-decahydro-6H-7-oxa-cyclopenta[a]phenanthren-3-one
Show/Hide
|
C34H37NO3
|
1
|
| 1 |
IC50 = 22.1 nM
|
|
|
|
CP0490381
|
(3S,10'S,11'S,15'S,17'R)-17'-[4-(dimethylamino)phenyl]-5-ethyl-15'-methyl-2-methylidene-2H-spiro[1,4-oxazole-3,14'-tetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecane]-1',6'-dien-5'-one
Show/Hide
|
C31H38N2O2
|
1
|
| 1 |
IC50 = 23 nM
|
|
|
|
CP0431297
|
(8S,11R,13S,14S,17S)-17-hydroxy-13-methyl-11-(2-methyl-1,3-benzoxazol-5-yl)-17-prop-1-ynyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one
Show/Hide
|
C29H31NO3
|
1
|
| 1 |
IC50 = 23 nM
|
|
|
|
CP0496703
|
N-ethyl-4-fluoro-N-[3,3,3-trifluoro-2-hydroxy-2-[[(6-methyl-1-phenylpyrazolo[3,4-d]pyrimidin-4-yl)amino]methyl]propyl]benzenesulfonamide
Show/Hide
|
C24H24F4N6O3S
|
1
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| 1 |
IC50 = 25.12 nM
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CP0422914
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(1R,3S,3aR,3bS,10R)-1-Hydroxy-10-(4-methoxy-phenyl)-12a-methyl-1-(4-trifluoromethyl-phenylethynyl)-2,3,3a,3b,4,5,9,10,12,12a-decahydro-1H,8H-11-oxa-naphtho[2,1-e]azulen-7-one
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C34H33F3O4
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1
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| 1 |
IC50 = 26 nM
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CP0467204
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(8S,11R,13S,14R,17S)-17-(4-bromo-phenylethynyl)-11-(4-dimethylamino-phenyl)-17-hydroxy-13-methyl-1,2,8,11,12,13,14,15,16,17-decahydro-6H-7-oxa-cyclopenta[a]phenanthren-3-one
Show/Hide
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C33H34BrNO3
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1
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| 1 |
IC50 = 31.3 nM
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CP0480390
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5-amino-N-[2-[[ethyl-(4-fluorophenyl)sulfonylamino]methyl]-3,3,3-trifluoro-2-hydroxypropyl]-1-phenylpyrazole-4-carboxamide
Show/Hide
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C22H23F4N5O4S
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1
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| 1 |
IC50 = 31.62 nM
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CP0435576
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(8S,11R,13S,14R,17S)-17-cyclopropylethynyl-11-(4-dimethylamino-phenyl)-17-hydroxy-13-methyl-1,2,8,11,12,13,14,15,16,17-decahydro-6H-7-oxa-cyclopenta[a]phenanthren-3-one
Show/Hide
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C30H35NO3
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1
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| 1 |
IC50 = 33.4 nM
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CP0449766
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(8S,11R,13S,14R,17S)-17-(3,5-difluoro-phenylethynyl)-11-(4-dimethylamino-phenyl)-17-hydroxy-13-methyl-1,2,8,11,12,13,14,15,16,17-decahydro-6H-7-oxa-cyclopenta[a]phenanthren-3-one
Show/Hide
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C33H33F2NO3
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1
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| 1 |
IC50 = 34.4 nM
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CP0436546
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(8S,11R,13S,14R,17S)-11-(4-dimethylamino-phenyl)-17-hydroxy-13-methyl-17-m-tolylethynyl-1,2,8,11,12,13,14,15,16,17-decahydro-6H-7-oxa-cyclopenta[a]phenanthren-3-one
Show/Hide
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C34H37NO3
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1
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| 1 |
IC50 = 36.3 nM
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|
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CP0436544
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(8S,11R,13S,14R)-11-(4-dimethylamino-phenyl)-17-(4-fluoro-phenylethynyl)-17-hydroxy-13-methyl-1,2,8,11,12,13,14,15,16,17-decahydro-6H-7-oxa-cyclopenta[a]phenanthren-3-one
Show/Hide
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C33H34FNO3
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1
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| 1 |
IC50 = 37.6 nM
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CP0428833
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(1R,3S,3aR,3bS,10R)-1-Hydroxy-10-(4-methoxy-phenyl)-12a-methyl-1-prop-1-ynyl-2,3,3a,3b,4,5,9,10,12,12a-decahydro-1H,8H-11-oxa-naphtho[2,1-e]azulen-7-one
Show/Hide
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C28H32O4
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1
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| 1 |
IC50 = 41 nM
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CP0437234
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4-[(8S,11R,13S,14R,17S)-11-(4-dimethylamino-phenyl)-17-hydroxy-13-methyl-3-oxo-1,2,3,6,8,11,12,13,14,15,16,17-dodecahydro-7-oxa-cyclopenta[a]phenanthren-17-ylethynyl]-benzonitrile
Show/Hide
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C34H34N2O3
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1
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| 1 |
IC50 = 41.3 nM
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CP0458933
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(8S,11R,13S,14R,17S)-17-(4-chloro-phenylethynyl)-11-(4-dimethylamino-phenyl)-17-hydroxy-13-methyl-1,2,8,11,12,13,14,15,16,17-decahydro-6H-7-oxa-cyclopenta[a]phenanthren-3-one
Show/Hide
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C33H34ClNO3
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1
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| 1 |
IC50 = 43.5 nM
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CP0431296
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(8S,11R,13S,14S,17S)-11-(1,3-benzoxazol-5-yl)-17-hydroxy-13-methyl-17-prop-1-ynyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one
Show/Hide
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C28H29NO3
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1
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| 1 |
IC50 = 45 nM
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|
