| Compound ID |
Compound Name |
Compound Formula |
|
CP0226504
|
[(1R,2R,6R,10R,11R,13R,15R,17R)-13-benzyl-6-hydroxy-4,17-dimethyl-5-oxo-15-prop-1-en-2-yl-12,14,18-trioxapentacyclo[11.4.1.01,10.02,6.011,15]octadeca-3,8-dien-8-yl]methyl 2-(4-hydroxy-3-methoxyphenyl)acetate
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|
C37H40O9
|
3
|
| 1 |
Activity = 0.356 nM
|
|
|
| 2 |
Activity = 1.14 nM
|
|
|
| 3 |
Kd = 1.23 nM
|
|
|
|
CP0890389
|
1-((2-(4-(methyl-[3H])piperidin-1-yl-4-[3H])-6-(trifluoromethyl)pyridin-3-yl)-methyl)-3-(3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-8-yl)urea
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|
C22H24F3N5O3
|
3
|
| 1 |
Activity = 0.518 nM
|
|
|
| 2 |
Activity = 0.534 nM
|
|
|
| 3 |
Kd = 0.59 nM
|
|
|
|
CP0222429
|
RESINIFERATOXIN
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|
C37H40O9
|
2
|
| 1 |
EC50 = 0.92 nM
|
|
|
| 2 |
Ki = 1.23 nM
|
|
|
|
CP0414764
|
[(2R)-2-[(4-tert-butylphenyl)methyl]-3-[(4-hydroxy-3-methoxyphenyl)methylcarbamothioylamino]propyl] 2,2-dimethylpropanoate
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|
C28H40N2O4S
|
2
|
| 1 |
EC50 = 0.99 nM
|
|
|
| 2 |
Ki = 3.06 nM
|
|
|
|
CP0434050
|
2,2-Dimethyl-propionic acid 2-(4-tert-butyl-benzyl)-3-[3-(4-hydroxy-3-methoxy-benzyl)-thioureido]-propyl ester
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|
C28H40N2O4S
|
2
|
| 1 |
EC50 = 1.34 nM
|
|
|
| 2 |
Ki = 6.1 nM
|
|
|
|
CP0330503
|
(2S)-2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
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|
C23H28F4N4O3S
|
8
|
| 1 |
EC50 = 2.22 nM
|
|
|
| 2 |
IC50 = 6.3 nM
|
|
|
| 3 |
Ki = 0.2 nM
|
|
|
| 4 |
Ki = 0.3 nM
|
|
|
| 5 |
Ki = 1.26 nM
|
|
|
| 6 |
Ki = 2.94 nM
|
|
|
| 7 |
Ki = 2.95 nM
|
|
|
| 8 |
Ki = 7.9 nM
|
|
|
|
CP0487425
|
1-[[2-(dipropylamino)-6-(trifluoromethyl)pyridin-3-yl]methyl]-3-(1-oxo-2H-isoquinolin-5-yl)urea
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|
C23H26F3N5O2
|
1
|
| 1 |
EC50 = 2.79 nM
|
|
|
|
CP0512476
|
1-(1-oxo-2H-isoquinolin-5-yl)-3-[[2-(3-propan-2-ylphenyl)-6-(trifluoromethyl)pyridin-3-yl]methyl]urea
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|
C26H23F3N4O2
|
1
|
| 1 |
EC50 = 3.07 nM
|
|
|
|
CP0487435
|
1-[[2-(4-benzylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]-3-(1-oxo-2H-isoquinolin-5-yl)urea
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|
C29H28F3N5O2
|
1
|
| 1 |
EC50 = 5.81 nM
