Brief Information of the Compound and Protein
Compound Name
N1-(4-Chloro-3-(trifluoromethyl)phenyl)-N3-(3-(4-(4-methylpiperazin-1-yl)phenyl)-1H-indazol-6-yl)malonamide
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PubChem ID
CID: 155569613
Canonical SMILES
CN1CCN(c2ccc(-c3n[nH]c4cc(NC(=O)CC(=O)Nc5ccc(Cl)c(C(F)(F)F)c5)ccc34)cc2)CC1
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Compound Formula C28H26ClF3N6O2
Compound Structure
Protein Name
Mast/stem cell growth factor receptor Kit
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase PDGFR family
Uniprot ID
P10721
Gene Name
KIT
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000077 Ba/F3 Mus musculus (Mouse)  2
1
GI50 = 12 nM
   TI
   LI
   LO
   TS
2
GI50 = 25 nM
   TI
   LI
   LO
   TS