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CP0421973
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(8S,11R,13S,14R,17S)-11-(4-dimethylamino-phenyl)-17-hydroxy-13-methyl-17-(3-trifluoromethyl-phenylethynyl)-1,2,8,11,12,13,14,15,16,17-decahydro-6H-7-oxa-cyclopenta[a]phenanthren-3-one
Show/Hide
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C34H34F3NO3
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1
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| 1 |
IC50 = 45.4 nM
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CP0461951
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(8S,11R,13S,14R,17S)-17-(3-chloro-phenylethynyl)-11-(4-dimethylamino-phenyl)-17-hydroxy-13-methyl-1,2,8,11,12,13,14,15,16,17-decahydro-6H-7-oxa-cyclopenta[a]phenanthren-3-one
Show/Hide
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C33H34ClNO3
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1
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| 1 |
IC50 = 48.9 nM
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CP0313880
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N-[(2S)-1-[[1-(3-methoxyphenyl)-6-methylindazol-4-yl]amino]propan-2-yl]-2,4,6-trimethylbenzenesulfonamide
Show/Hide
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C27H32N4O3S
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2
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| 1 |
IC50 = 50.12 nM
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|
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| 2 |
IC50 = 199.53 nM
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CP0480356
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(8S,11R,13S,14R,17S)-11-(4-dimethylamino-phenyl)-17-hydroxy-13-methyl-17-(2-trifluoromethyl-phenylethynyl)-1,2,8,11,12,13,14,15,16,17-decahydro-6H-7-oxa-cyclopenta[a]phenanthren-3-one
Show/Hide
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C34H34F3NO3
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1
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| 1 |
IC50 = 51 nM
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CP0435579
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(8S,11R,13S,14R,17S)-11-(4-dimethylamino-phenyl)-17-hydroxy-13-methyl-17-trifluoroprop-1-ynyl-1,2,8,11,12,13,14,15,16,17-decahydro-6H-7-oxa-cyclopenta[a]phenanthren-3-one
Show/Hide
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C28H30F3NO3
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1
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| 1 |
IC50 = 55.5 nM
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CP0449765
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(8S,11R,13S,14R,17S)-11-(4-dimethylamino-phenyl)-17-hydroxy-13-methyl-17-thiophen-3-ylethynyl-1,2,8,11,12,13,14,15,16,17-decahydro-6H-7-oxa-cyclopenta[a]phenanthren-3-one
Show/Hide
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C31H33NO3S
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1
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| 1 |
IC50 = 56 nM
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CP0467221
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(8S,11R,13S,14R,17S)-11-(4-dimethylamino-phenyl)-17-(3-fluoro-phenylethynyl)-17-hydroxy-13-methyl-1,2,8,11,12,13,14,15,16,17-decahydro-6H-7-oxa-cyclopenta[a]phenanthren-3-one
Show/Hide
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C33H34FNO3
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1
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| 1 |
IC50 = 56.6 nM
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CP0507964
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(1R,3S,3aR,3bS,10R)-1-Hydroxy-1-isopropenyl-12a-methyl-10-(4-methylsulfanyl-phenyl)-2,3,3a,3b,4,5,9,10,12,12a-decahydro-1H,8H-11-oxa-naphtho[2,1-e]azulen-7-one
Show/Hide
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C28H34O3S
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1
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| 1 |
IC50 = 58 nM
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|
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CP0513479
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N-[(8S,11R,13S,14S,17S)-11-(1,3-benzoxazol-5-yl)-13-methyl-3-oxo-17-prop-1-ynyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl]formamide
Show/Hide
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C29H30N2O3
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1
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| 1 |
IC50 = 60 nM
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|
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CP0513480
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(8S,11R,13S,14S,17S)-17-hydroxy-13-methyl-17-prop-1-ynyl-11-[2-(trifluoromethyl)-1,3-benzoxazol-5-yl]-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one
Show/Hide
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C29H28F3NO3
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1
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| 1 |
IC50 = 61 nM
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|
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CP0428831
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(1'S,2R,2'S,6'R,9'R)-9'-[4-(dimethylamino)phenyl]-6'-methyl-3-methylidene-8'-oxaspiro[oxolane-2,5'-tetracyclo[8.8.0.0^{2,6}.0^{11,16}]octadecane]-10',15'-dien-14'-one
Show/Hide
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C30H37NO3
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1
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| 1 |
IC50 = 62 nM
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|
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CP0528557
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(8S,11R,13S,14R,17S)-17-(2-bromo-phenylethynyl)-11-(4-dimethylamino-phenyl)-17-hydroxy-13-methyl-1,2,8,11,12,13,14,15,16,17-decahydro-6H-7-oxa-cyclopenta[a]phenanthren-3-one
Show/Hide
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C33H34BrNO3
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1
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| 1 |
IC50 = 62.7 nM
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|
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CP0494070