|
|
|
|
CP0447073
|
(4-amino-3-methoxyphenyl) [(1R,2R,6R,10S,11R,13S,15R,17R)-13-benzyl-6-hydroxy-4,17-dimethyl-5-oxo-15-prop-1-en-2-yl-12,14,18-trioxapentacyclo[11.4.1.01,10.02,6.011,15]octadeca-3,8-dien-8-yl]methyl carbonate
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|
C36H39NO9
|
2
|
| 1 |
EC50 = 6.28 nM
|
|
|
| 2 |
Ki = 140 nM
|
|
|
|
CP0536351
|
N-[[2-[4-benzyl-4-(dimethylamino)piperidin-1-yl]-4-(trifluoromethyl)phenyl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
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|
C32H38F4N4O3S
|
2
|
| 1 |
EC50 = 8.2 nM
|
|
|
| 2 |
Ki = 3.79 nM
|
|
|
|
CP0536350
|
1-[[2-[4-benzyl-4-(dimethylamino)piperidin-1-yl]-4-(trifluoromethyl)phenyl]methyl]-3-isoquinolin-5-ylurea
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|
C32H34F3N5O
|
2
|
| 1 |
EC50 = 8.8 nM
|
|
|
| 2 |
Ki = 0.67 nM
|
|
|
|
CP0468924
|
1-[[2-[4-benzyl-4-(dimethylamino)piperidin-1-yl]-4-(trifluoromethyl)phenyl]methyl]-3-(7-hydroxynaphthalen-1-yl)urea
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|
C33H35F3N4O2
|
2
|
| 1 |
EC50 = 8.9 nM
|
|
|
| 2 |
Ki = 0.46 nM
|
|
|
|
CP0461819
|
[(2S)-2-[(4-tert-butylphenyl)methyl]-3-[(4-hydroxy-3-methoxyphenyl)methylcarbamothioylamino]propyl] 2,2-dimethylpropanoate
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|
C28H40N2O4S
|
2
|
| 1 |
EC50 = 9.55 nM
|
|
|
| 2 |
Ki = 6.58 nM
|
|
|
|
CP0512475
|
1-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]-3-(1-oxo-2H-isoquinolin-5-yl)urea
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|
C23H24F3N5O2
|
2
|
| 1 |
EC50 = 9.59 nM
|
|
|
| 2 |
Ki = 35.3 nM
|
|
|
|
CP0538570
|
1-[[5-tert-butyl-2-(3-chlorophenyl)pyrazol-3-yl]methyl]-3-(1-oxo-2H-isoquinolin-5-yl)urea
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|
C24H24ClN5O2
|
1
|
| 1 |
EC50 = 9.59 nM
|
|
|
|
CP0470977
|
1-[[2-[4-benzyl-4-(dimethylamino)piperidin-1-yl]-4-(trifluoromethyl)phenyl]methyl]-3-(7-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl)urea
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|
C33H39F3N4O2
|
2
|
| 1 |
EC50 = 10.1 nM
|
|
|
| 2 |
Ki = 0.95 nM
|
|
|
|
CP0533905
|
1-(1-oxo-2H-isoquinolin-5-yl)-3-[[2-piperidin-1-yl-6-(trifluoromethyl)pyridin-3-yl]methyl]urea
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|
C22H22F3N5O2
|
1
|
| 1 |
EC50 = 13.2 nM
|
|
|
|
CP0512473
|
1-[[2-(cyclopentylmethoxy)-6-(trifluoromethyl)pyridin-3-yl]methyl]-3-(1-oxo-2H-isoquinolin-5-yl)urea
