| Compound ID |
Compound Name |
Compound Formula |
|
CP0416039
|
N-(3-fluorophenyl)-N'-[3-[(E)-2-pyridin-2-ylethenyl]-1H-indazol-6-yl]propanediamide
Show/Hide
|
C23H18FN5O2
|
19
|
| 1 |
EC50 = 34 nM
|
|
|
| 2 |
EC50 = 77 nM
|
|
|
| 3 |
EC50 = 750 nM
|
|
|
| 4 |
EC50 = 1000 nM
|
|
|
| 5 |
EC50 > 1000 nM
|
|
|
| 6 |
GI50 = 8 nM
|
|
|
| 7 |
GI50 = 26 nM
|
|
|
| 8 |
GI50 = 31 nM
|
|
|
| 9 |
GI50 = 44 nM
|
|
|
| 10 |
GI50 = 122 nM
|
|
|
| 11 |
GI50 = 157 nM
|
|
|
| 12 |
GI50 = 265 nM
|
|
|
| 13 |
GI50 = 525 nM
|
|
|
| 14 |
GI50 = 868 nM
|
|
|
| 15 |
GI50 = 1150 nM
|
|
|
| 16 |
GI50 = 3460 nM
|
|
|
| 17 |
GI50 = 6000 nM
|
|
|
| 18 |
GI50 = 6060 nM
|
|
|
| 19 |
GI50 = 6840 nM
|
|
|
|
CP0394288
|
N-[4-[[5-fluoro-7-(2-methoxyethoxy)quinazolin-4-yl]amino]phenyl]-2-(4-propan-2-yltriazol-1-yl)acetamide
Show/Hide
|
C24H26FN7O3
|
13
|
| 1 |
GI50 = 1 nM
|
|
|
| 2 |
GI50 = 2 nM
|
|
|
| 3 |
GI50 = 3 nM
|
|
|
| 4 |
GI50 = 4 nM
|
|
|
| 5 |
GI50 = 7 nM
|
|
|
| 6 |
GI50 = 8 nM
|
|
|
| 7 |
GI50 = 9 nM
|
|
|
| 8 |
GI50 = 14 nM
|
|
|
| 9 |
GI50 = 16 nM
|
|
|
| 10 |
GI50 = 18 nM
|
|
|
| 11 |
GI50 = 22 nM
|
|
|
| 12 |
GI50 = 51 nM
|
|
|
| 13 |
GI50 = 971 nM
|
|
|
|
CP0002778
|
4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide
Show/Hide
|
C29H31N7O
|
47
|
| 1 |
GI50 = 1 nM
|
|
|
| 2 |
GI50 = 5 nM
|
|
|
| 3 |
GI50 = 17 nM
|
|
|
| 4 |
GI50 = 24.9 nM
|
|
|
| 5 |
GI50 = 36 nM
|
|
|
| 6 |
GI50 = 39 nM
|
|
|
| 7 |
GI50 = 45.1 nM
|
|
|
| 8 |
GI50 = 70 nM
|
|
|
| 9 |
GI50 = 100 nM
|
|
|
| 10 |
GI50 = 102 nM
|
|
|
| 11 |
GI50 = 115 nM
|
|
|
| 12 |
GI50 = 148.2 nM
|
|
|
| 13 |
GI50 = 192 nM
|
|
|
| 14 |
GI50 = 216 nM
|
|
|
| 15 |
GI50 = 223 nM
|
|
|
| 16 |
GI50 = 267 nM
|
|
|
| 17 |
GI50 = 312 nM
|
|
|
| 18 |
GI50 = 360 nM
|
|
|
| 19 |
GI50 = 364 nM
|
|
|
| 20 |
GI50 = 370 nM
|
|
|
| 21 |
GI50 = 381.9 nM
|
|
|
| 22 |
GI50 = 392 nM
|
|
|
| 23 |
GI50 = 400 nM
|
|
|
| 24 |
GI50 = 406 nM
|
|
|
| 25 |
GI50 = 535 nM
|
|
|
| 26 |
GI50 = 590 nM
|
|
|
| 27 |
GI50 = 669 nM
|
|
|
| 28 |
GI50 = 700 nM
|
|
|
| 29 |
GI50 = 701 nM
|
|
|
| 30 |
GI50 = 803 nM
|
|
|
| 31 |
GI50 = 803.1 nM
|
|
|
| 32 |
GI50 = 823 nM
|
|
|
| 33 |
GI50 = 1191 nM
|
|
|
| 34 |
GI50 = 1245 nM
|
|
|
| 35 |
GI50 = 1290 nM
|
|
|
| 36 |
GI50 = 1466 nM
|
|
|
| 37 |
GI50 = 1523 nM
|
|
|
| 38 |
GI50 = 1570 nM
|
|
|
| 39 |
GI50 = 2300 nM
|
|
|
| 40 |
GI50 = 2490 nM
|
|
|
| 41 |
GI50 = 2749 nM
|
|
|
| 42 |
GI50 = 3947 nM
|
|
|
| 43 |
GI50 = 5200 nM
|
|
|
| 44 |
GI50 = 6670 nM
|
|
|
| 45 |
GI50 = 9600 nM
|
|
|
| 46 |
GI50 = 9930 nM
|
|
|
| 47 |
GI50 > 10000 nM
|
|
|
|
CP0002211
|
N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide
Show/Hide
|
C22H27FN4O2
|
25
|
| 1 |
GI50 = 2 nM
|
|
|
| 2 |
GI50 = 4 nM
|
|
|
| 3 |
GI50 = 5 nM
|
|
|
| 4 |
GI50 = 6 nM
|
|
|
| 5 |
GI50 = 7 nM
|
|
|
| 6 |
GI50 = 9 nM
|
|
|
| 7 |
GI50 = 12 nM
|
|
|
| 8 |
GI50 = 20 nM
|
|
|
| 9 |
GI50 = 23 nM
|
|
|
| 10 |
GI50 = 24 nM
|
|
|
| 11 |
GI50 = 27 nM
|
|
|
| 12 |
GI50 = 53 nM
|
|
|
| 13 |
GI50 = 78 nM
|
|
|
| 14 |
GI50 = 110 nM
|
|
|
| 15 |
GI50 = 214 nM
|
|
|
| 16 |
GI50 = 271 nM
|
|
|
| 17 |
GI50 = 398 nM
|
|
|
| 18 |
GI50 = 420 nM
|
|
|
| 19 |
GI50 = 430 nM
|
|
|
| 20 |
GI50 = 510 nM
|
|
|
| 21 |
GI50 = 584 nM
|
|
|
| 22 |
GI50 = 638 nM
|
|
|
| 23 |
GI50 = 696 nM
|
|
|
| 24 |
GI50 = 782 nM
|
|
|
| 25 |
GI50 = 1380 nM
|
|
|
|
CP0864259
|
N-{4-[(5-Fluoro-7-methoxyquinazolin-4-yl)amino]phenyl}-2-[4-(propan-2-yl)-1H-1,2,3-triazol-1-yl]acetamide
Show/Hide
|
C22H22FN7O2
|
3
|
| 1 |
GI50 = 2 nM
|
|
|
| 2 |
GI50 = 25 nM
|
|
|
| 3 |
GI50 = 68 nM
|
|
|
|
CP0869515
|
(E)-N1-(4-Chloro-3-(trifluoromethyl)phenyl)-N3-(3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)malonamide
Show/Hide
|
C24H17ClF3N5O2
|
2
|
| 1 |
GI50 = 2 nM
|
|
|
| 2 |
GI50 = 25 nM
|
|
|
|
CP0010193
|
AG-013736
Show/Hide
|
C22H18N4OS
|
14
|
| 1 |
GI50 = 2 nM
|
|
|
| 2 |
GI50 = 5 nM
|
|
|
| 3 |
GI50 = 7 nM
|
|
|
| 4 |
GI50 = 12 nM
|
|
|
| 5 |
GI50 = 13 nM
|
|
|
| 6 |
GI50 = 14 nM
|
|
|
| 7 |
GI50 = 105 nM
|
|
|
| 8 |
GI50 = 108 nM
|
|
|
| 9 |
GI50 = 129 nM
|
|
|
| 10 |
GI50 = 156 nM
|
|
|
| 11 |
GI50 = 406 nM
|
|
|
| 12 |
GI50 = 1720 nM
|
|
|
| 13 |
GI50 = 1820 nM
|
|
|
| 14 |
GI50 = 2020 nM
|
|
|
|
CP0855257
|
N-(4-((6,7-Dimethoxyquinazolin-4-yl)oxy)phenyl)-2-(4-isopropyl-1H-1,2,3-triazol-1-yl)acetamide
Show/Hide
|
C23H24N6O4
|
3
|
| 1 |
GI50 = 3 nM
|
|
|
| 2 |
GI50 = 17 nM
|
|
|
| 3 |
GI50 = 19 nM
|
|
|
|
CP0864256
|
N-{4-[(5,7-Dimethoxyquinazolin-4-yl)amino]phenyl}-2-[4-(propan-2-yl)-1H-1,2,3-triazol-1-yl]acetamide
Show/Hide
|
C23H25N7O3
|
3
|
| 1 |
GI50 = 3 nM
|
|
|
| 2 |
GI50 = 48 nM
|
|
|
| 3 |
GI50 = 107 nM
|
|
|
|
CP0851621
|
Ripretinib
Show/Hide
|
C24H21BrFN5O2
|
14
|
| 1 |
GI50 = 3 nM
|
|
|
| 2 |
GI50 = 4 nM
|
|
|
| 3 |
GI50 = 6 nM
|
|
|
| 4 |
GI50 = 13 nM
|
|
|
| 5 |
GI50 = 14 nM
|
|
|
| 6 |
GI50 = 23 nM
|
|
|
| 7 |
GI50 = 31 nM
|
|
|
| 8 |
GI50 = 34 nM
|
|
|
| 9 |
GI50 = 37 nM
|
|
|
| 10 |
GI50 = 48 nM
|
|
|
| 11 |
GI50 = 75 nM
|
|
|
| 12 |
GI50 = 78 nM
|
|
|
| 13 |
GI50 = 130 nM
|
|
|
| 14 |
GI50 = 205 nM
|
|
|
|
CP0132005
|
2-[4-(6,7-dimethoxyquinazolin-4-yl)oxyphenyl]-N-(1-propan-2-ylpyrazol-4-yl)acetamide
Show/Hide
|
C24H25N5O4
|
3
|
| 1 |
GI50 = 4 nM
|
|
|
| 2 |
GI50 = 12 nM
|
|
|
| 3 |
GI50 = 70 nM
|
|
|
|
CP0855259
|
2-(4-(6,7-dimethoxyquinolin-4-yloxy)-2-methoxyphenyl)-N-(1-isopropyl-1H-pyrazol-4-yl)acetamide
Show/Hide
|
C26H28N4O5
|
3
|
| 1 |
GI50 = 6 nM
|
|
|
| 2 |
GI50 = 7 nM
|
|
|
| 3 |
GI50 = 8 nM
|
|
|
|
CP0851623
|
N-(4-((5,7-Dimethoxyquinazolin-4-yl)oxy)phenyl)-2-(4-isopropyl-1H-1,2,3-triazol-1-yl)acetamide
Show/Hide
|
C23H24N6O4
|
3
|
| 1 |
GI50 = 7 nM
|
|
|
| 2 |
GI50 = 50 nM
|
|
|
| 3 |
GI50 = 55 nM
|
|
|
|
CP0399068
|
2-[4-(6,7-dimethoxyquinazolin-4-yl)oxyphenyl]-N-(1-ethylpyrazol-4-yl)acetamide
Show/Hide
|
C23H23N5O4
|
3
|
| 1 |
GI50 = 7 nM
|
|
|
| 2 |
GI50 = 44 nM
|
|
|
| 3 |
GI50 = 488 nM
|
|
|
|
CP0851622
|
N-(4-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-2-(1-isopropyl-1H-pyrazol-4-yl)acetamide
Show/Hide
|
C25H26N4O4
|
3
|
| 1 |
GI50 = 7 nM
|
|
|
| 2 |
GI50 = 26 nM
|
|
|
| 3 |
GI50 = 47 nM
|
|
|
|
CP0864260
|
2-(4-(6,7-dimethoxyquinazolin-4-yloxy)-2-methoxyphenyl)-N-(1-isopropyl-1H-pyrazol-4-yl)acetamide
Show/Hide
|
C25H27N5O5
|
3
|
| 1 |
GI50 = 8 nM
|
|
|
| 2 |
GI50 = 12 nM
|
|
|
| 3 |
GI50 = 26 nM
|
|
|
|
CP0887633
|
N-(5-((6,7-Dimethoxyquinolin-4-yl)oxy)pyridin-2-yl)-2-(1-isopropyl-1H-pyrazol-4-yl)acetamide
Show/Hide
|
C24H25N5O4
|
3
|
| 1 |
GI50 = 8 nM
|
|
|
| 2 |
GI50 = 150 nM
|
|
|
| 3 |
GI50 = 518 nM
|
|
|
|
CP0410995
|
US10807985, Compound 44
Show/Hide
|
C26H27FN10
|
15
|
| 1 |
GI50 = 8 nM
|
|
|
| 2 |
GI50 = 17 nM
|
|
|
| 3 |
GI50 = 19 nM
|
|
|
| 4 |
GI50 = 28 nM
|
|
|
| 5 |
GI50 = 29 nM
|
|
|
| 6 |
GI50 = 34 nM
|
|
|
| 7 |
GI50 = 42 nM
|
|
|
| 8 |
GI50 = 69 nM
|
|
|
| 9 |
GI50 = 78 nM
|
|
|
| 10 |
GI50 = 117 nM
|
|
|
| 11 |
GI50 = 167 nM
|
|
|
| 12 |
GI50 = 292 nM
|
|
|
| 13 |
GI50 = 427 nM
|
|
|
| 14 |
GI50 = 751 nM
|
|
|
| 15 |
GI50 = 860 nM
|
|
|
|
CP0864258
|
N-(4-((6,7-Dimethoxyquinazolin-4-yl)oxy)phenyl)-2-(3-isopropyl-1H-pyrazol-5-yl)acetamide
Show/Hide
|
C24H25N5O4
|
1
|
| 1 |
GI50 = 9 nM
|
|
|
|
CP0184289
|
1-(3-methyl-4-morpholin-4-ylphenyl)-3-[4-(3-methyl-2H-pyrazolo[3,4-b]pyridin-4-yl)phenyl]urea