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4-chloro-N-[[4-chloro-3-(trifluoromethyl)phenyl]methyl]-1,3-dimethylpyrazolo[3,4-b]pyridine-5-carboxamide
Show/Hide
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C17H13Cl2F3N4O
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1
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| 1 |
IC50 = 63.1 nM
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|
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CP0507686
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4-chloro-N-[[4-chloro-3-(trifluoromethyl)phenyl]methyl]-1-ethylpyrazolo[3,4-b]pyridine-5-carboxamide
Show/Hide
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C17H13Cl2F3N4O
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1
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| 1 |
IC50 = 63.1 nM
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CP0528558
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(8S,11R,13S,14R,17S)-17-(2-chloro-phenylethynyl)-11-(4-dimethylamino-phenyl)-17-hydroxy-13-methyl-1,2,8,11,12,13,14,15,16,17-decahydro-6H-7-oxa-cyclopenta[a]phenanthren-3-one
Show/Hide
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C33H34ClNO3
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1
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| 1 |
IC50 = 64.8 nM
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CP0464693
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(8S,11R,13S,14R,17S)-11-(4-dimethylamino-phenyl)-17-(2-fluoro-phenylethynyl)-17-hydroxy-13-methyl-1,2,8,11,12,13,14,15,16,17-decahydro-6H-7-oxa-cyclopenta[a]phenanthren-3-one
Show/Hide
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C33H34FNO3
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1
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| 1 |
IC50 = 65.1 nM
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CP0462023
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(8S,11R,13S,14R,17S)-17-(4-tert-butyl-phenylethynyl)-11-(4-dimethylamino-phenyl)-17-hydroxy-13-methyl-1,2,8,11,12,13,14,15,16,17-decahydro-6H-7-oxa-cyclopenta[a]phenanthren-3-one
Show/Hide
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C37H43NO3
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1
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| 1 |
IC50 = 65.8 nM
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CP0402611
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(1R,3S,3aR,3bS,10R)-10-(4-Dimethylamino-phenyl)-1-ethynyl-1-hydroxy-12a-methyl-2,3,3a,3b,4,5,9,10,12,12a-decahydro-1H,8H-11-oxa-naphtho[2,1-e]azulen-7-one
Show/Hide
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C28H33NO3
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1
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| 1 |
IC50 = 68 nM
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CP0136086
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1,1,1-trifluoro-2-[(1-methyl-3,4-dihydro-2H-naphthalen-1-yl)methyl]-3-[(2-methylquinolin-5-yl)amino]propan-2-ol
Show/Hide
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C25H27F3N2O
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1
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| 1 |
IC50 = 77.62 nM
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CP0528553
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(8S,11R,13S,14R,17S)-11-(4-dimethylamino-phenyl)-17-hydroxy-17-(4-methoxy-phenylethynyl)-13-methyl-1,2,8,11,12,13,14,15,16,17-decahydro-6H-7-oxa-cyclopenta[a]phenanthren-3-one
Show/Hide
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C34H37NO4
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1
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| 1 |
IC50 = 80.3 nM
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CP0504936
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(3S,10'S,11'S,15'S,17'R)-17'-[4-(dimethylamino)phenyl]-5,15'-dimethyl-2-methylidene-2H-spiro[1,4-oxazole-3,14'-tetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecane]-1',6'-dien-5'-one
Show/Hide
|
C30H36N2O2
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1
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| 1 |
IC50 = 82 nM
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|
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CP0421974
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(8S,11R,13S,14R,17S)-11-(4-Dimethylamino-phenyl)-17-hydroxy-13-methyl-17-prop-1-ynyl-1,2,8,11,12,13,14,15,16,17-decahydro-6H-7-oxa-cyclopenta[a]phenanthren-3-one
Show/Hide
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C28H33NO3
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1
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| 1 |
IC50 = 86.5 nM
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CP0402610
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(1R,3S,3aR,3bS,10R)-10-(4-Dimethylamino-phenyl)-1-hydroxy-12a-methyl-1-phenylethynyl-2,3,3a,3b,4,5,9,10,12,12a-decahydro-1H,8H-11-oxa-naphtho[2,1-e]azulen-7-one
Show/Hide
|
C34H37NO3
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1
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| 1 |
IC50 = 102 nM
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|
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CP0261725
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1,1,1-trifluoro-2-[(isoquinolin-5-ylamino)methyl]-3-(1-methyl-3,4-dihydro-2H-naphthalen-1-yl)propan-2-ol
Show/Hide
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C24H25F3N2O
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1
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| 1 |
IC50 = 102.33 nM
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CP0402608
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(1R,3S,3aR,3bS,10R)-1-Ethynyl-1-hydroxy-10-(4-methoxy-phenyl)-12a-methyl-2,3,3a,3b,4,5,9,10,12,12a-decahydro-1H,8H-11-oxa-naphtho[2,1-e]azulen-7-one
Show/Hide
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C27H30O4
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1
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| 1 |
IC50 = 110 nM
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CP0465249