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|
C23H23F3N4O3
|
1
|
| 1 |
EC50 = 15.5 nM
|
|
|
|
CP0404349
|
[(1R,2R,6R,10S,11R,13S,15R,17R)-13-benzyl-6-hydroxy-4,17-dimethyl-5-oxo-15-prop-1-en-2-yl-12,14,18-trioxapentacyclo[11.4.1.01,10.02,6.011,15]octadeca-3,8-dien-8-yl]methyl (3-fluoro-4-hydroxy-5-methoxyphenyl) carbonate
Show/Hide
|
C36H37FO10
|
2
|
| 1 |
EC50 = 16.3 nM
|
|
|
| 2 |
Ki = 138 nM
|
|
|
|
CP0386212
|
[(1R,2R,6R,10S,11R,13S,15R,17R)-13-benzyl-6-hydroxy-4,17-dimethyl-5-oxo-15-prop-1-en-2-yl-12,14,18-trioxapentacyclo[11.4.1.01,10.02,6.011,15]octadeca-3,8-dien-8-yl]methyl [4-(methanesulfonamido)-3-methoxyphenyl] carbonate
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|
C37H41NO11S
|
2
|
| 1 |
EC50 = 16.5 nM
|
|
|
| 2 |
Ki = 82 nM
|
|
|
|
CP0397472
|
(4-amino-3-fluoro-5-methoxyphenyl) [(1R,2R,6R,10S,11R,13S,15R,17R)-13-benzyl-6-hydroxy-4,17-dimethyl-5-oxo-15-prop-1-en-2-yl-12,14,18-trioxapentacyclo[11.4.1.01,10.02,6.011,15]octadeca-3,8-dien-8-yl]methyl carbonate
Show/Hide
|
C36H38FNO9
|
2
|
| 1 |
EC50 = 17.9 nM
|
|
|
| 2 |
Ki = 830 nM
|
|
|
|
CP0470975
|
1-[[2-[4-benzyl-4-(dimethylamino)piperidin-1-yl]-4-(trifluoromethyl)phenyl]methyl]-3-isoquinolin-8-ylurea
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|
C32H34F3N5O
|
2
|
| 1 |
EC50 = 18.68 nM
|
|
|
| 2 |
Ki = 12.3 nM
|
|
|
|
CP0470979
|
1-[[2-[4-benzyl-4-(dimethylamino)piperidin-1-yl]-4-(trifluoromethyl)phenyl]methyl]-3-[3-fluoro-4-(methanesulfonamidomethyl)phenyl]urea
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|
C31H37F4N5O3S
|
2
|
| 1 |
EC50 = 25 nM
|
|
|
| 2 |
Ki = 16.4 nM
|
|
|
|
CP0383001
|
1-[[2-[4-benzyl-4-(dimethylamino)piperidin-1-yl]-4-(trifluoromethyl)phenyl]methyl]-3-(2-oxo-1H-quinolin-5-yl)urea
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|
C32H34F3N5O2
|
2
|
| 1 |
EC50 = 30.6 nM
|
|
|
| 2 |
Ki = 1.67 nM
|
|
|
|
CP0470715
|
1-[[2-[4-benzyl-4-(dimethylamino)piperidin-1-yl]-4-(trifluoromethyl)phenyl]methyl]-3-(2,3-dihydro-1-benzofuran-6-yl)urea
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|
C31H35F3N4O2
|
2
|
| 1 |
EC50 = 31.3 nM
|
|
|
| 2 |
Ki = 41.4 nM
|
|
|
|
CP0383002
|
1-[[2-[4-benzyl-4-(dimethylamino)piperidin-1-yl]-4-(trifluoromethyl)phenyl]methyl]-3-quinolin-5-ylurea
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|
C32H34F3N5O
|
2
|
| 1 |
EC50 = 32 nM
|
|
|
| 2 |
Ki = 10.8 nM
|
|
|
|
CP0487426
|
