Brief Information of the Compound and Protein
Compound Name
N-[4-methyl-3-[1-(6-methylpyridine-3-carbonyl)piperidin-4-yl]oxyphenyl]-4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)benzamide
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PubChem ID
CID: 132546210
Canonical SMILES
CN1CCN(Cc2ccc(cc2C(F)(F)F)C(=O)Nc2ccc(C)c(OC3CCN(CC3)C(=O)c3ccc(C)nc3)c2)CC1
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Compound Formula C33H38F3N5O3
Compound Structure
Protein Name
Mast/stem cell growth factor receptor Kit
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase PDGFR family
Uniprot ID
P10721
Gene Name
KIT
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000077 Ba/F3 Mus musculus (Mouse)  9
1
GI50 = 78 nM
   TI
   LI
   LO
   TS
2
GI50 = 124 nM
   TI
   LI
   LO
   TS
3
GI50 = 149 nM
   TI
   LI
   LO
   TS
4
GI50 = 221 nM
   TI
   LI
   LO
   TS
5
GI50 = 1010 nM
   TI
   LI
   LO
   TS
6
GI50 = 1840 nM
   TI
   LI
   LO
   TS
7
GI50 = 1850 nM
   TI
   LI
   LO
   TS
8
GI50 = 2870 nM
   TI
   LI
   LO
   TS
9
GI50 = 5060 nM
   TI
   LI
   LO
   TS