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(8S,11R,13S,14R,17S)-11-(4-dimethylamino-phenyl)-17-hydroxy-13-methyl-17-(4-trifluoromethyl-phenylethynyl)-1,2,8,11,12,13,14,15,16,17-decahydro-6H-7-oxa-cyclopenta[a]phenanthren-3-one
Show/Hide
|
C34H34F3NO3
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1
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| 1 |
IC50 = 111 nM
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|
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CP0528556
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(8S,11R,13S,14R,17S)-11-(4-dimethylamino-phenyl)-17-hydroxy-13-methyl-17-o-tolylethynyl-1,2,8,11,12,13,14,15,16,17-decahydro-6H-7-oxa-cyclopenta[a]phenanthren-3-one
Show/Hide
|
C34H37NO3
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1
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| 1 |
IC50 = 113.2 nM
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CP0397051
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(1'S,2R,2'S,6'R,9'R)-9'-(4-methoxyphenyl)-6'-methyl-3-methylidene-8'-oxaspiro[oxolane-2,5'-tetracyclo[8.8.0.0^{2,6}.0^{11,16}]octadecane]-10',15'-dien-14'-one
Show/Hide
|
C29H34O4
|
1
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| 1 |
IC50 = 132 nM
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|
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CP0500463
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N-[(8S,11R,13S,14S,17S)-13-methyl-3-oxo-17-prop-1-ynyl-11-[2-(trifluoromethyl)-1,3-benzoxazol-5-yl]-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl]formamide
Show/Hide
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C30H29F3N2O3
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1
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| 1 |
IC50 = 142 nM
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CP0404923
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(1R,3S,3aR,3bS,10R)-10-(4-Dimethylamino-phenyl)-1-hydroxy-1-isopropenyl-12a-methyl-2,3,3a,3b,4,5,9,10,12,12a-decahydro-1H,8H-11-oxa-naphtho[2,1-e]azulen-7-one
Show/Hide
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C29H37NO3
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1
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| 1 |
IC50 = 150 nM
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CP0494071
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4-chloro-N-[(3,5-dimethylphenyl)methyl]-1-ethylpyrazolo[3,4-b]pyridine-5-carboxamide
Show/Hide
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C18H19ClN4O
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1
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| 1 |
IC50 = 158.49 nM
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CP0437427
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(8S,11R,13S,14R,17S)-11-(4-dimethylamino-phenyl)-17-(3,3-dimethyl-but-1-ynyl)-17-hydroxy-13-methyl-1,2,8,11,12,13,14,15,16,17-decahydro-6H-7-oxa-cyclopenta[a]phenanthren-3-one
Show/Hide
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C31H39NO3
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1
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| 1 |
IC50 = 166.9 nM
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CP0437235
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(8S,11R,13S,14R,17S)-11-(4-dimethylamino-phenyl)-17-hydroxy-13-methyl-17-pyridin-2-ylethynyl-1,2,8,11,12,13,14,15,16,17-decahydro-6H-7-oxa-cyclopenta[a]phenanthren-3-one
Show/Hide
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C32H34N2O3
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1
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| 1 |
IC50 = 175.3 nM
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CP0494072
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4-chloro-N-[(3,5-dimethylphenyl)methyl]-1,3-dimethylpyrazolo[3,4-b]pyridine-5-carboxamide
Show/Hide
|
C18H19ClN4O
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1
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| 1 |
IC50 = 199.53 nM
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|
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CP0298225
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3-[4-[[(2S)-2-(methanesulfonamido)propyl]amino]-6-methylindazol-1-yl]-N-propan-2-ylbenzamide
Show/Hide
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C22H29N5O3S
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2
|
| 1 |
IC50 = 199.53 nM
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| 2 |
IC50 = 1995.26 nM
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CP0461741
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(8S,11R,13S,14R,17R)-11-(4-dimethylamino-phenyl)-17-ethynyl-17-hydroxy-13-methyl-1,2,8,11,12,13,14,15,16,17-decahydro-6H-7-oxa-cyclopenta[a]phenanthren-3-one
Show/Hide
|
C27H31NO3
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1
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| 1 |
IC50 = 204.3 nM
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|
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CP0393072
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(3S,10'S,11'S,15'S,17'R)-17'-(4-acetylphenyl)-5-ethyl-15'-methyl-2-methylidene-2H-spiro[1,4-oxazole-3,14'-tetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecane]-1',6'-dien-5'-one
Show/Hide
|
C31H35NO3
|
1
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| 1 |
IC50 = 210 nM
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|
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CP0144276
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2-[(1-ethyl-3,4-dihydro-2H-naphthalen-1-yl)methyl]-1,1,1-trifluoro-3-(1H-indol-2-yl)propan-2-ol
Show/Hide
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C24H26F3NO
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1
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| 1 |
IC50 = 245.47 nM
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|
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CP0435776
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(8S,11R,13S,14R,17S)-11-(4-dimethylamino-phenyl)-17-hydroxy-13-methyl-17-pyridin-4-ylethynyl-1,2,8,11,12,13,14,15,16,17-decahydro-6H-7-oxa-cyclopenta[a]phenanthren-3-one
Show/Hide
|
C32H34N2O3
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1
|
| 1 |
IC50 = 246.5 nM
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|