1-[[2-(3-chlorophenyl)-5-(trifluoromethyl)pyrazol-3-yl]methyl]-3-(1-oxo-2H-isoquinolin-5-yl)urea
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|
C21H15ClF3N5O2
|
1
|
| 1 |
EC50 = 41.4 nM
|
|
|
|
CP0470976
|
1-[[2-[4-benzyl-4-(dimethylamino)piperidin-1-yl]-4-(trifluoromethyl)phenyl]methyl]-3-quinolin-7-ylurea
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|
C32H34F3N5O
|
2
|
| 1 |
EC50 = 42 nM
|
|
|
| 2 |
Ki = 14.1 nM
|
|
|
|
CP0443799
|
1-[[2-[4-benzyl-4-(dimethylamino)piperidin-1-yl]-4-(trifluoromethyl)phenyl]methyl]-3-(1-oxo-2H-isoquinolin-5-yl)urea
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|
C32H34F3N5O2
|
2
|
| 1 |
EC50 = 43.7 nM
|
|
|
| 2 |
Ki = 111 nM
|
|
|
|
CP0049976
|
(6E)-N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methylnon-6-enamide
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|
C18H27NO3
|
3
|
| 1 |
EC50 = 44.8 nM
|
|
|
| 2 |
Ki = 1140 nM
|
|
|
| 3 |
Ki = 2530 nM
|
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|
|
CP0460555
|
1-[[2-[4-benzyl-4-(dimethylamino)piperidin-1-yl]-4-(trifluoromethyl)phenyl]methyl]-3-isoquinolin-7-ylurea
Show/Hide
|
C32H34F3N5O
|
2
|
| 1 |
EC50 = 56.1 nM
|
|
|
| 2 |
Ki = 7.33 nM
|
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|
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CP0492742
|
1-[[2-(cyclobutylmethoxy)-6-(trifluoromethyl)pyridin-3-yl]methyl]-3-(1-oxo-2H-isoquinolin-5-yl)urea
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|
C22H21F3N4O3
|
1
|
| 1 |
EC50 = 63.2 nM
|
|
|
|
CP0512474
|
1-[[2-cyclohexylsulfanyl-6-(trifluoromethyl)pyridin-3-yl]methyl]-3-(1-oxo-2H-isoquinolin-5-yl)urea
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|
C23H23F3N4O2S
|
1
|
| 1 |
EC50 = 69.3 nM
|
|
|
|
CP0570082
|
1-(1-oxo-2H-isoquinolin-5-yl)-3-[[2-phenylmethoxy-6-(trifluoromethyl)pyridin-3-yl]methyl]urea
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|
C24H19F3N4O3
|
1
|
| 1 |
EC50 = 78.6 nM
|
|
|
|
CP0517018
|
1-[[2-(2-methylpropoxy)-6-(trifluoromethyl)pyridin-3-yl]methyl]-3-(1-oxo-2H-isoquinolin-5-yl)urea
Show/Hide
|
C21H21F3N4O3
|
1
|
| 1 |
EC50 = 78.7 nM
|
|
|
|
CP0470972
|
1-[[2-[4-benzyl-4-(dimethylamino)piperidin-1-yl]-4-(trifluoromethyl)phenyl]methyl]-3-[3-fluoro-4-(hydroxymethyl)phenyl]urea
Show/Hide
|
C30H34F4N4O2
|
2
|
| 1 |
EC50 = 81 nM
|
|
|
| 2 |
Ki = 27.9 nM
|
|
|
|
CP0443801
|
1-[[2-[4-benzyl-4-(dimethylamino)piperidin-1-yl]-4-(trifluoromethyl)phenyl]methyl]-3-[[3-fluoro-4-(methanesulfonamido)phenyl]methyl]urea
