General Information of the Compound
Compound ID
CP0397051
Compound Name
(1'S,2R,2'S,6'R,9'R)-9'-(4-methoxyphenyl)-6'-methyl-3-methylidene-8'-oxaspiro[oxolane-2,5'-tetracyclo[8.8.0.0^{2,6}.0^{11,16}]octadecane]-10',15'-dien-14'-one
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Structure
Formula
C29H34O4
Molecular Weight
446.587
Canonical SMILES
COc1ccc(cc1)[C@H]1OC[C@@]2(C)[C@@H](CC[C@]22OCCC2=C)[C@@H]2CCC3=CC(=O)CCC3=C12
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InChI
InChI=1S/C29H34O4/c1-18-13-15-33-29(18)14-12-25-24-10-6-20-16-21(30)7-11-23(20)26(24)27(32-17-28(25,29)2)19-4-8-22(31-3)9-5-19/h4-5,8-9,16,24-25,27H,1,6-7,10-15,17H2,2-3H3/t24-,25-,27+,28-,29+/m0/s1
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InChIKey
DJRBZWVBECJRTM-DCJUPOQYSA-N
Physicochemical Property
logP
5.894
Rotatable Bonds
2
Heavy Atom Count
33
Polar Areas
44.76
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
4
Complexity
33

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 45271616
ChEMBL ID
CHEMBL564234
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00967, Glucocorticoid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000068 A-549 Homo sapiens (Human)  1
1
IC50 = 132 nM
   TI
   LI
   LO
   TS
Protein ID: PT01172, Progesterone receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000078 T-47D Homo sapiens (Human)  1
1
IC50 = 7 nM
   TI
   LI
   LO
   TS