Bioactivity Information

Brief Information of the Compound and Protein

Compound Name

Compound Info

N-(3-fluorophenyl)-N'-[3-[(E)-2-pyridin-2-ylethenyl]-1H-indazol-6-yl]propanediamide

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PubChem ID

CID: 138454794

Canonical SMILES	Fc1cccc(NC(=O)CC(=O)Nc2ccc3c(\C=C\c4ccccn4)n[nH]c3c2)c1 Show/Hide
Compound Formula	C23H18FN5O2

Compound Structure

Protein Name

Protein Info

Mast/stem cell growth factor receptor Kit

Protein Classification

Enzyme

Kinase

Protein Kinase

TK protein kinase group

Tyrosine protein kinase PDGFR family

Uniprot ID

P10721

Gene Name

KIT

Table of Molecular Bioactivities Related to the Compound and Protein

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000077	Ba/F3 Cell Line Info	Mus musculus (Mouse)	19
1	EC50 = 34 nM	TI LI LO TS
2	EC50 = 77 nM	TI LI LO TS
3	EC50 = 750 nM	TI LI LO TS
4	EC50 = 1000 nM	TI LI LO TS
5	EC50 > 1000 nM	TI LI LO TS
6	GI50 = 8 nM	TI LI LO TS
7	GI50 = 26 nM	TI LI LO TS
8	GI50 = 31 nM	TI LI LO TS
9	GI50 = 44 nM	TI LI LO TS
10	GI50 = 122 nM	TI LI LO TS
11	GI50 = 157 nM	TI LI LO TS
12	GI50 = 265 nM	TI LI LO TS
13	GI50 = 525 nM	TI LI LO TS
14	GI50 = 868 nM	TI LI LO TS
15	GI50 = 1150 nM	TI LI LO TS
16	GI50 = 3460 nM	TI LI LO TS
17	GI50 = 6000 nM	TI LI LO TS
18	GI50 = 6060 nM	TI LI LO TS
19	GI50 = 6840 nM	TI LI LO TS
CL000725	COLO 320DM Cell Line Info	Homo sapiens (Human)	3
1	EC50 = 1430 nM	TI LI LO TS
2	EC50 = 1810 nM	TI LI LO TS
3	EC50 = 2050 nM	TI LI LO TS
CL000013	Sf9 Cell Line Info	Spodoptera frugiperda (Fall armyworm)	2
1	IC50 = 45 nM	TI LI LO TS
2	IC50 = 536 nM	TI LI LO TS