Brief Information of the Compound and Protein
Compound Name
 Compound Info 
1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-5-methyl-phenyl)urea
    Show/Hide
 PubChem ID
CID: 11485656
SID: 16587270
Canonical SMILES
Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)-c2cccc3[nH]nc(N)c23)c1
    Show/Hide
Compound Formula C21H18FN5O
Compound Structure
Protein Name
 Protein Info 
Mast/stem cell growth factor receptor Kit
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase PDGFR family
Uniprot ID
P10721
Gene Name
KIT
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000077 Ba/F3
 Cell Line Info 
Mus musculus (Mouse)  2
1
GI50 = 37.1 nM
   TI
   LI
   LO
   TS
2
GI50 = 88.7 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 14 nM
2 IC50 = 16 nM
3 Kd = 1.7 nM
4 Kd = 1.9 nM
5 Kd = 2 nM
6 Kd = 3.8 nM
7 Kd = 17 nM
8 Kd = 21 nM
9 Kd = 81 nM
10 Kd = 1100 nM