Brief Information of the Compound and Protein
Compound Name
 Compound Info 
2-[(5S)-2-[4-(dimethylamino)phenyl]-5H-chromeno[2,3-b]pyridin-5-yl]-2-methyl-N-(1,3,4-thiadiazol-2-yl)propanamide
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 PubChem ID
CID: 56593851
SID: 134225609
Canonical SMILES
CN(C)c1ccc(cc1)-c1ccc2[C@H](c3ccccc3Oc2n1)C(C)(C)C(=O)Nc1nncs1
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Compound Formula C26H25N5O2S
Compound Structure
Protein Name
 Protein Info 
Glucocorticoid receptor
Protein Classification
Transcription factor
>
Nuclear receptor
>
Nuclear hormone receptor subfamily 3
>
Nuclear hormone receptor subfamily 3 group C
>
Nuclear hormone receptor subfamily 3 group C member 1
Uniprot ID
P04150
Gene Name
NR3C1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000068 A-549
 Cell Line Info 
Homo sapiens (Human)  2
1
EC50 = 13.6 nM
   TI
   LI
   LO
   TS
2
EC50 = 20 nM
   TI
   LI
   LO
   TS
CL000017 HeLa
 Cell Line Info 
Homo sapiens (Human)  2
1
EC50 = 242 nM
   TI
   LI
   LO
   TS
2
EC50 = 926 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 3.8 nM