General Information of the Compound
| Compound ID |
CP0008077
|
||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Compound Name |
(1R,2S,10S,11S,13R,14R,15S,17S)-1-fluoro-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,13,15-trimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-dien-5-one
Show/Hide
|
||||||||||||||||||
| Synonyms |
(3H)-Dexamethasone
1-Dehydro-16.alpha.-methyl-9.alpha.-fluorohydrocortisone
1-Dehydro-16alpha-methyl-9alpha-fluorohydrocortisone
16-alpha-Methyl-9-alpha-fluoro-1-dehydrocortisol
16-alpha-Methyl-9-alpha-fluoro-delta(sup 1)-hydrocortisone
16-alpha-Methyl-9-alpha-fluoro-delta1-hydrocortisone
16-alpha-Methyl-9-alpha-fluoroprednisolone
16.alpha.-Methyl-9.alpha.-fluoro-1-dehydrocortisol
16.alpha.-Methyl-9.alpha.-fluoroprednisolone
16alpha-Methyl-9alpha-fluoro-1-dehydrocortisol
16alpha-Methyl-9alpha-fluoro-delta(sup 1)-hydrocortisone
16alpha-Methyl-9alpha-fluoroprednisolone
9-alpha-Fluoro-16-alpha-methylprednisolone
9.alpha.-Fluoro-16.alpha.-methylprednisolone
9A-FLUORO-16BETA-METHYLPREDNISOLONE
9alpha-Fluoro-16alpha-methylprednisolone
Adexone
Aeroseb-D
Aeroseb-Dex
Alcon Brand of Dexamethasone
Anaflogistico
Aphtasolon
Aphthasolone
Auxiron
Azium
Azium (Veterinary)
Bisu DS
Calonat
Corson
Corsone
Cortisumman
DXM
Decacort
Decacortin
Decaderm
Decadron
Decadron (TN)
Decadron Tablets, Elixir
Decadron, Dexamethasone
Decadron-LA
Decagel
Decaject
Decaject L.ADecaject-L.ADecalix
Decameth
Decasone
Decaspray
Dectancyl
Dekacort
Delta(sup 1)-9-alpha-Fluoro-16-alpha-methylcortisol
Delta1-9alpha-Fluoro-16alpha-methylcortisol
Deltafluorene
Dergramin
Deronil
Desadrene
Desametasone
Desametasone [DCIT]
Desamethasone
Desameton
Deseronil
Dex-ide
Dexa Mamallet
Dexa-Cortidelt;Dexa-Cortisyl
Dexa-Cortisyl
Dexa-Mamallet
Dexa-Scheroson
Dexa-sine
Dexacen-4
Dexacort
Dexacortal
Dexacortin
Dexadeltone
Dexafarma
Dexair
Dexalona
Dexaltin
Dexametasona
Dexametasona [INN-Spanish]
Dexameth
Dexamethansone
Dexamethasone
Dexamethasone (JP15/USP/INN)
Dexamethasone Base
Dexamethasone Intensol
Dexamethasone [INN:BAN:JAN]
Dexamethasone alcohol
Dexamethasonum
Dexamethasonum [INN-Latin]
Dexamethazone
Dexamonozon
Dexapolcort
Dexaprol
Dexason
Dexasone
Dexinolon
Dexinoral
Dexone
Dexone 0.5
Dexone 0.75
Dexone 1.5
Dexone 4
Dexonium
Dexpak
Dextelan
Dezone
Dinormon
Dxms
ECR Brand of Dexamethasone
Fluormethylprednisolone
Fluormone
Fluorocort
Fortecortin
Foy Brand of Dexamethasone
Gammacorten
Hexadecadrol
Hexadrol
Hexadrol Elixir
Hexadrol Tablets
Hl-dex
ICN Brand of Dexamethasone
IontoDex
Isopto-Dex
Lokalison F
Loverine
Luxazone
MK 125
Maxidex
Mediamethasone
Merck Brand of Dexamethasone
Merz Brand 1 of Dexamethasone
Merz Brand 2 of Dexamethasone
Methylfluorprednisolone
Mexidex
Millicorten
Mymethasone
OTO-104
Ocu-trol;Pet-Derm Iii
Oradexon
Pet Derm III
Policort
Posurdex
Prednisolon F
Prednisolone F
Prodex
SK-Dexamethasone
Spoloven
Sunia Sol D
Superprednol
Turbinaire
Visumetazone
Show/Hide
|
||||||||||||||||||
| Structure |
|
||||||||||||||||||
| Formula |
C22H29FO5
|
||||||||||||||||||
| Molecular Weight |
392.467
|
||||||||||||||||||
| Canonical SMILES |
C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO
Show/Hide
|
||||||||||||||||||
| InChI |
InChI=1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1
Show/Hide
|
||||||||||||||||||
| InChIKey |
UREBDLICKHMUKA-CXSFZGCWSA-N
|
||||||||||||||||||
| CAS |
137098-19-2
8054-59-9
50-02-2
23495-06-9
|
||||||||||||||||||
| Physicochemical Property |
"RO5" indicates the cutoff set by lipinski's rule of five: (1) Molecular weight less than 500 Dalton; (2) xlogp less than 5; (3) No more than 5 hbonddonor (Hydrogen Bond Donor Count); (4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count); (5) No more than 10 rotbonds (Rotatable Bond Count). Show/Hide
|
||||||||||||||||||
| Click to Show/Hide the External Link(s) of This Compound | |||||||||||||||||||
| PubChem ID | |||||||||||||||||||
| ChEMBL ID | |||||||||||||||||||
| DrugBank ID | |||||||||||||||||||
Map of Molecular Bioactivity Related to the Compound
|
Map of Molecular Bioactivity Related to the Compound Compound Cell Line Protein Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity |
|
|---|
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00894, Androgen receptor
Protein ID: PT01546, ATP-dependent translocase ABCB1
Protein ID: PT01685, ATP-dependent translocase ABCB1
Protein ID: PT06079, ATP-dependent translocase ABCB1
Protein ID: PT00967, Glucocorticoid receptor
Cell-based Assay
Biochemical Assays
Protein ID: PT00870, Glucocorticoid receptor
Protein ID: PT02997, Isocitrate dehydrogenase [NADP] cytoplasmic
Protein ID: PT01154, Mineralocorticoid receptor
Protein ID: PT01718, Nitric oxide synthase, inducible
Protein ID: PT04880, Nuclear receptor subfamily 1 group I member 2
Protein ID: PT01172, Progesterone receptor
Clinical Information about the Compound
Drug 1 ( Dexamethasone )
| Drug Name | Dexamethasone | ||
|---|---|---|---|
| Company | Swiss Pharma | ||
| Indication | |||
| Target(s) |
Glucocorticoid receptor (NR3C1)
Agonist
|
||