General Information of the Protein
Protein ID
PT01685
Protein Name
ATP-dependent translocase ABCB1
Secondarily
Protein Name
ATP-binding cassette sub-family B member 1A
MDR1A
Multidrug resistance protein 1A
Multidrug resistance protein 3
P-glycoprotein 3
Phospholipid transporter ABCB1
Gene Name
ABCB1A
Secondarily
Gene Name
Abcb4
Mdr1a
Mdr3
Pgy-3
Pgy3
Sequence
MELEEDLKGRADKNFSKMGKKSKKEKKEKKPAVSVLTMFRYAGWLDRLYMLVGTLAAIIHGVALPLMMLIFGDMTDSFASVGNVSKNSTNMSEADKRAMFAKLEEEMTTYAYYYTGIGAGVLIVAYIQVSFWCLAAGRQIHKIRQKFFHAIMNQEIGWFDVHDVGELNTRLTDDVSKINEGIGDKIGMFFQAMATFFGGFIIGFTRGWKLTLVILAISPVLGLSAGIWAKILSSFTDKELHAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNNNLEEAKRLGIKKAITANISMGAAFLLIYASYALAFWYGTSLVISKEYSIGQVLTVFFSVLIGAFSVGQASPNIEAFANARGAAYEVFKIIDNKPSIDSFSKSGHKPDNIQGNLEFKNIHFSYPSRKEVQILKGLNLKVKSGQTVALVGNSGCGKSTTVQLMQRLYDPLDGMVSIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGREDVTMDEIEKAVKEANAYDFIMKLPHQFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHDELMREKGIYFKLVMTQTAGNEIELGNEACKSKDEIDNLDMSSKDSGSSLIRRRSTRKSICGPHDQDRKLSTKEALDEDVPPASFWRILKLNSTEWPYFVVGIFCAIINGGLQPAFSVIFSKVVGVFTNGGPPETQRQNSNLFSLLFLILGIISFITFFLQGFTFGKAGEILTKRLRYMVFKSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGATGSRLAVIFQNIANLGTGIIISLIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTREQKFETMYAQSLQIPYRNAMKKAHVFGITFSFTQAMMYFSYAACFRFGAYLVTQQLMTFENVLLVFSAIVFGAMAVGQVSSFAPDYAKATVSASHIIRIIEKTPEIDSYSTQGLKPNMLEGNVQFSGVVFNYPTRPSIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGSVFLDGKEIKQLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSYEEIVRAAKEANIHQFIDSLPDKYNTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVIQNGKVKEHGTHQQLLAQKGIYFSMVSVQAGAKRS
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Organism
Mus musculus, Mouse
Protein Classification
Transporter
>
Primary active transporter
>
ATP-binding cassette
>
ABCB subfamily
Function
Translocates drugs and phospholipids across the membrane. Catalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D-glucosylceramides and sphingomyelins (PubMed:8898203). Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells (By similarity).