Show/Hide
|
C25H26N6O2
|
12
|
| 1 |
GI50 = 10.5 nM
|
|
|
| 2 |
GI50 = 10.6 nM
|
|
|
| 3 |
GI50 = 11.1 nM
|
|
|
| 4 |
GI50 = 11.6 nM
|
|
|
| 5 |
GI50 = 18.1 nM
|
|
|
| 6 |
GI50 = 36.4 nM
|
|
|
| 7 |
GI50 = 39.2 nM
|
|
|
| 8 |
GI50 = 96.5 nM
|
|
|
| 9 |
GI50 = 134.1 nM
|
|
|
| 10 |
GI50 = 136.5 nM
|
|
|
| 11 |
GI50 = 330.3 nM
|
|
|
| 12 |
GI50 > 10000 nM
|
|
|
|
CP0867286
|
N1-(4-Chloro-3-(trifluoromethyl)phenyl)-N3-(3-(4-(4-methylpiperazin-1-yl)phenyl)-1H-indazol-6-yl)malonamide
Show/Hide
|
C28H26ClF3N6O2
|
2
|
| 1 |
GI50 = 12 nM
|
|
|
| 2 |
GI50 = 25 nM
|
|
|
|
CP0892598
|
N1-(4-Chloro-3-(trifluoromethyl)phenyl)-N3-(3-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-1H-indazol-6-yl)malonamide
Show/Hide
|
C29H28ClF3N6O2
|
2
|
| 1 |
GI50 = 12 nM
|
|
|
| 2 |
GI50 = 19 nM
|
|
|
|
CP0893381
|
2-(5-(6,7-dimethoxyquinolin-4-yloxy)-3-methoxypyridin-2-yl)-N-(1-isopropyl-1H-pyrazol-4-yl)acetamide
Show/Hide
|
C25H27N5O5
|
3
|
| 1 |
GI50 = 13 nM
|
|
|
| 2 |
GI50 = 27 nM
|
|
|
| 3 |
GI50 = 61 nM
|
|
|
|
CP0869654
|
N-(1-(4-(3-(3-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-ureido)-2-(trifluoromethyl)phenyl)piperidin-4-yl)nicotinamide
Show/Hide
|
C36H33F3N6O5
|
2
|
| 1 |
GI50 = 20 nM
|
|
|
| 2 |
GI50 = 321 nM
|
|
|
|
CP0855258
|
2-(5-(6,7-dimethoxyquinazolin-4-yloxy)-3-methoxypyridin-2-yl)-N-(1-isopropyl-1H-pyrazol-4-yl)acetamide
Show/Hide
|
C24H26N6O5
|
3
|
| 1 |
GI50 = 21 nM
|
|
|
| 2 |
GI50 = 60 nM
|
|
|
| 3 |
GI50 = 176 nM
|
|
|
|
CP0893382
|
N-(4-((6,7-Dimethoxyquinazolin-4-yl)oxy)phenyl)-2-(1-ethyl-1H-pyrazol-4-yl)acetamide
Show/Hide
|
C23H23N5O4
|
3
|
| 1 |
GI50 = 21 nM
|
|
|
| 2 |
GI50 = 141 nM
|
|
|
| 3 |
GI50 = 250 nM
|
|
|
|
CP0864257
|
N-[4-(6,7-Dimethoxyquinazolin-4-yl)oxyphenyl]-2-(1-isopropylpyrazol-4-yl)acetamide
Show/Hide
|
C24H25N5O4
|
1
|
| 1 |
GI50 = 21 nM
|
|
|
|
CP0934521
|
N-(4-((6,7-Dimethoxyquinazolin-4-yl)oxy)phenyl)-2-(4-isopropyl-1H-pyrazol-1-yl)acetamide
Show/Hide
|
C24H25N5O4
|
1
|
| 1 |
GI50 = 21 nM
|
|
|
|
CP0965335
|
N-(4-((6,7-Dimethoxyquinazolin-4-yl)oxy)phenyl)-2-(4-isopropyl-1H-imidazol-1-yl)acetamide
Show/Hide
|
C24H25N5O4
|
1
|
| 1 |
GI50 = 21 nM
|
|
|
|
CP0043225
|
4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]-3-fluorophenoxy]-N-methylpyridine-2-carboxamide
Show/Hide
|
C21H15ClF4N4O3
|
16
|
| 1 |
GI50 = 21 nM
|
|
|
| 2 |
GI50 = 33 nM
|
|
|
| 3 |
GI50 = 47 nM
|
|
|
| 4 |
GI50 = 49 nM
|
|
|
| 5 |
GI50 = 63 nM
|
|
|
| 6 |
GI50 = 94 nM
|
|
|
| 7 |
GI50 = 108 nM
|
|
|
| 8 |
GI50 = 114 nM
|
|
|
| 9 |
GI50 = 231 nM
|
|
|
| 10 |
GI50 = 290 nM
|
|
|
| 11 |
GI50 = 549 nM
|
|
|
| 12 |
GI50 = 833 nM
|
|
|
| 13 |
GI50 = 834 nM
|
|
|
| 14 |
GI50 = 943 nM
|
|
|
| 15 |
GI50 = 1270 nM
|
|
|
| 16 |
GI50 = 2371 nM
|
|
|
|
CP0871877
|
N1-(4-Chloro-3-(trifluoromethyl)phenyl)-N3-(3-(1-methyl-1H-pyrazol-4-yl)-1H-indazol-6-yl)malonamide
Show/Hide
|
C21H16ClF3N6O2
|
2
|
| 1 |
GI50 = 23 nM
|
|
|
| 2 |
GI50 = 350 nM
|
|
|
|
CP0897977
|
N-(4-Methyl-3-((1-(thiophene-3-carbonyl)piperidin-4-yl)oxy)-phenyl)-4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)-benzamide
Show/Hide
|
C31H35F3N4O3S
|
1
|
| 1 |
GI50 = 26 nM
|
|
|
|
CP0960399
|
N-(4-((6,7-Dimethoxyquinazolin-4-yl)oxy)phenyl)-2-(5-isopropyl-1,3,4-thiadiazol-2-yl)acetamide
Show/Hide
|
C23H23N5O4S
|
1
|
| 1 |
GI50 = 26 nM
|
|
|
|
CP0451447
|
N-[4-methyl-3-[1-(5-methylpyridine-3-carbonyl)piperidin-4-yl]oxyphenyl]-4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)benzamide
Show/Hide
|
C33H38F3N5O3
|
1
|
| 1 |
GI50 = 28 nM
|
|
|
|
CP0944511
|
N-(3-((1-Isonicotinoylpiperidin-4-yl)oxy)-4-methylphenyl)-4-methyl-3-(trifluoromethyl)benzamide
Show/Hide
|
C27H26F3N3O3
|
1
|
| 1 |
GI50 = 31 nM
|
|
|
|
CP0441015
|
N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-3-[[3-[(E)-2-pyridin-2-ylethenyl]-1H-indazol-6-yl]sulfanyl]propanamide
Show/Hide
|
C30H31F3N6OS
|
1
|
| 1 |
GI50 = 33 nM
|
|
|
|
CP0948148
|
N-(1-(4-(3-(3-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-ureido)-2-(trifluoromethyl)phenyl)piperidin-4-yl)ethanesulfonamide
Show/Hide
|
C32H34F3N5O6S
|
2
|
| 1 |
GI50 = 34 nM
|
|
|
| 2 |
GI50 = 330 nM
|
|
|
|
CP0908559
|
N-(4-((6,7-Dimethoxyquinazolin-4-yl)oxy)phenyl)-2-(3-isopropyl-1H-pyrazol-1-yl)acetamide
Show/Hide
|
C24H25N5O4
|
1
|
| 1 |
GI50 = 35 nM
|
|
|
|
CP0895611
|
N-(3-((1-(5-Chloronicotinoyl)piperidin-4-yl)oxy)-4-methylphenyl)-4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)benzamide
Show/Hide
|
C32H35ClF3N5O3
|
1
|
| 1 |
GI50 = 37 nM
|
|
|
|
CP0878927
|
N-(1-(4-(3-(3-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-ureido)-2-(trifluoromethyl)phenyl)piperidin-4-yl)-2-(piperidin-1-yl)acetamide
Show/Hide
|
C37H41F3N6O5
|
2
|
| 1 |
GI50 = 37 nM
|
|
|
| 2 |
GI50 = 120 nM
|
|
|
|
CP0036099
|
1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-5-methyl-phenyl)urea
Show/Hide
|
C21H18FN5O
|
2
|
| 1 |
GI50 = 37.1 nM
|
|
|
| 2 |
GI50 = 88.7 nM
|
|
|
|
CP0869388
|
N-(1-(4-(3-(3-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-ureido)-2-(trifluoromethyl)phenyl)piperidin-4-yl)-2-(dimethylamino)acetamide
Show/Hide
|
C34H37F3N6O5
|
2
|
| 1 |
GI50 = 38 nM
|
|
|
| 2 |
GI50 = 53 nM
|
|
|
|
CP0948149
|
N-(1-(4-(3-(3-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-ureido)-2-(trifluoromethyl)phenyl)piperidin-4-yl)-1-ethylpiperidine-4-carboxamide
Show/Hide
|
C38H43F3N6O5
|
2
|
| 1 |
GI50 = 39 nM
|
|
|
| 2 |
GI50 = 87 nM
|
|
|
|
CP0385350
|
N-[4-methyl-3-[1-(pyridine-4-carbonyl)piperidin-4-yl]oxyphenyl]-3-(trifluoromethyl)benzamide
Show/Hide
|
C26H24F3N3O3
|
9
|
| 1 |
GI50 = 40 nM
|
|
|
| 2 |
GI50 = 150 nM
|
|
|
| 3 |
GI50 = 190 nM
|
|
|
| 4 |
GI50 = 1030 nM
|
|
|
| 5 |
GI50 = 1050 nM
|
|
|
| 6 |
GI50 = 1060 nM
|
|
|
| 7 |
GI50 = 5310 nM
|
|
|
| 8 |
GI50 = 8240 nM
|
|
|
| 9 |
GI50 > 10000 nM
|
|
|
|
CP0421231
|
N-[[1-[4-[[3-(6,7-dimethoxyquinolin-4-yl)oxyphenyl]carbamoylamino]-2-(trifluoromethyl)phenyl]piperidin-4-yl]methyl]propanamide
Show/Hide
|
C34H36F3N5O5
|
7
|
| 1 |
GI50 = 40 nM
|
|
|
| 2 |
GI50 = 57 nM
|
|
|
| 3 |
GI50 = 63 nM
|
|
|
| 4 |
GI50 = 73 nM
|
|
|
| 5 |
GI50 = 320 nM
|
|
|
| 6 |
GI50 = 360 nM
|
|
|
| 7 |
GI50 = 670 nM
|
|
|
|
CP0958862
|
N-(4-((6,7-Dimethoxyquinazolin-4-yl)oxy)phenyl)-2-(5-isopropyl-2H-tetrazol-2-yl)acetamide
Show/Hide
|
C22H23N7O4
|
1
|
| 1 |
GI50 = 42 nM
|
|
|
|
CP0948150
|
N-(1-(4-(3-(3-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-ureido)-2-(trifluoromethyl)phenyl)piperidin-4-yl)-3-morpholinopropanamide
Show/Hide
|
C37H41F3N6O6
|
2
|
| 1 |
GI50 = 42 nM
|
|
|
| 2 |
GI50 = 59 nM
|
|
|
|
CP0871893
|
N1-(4-Chloro-3-(trifluoromethyl)phenyl)-N3-(3-(pyridin-3-yl)-1H-indazol-6-yl)malonamide
Show/Hide
|
C22H15ClF3N5O2
|
2
|
| 1 |
GI50 = 45 nM
|
|
|
| 2 |
GI50 = 320 nM
|
|
|
|
CP0869655
|
N-(1-(4-(3-(3-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-ureido)-2-(trifluoromethyl)phenyl)piperidin-4-yl)acetamide
Show/Hide
|
C32H32F3N5O5
|
2
|
| 1 |
GI50 = 46 nM
|
|
|
| 2 |
GI50 = 110 nM
|
|
|
|
CP0871875
|
N1-(4-Chloro-3-(trifluoromethyl)phenyl)-N3-(3-(4-(methylcarbamoyl)phenyl)-1H-indazol-6-yl)malonamide
Show/Hide
|
C25H19ClF3N5O3
|
2
|
| 1 |
GI50 = 57 nM
|
|
|
| 2 |
GI50 = 338 nM
|
|
|
|
CP0867284
|
N1-(4-Chloro-3-(trifluoromethyl)phenyl)-N3-(3-(6-methylpyridin-3-yl)-1H-indazol-6-yl)malonamide
