Brief Information of the Compound and Protein
Compound Name
1-[4-(3-methyl-2H-pyrazolo[3,4-b]pyridin-4-yl)phenyl]-3-quinolin-3-ylurea
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PubChem ID
CID: 137653919
Canonical SMILES
Cc1n[nH]c2nccc(-c3ccc(NC(=O)Nc4cnc5ccccc5c4)cc3)c12
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Compound Formula C23H18N6O
Compound Structure
Protein Name
Mast/stem cell growth factor receptor Kit
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase PDGFR family
Uniprot ID
P10721
Gene Name
KIT
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000077 Ba/F3 Mus musculus (Mouse)  2
1
GI50 = 83.3 nM
   TI
   LI
   LO
   TS
2
GI50 = 217.3 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 1.9 nM