Brief Information of the Compound and Protein
Compound Name
 Compound Info 
1-(3-methyl-4-morpholin-4-ylphenyl)-3-[4-(3-methyl-2H-pyrazolo[3,4-b]pyridin-4-yl)phenyl]urea
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 PubChem ID
CID: 132585195
Canonical SMILES
Cc1n[nH]c2nccc(-c3ccc(NC(=O)Nc4ccc(N5CCOCC5)c(C)c4)cc3)c12
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Compound Formula C25H26N6O2
Compound Structure
Protein Name
 Protein Info 
Mast/stem cell growth factor receptor Kit
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase PDGFR family
Uniprot ID
P10721
Gene Name
KIT
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000077 Ba/F3
 Cell Line Info 
Mus musculus (Mouse)  12
1
GI50 = 10.5 nM
   TI
   LI
   LO
   TS
2
GI50 = 10.6 nM
   TI
   LI
   LO
   TS
3
GI50 = 11.1 nM
   TI
   LI
   LO
   TS
4
GI50 = 11.6 nM
   TI
   LI
   LO
   TS
5
GI50 = 18.1 nM
   TI
   LI
   LO
   TS
6
GI50 = 36.4 nM
   TI
   LI
   LO
   TS
7
GI50 = 39.2 nM
   TI
   LI
   LO
   TS
8
GI50 = 96.5 nM
   TI
   LI
   LO
   TS
9
GI50 = 134.1 nM
   TI
   LI
   LO
   TS
10
GI50 = 136.5 nM
   TI
   LI
   LO
   TS
11
GI50 = 330.3 nM
   TI
   LI
   LO
   TS
12
GI50 > 10000 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 2.4 nM