Show/Hide
|
C23H17ClF3N5O2
|
2
|
| 1 |
GI50 = 59 nM
|
|
|
| 2 |
GI50 = 183 nM
|
|
|
|
CP0869390
|
N-(1-(4-(3-(3-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-ureido)-2-(trifluoromethyl)phenyl)piperidin-4-yl)propane-1-sulfonamide
Show/Hide
|
C33H36F3N5O6S
|
2
|
| 1 |
GI50 = 59 nM
|
|
|
| 2 |
GI50 = 950 nM
|
|
|
|
CP0906497
|
1-Acetyl-N-(1-(4-(3-(3-((6,7-dimethoxyquinolin-4-yl)oxy)-phenyl)ureido)-2-(trifluoromethyl)phenyl)piperidin-4-yl)-piperidine-4-carboxamide
Show/Hide
|
C38H41F3N6O6
|
2
|
| 1 |
GI50 = 59 nM
|
|
|
| 2 |
GI50 = 230 nM
|
|
|
|
CP0859246
|
N-(3-((1-(2-Chloronicotinoyl)piperidin-4-yl)oxy)-4-methylphenyl)-4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)benzamide
Show/Hide
|
C32H35ClF3N5O3
|
1
|
| 1 |
GI50 = 62 nM
|
|
|
|
CP0893566
|
N-(3-((1-(2-Fluoronicotinoyl)piperidin-4-yl)oxy)-4-methylphenyl)-4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)benzamide
Show/Hide
|
C32H35F4N5O3
|
1
|
| 1 |
GI50 = 63 nM
|
|
|
|
CP0878928
|
N-(1-(4-(3-(3-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-ureido)-2-(trifluoromethyl)phenyl)piperidin-4-yl)-cyclopropanesulfonamide
Show/Hide
|
C33H34F3N5O6S
|
2
|
| 1 |
GI50 = 63 nM
|
|
|
| 2 |
GI50 = 140 nM
|
|
|
|
CP0944510
|
N-(3-((1-(Isoxazole-5-carbonyl)piperidin-4-yl)oxy)-4-methylphenyl)-4-methyl-3-(trifluoromethyl)benzamide
Show/Hide
|
C25H24F3N3O4
|
1
|
| 1 |
GI50 = 65 nM
|
|
|
|
CP0899400
|
N-(4-((4-Methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)carbamoyl)-2-(trifluoromethyl)benzyl)nicotinamide
Show/Hide
|
C31H24F3N7O2
|
1
|
| 1 |
GI50 = 66 nM
|
|
|
|
CP0915773
|
N-(1-(4-(3-(3-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-ureido)-2-(trifluoromethyl)phenyl)piperidin-4-yl)-propionamide
Show/Hide
|
C33H34F3N5O5
|
2
|
| 1 |
GI50 = 71 nM
|
|
|
| 2 |
GI50 = 120 nM
|
|
|
|
CP0904156
|
N-(4-((6,7-Dimethoxyquinazolin-4-yl)oxy)phenyl)-2-(2-isopropyl-2H-1,2,3-triazol-4-yl)acetamide
Show/Hide
|
C23H24N6O4
|
1
|
| 1 |
GI50 = 75 nM
|
|
|
|
CP0190068
|
N-[4-methyl-3-[1-(6-methylpyridine-3-carbonyl)piperidin-4-yl]oxyphenyl]-4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)benzamide
Show/Hide
|
C33H38F3N5O3
|
9
|
| 1 |
GI50 = 78 nM
|
|
|
| 2 |
GI50 = 124 nM
|
|
|
| 3 |
GI50 = 149 nM
|
|
|
| 4 |
GI50 = 221 nM
|
|
|
| 5 |
GI50 = 1010 nM
|
|
|
| 6 |
GI50 = 1840 nM
|
|
|
| 7 |
GI50 = 1850 nM
|
|
|
| 8 |
GI50 = 2870 nM
|
|
|
| 9 |
GI50 = 5060 nM
|
|
|
|
CP0864261
|
N-(4-((6,7-Dimethoxyquinazolin-4-yl)oxy)-2-methoxyphenyl)-2-(1-ethyl-1H-pyrazol-4-yl)acetamide
Show/Hide
|
C24H25N5O5
|
3
|
| 1 |
GI50 = 78 nM
|
|
|
| 2 |
GI50 = 86 nM
|
|
|
| 3 |
GI50 = 251 nM
|
|
|
|
CP0160345
|
2-[4-[(6,7-dimethoxyquinazolin-4-yl)amino]phenyl]-N-(1-propan-2-ylpyrazol-4-yl)acetamide
Show/Hide
|
C24H26N6O3
|
3
|
| 1 |
GI50 = 78 nM
|
|
|
| 2 |
GI50 = 337 nM
|
|
|
| 3 |
GI50 = 2592 nM
|
|
|
|
CP0966172
|
N-(1-(4-(3-(3-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-ureido)-2-(trifluoromethyl)phenyl)piperidin-4-yl)-1-methylpiperidine-4-carboxamide
Show/Hide
|
C37H41F3N6O5
|
2
|
| 1 |
GI50 = 81 nM
|
|
|
| 2 |
GI50 = 160 nM
|
|
|
|
CP0963778
|
4-Methyl-N-(4-methyl-3-((1-nicotinoylpiperidin-4-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide
Show/Hide
|
C27H26F3N3O3
|
1
|
| 1 |
GI50 = 83 nM
|
|
|
|
CP0869389
|
N-(1-(4-(3-(3-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-ureido)-2-(trifluoromethyl)phenyl)piperidin-4-yl)tetrahydro-2H-pyran-4-carboxamide
Show/Hide
|
C36H38F3N5O6
|
2
|
| 1 |
GI50 = 83 nM
|
|
|
| 2 |
GI50 = 87 nM
|
|
|
|
CP0205730
|
1-[4-(3-methyl-2H-pyrazolo[3,4-b]pyridin-4-yl)phenyl]-3-quinolin-3-ylurea
Show/Hide
|
C23H18N6O
|
2
|
| 1 |
GI50 = 83.3 nM
|
|
|
| 2 |
GI50 = 217.3 nM
|
|
|
|
CP0898929
|
(E)-N1-(3-(2-(Pyridin-2-yl)vinyl)-1H-indazol-6-yl)-N3-(3-(trifluoromethyl)phenyl)malonamide
Show/Hide
|
C24H18F3N5O2
|
2
|
| 1 |
GI50 = 86 nM
|
|
|
| 2 |
GI50 = 216 nM
|
|
|
|
CP0904155
|
2-(1-(Difluoromethyl)-1H-pyrazol-4-yl)-N-(4-((6,7-dimethoxyquinazolin-4-yl)oxy)phenyl)acetamide
Show/Hide
|
C22H19F2N5O4
|
1
|
| 1 |
GI50 = 87 nM
|
|
|
|
CP0914113
|
4-Methyl-N-(4-methyl-3-((1-(thiazole-5-carbonyl)piperidin-4-yl)-oxy)phenyl)-3-(trifluoromethyl)benzamide
Show/Hide
|
C25H24F3N3O3S
|
1
|
| 1 |
GI50 = 100 nM
|
|
|
|
CP0899401
|
N-(4-Methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)-3-propionamido-5-(trifluoromethyl)benzamide
Show/Hide
|
C27H23F3N6O2
|
1
|
| 1 |
GI50 = 104 nM
|
|
|
|
CP0916749
|
N-(4-Methyl-3-((1-nicotinoylpiperidin-4-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide
Show/Hide
|
C26H24F3N3O3
|
1
|
| 1 |
GI50 = 110 nM
|
|
|
|
CP0893383
|
N-(4-((6,7-Dimethoxyquinazolin-4-yl)oxy)phenyl)-2-(1-isopropyl-1H-1,2,3-triazol-4-yl)acetamide
Show/Hide
|
C23H24N6O4
|
1
|
| 1 |
GI50 = 111 nM
|
|
|
|
CP0867285
|
(E)-N1-(3-Chlorophenyl)-N3-(3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)malonamide
Show/Hide
|
C23H18ClN5O2
|
2
|
| 1 |
GI50 = 111 nM
|
|
|
| 2 |
GI50 = 923 nM
|
|
|
|
CP0915175
|
(E)-N1-(4-Fluorophenyl)-N3-(3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)malonamide
Show/Hide
|
C23H18FN5O2
|
2
|
| 1 |
GI50 = 111 nM
|
|
|
| 2 |
GI50 = 554 nM
|
|
|
|
CP0867287
|
(E)-N1-(3-Bromophenyl)-N3-(3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)malonamide
Show/Hide
|
C23H18BrN5O2
|
2
|
| 1 |
GI50 = 113 nM
|
|
|
| 2 |
GI50 = 943 nM
|
|
|
|
CP0945741
|
(E)-N1-Phenyl-N3-(3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)-malonamide
Show/Hide
|
C23H19N5O2
|
2
|
| 1 |
GI50 = 117 nM
|
|
|
| 2 |
GI50 = 2220 nM
|
|
|
|
CP0958479
|
(R)-2-Amino-N-(1-(4-(3-(3-((6,7-dimethoxyquinolin-4-yl)-oxy)phenyl)ureido)-2-(trifluoromethyl)phenyl)piperidin-4-yl)-propanamide hydrochloride
Show/Hide
|
C33H36ClF3N6O5
|
2
|
| 1 |
GI50 = 120 nM
|
|
|
| 2 |
GI50 = 480 nM
|
|
|
|
CP0954088
|
1-(Cyclopropanecarbonyl)-N-(1-(4-(3-(3-((6,7-dimethoxyquinolin-4-yl)oxy)phenyl)ureido)-2-(trifluoromethyl)phenyl)-piperidin-4-yl)piperidine-4-carboxamide
Show/Hide
|
C40H43F3N6O6
|
2
|
| 1 |
GI50 = 120 nM
|
|
|
| 2 |
GI50 = 130 nM
|
|
|
|
CP0909701
|
tert-Butyl 3-((1-(4-(3-(3-((6,7-Dimethoxyquinolin-4-yl)oxy)-phenyl)ureido)-2-(trifluoromethyl)phenyl)piperidin-4-yl)-carbamoyl)piperidine-1-carboxylate
Show/Hide
|
C41H47F3N6O7
|
2
|
| 1 |
GI50 = 130 nM
|
|
|
| 2 |
GI50 = 170 nM
|
|
|
|
CP0954090
|
2-Amino-N-(1-(4-(3-(3-((6,7-dimethoxyquinolin-4-yl)oxy)-phenyl)ureido)-2-(trifluoromethyl)phenyl)piperidin-4-yl)-acetamide hydrochloride
Show/Hide
|
C32H34ClF3N6O5
|
2
|
| 1 |
GI50 = 130 nM
|
|
|
| 2 |
GI50 = 581 nM
|
|
|
|
CP0888593
|
3-Fluoro-N-(4-methyl-3-((1-nicotinoylpiperidin-4-yl)oxy)phenyl)-5-(trifluoromethyl)benzamide
Show/Hide
|
C26H23F4N3O3
|
1
|
| 1 |
GI50 = 150 nM
|
|
|
|
CP0963777
|
3-Chloro-N-(3-((1-(isoxazole-5-carbonyl)piperidin-4-yl)oxy)-4-methylphenyl)-5-(trifluoromethyl)benzamide
Show/Hide
|
C24H21ClF3N3O4
|
1
|
| 1 |
GI50 = 150 nM
|
|
|
|
CP0868827
|
3-Chloro-N-(4-methyl-3-((1-nicotinoylpiperidin-4-yl)oxy)phenyl)-5-(trifluoromethyl)benzamide
Show/Hide
|
C26H23ClF3N3O3
|
1
|
| 1 |
GI50 = 160 nM
|
|
|
|
CP0897981
|
N-(3-((1-Acryloylpiperidin-4-yl)oxy)-4-methylphenyl)-4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)benzamide
Show/Hide
|
C29H35F3N4O3
|
1
|
| 1 |
GI50 = 160 nM
|
|
|
|
CP0401091
|