Show/Hide
|
C31H37F4N5O3S
|
2
|
| 1 |
EC50 = 85.9 nM
|
|
|
| 2 |
Ki = 266 nM
|
|
|
|
CP0443798
|
1-[[2-[4-benzyl-4-(dimethylamino)piperidin-1-yl]-4-(trifluoromethyl)phenyl]methyl]-3-[3-fluoro-4-[(sulfamoylamino)methyl]phenyl]urea
Show/Hide
|
C30H36F4N6O3S
|
2
|
| 1 |
EC50 = 120 nM
|
|
|
| 2 |
Ki = 15.3 nM
|
|
|
|
CP0475186
|
1-[[2-[4-benzyl-4-(dimethylamino)piperidin-1-yl]-4-(trifluoromethyl)phenyl]methyl]-3-isoquinolin-6-ylurea
Show/Hide
|
C32H34F3N5O
|
2
|
| 1 |
EC50 = 156 nM
|
|
|
| 2 |
Ki = 62 nM
|
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|
|
CP0487429
|
1-[[2-butoxy-6-(trifluoromethyl)pyridin-3-yl]methyl]-3-(1-oxo-2H-isoquinolin-5-yl)urea
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|
C21H21F3N4O3
|
1
|
| 1 |
EC50 = 160 nM
|
|
|
|
CP0404347
|
[(1R,2R,6R,10S,11R,13S,15R,17R)-13-benzyl-6-hydroxy-4,17-dimethyl-5-oxo-15-prop-1-en-2-yl-12,14,18-trioxapentacyclo[11.4.1.01,10.02,6.011,15]octadeca-3,8-dien-8-yl]methyl (3-chloro-4-hydroxy-5-methoxyphenyl) carbonate
Show/Hide
|
C36H37ClO10
|
3
|
| 1 |
EC50 = 183 nM
|
|
|
| 2 |
Ki = 50 nM
|
|
|
| 3 |
Ki = 451 nM
|
|
|
|
CP0552918
|
1-(1-oxo-2H-isoquinolin-5-yl)-3-[[2-pyrrolidin-1-yl-6-(trifluoromethyl)pyridin-3-yl]methyl]urea
Show/Hide
|
C21H20F3N5O2
|
1
|
| 1 |
EC50 = 258 nM
|
|
|
|
CP0391842
|
(E)-3-(4-tert-Butyl-phenyl)-N-(4-hydroxy-3-methoxy-phenyl)-acrylamide
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|
C20H23NO3
|
1
|
| 1 |
EC50 = 440 nM
|
|
|
|
CP0492478
|
N-[(5-chloro-1,3-thiazol-2-yl)methyl]-1,2-benzothiazol-5-amine
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|
C11H8ClN3S2
|
1
|
| 1 |
EC50 > 15848.93 nM
|
|
|
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CP0538205
|
N-[(5-chloro-1-methylimidazol-2-yl)methyl]-1,2-benzothiazol-5-amine
Show/Hide
|
C12H11ClN4S
|
1
|
| 1 |
EC50 > 15848.93 nM
|
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|
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CP0538206
|
N-[(5-chloro-1,3-thiazol-2-yl)methyl]-1,2-benzothiazol-6-amine
Show/Hide
|
C11H8ClN3S2
|
1
|
| 1 |
EC50 > 15848.93 nM
|
|
|
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CP0548251
|
5-chloro-N-[(5-chloro-1,3-thiazol-2-yl)methyl]-1,2-benzothiazol-6-amine
Show/Hide
|
C11H7Cl2N3S2
|
1
|
| 1 |
EC50 > 15848.93 nM
|
|
|
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CP0208692
|
