Bioactivity Information | MolBiC

Brief Information of the Compound and Protein

Compound Name

Compound Info

AG-013736

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PubChem ID

CID: 6450551

SID: 26683791

Canonical SMILES	CNC(=O)c1ccccc1Sc1ccc2c(\C=C\c3ccccn3)n[nH]c2c1 Show/Hide
Compound Formula	C22H18N4OS

Compound Structure

Protein Name

Protein Info

Mast/stem cell growth factor receptor Kit

Protein Classification

Enzyme

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Kinase

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Protein Kinase

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TK protein kinase group

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Tyrosine protein kinase PDGFR family

Uniprot ID

P10721

Gene Name

KIT

Table of Molecular Bioactivities Related to the Compound and Protein

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000077	Ba/F3 Cell Line Info	Mus musculus (Mouse)	14
1	GI50 = 2 nM	TI LI LO TS
2	GI50 = 5 nM	TI LI LO TS
3	GI50 = 7 nM	TI LI LO TS
4	GI50 = 12 nM	TI LI LO TS
5	GI50 = 13 nM	TI LI LO TS
6	GI50 = 14 nM	TI LI LO TS
7	GI50 = 105 nM	TI LI LO TS
8	GI50 = 108 nM	TI LI LO TS
9	GI50 = 129 nM	TI LI LO TS
10	GI50 = 156 nM	TI LI LO TS
11	GI50 = 406 nM	TI LI LO TS
12	GI50 = 1720 nM	TI LI LO TS
13	GI50 = 1820 nM	TI LI LO TS
14	GI50 = 2020 nM	TI LI LO TS

Biochemical Assays

1	Kd = 0.49 nM
2	Kd = 1.4 nM
3	Kd = 1.7 nM
4	Kd = 3.2 nM
5	Kd = 3.5 nM
6	Kd = 3.7 nM
7	Kd = 13 nM
8	Kd = 1300 nM
9	Kd = 1800 nM
10	Kd = 4200 nM