4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[1-(pyridine-4-carbonyl)piperidin-4-yl]oxyphenyl]-3-(trifluoromethyl)benzamide
Show/Hide
|
C32H36F3N5O3
|
1
|
| 1 |
GI50 = 170 nM
|
|
|
|
CP0387299
|
4-(methylamino)-2-[4-methyl-3-(propanoylamino)anilino]-N-[2-methyl-5-[[3-(trifluoromethyl)benzoyl]amino]phenyl]pyrimidine-5-carboxamide
Show/Hide
|
C31H30F3N7O3
|
1
|
| 1 |
GI50 = 170 nM
|
|
|
|
CP0869513
|
(E)-N1-(3-(2-(Pyridin-2-yl)vinyl)-1H-indazol-6-yl)-N3-(m-tolyl)malonamide
Show/Hide
|
C24H21N5O2
|
2
|
| 1 |
GI50 = 170 nM
|
|
|
| 2 |
GI50 = 1430 nM
|
|
|
|
CP0953242
|
N-(4-((6,7-Dimethoxyquinazolin-4-yl)oxy)phenyl)-2-(3-isopropyl-1H-1,2,4-triazol-1-yl)acetamide
Show/Hide
|
C23H24N6O4
|
1
|
| 1 |
GI50 = 175 nM
|
|
|
|
CP0913817
|
N1-(4-Chloro-3-(trifluoromethyl)phenyl)-N3-(3-(3-fluorophenyl)-1H-indazol-6-yl)malonamide
Show/Hide
|
C23H15ClF4N4O2
|
2
|
| 1 |
GI50 = 179 nM
|
|
|
| 2 |
GI50 = 1120 nM
|
|
|
|
CP0897980
|
N-(3-((1-(6,7-Dimethoxyquinazolin-4-yl)piperidin-4-yl)oxy)-4-methylphenyl)-4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)benzamide
Show/Hide
|
C36H41F3N6O4
|
1
|
| 1 |
GI50 = 190 nM
|
|
|
|
CP0906498
|
N-(1-(4-(3-(3-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-ureido)-2-(trifluoromethyl)phenyl)piperidin-4-yl)-3-(1-methylpiperidin-2-yl)propanamide
Show/Hide
|
C39H45F3N6O5
|
2
|
| 1 |
GI50 = 190 nM
|
|
|
| 2 |
GI50 = 200 nM
|
|
|
|
CP0451979
|
4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[1-(pyridine-2-carbonyl)piperidin-4-yl]oxyphenyl]-3-(trifluoromethyl)benzamide
Show/Hide
|
C32H36F3N5O3
|
1
|
| 1 |
GI50 = 200 nM
|
|
|
|
CP0888364
|
N-(3-((1-(2-Aminopyrimidine-5-carbonyl)piperidin-4-yl)oxy)-4-methylphenyl)-4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)benzamide
Show/Hide
|
C31H36F3N7O3
|
1
|
| 1 |
GI50 = 200 nM
|
|
|
|
CP0878925
|
N-(1-(4-(3-(3-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-ureido)-2-(trifluoromethyl)phenyl)piperidin-4-yl)-2-(3-methylpiperidin-1-yl)acetamide
Show/Hide
|
C38H43F3N6O5
|
2
|
| 1 |
GI50 = 200 nM
|
|
|
| 2 |
GI50 = 330 nM
|
|
|
|
CP0446640
|
N-[4-methyl-3-[1-(4-methylpyridine-3-carbonyl)piperidin-4-yl]oxyphenyl]-4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)benzamide
Show/Hide
|
C33H38F3N5O3
|
1
|
| 1 |
GI50 = 210 nM
|
|
|
|
CP0902838
|
N-(4-((4-Methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)carbamoyl)benzyl)nicotinamide
Show/Hide
|
C30H25N7O2
|
1
|
| 1 |
GI50 = 216 nM
|
|
|
|
CP0881888
|
N-(3-((1-(Isoxazole-5-carbonyl)piperidin-4-yl)oxy)-4-methylphenyl)-3-(trifluoromethyl)benzamide
Show/Hide
|
C24H22F3N3O4
|
1
|
| 1 |
GI50 = 220 nM
|
|
|
|
CP0890778
|
N-(4-Methyl-3-((1-nicotinoylpiperidin-4-yl)oxy)phenyl)-4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)benzamide
Show/Hide
|
C32H36F3N5O3
|
1
|
| 1 |
GI50 = 220 nM
|
|
|
|
CP0869512
|
(E)-N-(4-Chloro-3-(trifluoromethyl)phenyl)-N-(3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)cyclopropane-1,1-dicarboxamide
Show/Hide
|
C26H19ClF3N5O2
|
2
|
| 1 |
GI50 = 230 nM
|
|
|
| 2 |
GI50 = 1000 nM
|
|
|
|
CP0915176
|
(E)-N1-(3-Methoxyphenyl)-N3-(3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)malonamide
Show/Hide
|
C24H21N5O3
|
2
|
| 1 |
GI50 = 234 nM
|
|
|
| 2 |
GI50 = 2740 nM
|
|
|
|
CP0934522
|
N-(4-((6,7-Dimethoxyquinazolin-4-yl)oxy)phenyl)-2-(1-isopropyl-1H-imidazol-4-yl)acetamide
Show/Hide
|
C24H25N5O4
|
1
|
| 1 |
GI50 = 240 nM
|
|
|
|
CP0229003
|
1-(3-methylphenyl)-3-[4-(3-methyl-2H-pyrazolo[3,4-b]pyridin-4-yl)phenyl]urea
Show/Hide
|
C21H19N5O
|
2
|
| 1 |
GI50 = 248 nM
|
|
|
| 2 |
GI50 = 317.6 nM
|
|
|
|
CP0854595
|
3-Acrylamido-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)-5-(trifluoromethyl)benzamide
Show/Hide
|
C27H21F3N6O2
|
1
|
| 1 |
GI50 = 250 nM
|
|
|
|
CP0966173
|
N-((1-(4-(3-(3-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-ureido)-2-(trifluoromethyl)phenyl)piperidin-4-yl)methyl)-3-(1-methylpiperidin-2-yl)propanamide
Show/Hide
|
C40H47F3N6O5
|
2
|
| 1 |
GI50 = 250 nM
|
|
|
| 2 |
GI50 = 460 nM
|
|
|
|
CP0876835
|
N-(1-(4-(3-(3-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-ureido)-2-(trifluoromethyl)phenyl)piperidin-4-yl)-3-(piperidin-1-yl)propanamide
Show/Hide
|
C38H43F3N6O5
|
2
|
| 1 |
GI50 = 260 nM
|
|
|
| 2 |
GI50 = 440 nM
|
|
|
|
CP0883945
|
N-(3-((1-(Furan-3-carbonyl)piperidin-4-yl)oxy)-4-methylphenyl)-4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)benzamide
Show/Hide
|
C31H35F3N4O4
|
1
|
| 1 |
GI50 = 270 nM
|
|
|
|
CP0958476
|
N-(1-(4-(3-(3-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-ureido)-2-(trifluoromethyl)phenyl)piperidin-3-yl)-propionamide
Show/Hide
|
C33H34F3N5O5
|
2
|
| 1 |
GI50 = 280 nM
|
|
|
| 2 |
GI50 = 920 nM
|
|
|
|
CP0942783
|
N-(4-Methyl-3-((1-propionylpiperidin-4-yl)oxy)phenyl)-4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)benzamide
Show/Hide
|
C29H37F3N4O3
|
1
|
| 1 |
GI50 = 300 nM
|
|
|
|
CP0906653
|
4-(Acrylamidomethyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)-3-(trifluoromethyl)benzamide
Show/Hide
|
C28H23F3N6O2
|
1
|
| 1 |
GI50 = 300 nM
|
|
|
|
CP0867289
|
(E)-N1-(2-Fluorophenyl)-N3-(3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)malonamide
Show/Hide
|
C23H18FN5O2
|
2
|
| 1 |
GI50 = 312 nM
|
|
|
| 2 |
GI50 = 2160 nM
|
|
|
|
CP0884002
|
N-(4-Methyl-3-((1-(quinoline-3-carbonyl)piperidin-4-yl)oxy)-phenyl)-4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)benzamide
Show/Hide
|
C36H38F3N5O3
|
1
|
| 1 |
GI50 = 320 nM
|
|
|
|
CP0952151
|
N-(4-Methyl-3-((1-picolinoylpiperidin-4-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide
Show/Hide
|
C26H24F3N3O3
|
1
|
| 1 |
GI50 = 330 nM
|
|
|
|
CP0898925
|
N1-(3-(3-Carbamoylphenyl)-1H-indazol-6-yl)-N3-(4-chloro-3-(trifluoromethyl)phenyl)malonamide
Show/Hide
|
C24H17ClF3N5O3
|
2
|
| 1 |
GI50 = 339 nM
|
|
|
| 2 |
GI50 = 1550 nM
|
|
|
|
CP0921362
|
5-(tert-Butyl)-N-(4-methyl-3-((1-nicotinoylpiperidin-4-yl)oxy)-phenyl)isoxazole-3-carboxamide
Show/Hide
|
C26H30N4O4
|
1
|
| 1 |
GI50 = 340 nM
|
|
|
|
CP0903642
|
N-(4-Chloro-3-((1-nicotinoylpiperidin-4-yl)oxy)phenyl)-4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)benzamide
Show/Hide
|
C31H33ClF3N5O3
|
1
|
| 1 |
GI50 = 340 nM
|
|
|
|
CP0954091
|
N-(4-(4-(3-(3-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-ureido)piperidin-1-yl)-3-(trifluoromethyl)phenyl)-propionamide
Show/Hide
|
C33H34F3N5O5
|
2
|
| 1 |
GI50 = 340 nM
|
|
|
| 2 |
GI50 > 10000 nM
|
|
|
|
CP0915772
|
N-(1-(4-(3-(3-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-ureido)-2-(trifluoromethyl)phenyl)piperidin-4-yl)-3,3-dimethylbutanamide
Show/Hide
|
C36H40F3N5O5
|
2
|
| 1 |
GI50 = 340 nM
|
|
|
| 2 |
GI50 = 430 nM
|
|
|
|
CP0859245
|
N-(4-Methyl-3-((1-(2-methylnicotinoyl)piperidin-4-yl)oxy)-phenyl)-4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)-benzamide
Show/Hide
|
C33H38F3N5O3
|
1
|
| 1 |
GI50 = 370 nM
|
|
|
|
CP0389976
|
4-(methylamino)-2-[4-methyl-3-(prop-2-enoylamino)anilino]-N-[2-methyl-5-[[3-(trifluoromethyl)benzoyl]amino]phenyl]pyrimidine-5-carboxamide
Show/Hide
|
C31H28F3N7O3
|
1
|
| 1 |
GI50 = 380 nM
|
|
|
|
CP0869514
|
(E)-N1-(3,5-Difluorophenyl)-N3-(3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)malonamide
Show/Hide
|
C23H17F2N5O2
|
2
|
| 1 |
GI50 = 399 nM
|
|
|
| 2 |
GI50 = 1870 nM
|
|
|
|
CP0906496
|