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CP0171861
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2-[(1-ethyl-5-nitro-3,4-dihydro-2H-naphthalen-1-yl)methyl]-3,3,3-trifluoro-2-hydroxy-N-(4-methyl-1-oxo-2,3-benzoxazin-6-yl)propanamide
Show/Hide
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C25H24F3N3O6
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2
|
| 1 |
IC50 = 251.19 nM
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| 2 |
IC50 > 10000 nM
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CP0418008
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4-chloro-N-[[4-(3,5-dimethyl-1,2-oxazol-4-yl)phenyl]methyl]-3-methyl-1-propan-2-ylpyrazolo[3,4-b]pyridine-5-carboxamide
Show/Hide
|
C23H24ClN5O2
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1
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| 1 |
IC50 = 251.19 nM
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CP0469051
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4-chloro-N-[(4-chlorophenyl)methyl]-1-ethylpyrazolo[3,4-b]pyridine-5-carboxamide
Show/Hide
|
C16H14Cl2N4O
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1
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| 1 |
IC50 = 251.19 nM
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CP0507687
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4-chloro-N-[[4-(3,5-dimethyl-1,2-oxazol-4-yl)phenyl]methyl]-3-methyl-1-(pyridin-2-ylmethyl)pyrazolo[3,4-b]pyridine-5-carboxamide
Show/Hide
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C26H23ClN6O2
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1
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| 1 |
IC50 = 251.19 nM
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CP0521457
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4-chloro-N-[[4-(3,5-dimethyl-1,2-oxazol-4-yl)phenyl]methyl]-3-methyl-1-propylpyrazolo[3,4-b]pyridine-5-carboxamide
Show/Hide
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C23H24ClN5O2
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1
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| 1 |
IC50 = 251.19 nM
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CP0298226
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N-[(2S)-1-[[1-[3-[3-(hydroxymethyl)piperidine-1-carbonyl]phenyl]-6-methylindazol-4-yl]amino]propan-2-yl]cyclopropanesulfonamide
Show/Hide
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C27H35N5O4S
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2
|
| 1 |
IC50 = 251.19 nM
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| 2 |
IC50 > 6309.57 nM
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CP0041675
|
5-amino-N-[2-[(1-cyclopentyl-3,4-dihydro-2H-naphthalen-1-yl)methyl]-3,3,3-trifluoro-2-hydroxypropyl]-1-(2,4-difluorophenyl)pyrazole-4-carboxamide
Show/Hide
|
C29H31F5N4O2
|
1
|
| 1 |
IC50 = 275.42 nM
|
|
|
|
CP0399452
|
(8S,11R,13S,14R,17S)-11-(4-Dimethylamino-phenyl)-17-hydroxy-13-methyl-17-phenylethynyl-1,2,8,11,12,13,14,15,16,17-decahydro-6H-7-oxa-cyclopenta[a]phenanthren-3-one
Show/Hide
|
C33H35NO3
|
1
|
| 1 |
IC50 = 304 nM
|
|
|
|
CP0536358
|
(8S,11R,13S,14R,17S)-11-(4-dimethylamino-phenyl)-17-hydroxy-17-(3-methoxy-prop-1-ynyl)-11,13-dimethyl-1,2,8,11,12,13,14,15,16,17-decahydro-6H-7-oxa-cyclopenta[a]phenanthren-3-one
Show/Hide
|
C30H37NO4
|
1
|
| 1 |
IC50 = 315 nM
|
|
|
|
CP0192544
|
2-[(1-ethyl-7-nitro-3,4-dihydro-2H-naphthalen-1-yl)methyl]-3,3,3-trifluoro-2-hydroxy-N-(4-methyl-1-oxo-2,3-benzoxazin-6-yl)propanamide
Show/Hide
|
C25H24F3N3O6
|
2
|
| 1 |
IC50 = 316.23 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0503901
|
1-benzyl-4-chloro-N-[[4-(3,5-dimethyl-1,2-oxazol-4-yl)phenyl]methyl]pyrazolo[3,4-b]pyridine-5-carboxamide
Show/Hide
|
C26H22ClN5O2
|
1
|
| 1 |
IC50 = 316.23 nM
|
|
|
|
CP0521458
|
4-chloro-N-[[4-(3,5-dimethyl-1,2-oxazol-4-yl)phenyl]methyl]-3-methyl-1-phenylpyrazolo[3,4-b]pyridine-5-carboxamide
Show/Hide
|
C26H22ClN5O2
|
1
|
| 1 |
IC50 = 316.23 nM
|
|
|
|
CP0465209
|
(8S,11R,13S,14R,17S)-11-(4-dimethylamino-phenyl)-17-hydroxy-13-methyl-17-pyridin-3-ylethynyl-1,2,8,11,12,13,14,15,16,17-decahydro-6H-7-oxa-cyclopenta[a]phenanthren-3-one
Show/Hide
|
C32H34N2O3
|
1
|
| 1 |
IC50 = 341.6 nM
|
|
|
|
CP0344426
|
2-[(5-chloro-1,2,3,4-tetrahydronaphthalen-1-yl)methyl]-3,3,3-trifluoro-2-hydroxy-N-(4-methyl-1-oxo-2,3-benzoxazin-6-yl)propanamide
Show/Hide
|
C23H20ClF3N2O4
|
2
|
| 1 |
IC50 = 398.11 nM
|
|
|
| 2 |
IC50 > 1000 nM
|
|
|
|
CP0522310
|
4-chloro-1-ethyl-N-[(3-methylphenyl)methyl]pyrazolo[3,4-b]pyridine-5-carboxamide
Show/Hide
|
C17H17ClN4O
|
1
|
| 1 |
IC50 = 398.11 nM
|
|
|
|
CP0539611
|
4-chloro-1-ethyl-N-[(2-methylphenyl)methyl]pyrazolo[3,4-b]pyridine-5-carboxamide
Show/Hide
|
C17H17ClN4O
|
1
|
| 1 |
IC50 = 398.11 nM
|
|
|
|
CP0551874
|
(3S,10'S,11'S,15'S,17'R)-17'-(4-acetylphenyl)-5,15'-dimethyl-2-methylidene-2H-spiro[1,4-oxazole-3,14'-tetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecane]-1',6'-dien-5'-one
Show/Hide
|
C30H33NO3
|
1
|
| 1 |
IC50 = 460 nM
|
|
|
|
CP0340130
|
3,3,3-trifluoro-2-[(5-fluoro-1,2,3,4-tetrahydronaphthalen-1-yl)methyl]-2-hydroxy-N-(4-methyl-1-oxo-2,3-benzoxazin-6-yl)propanamide
Show/Hide
|
C23H20F4N2O4
|
2
|
| 1 |
IC50 = 501.19 nM
|
|
|
| 2 |
IC50 > 1000 nM
|
|
|
|
CP0539612
|
4-chloro-1-cyclopentyl-N-[[4-(3,5-dimethyl-1,2-oxazol-4-yl)phenyl]methyl]pyrazolo[3,4-b]pyridine-5-carboxamide
Show/Hide
|
C24H24ClN5O2
|
1
|
| 1 |
IC50 = 501.19 nM
|
|
|
|
CP0378277
|
(3S,10'S,11'S,15'S,17'R)-17'-[4-(dimethylamino)phenyl]-15'-methyl-2-methylidene-2H-spiro[1,4-oxazole-3,14'-tetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecane]-1',6'-dien-5'-one
Show/Hide
|
C29H34N2O2
|
1
|
| 1 |
IC50 = 540 nM
|
|
|
|
CP0524349
|
(8S,11R,13S,14R,17S)-11-(4-dimethylamino-phenyl)-17-hydroxy-17-(3-hydroxy-3-methyl-but-1-ynyl)-11,13-dimethyl-1,2,8,11,12,13,14,15,16,17-decahydro-6H-7-oxa-cyclopenta[a]phenanthren-3-one
Show/Hide
|
C30H37NO4
|
1
|
| 1 |
IC50 = 558 nM
|
|
|
|
CP0496631
|
(3S,10'S,11'S,15'S,17'R)-17'-(3-fluoro-4-methoxyphenyl)-5,15'-dimethyl-2-methylidene-2H-spiro[1,4-oxazole-3,14'-tetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecane]-1',6'-dien-5'-one
Show/Hide
|
C29H32FNO3
|
1
|
| 1 |
IC50 = 660 nM
|
|
|
|
CP0367888
|