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Uniprot ID
Primary ID:
P21447

Secondarily ID:
Q5I1Y5
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Subcellular Location
Cell membrane
Apical cell membrane
Cytoplasm
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000009 , LLC-PK1
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0041632
 Compound Info 
ITRAZOLE
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C35H38Cl2N8O4
  1
1
IC50 = 200 nM
 Bioactivity Info 
   TI
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CP0667196
 Compound Info 
Ivermectin
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C95H146O28
  1
1
IC50 = 500 nM
 Bioactivity Info 
   TI
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CP0040184
 Compound Info 
1-[(4-fluorophenyl)methyl]-N-{1-[2-(4-methoxyphenyl)ethyl]piperidin-4-yl}-1H-1,3-benzodiazol-2-amine
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C28H31FN4O
  1
1
IC50 = 1300 nM
 Bioactivity Info 
   TI
   LI
   LO
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CP0010655
 Compound Info 
(3S,4aS,8aS)-N-tert-butyl-2-[(2R,3R)-2-hydroxy-3-[(3-hydroxy-2-methylphenyl)formamido]-4-(phenylsulfanyl)butyl]-decahydroisoquinoline-3-carboxamide
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C32H45N3O4S
  1
1
IC50 = 2300 nM
 Bioactivity Info 
   TI
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CP0055461
 Compound Info 
CHEBI:7550
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C26H29N3O6
  1
1
IC50 = 2500 nM
 Bioactivity Info 
   TI
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CP0005212
 Compound Info 
US8987315, Ketoconazole
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C26H28Cl2N4O4
  2
1
IC50 = 3800 nM
 Bioactivity Info 
   TI
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2
Ki = 12800 nM
 Bioactivity Info 
   TI
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CP0030899
 Compound Info 
1-[(2-chlorophenyl)-diphenylmethyl]imidazole
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C22H17ClN2
  2
1
IC50 = 4800 nM
 Bioactivity Info 
   TI
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2
Ki = 18300 nM
 Bioactivity Info 
   TI
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CP0036222
 Compound Info 
(3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33-[(1R,2R,4E)-1-hydroxy-2-methylhex-4-en-1-yl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-bis(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29,32-undecone
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C62H111N11O12
  2
1
IC50 = 4800 nM
 Bioactivity Info 
   TI
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2
Ki = 3650 nM
 Bioactivity Info 
   TI
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CP0027419
 Compound Info 
1-(1-(4,4-bis(4-fluorophenyl)butyl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one
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C28H29F2N3O
  1
1
IC50 = 4900 nM
 Bioactivity Info 
   TI
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CP0013607
 Compound Info 
2-methoxyacetic acid [(1S,2S)-2-[2-[3-(1H-benzimidazol-2-yl)propyl-methyl-amino]ethyl]-6-fluoro-1-isopropyl-tetralin-2-yl] ester;hydrate;hydrochloride
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C29H38FN3O3
  1
1
IC50 = 7400 nM
 Bioactivity Info 
   TI
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CP0063077
 Compound Info 
1-[2-(2,4-dichlorobenzyl)oxy-2-(2,4-dichlorophenyl)ethyl]imidazole;nitric acid
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C18H14Cl4N2O
  2
1
IC50 = 7800 nM
 Bioactivity Info 
   TI
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2
Ki = 22200 nM
 Bioactivity Info 
   TI
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CP0036382
 Compound Info 
CAS_52-53-9
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C27H38N2O4
  1
1
IC50 = 10000 nM
 Bioactivity Info 
   TI
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CP0034615
 Compound Info 
(6-Methoxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2.2.2]oct-2-yl)-methanol
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C20H24N2O2
  1
1
IC50 = 13000 nM
 Bioactivity Info 
   TI
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CP0033565
 Compound Info 
(+/-)1-(4-tert-butylphenyl)-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butan-1-ol
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C32H41NO2
  1
1
IC50 = 23000 nM
 Bioactivity Info 
   TI
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CP0000305
 Compound Info 
(-)-(etorphine)
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C17H19NO3
  1
1
IC50 > 50000 nM
 Bioactivity Info 
   TI
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CP0008077
 Compound Info 
(1R,2S,10S,11S,13R,14R,15S,17S)-1-fluoro-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,13,15-trimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-dien-5-one