N-(3-(6,7-dimethoxyquinolin-4-yloxy)phenyl)-4-(4-propionamidopiperidin-1-yl)-3-(trifluoromethyl)benzamide
Show/Hide
|
C33H33F3N4O5
|
2
|
| 1 |
GI50 = 400 nM
|
|
|
| 2 |
GI50 = 2700 nM
|
|
|
|
CP0891179
|
N-(4-((4-Methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)carbamoyl)phenyl)nicotinamide
Show/Hide
|
C29H23N7O2
|
1
|
| 1 |
GI50 = 426 nM
|
|
|
|
CP0958475
|
N-(1-(4-(3-(3-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-ureido)-2-(trifluoromethyl)phenyl)piperidin-4-yl)-2-methylpiperidine-4-carboxamide
Show/Hide
|
C36H40ClF3N6O5
|
2
|
| 1 |
GI50 = 460 nM
|
|
|
| 2 |
GI50 = 650 nM
|
|
|
|
CP0961373
|
N-(3-((1-Nicotinoylpiperidin-4-yl)oxy)phenyl)-3-(trifluoromethyl)-benzamide
Show/Hide
|
C25H22F3N3O3
|
1
|
| 1 |
GI50 = 490 nM
|
|
|
|
CP0897978
|
N-(3-((1-Benzoylpiperidin-4-yl)oxy)-4-methylphenyl)-4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)benzamide
Show/Hide
|
C33H37F3N4O3
|
1
|
| 1 |
GI50 = 550 nM
|
|
|
|
CP0860664
|
N-(4-Methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)-4-(vinylsulfonamidomethyl)benzamide
Show/Hide
|
C26H24N6O3S
|
1
|
| 1 |
GI50 = 580 nM
|
|
|
|
CP0867288
|
(E)-N1-(3-(Dimethylamino)phenyl)-N3-(3-(2-(pyridin-2-yl)-vinyl)-1H-indazol-6-yl)malonamide
Show/Hide
|
C25H24N6O2
|
2
|
| 1 |
GI50 = 594 nM
|
|
|
| 2 |
GI50 = 3870 nM
|
|
|
|
CP0942862
|
N-(4-Methyl-3-((1-(phenylsulfonyl)piperidin-4-yl)oxy)phenyl)-4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)benzamide
Show/Hide
|
C32H37F3N4O4S
|
1
|
| 1 |
GI50 = 600 nM
|
|
|
|
CP0944509
|
N-(3-((1-Acryloylpiperidin-4-yl)oxy)-4-methylphenyl)-3-(trifluoromethyl)benzamide
Show/Hide
|
C23H23F3N2O3
|
1
|
| 1 |
GI50 = 620 nM
|
|
|
|
CP0192497
|
N-(1,3-dimethylpyrazol-4-yl)-2-[2-methoxy-4-(7-methoxyquinolin-4-yl)oxyphenyl]acetamide
Show/Hide
|
C24H24N4O4
|
3
|
| 1 |
GI50 = 685 nM
|
|
|
| 2 |
GI50 = 786 nM
|
|
|
| 3 |
GI50 = 1918 nM
|
|
|
|
CP0954089
|
N-(1-(4-(3-(3-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-ureido)-2-(trifluoromethyl)phenyl)piperidin-4-yl)cyclohex-1-ene-1-carboxamide
Show/Hide
|
C37H38F3N5O5
|
1
|
| 1 |
GI50 = 760 nM
|
|
|
|
CP0883947
|
N-(4-Methyl-3-((1-(2-(pyridin-3-yl)acetyl)piperidin-4-yl)oxy)-phenyl)-4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)-benzamide
Show/Hide
|
C33H38F3N5O3
|
1
|
| 1 |
GI50 = 780 nM
|
|
|
|
CP0905161
|
(E)-N1-(2,5-Difluorophenyl)-N3-(3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)malonamide
Show/Hide
|
C23H17F2N5O2
|
2
|
| 1 |
GI50 = 847 nM
|
|
|
| 2 |
GI50 = 3460 nM
|
|
|
|
CP0137907
|
2-(4-methylpiperazin-1-yl)-N-[4-methyl-5-[3-[(E)-2-pyridin-2-ylethenyl]-1H-indazol-6-yl]-1,3-thiazol-2-yl]acetamide
Show/Hide
|
C25H27N7OS
|
1
|
| 1 |
GI50 = 923.2 nM
|
|
|
|
CP0881890
|
N-(4-Chloro-3-((1-nicotinoylpiperidin-4-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide
Show/Hide
|
C25H21ClF3N3O3
|
1
|
| 1 |
GI50 = 960 nM
|
|
|
|
CP0368507
|
1-[4-[3-(hydroxymethyl)-2H-pyrazolo[3,4-b]pyridin-4-yl]phenyl]-3-(3-methylphenyl)urea
Show/Hide
|
C21H19N5O2
|
2
|
| 1 |
GI50 = 1068 nM
|
|
|
| 2 |
GI50 = 1841 nM
|
|
|
|
CP0869516
|
(E)-1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)urea
Show/Hide
|
C22H15ClF3N5O
|
2
|
| 1 |
GI50 = 1150 nM
|
|
|
| 2 |
GI50 = 1600 nM
|
|
|
|
CP0945742
|
(E)-N1-(Perfluorophenyl)-N3-(3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)malonamide
Show/Hide
|
C23H14F5N5O2
|
2
|
| 1 |
GI50 = 1300 nM
|
|
|
| 2 |
GI50 = 2950 nM
|
|
|
|
CP0941781
|
N-(4-((6,7-Dimethoxyquinazolin-4-yl)oxy)phenyl)-2-(1-isopropyl-1H-1,2,4-triazol-3-yl)acetamide
Show/Hide
|
C23H24N6O4
|
1
|
| 1 |
GI50 = 1369 nM
|
|
|
|
CP0954340
|
3-Methoxy-N-(4-methyl-3-((1-nicotinoylpiperidin-4-yl)oxy)-phenyl)benzamide
Show/Hide
|
C26H27N3O4
|
1
|
| 1 |
GI50 = 1480 nM
|
|
|
|
CP0854605
|
3-Acrylamido-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide
Show/Hide
|
C26H22N6O2
|
1
|
| 1 |
GI50 = 1530 nM
|
|
|
|
CP0868892
|
N-(4-Methyl-3-((1-propionylpiperidin-4-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide
Show/Hide
|
C23H25F3N2O3
|
1
|
| 1 |
GI50 = 1550 nM
|
|
|
|
CP0890764
|
N-(4-Methyl-3-((1-(6-oxo-1,6-dihydropyridine-3-carbonyl)-piperidin-4-yl)oxy)phenyl)-4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)benzamide
Show/Hide
|
C32H36F3N5O4
|
1
|
| 1 |
GI50 = 1600 nM
|
|
|
|
CP0883946
|
N-(3-((1-(2-(Dimethylamino)acetyl)piperidin-4-yl)oxy)-4-methylphenyl)-4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)benzamide
Show/Hide
|
C30H40F3N5O3
|
1
|
| 1 |
GI50 = 1630 nM
|
|
|
|
CP0203048
|
1-[4-(3-methyl-2H-pyrazolo[3,4-b]pyridin-4-yl)phenyl]-3-(3-phenylpropyl)urea
Show/Hide
|
C23H23N5O
|
2
|
| 1 |
GI50 = 1669 nM
|
|
|
| 2 |
GI50 = 3025 nM
|
|
|
|
CP0898933
|
(E)-4-Chloro-N-(3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)-3-(trifluoromethyl)benzamide
Show/Hide
|
C22H14ClF3N4O
|
2
|
| 1 |
GI50 = 1710 nM
|
|
|
| 2 |
GI50 = 2970 nM
|
|
|
|
CP0203090
|
1-hexyl-3-[4-(3-methyl-2H-pyrazolo[3,4-b]pyridin-4-yl)phenyl]urea
Show/Hide
|
C20H25N5O
|
2
|
| 1 |
GI50 = 1779 nM
|
|
|
| 2 |
GI50 = 3028 nM
|
|
|
|
CP0909466
|
N1-(4-Chloro-3-(trifluoromethyl)phenyl)-N3-(3-methyl-1H-indazol-6-yl)malonamide
Show/Hide
|
C18H14ClF3N4O2
|
2
|
| 1 |
GI50 = 1880 nM
|
|
|
| 2 |
GI50 > 10000 nM
|
|
|
|
CP0065873
|
1-[(3R)-3-[4-amino-3-(4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]-2-(dimethylamino)ethanone
Show/Hide
|
C26H29N7O2
|
1
|
| 1 |
GI50 = 1900 nM
|
|
|
|
CP0224766
|
4-(methylamino)-2-[4-methyl-3-(prop-2-enoylamino)anilino]-N-[2-methyl-5-[(3,4,5-trimethoxybenzoyl)amino]phenyl]pyrimidine-5-carboxamide
Show/Hide
|
C33H35N7O6
|
1
|
| 1 |
GI50 = 2010 nM
|
|
|
|
CP0888365
|
N-(4-Methyl-3-((1-(pyrimidin-2-yl)piperidin-4-yl)oxy)phenyl)-4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)benzamide
Show/Hide
|
C30H35F3N6O2
|
1
|
| 1 |
GI50 = 2500 nM
|
|
|
|
CP0891184
|
4-((N-(2-(Dimethylamino)ethyl)pivalamido)methyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide
Show/Hide
|
C33H39N7O2
|
1
|
| 1 |
GI50 = 2530 nM
|
|
|
|
CP0945300
|
1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(4-methyl-3-((1-nicotinoylpiperidin-4-yl)oxy)phenyl)urea
Show/Hide
|
C26H24ClF3N4O3
|
1
|
| 1 |
GI50 = 2600 nM
|
|
|
|
CP0910615
|
N1-(4-Chloro-3-(trifluoromethyl)phenyl)-N3-(1H-indazol-6-yl)malonamide
Show/Hide
|
C17H12ClF3N4O2
|
2
|
| 1 |
GI50 = 2670 nM
|
|
|
| 2 |
GI50 > 10000 nM
|
|
|
|
CP0387298
|
4-(methylamino)-2-[4-methyl-3-(propanoylamino)anilino]-N-[2-methyl-5-[(3,4,5-trimethoxybenzoyl)amino]phenyl]pyrimidine-5-carboxamide
Show/Hide
|
C33H37N7O6
|
1
|
| 1 |
GI50 = 2800 nM
|
|
|
|
CP0859247
|
N-(4-Methyl-3-((1-nicotinoylazetidin-3-yl)methoxy)phenyl)-4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)benzamide
Show/Hide
|
C31H34F3N5O3
|
1
|
| 1 |
GI50 = 2860 nM
|
|
|
|
CP0948271
|
N-(4-Methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)-3-(propionamidomethyl)benzamide
Show/Hide
|
C27H26N6O2
|
1
|
| 1 |
GI50 = 2920 nM
|
|
|
|
CP0064831
|
US8586600, II-1
Show/Hide
|
C26H22N6O2
|
1
|
| 1 |
GI50 = 2940 nM
|
|
|
|
CP0871876
|
(E)-2-(4-Chloro-3-(trifluoromethyl)phenyl)-N-(3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)acetamide
Show/Hide
|
C23H16ClF3N4O
|
2
|
| 1 |
GI50 = 3180 nM
|
|
|
| 2 |
GI50 = 5500 nM
|
|
|
|
CP0942782
|