2-[(1-tert-butyl-3,4-dihydro-2H-naphthalen-1-yl)methyl]-3,3,3-trifluoro-2-hydroxy-N-(4-methyl-1-oxo-2,3-benzoxazin-6-yl)propanamide
Show/Hide
|
C27H29F3N2O4
|
2
|
| 1 |
IC50 = 776.25 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0171916
|
2-[(5-bromo-1,2,3,4-tetrahydronaphthalen-1-yl)methyl]-3,3,3-trifluoro-2-hydroxy-N-(4-methyl-1-oxo-2,3-benzoxazin-6-yl)propanamide
Show/Hide
|
C23H20BrF3N2O4
|
2
|
| 1 |
IC50 = 794.33 nM
|
|
|
| 2 |
IC50 > 1000 nM
|
|
|
|
CP0340504
|
2-[(1-ethyl-6-nitro-3,4-dihydro-2H-naphthalen-1-yl)methyl]-3,3,3-trifluoro-2-hydroxy-N-(4-methyl-1-oxo-2,3-benzoxazin-6-yl)propanamide
Show/Hide
|
C25H24F3N3O6
|
2
|
| 1 |
IC50 = 794.33 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0514882
|
4-chloro-N-[[4-(3,5-dimethyl-1,2-oxazol-4-yl)phenyl]methyl]-3-methyl-1-(2-methylphenyl)pyrazolo[3,4-b]pyridine-5-carboxamide
Show/Hide
|
C27H24ClN5O2
|
1
|
| 1 |
IC50 = 794.33 nM
|
|
|
|
CP0297077
|
(2S)-1-[3-[4-[[(2S)-2-(cyclopropylsulfonylamino)propyl]amino]-6-methylindazol-1-yl]benzoyl]pyrrolidine-2-carboxamide
Show/Hide
|
C26H32N6O4S
|
2
|
| 1 |
IC50 = 794.33 nM
|
|
|
| 2 |
IC50 = 3981.07 nM
|
|
|
|
CP0469052
|
N-benzyl-4-chloro-1-methylpyrazolo[3,4-b]pyridine-5-carboxamide
Show/Hide
|
C15H13ClN4O
|
1
|
| 1 |
IC50 = 1000 nM
|
|
|
|
CP0240435
|
4-[1-(4-fluorophenyl)indazol-5-yl]-N-propan-2-yl-3-(trifluoromethyl)benzenesulfonamide
Show/Hide
|
C23H19F4N3O2S
|
2
|
| 1 |
IC50 = 1258.93 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0371245
|
3,3,3-trifluoro-2-hydroxy-N-(4-methyl-1-oxo-2,3-benzoxazin-6-yl)-2-[(1-phenyl-3,4-dihydro-2H-naphthalen-1-yl)methyl]propanamide
Show/Hide
|
C29H25F3N2O4
|
2
|
| 1 |
IC50 = 1380.38 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0402612
|
(1S,3S,3aR,3bS,10R)-10-(4-Dimethylamino-phenyl)-1-hydroxy-12a-methyl-2,3,3a,3b,4,5,9,10,12,12a-decahydro-1H,8H-11-oxa-naphtho[2,1-e]azulen-7-one
Show/Hide
|
C26H33NO3
|
1
|
| 1 |
IC50 = 1400 nM
|
|
|
|
CP0238236
|
N-[4-[1-(4-fluorophenyl)indazol-5-yl]-3-(trifluoromethyl)phenyl]methanesulfonamide
Show/Hide
|
C21H15F4N3O2S
|
2
|
| 1 |
IC50 = 1584.89 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0238237
|
N-[4-[1-(4-fluorophenyl)indazol-5-yl]-3-(trifluoromethyl)phenyl]benzenesulfonamide
Show/Hide
|
C26H17F4N3O2S
|
2
|
| 1 |
IC50 = 1584.89 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0192548
|
2-[(5-amino-1,2,3,4-tetrahydronaphthalen-1-yl)methyl]-3,3,3-trifluoro-2-hydroxy-N-(4-methyl-1-oxo-2,3-benzoxazin-6-yl)propanamide
Show/Hide
|
C23H22F3N3O4
|
2
|
| 1 |
IC50 = 1995.26 nM
|
|
|
| 2 |
IC50 > 1000 nM
|
|
|
|
CP0125700
|
N-ethyl-4-[1-(4-fluorophenyl)indazol-5-yl]-3-(trifluoromethyl)benzenesulfonamide
Show/Hide
|
C22H17F4N3O2S
|
2
|
| 1 |
IC50 = 1995.26 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0125778
|
N-[4-[1-(4-fluorophenyl)indazol-5-yl]-3-(trifluoromethyl)phenyl]propane-1-sulfonamide
Show/Hide
|
C23H19F4N3O2S
|
2
|
| 1 |
IC50 = 1995.26 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0212080
|
4-[1-(4-fluorophenyl)indazol-5-yl]-N-(2-hydroxyethyl)-3-(trifluoromethyl)benzenesulfonamide
Show/Hide
|
C22H17F4N3O3S
|
2
|
| 1 |
IC50 = 1995.26 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0265359
|
N-[4-[1-(4-fluorophenyl)indazol-5-yl]-3-(trifluoromethyl)phenyl]ethanesulfonamide
Show/Hide
|
C22H17F4N3O2S
|
2
|
| 1 |
IC50 = 1995.26 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0105359
|
4-[1-(4-fluorophenyl)indazol-5-yl]-N-propyl-3-(trifluoromethyl)benzenesulfonamide
Show/Hide
|
C23H19F4N3O2S
|
2
|
| 1 |
IC50 = 3162.28 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0165963
|
4-[1-(4-fluorophenyl)indazol-5-yl]-N-(2-methylpropyl)-3-(trifluoromethyl)benzenesulfonamide
Show/Hide
|
C24H21F4N3O2S
|
2
|
| 1 |
IC50 = 3162.28 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0306644
|
4-[1-(4-fluorophenyl)indazol-5-yl]-N-phenyl-3-(trifluoromethyl)benzenesulfonamide
Show/Hide
|
C26H17F4N3O2S
|
2
|
| 1 |
IC50 = 3162.28 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0274332
|
2-[(1-ethyl-3,4-dihydro-2H-naphthalen-1-yl)methyl]-1,1,1-trifluoro-3-quinolin-4-ylpropan-2-ol
Show/Hide
|
C25H26F3NO
|
1
|
| 1 |
IC50 = 5011.87 nM
|
|
|
|
CP0171860
|
2-[(4-ethyl-2,3-dihydrochromen-4-yl)methyl]-3,3,3-trifluoro-2-hydroxy-N-(4-methyl-1-oxo-2,3-benzoxazin-6-yl)propanamide
Show/Hide
|
C24H23F3N2O5
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0490394
|
(3S,10'S,11'S,15'S,17'R)-5-ethyl-17'-(3-fluoro-4-methoxyphenyl)-15'-methyl-2-methylidene-2H-spiro[1,4-oxazole-3,14'-tetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecane]-1',6'-dien-5'-one
Show/Hide
|
C30H34FNO3
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0038930
|
1-(4-fluorophenyl)-5-[2-(trifluoromethyl)phenyl]indazole
Show/Hide
|
C20H12F4N2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0039378
|
5-(2-ethoxyphenyl)-1-(4-fluorophenyl)indazole
Show/Hide
|
C21H17FN2O
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0092995
|
N-[4-[1-(4-fluorophenyl)indazol-5-yl]-3-(trifluoromethyl)phenyl]-2,4,6-tri(propan-2-yl)benzenesulfonamide
Show/Hide
|
C35H35F4N3O2S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0095575
|
1-(4-fluorophenyl)-5-[3-(trifluoromethyl)phenyl]indazole
Show/Hide
|
C20H12F4N2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0125697
|
4-[1-(4-fluorophenyl)indazol-5-yl]benzonitrile
Show/Hide
|
C20H12FN3
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0128616
|
1-(4-fluorophenyl)-5-(2-methylphenyl)indazole
Show/Hide
|
C20H15FN2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0146265
|
1-(4-fluorophenyl)-5-phenylindazole
Show/Hide
|
C19H13FN2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0151324
|
1-(4-fluorophenyl)-5-(4-methylphenyl)indazole
Show/Hide
|
C20H15FN2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0161719
|
4-tert-butyl-N-[4-[1-(4-fluorophenyl)indazol-5-yl]-3-(trifluoromethyl)phenyl]benzenesulfonamide
Show/Hide
|
C30H25F4N3O2S
|
2
|
| 1 |
IC50 > 10000 nM
|
|
|
| 2 |
IC50 = 10000 nM
|
|
|
|
CP0180356
|
3-[1-(4-fluorophenyl)indazol-5-yl]benzonitrile
Show/Hide
|
C20H12FN3
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0258954
|
3-[1-(4-fluorophenyl)indazol-5-yl]phenol
Show/Hide
|
C19H13FN2O
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0278520
|
4-[1-(4-fluorophenyl)indazol-5-yl]phenol
Show/Hide
|
C19H13FN2O