(2E)-3-(4-tert-butylphenyl)-N-(2,3-dihydro-1,4-benzodioxin-6-yl)prop-2-enamide
Show/Hide
|
C21H23NO3
|
1
|
| 1 |
EC50 > 4000 nM
|
|
|
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CP0377429
|
6-(4-tert-butylphenyl)-N-(2,3-dihydro-1,4-benzodioxin-6-yl)pyridazin-4-amine
Show/Hide
|
C22H23N3O2
|
1
|
| 1 |
EC50 > 4000 nM
|
|
|
|
CP0377430
|
7-({6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl}oxy)quinoline
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|
C20H12F3N3O
|
3
|
| 1 |
EC50 > 4000 nM
|
|
|
| 2 |
IC50 = 3.7 nM
|
|
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| 3 |
IC50 = 4.2 nM
|
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CP0377431
|
N-{6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl}quinolin-7-amine
Show/Hide
|
C20H13F3N4
|
3
|
| 1 |
EC50 > 4000 nM
|
|
|
| 2 |
IC50 = 0.3 nM
|
|
|
| 3 |
IC50 = 0.6 nM
|
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CP0377432
|
N-(2,3-dihydro-1,4-benzodioxin-6-yl)-6-[4-(trifluoromethyl)phenyl]pyrimidin-4-amine
Show/Hide
|
C19H14F3N3O2
|
3
|
| 1 |
EC50 > 4000 nM
|
|
|
| 2 |
IC50 = 120 nM
|
|
|
| 3 |
IC50 = 250 nM
|
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CP0433963
|
4-(4-tert-butylphenyl)-6-(2,3-dihydro-1,4-benzodioxin-6-yloxy)pyrimidine
Show/Hide
|
C22H22N2O3
|
1
|
| 1 |
EC50 > 4000 nM
|
|
|
|
CP0435880
|
2-(4-tert-butylphenyl)-N-(2,3-dihydro-1,4-benzodioxin-6-yl)pyridin-4-amine
Show/Hide
|
C23H24N2O2
|
1
|
| 1 |
EC50 > 4000 nM
|
|
|
|
CP0435883
|
4-(4-tert-butylphenyl)-6-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)pyrimidine
Show/Hide
|
C23H24N2O2
|
1
|
| 1 |
EC50 > 4000 nM
|
|
|
|
CP0437362
|
5-(4-tert-butylphenyl)-N-(2,3-dihydro-1,4-benzodioxin-6-yl)pyridazin-3-amine
Show/Hide
|
C22H23N3O2
|
1
|
| 1 |
EC50 > 4000 nM
|
|
|
|
CP0437363
|
6-(4-tert-butylphenyl)-N-(2,3-dihydro-1,4-benzodioxin-6-yl)-N-methylpyrimidin-4-amine
Show/Hide
|
C23H25N3O2
|
1
|
| 1 |
EC50 > 4000 nM
|
|
|
|
CP0437364
|
6-(4-tert-butylphenyl)-N-(2,3-dihydro-1,4-benzodioxin-6-yl)pyrimidin-4-amine
Show/Hide
|
C22H23N3O2
|
3
|
| 1 |
EC50 > 4000 nM
|
|
|
| 2 |
IC50 = 51 nM
|
|
|
| 3 |
IC50 = 270 nM
|
|
|
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CP0461762
|
6-(4-tert-butylphenyl)-N-(2,3-dihydro-1,4-benzodioxin-6-yl)pyridin-2-amine
Show/Hide
|
C23H24N2O2
|
1
|
| 1 |
EC50 > 4000 nM
|
|
|
|
CP0461763
|
(3E)-3-[(4-tert-butylphenyl)methylidene]-1-(2,3-dihydro-1,4-benzodioxin-6-yl)piperidin-2-one
Show/Hide
|