N-(2-(2-Methyl-5-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)benzamido)phenoxy)ethyl)nicotinamide
Show/Hide
|
C29H32F3N5O3
|
1
|
| 1 |
GI50 = 3300 nM
|
|
|
|
CP0948151
|
N-(1-(4-(3-(3-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-ureido)-2-(trifluoromethyl)phenyl)piperidin-4-yl)methanesulfonamide
Show/Hide
|
C31H32F3N5O6S
|
2
|
| 1 |
GI50 = 3800 nM
|
|
|
| 2 |
GI50 = 3900 nM
|
|
|
|
CP0897979
|
N-(4-Methyl-3-((1-nicotinoylpyrrolidin-3-yl)methoxy)phenyl)-4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)benzamide
Show/Hide
|
C32H36F3N5O3
|
1
|
| 1 |
GI50 = 3820 nM
|
|
|
|
CP0864071
|
4-((N-Isopentylacrylamido)methyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide
Show/Hide
|
C32H34N6O2
|
1
|
| 1 |
GI50 = 3940 nM
|
|
|
|
CP0899397
|
3-(Acrylamidomethyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide
Show/Hide
|
C27H24N6O2
|
1
|
| 1 |
GI50 = 4750 nM
|
|
|
|
CP0945316
|
N-(4-Methyl-3-((1-nicotinoylpiperidin-4-yl)oxy)phenyl)benzo[d]-[1,3]dioxole-5-carboxamide
Show/Hide
|
C26H25N3O5
|
1
|
| 1 |
GI50 = 4800 nM
|
|
|
|
CP0909467
|
N1-(4-Chloro-3-(trifluoromethyl)phenyl)-N3-(3-(5-(methylcarbamoyl)pyridin-3-yl)-1H-indazol-6-yl)malonamide
Show/Hide
|
C24H18ClF3N6O3
|
2
|
| 1 |
GI50 = 4840 nM
|
|
|
| 2 |
GI50 > 10000 nM
|
|
|
|
CP0867480
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N-(4-Methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)-4-propionamidobenzamide
Show/Hide
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C26H24N6O2
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1
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| 1 |
GI50 = 4940 nM
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CP0883780
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4-(((2-(Dimethylamino)ethyl)amino)methyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide
Show/Hide
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C28H31N7O
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1
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| 1 |
GI50 = 5000 nM
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CP0953406
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4-((N-(2-(Diethylamino)ethyl)acrylamido)methyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide
Show/Hide
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C33H37N7O2
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1
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| 1 |
GI50 = 5140 nM
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CP0903825
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N-(4-Methyl-3-((1-nicotinoylpiperidin-4-yl)oxy)phenyl)quinoline-3-carboxamide
Show/Hide
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C28H26N4O3
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1
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| 1 |
GI50 = 5550 nM
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CP0941817
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4-((N-(2-(Dimethylamino)ethyl)butyramido)methyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide
Show/Hide
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C32H37N7O2
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1
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| 1 |
GI50 = 5750 nM
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CP0911799
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4-((N-(2-(Dimethylamino)ethyl)isobutyramido)methyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide
Show/Hide
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C32H37N7O2
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1
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| 1 |
GI50 = 6110 nM
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CP0905333
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(E)-N1-(3-(4-Methylpiperazin-1-yl)phenyl)-N3-(3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)malonamide
Show/Hide
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C28H29N7O2
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2
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| 1 |
GI50 = 6170 nM
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| 2 |
GI50 > 10000 nM
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CP0875440
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N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)-4-(propionamidomethyl)benzamide
Show/Hide
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C27H26N6O2
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1
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| 1 |
GI50 = 6220 nM
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CP0868803
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N-(2-(2-Methyl-5-(3-(trifluoromethyl)benzamido)phenoxy)ethyl)-nicotinamide
Show/Hide
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C23H20F3N3O3
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1
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| 1 |
GI50 = 7940 nM
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CP0903824
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N-(3-((1-Nicotinoylpiperidin-3-yl)oxy)phenyl)-3-(trifluoromethyl)-benzamide
Show/Hide
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C25H22F3N3O3
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1
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| 1 |
GI50 = 8070 nM
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CP0853244
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N-(2-(2-Methyl-5-(3-(trifluoromethyl)benzamido)phenoxy)ethyl)-isoxazole-5-carboxamide
Show/Hide
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C21H18F3N3O4
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1
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| 1 |
GI50 = 9970 nM
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CP0853245
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N-(3-((1-(Isoxazole-5-carbonyl)piperidin-3-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide
Show/Hide
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C23H20F3N3O4
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1
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| 1 |
GI50 > 10000 nM
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CP0881889
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N-(4-Methoxy-3-((1-nicotinoylpiperidin-4-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide
Show/Hide
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C26H24F3N3O4
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1
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| 1 |
GI50 > 10000 nM
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CP0917563
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N-(3-((1-(Isoxazole-5-carbonyl)piperidin-4-yl)oxy)-4-methylphenyl)-6-(trifluoromethyl)picolinamide
Show/Hide
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C23H21F3N4O4
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1
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| 1 |
GI50 > 10000 nM
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CP0963776
