Brief Information of the Compound and Protein
Compound Name
8-bromo-15-methyl-N-(1,3-thiazol-2-yl)tetracyclo[6.6.2.0^{2,7}.0^{9,14}]hexadeca-2,4,6,9(14),10,12-hexaene-15-carboxamide
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PubChem ID
CID: 44565615
Canonical SMILES
CC1(CC2(Br)c3ccccc3C1c1ccccc21)C(=O)Nc1nccs1
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Compound Formula C21H17BrN2OS
Compound Structure
Protein Name
Glucocorticoid receptor
Protein Classification
Transcription factor
>
Nuclear receptor
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Nuclear hormone receptor subfamily 3
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Nuclear hormone receptor subfamily 3 group C
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Nuclear hormone receptor subfamily 3 group C member 1
Uniprot ID
P04150
Gene Name
NR3C1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000068 A-549 Homo sapiens (Human)  2
1
EC50 = 9.9 nM
   TI
   LI
   LO
   TS
2
EC50 = 118.8 nM
   TI
   LI
   LO
   TS
CL000231 NP1 Homo sapiens (Human)  1
1
EC50 = 174.9 nM
   TI
   LI
   LO
   TS