C24H27NO3
|
1
|
| 1 |
EC50 > 4000 nM
|
|
|
|
CP0461764
|
5-(4-tert-butylphenyl)-N-(2,3-dihydro-1,4-benzodioxin-6-yl)pyridin-3-amine
Show/Hide
|
C23H24N2O2
|
1
|
| 1 |
EC50 > 4000 nM
|
|
|
|
CP0461766
|
3-[(4-tert-butylphenyl)methyl]-1-(2,3-dihydro-1,4-benzodioxin-6-yl)-1,2-dihydropyridin-2-one
Show/Hide
|
C24H25NO3
|
1
|
| 1 |
EC50 > 4000 nM
|
|
|
|
CP0464432
|
4-(4-tert-butylphenyl)-6-(2,3-dihydro-1,4-benzodioxin-6-ylsulfanyl)pyrimidine
Show/Hide
|
C22H22N2O2S
|
1
|
| 1 |
EC50 > 4000 nM
|
|
|
|
CP0500418
|
4-(4-tert-butylphenyl)-N-(2,3-dihydro-1,4-benzodioxin-6-yl)pyrimidin-2-amine
Show/Hide
|
C22H23N3O2
|
1
|
| 1 |
EC50 > 4000 nM
|
|
|
|
CP0500419
|
6-(4-tert-butylphenyl)-N-(2,3-dihydro-1,4-benzodioxin-6-yl)pyrazin-2-amine
Show/Hide
|
C22H23N3O2
|
1
|
| 1 |
EC50 > 4000 nM
|
|
|
|
CP0500420
|
4-(4-tert-butylphenyl)-N-(2,3-dihydro-1,4-benzodioxin-6-yl)pyridin-2-amine
Show/Hide
|
C23H24N2O2
|
1
|
| 1 |
EC50 > 4000 nM
|
|
|
|
CP0503994
|
N-[6-(4-tert-butylphenyl)pyrimidin-4-yl]quinolin-7-amine
Show/Hide
|
C23H22N4
|
3
|
| 1 |
EC50 > 4000 nM
|
|
|
| 2 |
IC50 = 1.9 nM
|
|
|
| 3 |
IC50 = 6.9 nM
|
|
|
|
CP0520484
|
N-[3-(4-tert-butylphenyl)phenyl]-2,3-dihydro-1,4-benzodioxin-6-amine
Show/Hide
|
C24H25NO2
|
1
|
| 1 |
EC50 > 4000 nM
|
|
|
|
CP0522660
|
4-(4-tert-butylphenyl)-N-(2,3-dihydro-1,4-benzodioxin-6-yl)-1,3,5-triazin-2-amine
Show/Hide
|
C21H22N4O2
|
1
|
| 1 |
EC50 > 4000 nM
|
|
|
|
CP0530850
|
2-(4-tert-butylphenyl)-N-(2,3-dihydro-1,4-benzodioxin-6-yl)pyrimidin-4-amine
Show/Hide
|
C22H23N3O2
|
1
|
| 1 |
EC50 > 4000 nM
|
|
|
|
CP0422042
|
3-amino-5-({6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl}oxy)-1,2-dihydroquinoxalin-2-one
Show/Hide
|
C19H12F3N5O2
|
3
|
| 1 |
IC50 = 0.4 nM
|
|
|
| 2 |
IC50 = 0.8 nM
|
|
|
| 3 |
IC50 = 0.9 nM
|
|
|
|
CP0466955
|
(2E)-3-[2-(piperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]-N-(quinolin-7-yl)prop-2-enamide
Show/Hide
|
C23H21F3N4O
|
2
|
| 1 |
IC50 = 0.42 nM
|
|
|
| 2 |
IC50 = 1 nM
|
|
|
|
CP0292074
|
(1R,3S)-4-chloro-N-(3-hydroxycyclohexyl)-5-(4-(trifluoromethyl)phenyl)isoxazole-3-carboxamide
Show/Hide
|
C17H16ClF3N2O3
|
2
|
| 1 |
IC50 = 0.5012 nM
|
|
|
| 2 |
IC50 = 3 nM
|
|
|
|
CP0384542
|
AMG 517
Show/Hide
|
C20H13F3N4O2S
|
3
|
| 1 |
IC50 = 0.62 nM
|
|
|
| 2 |
IC50 = 0.76 nM
|
|
|
| 3 |
IC50 = 1.3 nM
|
|
|
|
CP0465982
|
4-chloro-5-(4-chloro-3-fluorophenyl)-N-[(1R,3S)-3-hydroxycyclohexyl]-1,2-oxazole-3-carboxamide