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C22H29FO5
  1
1
IC50 > 50000 nM
 Bioactivity Info 
   TI
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CP0035927
 Compound Info 
(Cimetidine) N-Methyl-N''''-[2-(5-methyl-1H-imidazol-4-ylmethylsulfanyl)-ethyl]-guanidine,cyanide
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C10H16N6S
  1
1
IC50 > 50000 nM
 Bioactivity Info 
   TI
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CP0036175
 Compound Info 
1,3-thiazol-5-ylmethyl N-[(2S,3S,5S)-3-hydroxy-5-[(2S)-3-methyl-2-{[methyl({[2-(propan-2-yl)-1,3-thiazol-4-yl]methyl})carbamoyl]amino}butanamido]-1,6-diphenylhexan-2-yl]carbamate
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C37H48N6O5S2
  1
1
IC50 > 50000 nM
 Bioactivity Info 
   TI
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CP0036823
 Compound Info 
(-)-etoposide
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C29H32O13
  1
1
IC50 > 50000 nM
 Bioactivity Info 
   TI
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CP0037274
 Compound Info 
(S)-N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide
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C22H25NO6
  1
1
IC50 > 50000 nM
 Bioactivity Info 
   TI
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CP0038098
 Compound Info 
(1S,2R,10S,11S,14R,15S,17S)-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-5-one
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C21H30O5
  1
1
IC50 > 50000 nM
 Bioactivity Info 
   TI
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CP0038418
 Compound Info 
13-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-7-benzyl-3,3,14,14-tetramethyl-6,9,12-trioxo-1,2-dithia-5,8,11-triaza-cyclotetradecane-4-carboxylic acid
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C30H39N5O7S2
  1
1
IC50 > 50000 nM
 Bioactivity Info 
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CP0048327
 Compound Info 
(2S)-N-[(2S,3R)-4-[(3S,4aS,8aS)-3-(tert-butylcarbamoyl)-decahydroisoquinolin-2-yl]-3-hydroxy-1-phenylbutan-2-yl]-2-(quinolin-2-ylformamido)butanediamide
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C38H50N6O5
  1
1
IC50 > 50000 nM
 Bioactivity Info 
   TI
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CP0054979
 Compound Info 
DIGOXIN
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C41H64O14
  1
1
IC50 > 50000 nM
 Bioactivity Info 
   TI
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CP0055087
 Compound Info 
(3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-14-ethyl-7,12,13-trihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,7,9,11,13-hexamethyl-oxacyclotetradecane-2,10-dione
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C37H67NO13
  1
1
IC50 > 50000 nM
 Bioactivity Info 
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CP0075209
 Compound Info 
(2ALPHA,2''BETA,3BETA,4ALPHA,5BETA)-VINCALEUKOBLASTINE
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C46H58N4O9
  1
1
IC50 > 50000 nM
 Bioactivity Info 
   TI
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CP0078108
 Compound Info 
12-chloro-9-(2-fluorophenyl)-3-methyl-2,4,8-triazatricyclo[8.4.0.0^{2,6}]tetradeca-1(10),3,5,8,11,13-hexaene
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C18H13ClFN3
  1
1
IC50 > 50000 nM
 Bioactivity Info 
   TI
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CP0663086
 Compound Info 
Ranitidine
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C13H22N4O3S
  1
1
IC50 > 50000 nM
 Bioactivity Info 
   TI
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CP0068493
 Compound Info 
(2-{4-[(2-butyl-1-benzofuran-3-yl)carbonyl]-2,6-diiodophenoxy}ethyl)diethylamine
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C25H29I2NO3
  1
1
Ki = 2100 nM
 Bioactivity Info 
   TI
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CP0035720
 Compound Info 
(-)-reserpine
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C33H40N2O9
  1
1
Ki = 4030 nM
 Bioactivity Info 
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CP0084033
 Compound Info 
BROMOCRIPTINE
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C32H40BrN5O5
  1
1
Ki = 7480 nM
 Bioactivity Info 
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CP0194869
 Compound Info 
ERGOCRISTINE
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C35H39N5O5
  1
1
Ki = 39400 nM
 Bioactivity Info 
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CP0047240
 Compound Info 
(6aR,9R)-N-[(1S,2S,4R,7S)-2-hydroxy-7-(2-methylpropyl)-5,8-dioxo-4-propan-2-yl-3-oxa-6,9-diazatricyclo[7.3.0.02,6]dodecan-4-yl]-7-methyl-6,6a,8,9-tetrahydro-4H-indolo[4,3-fg]quinoline-9-carboxamide
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C32H41N5O5
  1
1
Ki = 43500 nM
 Bioactivity Info 
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Biochemical Assays
Compound ID Compound Name Compound Formula
CP0036382
 Compound Info 
CAS_52-53-9
   Show/Hide
C27H38N2O4
  1
1 Km = 10000 nM