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0293478
|
5-(3-ethoxyphenyl)-1-(4-fluorophenyl)indazole
Show/Hide
|
C21H17FN2O
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0294319
|
2-[1-(4-fluorophenyl)indazol-5-yl]benzonitrile
Show/Hide
|
C20H12FN3
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0302260
|
1-(4-fluorophenyl)-5-[4-(trifluoromethyl)phenyl]indazole
Show/Hide
|
C20H12F4N2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0335860
|
1-(4-fluorophenyl)-5-(3-methylphenyl)indazole
Show/Hide
|
C20H15FN2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0516153
|
(3S,10'S,11'S,15'S,17'R)-17'-(4-acetylphenyl)-15'-methyl-2-methylidene-2H-spiro[1,4-oxazole-3,14'-tetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecane]-1',6'-dien-5'-one
Show/Hide
|
C29H31NO3
|
1
|
| 1 |
IC50 = 14000 nM
|
|
|
|
CP0192546
|
3,3,3-trifluoro-2-hydroxy-N-(4-methyl-1-oxo-2,3-benzoxazin-6-yl)-2-[(5-nitro-1,2,3,4-tetrahydronaphthalen-1-yl)methyl]propanamide
Show/Hide
|
C23H20F3N3O6
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0276474
|
3,3,3-trifluoro-2-hydroxy-N-(4-methyl-1-oxo-2,3-benzoxazin-6-yl)-2-[(6-nitro-1,2,3,4-tetrahydronaphthalen-1-yl)methyl]propanamide
Show/Hide
|
C23H20F3N3O6
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0276476
|
2-[(5-cyano-1,2,3,4-tetrahydronaphthalen-1-yl)methyl]-3,3,3-trifluoro-2-hydroxy-N-(4-methyl-1-oxo-2,3-benzoxazin-6-yl)propanamide
Show/Hide
|
C24H20F3N3O4
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0276477
|
3,3,3-trifluoro-2-hydroxy-2-[(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)methyl]-N-(4-methyl-1-oxo-2,3-benzoxazin-6-yl)propanamide
Show/Hide
|
C24H23F3N2O5
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0283193
|
3,3,3-trifluoro-2-[(6-fluoro-1,2,3,4-tetrahydronaphthalen-1-yl)methyl]-2-hydroxy-N-(4-methyl-1-oxo-2,3-benzoxazin-6-yl)propanamide
Show/Hide
|
C23H20F4N2O4
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0291011
|
3,3,3-trifluoro-2-[(8-fluoro-1,2,3,4-tetrahydronaphthalen-1-yl)methyl]-2-hydroxy-N-(4-methyl-1-oxo-2,3-benzoxazin-6-yl)propanamide
Show/Hide
|
C23H20F4N2O4
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0339707
|
3,3,3-trifluoro-2-hydroxy-N-(4-methyl-1-oxo-2,3-benzoxazin-6-yl)-2-(1,2,3,4-tetrahydronaphthalen-1-ylmethyl)propanamide
Show/Hide
|
C23H21F3N2O4
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0340139
|
3,3,3-trifluoro-2-hydroxy-N-(4-methyl-1-oxo-2,3-benzoxazin-6-yl)-2-[(5-methyl-1,2,3,4-tetrahydronaphthalen-1-yl)methyl]propanamide
Show/Hide
|
C24H23F3N2O4
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0344481
|
3,3,3-trifluoro-2-[(7-fluoro-1,2,3,4-tetrahydronaphthalen-1-yl)methyl]-2-hydroxy-N-(4-methyl-1-oxo-2,3-benzoxazin-6-yl)propanamide
Show/Hide
|
C23H20F4N2O4
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0346426
|
3,3,3-trifluoro-2-hydroxy-N-(4-methyl-1-oxo-2,3-benzoxazin-6-yl)-2-[(7-nitro-1,2,3,4-tetrahydronaphthalen-1-yl)methyl]propanamide
Show/Hide
|
C23H20F3N3O6
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0187160
|
4-bromo-2-ethyl-5-methyl-N-[3,3,3-trifluoro-2-hydroxy-2-[(1-methyl-3,4-dihydro-2H-naphthalen-1-yl)methyl]propyl]pyrazole-3-carboxamide
Show/Hide
|
C22H27BrF3N3O2
|
1
|
| 1 |
IC50 < 1000 nM
|
|
|
|
CP0159947
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5-amino-N-[4-(5-fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-(trifluoromethyl)pentyl]-1-(4-fluorophenyl)pyrazole-4-carboxamide
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C24H25F5N4O3
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1
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| 1 |
IC50 < 1000 nM
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CP0252240
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5-amino-1-(2,4-difluorophenyl)-N-[2-[(1-ethyl-3,4-dihydro-2H-naphthalen-1-yl)methyl]-3,3,3-trifluoro-2-hydroxypropyl]pyrazole-4-carboxamide
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C26H27F5N4O2
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1
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| 1 |
IC50 < 1000 nM
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CP0439514
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(8S,11R,13S,14R,17S)-11-(4-dimethylamino-phenyl)-17-(3-dimethylamino-prop-1-ynyl)-17-hydroxy-13-methyl-1,2,8,11,12,13,14,15,16,17-decahydro-6H-7-oxa-cyclopenta[a]phenanthren-3-one
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C30H38N2O3
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1
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| 1 |
IC50 > 3000 nM
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CP0404922
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(1R,3S,3aR,3bS,10R)-1-Hydroxy-1-isopropenyl-10-(4-methanesulfonyl-phenyl)-12a-methyl-2,3,3a,3b,4,5,9,10,12,12a-decahydro-1H,8H-11-oxa-naphtho[2,1-e]azulen-7-one
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C28H34O5S
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1
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| 1 |
IC50 > 3000 nM
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CP0390894
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4-chloro-1,3-dimethyl-N-[2-(3-methylphenyl)pyrrolidin-1-yl]pyrazolo[3,4-b]pyridine-5-carboxamide
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C20H22ClN5O
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1
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| 1 |
IC50 > 6309.57 nM
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CP0469053
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4-chloro-1,3-dimethyl-N-(pyridin-2-ylmethyl)pyrazolo[3,4-b]pyridine-5-carboxamide
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C15H14ClN5O
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1
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| 1 |
IC50 > 6309.57 nM
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CP0494067
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4-chloro-N-[[4-(3,5-dimethyl-1,2-oxazol-4-yl)phenyl]methyl]-3-methyl-1-(4-methylphenyl)pyrazolo[3,4-b]pyridine-5-carboxamide
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C27H24ClN5O2
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1
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| 1 |
