General Information of the Compound
Compound ID
CP0431297
Compound Name
(8S,11R,13S,14S,17S)-17-hydroxy-13-methyl-11-(2-methyl-1,3-benzoxazol-5-yl)-17-prop-1-ynyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one
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Structure
Formula
C29H31NO3
Molecular Weight
441.571
Canonical SMILES
CC#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@H](C[C@]12C)c1ccc2oc(C)nc2c1
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InChI
InChI=1S/C29H31NO3/c1-4-12-29(32)13-11-24-22-8-5-18-14-20(31)7-9-21(18)27(22)23(16-28(24,29)3)19-6-10-26-25(15-19)30-17(2)33-26/h6,10,14-15,22-24,32H,5,7-9,11,13,16H2,1-3H3/t22-,23+,24-,28-,29-/m0/s1
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InChIKey
KDVSANSBFHATHQ-DTBAVYRLSA-N
Physicochemical Property
logP
5.79012
Rotatable Bonds
1
Heavy Atom Count
33
Polar Areas
63.33
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Complexity
33

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 57394288
ChEMBL ID
CHEMBL1950694
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00967, Glucocorticoid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000068 A-549 Homo sapiens (Human)  1
1
IC50 = 23 nM
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Protein ID: PT01172, Progesterone receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000078 T-47D Homo sapiens (Human)  1
1
IC50 = 35 nM
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