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N-(4-Methyl-3-((1-nicotinoylpiperidin-4-yl)oxy)phenyl)-6-(trifluoromethyl)picolinamide
Show/Hide
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C25H23F3N4O3
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1
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| 1 |
GI50 > 10000 nM
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CP0883937
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N-(4-Methoxy-3-((1-nicotinoylpiperidin-4-yl)oxy)phenyl)-4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)benzamide
Show/Hide
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C32H36F3N5O4
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1
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| 1 |
GI50 > 10000 nM
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CP0226713
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1-cyclopentyl-3-[4-(3-methyl-2H-pyrazolo[3,4-b]pyridin-4-yl)phenyl]urea
Show/Hide
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C19H21N5O
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1
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| 1 |
GI50 > 10000 nM
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CP0226718
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1-(3-methylphenyl)-3-[4-[3-(trifluoromethyl)-2H-pyrazolo[3,4-b]pyridin-4-yl]phenyl]urea
Show/Hide
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C21H16F3N5O
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1
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| 1 |
GI50 > 10000 nM
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CP0228997
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1-(2-fluoro-5-methylphenyl)-3-[4-(3-methyl-6-oxo-2,7-dihydropyrazolo[3,4-b]pyridin-4-yl)phenyl]urea
Show/Hide
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C21H18FN5O2
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1
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| 1 |
GI50 > 10000 nM
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CP0326453
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1-(2-fluoro-5-methylphenyl)-3-[4-(3-methyl-6-oxo-2,4,5,7-tetrahydropyrazolo[3,4-b]pyridin-4-yl)phenyl]urea
Show/Hide
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C21H20FN5O2
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1
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| 1 |
GI50 > 10000 nM
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CP0080859
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N-[2-(dimethylamino)ethyl]-N-[[4-[[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]carbamoyl]phenyl]methyl]pyridine-3-carboxamide
Show/Hide
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C34H34N8O2
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1
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| 1 |
GI50 > 10000 nM
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CP0218115
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US8586600, II-6
Show/Hide
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C27H24N6O2
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1
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| 1 |
GI50 > 10000 nM
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CP0867481
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N-(2-Hydroxyethyl)-N-(4-((4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)carbamoyl)benzyl)nicotinamide
Show/Hide
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C32H29N7O3
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1
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| 1 |
GI50 > 10000 nM
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CP0867482
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N-(2-(Dimethylamino)ethyl)-N-(4-((4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)carbamoyl)benzyl)isoxazole-5-carboxamide
Show/Hide
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C32H32N8O3
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1
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| 1 |
GI50 > 10000 nM
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CP0874420
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4-((2-(Dimethylamino)-N-(2-(dimethylamino)ethyl)acetamido)methyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide
Show/Hide
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C32H38N8O2
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1
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| 1 |
GI50 > 10000 nM
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CP0875470
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N-(4-((4-Methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)carbamoyl)benzyl)-N-(2-(pyrrolidin-1-yl)ethyl)nicotinamide
Show/Hide
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C36H36N8O2
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1
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| 1 |
GI50 > 10000 nM
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CP0887639
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N-(2-(Dimethylamino)ethyl)-N-(4-((4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)carbamoyl)benzyl)thiophene-2-carboxamide
Show/Hide
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C33H33N7O2S
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1
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| 1 |
GI50 > 10000 nM
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CP0891169
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4-((N-(2-(Dimethylamino)ethyl)acrylamido)methyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide
Show/Hide
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C31H33N7O2
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1
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| 1 |
GI50 > 10000 nM
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CP0891178
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(E)-4-((N-(2-(Dimethylamino)ethyl)but-2-enamido)methyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide
Show/Hide
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C32H35N7O2
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1
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| 1 |
GI50 > 10000 nM
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CP0899399
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4-((2-(Dimethylamino)-N-(2-hydroxyethyl)acetamido)methyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide
Show/Hide
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C30H33N7O3
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1
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| 1 |
GI50 > 10000 nM
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CP0906649
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N-(2-(Diethylamino)ethyl)-N-(4-((4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)carbamoyl)benzyl)nicotinamide
Show/Hide
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C36H38N8O2
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1
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| 1 |
GI50 > 10000 nM
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CP0911792