IC50 > 6309.57 nM
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CP0503900
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N-[[4-(3,5-dimethyl-1,2-oxazol-4-yl)phenyl]methyl]-1-ethyl-3,4-dimethylpyrazolo[3,4-b]pyridine-5-carboxamide
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C23H25N5O2
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1
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| 1 |
IC50 > 6309.57 nM
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CP0504537
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4-chloro-1-ethyl-N-propylpyrazolo[3,4-b]pyridine-5-carboxamide
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C12H15ClN4O
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1
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| 1 |
IC50 > 6309.57 nM
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CP0518711
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4-chloro-1-ethyl-N-(1,3-thiazol-5-ylmethyl)pyrazolo[3,4-b]pyridine-5-carboxamide
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C13H12ClN5OS
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1
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| 1 |
IC50 > 6309.57 nM
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CP0521455
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4-chloro-1-ethyl-N-methylpyrazolo[3,4-b]pyridine-5-carboxamide
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C10H11ClN4O
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1
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| 1 |
IC50 > 6309.57 nM
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CP0521456
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4-methoxy-N-[(4-methoxyphenyl)methyl]-1,3-dimethylpyrazolo[3,4-b]pyridine-5-carboxamide
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C18H20N4O3
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1
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| 1 |
IC50 > 6309.57 nM
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CP0427893
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(8S,11R,13S,14S,17S)-11-(4-(diphenylphosphoryl)phenyl)-17-hydroxy-13-methyl-17-(prop-1-ynyl)-1,2,7,8,11,12,13,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3(14H)-one
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C39H39O3P
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1
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| 1 |
Ki = 3 nM
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CP0426944
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(8S,11R,13S,14S,17S)-11-(4-diethoxyphosphorylphenyl)-17-hydroxy-13-methyl-17-prop-1-ynyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one
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C31H39O5P
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1
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| 1 |
Ki = 9 nM
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CP0427756
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(8S,11R,13S,14S,17R)-11-(4-diethoxyphosphorylphenyl)-17-hydroxy-13-methyl-17-prop-2-enyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one
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C31H41O5P
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1
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| 1 |
Ki = 10 nM
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CP0428068
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(8S,11R,13S,14S,17R)-17-allyl-11-(4-(diphenylphosphoryl)phenyl)-17-hydroxy-13-methyl-1,2,7,8,11,12,13,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3(14H)-one
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C39H41O3P
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1
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| 1 |
Ki = 10 nM
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CP0523129
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(8S,11R,13S,14S,17S)-11-(4-(diphenylphosphoryl)phenyl)-17-hydroxy-13-methyl-17-phenyl-1,2,7,8,11,12,13,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3(14H)-one
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C42H41O3P
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1
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| 1 |
Ki = 20 nM
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CP0445054
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(8S,11R,13S,14S,17R)-11-(4-diethoxyphosphorylphenyl)-13-methyl-3'-methylidenespiro[1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthrene-17,2'-oxolane]-3-one
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C32H41O5P
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1
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| 1 |
Ki = 56.3 nM
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CP0445052
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(8S,11R,13S,14S,17R)-11-[4-[ethoxy(methyl)phosphoryl]phenyl]-13-methyl-3'-methylidenespiro[1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthrene-17,2'-oxolane]-3-one
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C31H39O4P
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1
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| 1 |
Ki = 59.8 nM
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CP0445053
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methyl-[4-[(8S,11R,13S,14S,17R)-13-methyl-3'-methylidene-3-oxospiro[1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthrene-17,2'-oxolane]-11-yl]phenyl]phosphinic acid
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C29H35O4P
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1
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| 1 |
Ki > 3000 nM
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CP0505593
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ethoxy-[4-[(8S,11R,13S,14S,17R)-13-methyl-3'-methylidene-3-oxospiro[1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthrene-17,2'-oxolane]-11-yl]phenyl]phosphinic acid
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C30H37O5P
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1
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| 1 |
Ki > 3000 nM
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