General Information of the Compound
Compound ID
CP0428831
Compound Name
(1'S,2R,2'S,6'R,9'R)-9'-[4-(dimethylamino)phenyl]-6'-methyl-3-methylidene-8'-oxaspiro[oxolane-2,5'-tetracyclo[8.8.0.0^{2,6}.0^{11,16}]octadecane]-10',15'-dien-14'-one
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Structure
Formula
C30H37NO3
Molecular Weight
459.63
Canonical SMILES
CN(C)c1ccc(cc1)[C@H]1OC[C@@]2(C)[C@@H](CC[C@]22OCCC2=C)[C@@H]2CCC3=CC(=O)CCC3=C12
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InChI
InChI=1S/C30H37NO3/c1-19-14-16-34-30(19)15-13-26-25-11-7-21-17-23(32)10-12-24(21)27(25)28(33-18-29(26,30)2)20-5-8-22(9-6-20)31(3)4/h5-6,8-9,17,25-26,28H,1,7,10-16,18H2,2-4H3/t25-,26-,28+,29-,30+/m0/s1
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InChIKey
CEDQCHHKNHJFKO-WWHWENCNSA-N
Physicochemical Property
logP
5.9514
Rotatable Bonds
2
Heavy Atom Count
34
Polar Areas
38.77
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
4
Complexity
34

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44250279
SID: 85284220
ChEMBL ID
CHEMBL551863
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00967, Glucocorticoid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000068 A-549 Homo sapiens (Human)  1
1
IC50 = 62 nM
   TI
   LI
   LO
   TS
Protein ID: PT01172, Progesterone receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000078 T-47D Homo sapiens (Human)  1
1
IC50 = 1 nM
   TI
   LI
   LO
   TS