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4-((N-(2-(Dimethylamino)ethyl)cyclopropanecarboxamido)methyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide
Show/Hide
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C32H35N7O2
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1
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| 1 |
GI50 > 10000 nM
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CP0942328
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4-((N-(2-(Dimethylamino)ethyl)propionamido)methyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide
Show/Hide
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C31H35N7O2
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1
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| 1 |
GI50 > 10000 nM
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CP0955464
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N-(2-(Dimethylamino)ethyl)-4-methyl-N-(4-((4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)carbamoyl)benzyl)benzamide
Show/Hide
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C36H37N7O2
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1
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| 1 |
GI50 > 10000 nM
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CP0869387
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N-(1-(4-(3-(3-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-ureido)phenyl)piperidin-4-yl)propionamide
Show/Hide
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C32H35N5O5
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1
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| 1 |
GI50 > 10000 nM
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CP0958477
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N-(3-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-N-(4-(4-propionamidopiperidin-1-yl)-3-(trifluoromethyl)phenyl)-cyclopropane 1,1-Dicarboxamide
Show/Hide
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C37H38F3N5O6
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1
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| 1 |
GI50 > 10000 nM
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CP0922099
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N-(4-Methyl-3-((1-nicotinoylpiperidin-4-yl)oxy)phenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide
Show/Hide
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C31H37N5O3
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1
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| 1 |
GI50 > 5000 nM
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CP0388620
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methyl N-[4-[7-amino-3-(3,4-dimethoxyphenyl)-5-(1-methylpiperidin-4-yl)oxypyrazolo[1,5-a]pyrimidin-6-yl]phenyl]carbamate
Show/Hide
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C28H32N6O5
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1
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| 1 |
IC50 = 20 nM
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CP0418567
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3-[4-amino-7-[3-(hydroxymethyl)cyclobutyl]pyrrolo[2,3-d]pyrimidin-5-yl]phenol
Show/Hide
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C17H18N4O2
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1
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| 1 |
IC50 = 42 nM
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CP0061016
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3-(4-Amino-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-phenol
Show/Hide
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C17H18N4O
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1
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| 1 |
IC50 = 43 nM
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CP0385508
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2-[4-[4-[6-[(2R)-2-(3-fluorophenyl)pyrrolidin-1-yl]imidazo[1,2-b]pyridazin-3-yl]pyridin-2-yl]piperazin-1-yl]acetic acid
Show/Hide
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C27H28FN7O2
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1
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| 1 |
IC50 = 790 nM
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CP0388616
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3-(3,4-dimethoxyphenyl)-5-(1-methylpiperidin-4-yl)oxy-6-phenylpyrazolo[1,5-a]pyrimidin-7-amine
Show/Hide
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C26H29N5O3
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1
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| 1 |
IC50 = 910 nM
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CP0388615
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3-(3,4-dimethoxyphenyl)-5-(1-methylpiperidin-4-yl)oxy-6-(1,3-thiazol-2-yl)pyrazolo[1,5-a]pyrimidin-7-amine
Show/Hide
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C23H26N6O3S
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1
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| 1 |
IC50 = 1600 nM
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CP0388864
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4-[6-(benzylamino)imidazo[1,2-b]pyridazin-3-yl]benzonitrile
Show/Hide
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C20H15N5
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1
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| 1 |
IC50 = 2200 nM
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CP0661487
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3-(2,6-Dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea monophosphate
Show/Hide
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C26H34Cl2N7O7P
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1
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| 1 |
IC50 = 2501 nM
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CP0138866
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1-[4-[3-[4-amino-5-(2-fluoro-5-hydroxyphenyl)pyrrolo[2,3-d]pyrimidin-7-yl]cyclobutyl]piperazin-1-yl]ethanone
Show/Hide
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C22H25FN6O2
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1
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| 1 |
IC50 = 3400 nM
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CP0395047
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6-[(2R)-2-(3-fluorophenyl)pyrrolidin-1-yl]-3-pyridin-2-ylimidazo[1,2-b]pyridazine
Show/Hide
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C21H18FN5
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1
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| 1 |
IC50 = 5500 nM
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CP0385511
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1-[4-[6-[(2R)-2-(3-fluorophenyl)pyrrolidin-1-yl]imidazo[1,2-b]pyridazin-3-yl]pyridin-2-yl]piperidin-4-ol
Show/Hide
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C26H27FN6O
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1
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| 1 |
IC50 = 7000 nM
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