Brief Information of the Compound and Protein
Compound Name
(R)-2-Amino-N-(1-(4-(3-(3-((6,7-dimethoxyquinolin-4-yl)-oxy)phenyl)ureido)-2-(trifluoromethyl)phenyl)piperidin-4-yl)-propanamide hydrochloride
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PubChem ID
CID: 155533566
Canonical SMILES
COc1cc2nccc(Oc3cccc(NC(=O)Nc4ccc(N5CCC(NC(=O)[C@H](C)N)CC5)c(C(F)(F)F)c4)c3)c2cc1OC.Cl
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Compound Formula C33H36ClF3N6O5
Compound Structure
Protein Name
Mast/stem cell growth factor receptor Kit
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase PDGFR family
Uniprot ID
P10721
Gene Name
KIT
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000077 Ba/F3 Mus musculus (Mouse)  2
1
GI50 = 120 nM
   TI
   LI
   LO
   TS
2
GI50 = 480 nM
   TI
   LI
   LO
   TS