Brief Information of the Compound and Protein
Compound Name
 Compound Info 
N-[[1-[4-[[3-(6,7-dimethoxyquinolin-4-yl)oxyphenyl]carbamoylamino]-2-(trifluoromethyl)phenyl]piperidin-4-yl]methyl]propanamide
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 PubChem ID
CID: 132520995
Canonical SMILES
CCC(=O)NCC1CCN(CC1)c1ccc(NC(=O)Nc2cccc(Oc3ccnc4cc(OC)c(OC)cc34)c2)cc1C(F)(F)F
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Compound Formula C34H36F3N5O5
Compound Structure
Protein Name
 Protein Info 
Mast/stem cell growth factor receptor Kit
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase PDGFR family
Uniprot ID
P10721
Gene Name
KIT
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000077 Ba/F3
 Cell Line Info 
Mus musculus (Mouse)  7
1
GI50 = 40 nM
   TI
   LI
   LO
   TS
2
GI50 = 57 nM
   TI
   LI
   LO
   TS
3
GI50 = 63 nM
   TI
   LI
   LO
   TS
4
GI50 = 73 nM
   TI
   LI
   LO
   TS
5
GI50 = 320 nM
   TI
   LI
   LO
   TS
6
GI50 = 360 nM
   TI
   LI
   LO
   TS
7
GI50 = 670 nM
   TI
   LI
   LO
   TS
CL000854 GIST-5R
 Cell Line Info 
Homo sapiens (Human)  2
1
EC50 < 100 nM
   TI
   LI
   LO
   TS
2
GI50 = 26 nM
   TI
   LI
   LO
   TS
CL000122 GIST-T1
 Cell Line Info 
Homo sapiens (Human)  2
1
EC50 < 100 nM
   TI
   LI
   LO
   TS
2
GI50 = 4 nM
   TI
   LI
   LO
   TS
CL000013 Sf9
 Cell Line Info 
Spodoptera frugiperda (Fall armyworm)  2
1
IC50 = 33 nM
   TI
   LI
   LO
   TS
2
IC50 = 99 nM
   TI
   LI
   LO
   TS