General Information of the Compound
Compound ID
CP0513479
Compound Name
N-[(8S,11R,13S,14S,17S)-11-(1,3-benzoxazol-5-yl)-13-methyl-3-oxo-17-prop-1-ynyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl]formamide
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Structure
Formula
C29H30N2O3
Molecular Weight
454.57
Canonical SMILES
CC#C[C@@]1(CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@H](C[C@]12C)c1ccc2ocnc2c1)NC=O
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InChI
InChI=1S/C29H30N2O3/c1-3-11-29(31-16-32)12-10-24-22-7-4-18-13-20(33)6-8-21(18)27(22)23(15-28(24,29)2)19-5-9-26-25(14-19)30-17-34-26/h5,9,13-14,16-17,22-24H,4,6-8,10,12,15H2,1-2H3,(H,31,32)/t22-,23+,24-,28-,29-/m0/s1
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InChIKey
IXMWYDAQMMZUOZ-DTBAVYRLSA-N
Physicochemical Property
logP
5.2354
Rotatable Bonds
3
Heavy Atom Count
34
Polar Areas
72.2
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Complexity
34

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 57390754
ChEMBL ID
CHEMBL1950698
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00967, Glucocorticoid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000068 A-549 Homo sapiens (Human)  1
1
IC50 = 60 nM
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Protein ID: PT01172, Progesterone receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000078 T-47D Homo sapiens (Human)  1
1
IC50 = 41 nM
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