Brief Information of the Compound and Protein
Compound Name
 Compound Info 
4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]-3-fluorophenoxy]-N-methylpyridine-2-carboxamide
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 PubChem ID
CID: 11167602
SID: 123055398
Canonical SMILES
CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)c(F)c2)ccn1
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Compound Formula C21H15ClF4N4O3
Compound Structure
Protein Name
 Protein Info 
Mast/stem cell growth factor receptor Kit
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase PDGFR family
Uniprot ID
P10721
Gene Name
KIT
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000077 Ba/F3
 Cell Line Info 
Mus musculus (Mouse)  16
1
GI50 = 21 nM
   TI
   LI
   LO
   TS
2
GI50 = 33 nM
   TI
   LI
   LO
   TS
3
GI50 = 47 nM
   TI
   LI
   LO
   TS
4
GI50 = 49 nM
   TI
   LI
   LO
   TS
5
GI50 = 63 nM
   TI
   LI
   LO
   TS
6
GI50 = 94 nM
   TI
   LI
   LO
   TS
7
GI50 = 108 nM
   TI
   LI
   LO
   TS
8
GI50 = 114 nM
   TI
   LI
   LO
   TS
9
GI50 = 231 nM
   TI
   LI
   LO
   TS
10
GI50 = 290 nM
   TI
   LI
   LO
   TS
11
GI50 = 549 nM
   TI
   LI
   LO
   TS
12
GI50 = 833 nM
   TI
   LI
   LO
   TS
13
GI50 = 834 nM
   TI
   LI
   LO
   TS
14
GI50 = 943 nM
   TI
   LI
   LO
   TS
15
GI50 = 1270 nM
   TI
   LI
   LO
   TS
16
GI50 = 2371 nM
   TI
   LI
   LO
   TS
CL000123 GIST430
 Cell Line Info 
Homo sapiens (Human)  1
1
GI50 = 3000 nM
   TI
   LI
   LO
   TS
CL000013 Sf9
 Cell Line Info 
Spodoptera frugiperda (Fall armyworm)  1
1
IC50 = 116 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 6.1 nM
2 IC50 = 7 nM