Show/Hide
|
C16H15Cl2FN2O3
|
1
|
| 1 |
IC50 = 0.631 nM
|
|
|
|
CP0501670
|
4-chloro-5-[3-fluoro-4-(trifluoromethyl)phenyl]-N-[(1R,3S)-3-hydroxycyclohexyl]-1,2-oxazole-3-carboxamide
Show/Hide
|
C17H15ClF4N2O3
|
1
|
| 1 |
IC50 = 0.631 nM
|
|
|
|
CP0422363
|
8-[[6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl]amino]naphthalen-2-ol
Show/Hide
|
C21H14F3N3O
|
1
|
| 1 |
IC50 = 0.65 nM
|
|
|
|
CP0461499
|
(E)-3-(4-tert-Butyl-phenyl)-N-quinolin-7-yl-acrylamide
Show/Hide
|
C22H22N2O
|
2
|
| 1 |
IC50 = 1.1 nM
|
|
|
| 2 |
IC50 = 2.02 nM
|
|
|
|
CP0433209
|
7-chloro-8-[[6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl]amino]-1,2,3,4-tetrahydronaphthalen-2-ol
Show/Hide
|
C21H17ClF3N3O
|
1
|
| 1 |
IC50 = 1.1 nM
|
|
|
|
CP0433211
|
6-fluoro-8-[[6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl]amino]-1,2,3,4-tetrahydronaphthalen-2-ol
Show/Hide
|
C21H17F4N3O
|
1
|
| 1 |
IC50 = 1.1 nM
|
|
|
|
CP0372650
|
(E)-3-(2-Morpholin-4-yl-6-trifluoromethyl-pyridin-3-yl)-N-quinolin-7-yl-acrylamide
Show/Hide
|
C22H19F3N4O2
|
2
|
| 1 |
IC50 = 1.3 nM
|
|
|
| 2 |
IC50 = 1.9 nM
|
|
|
|
CP0412688
|
5-chloro-8-[[6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl]amino]-1,2,3,4-tetrahydronaphthalen-2-ol
Show/Hide
|
C21H17ClF3N3O
|
1
|
| 1 |
IC50 = 1.4 nM
|
|
|
|
CP0498643
|
ethyl 3-[(7-hydroxynaphthalen-1-yl)carbamoylamino]benzoate
Show/Hide
|
C20H18N2O4
|
1
|
| 1 |
IC50 = 1.7 nM
|
|
|
|
CP0122651
|
4-(3-Chloro-pyridin-2-yl)-piperazine-1-carboxylic acid (4-tert-butyl-phenyl)-amide
Show/Hide
|
C20H25ClN4O
|
3
|
| 1 |
IC50 = 1.83 nM
|
|
|
| 2 |
Ki = 4.32 nM
|
|
|
| 3 |
Ki = 10.5 nM
|
|
|
|
CP0501671
|
5-[3-fluoro-4-(trifluoromethyl)phenyl]-N-[(1R,3S)-3-hydroxycyclohexyl]-4-methyl-1,2-oxazole-3-carboxamide
Show/Hide
|
C18H18F4N2O3
|
1
|
| 1 |
IC50 = 1.995 nM
|
|
|
|
CP0457176
|
5-bromo-8-[[6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl]amino]-1,2,3,4-tetrahydronaphthalen-2-ol
Show/Hide
|
C21H17BrF3N3O
|
1
|
| 1 |
IC50 = 2.1 nM
|
|
|
|
CP0504351
|
1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(7-hydroxynaphthalen-1-yl)urea
Show/Hide
|
C18H12ClF3N2O2
|
1
|
| 1 |
IC50 = 2.2 nM
|
|
|
|
CP0404815
|
(E)-3-(4-tert-Butyl-phenyl)-N-(2-oxo-1,2,3,4-tetrahydro-quinolin-7-yl)-acrylamide
Show/Hide
|
C22H24N2O2
|
2
|
| 1 |
IC50 = 2.5 nM
|
|
|
| 2 |
IC50 = 71 nM
|
|
|
|
CP0396648
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
|
C23H28F4N4O3S
|
6
|
| 1 |
IC50 = 2.56 nM
|
|
|
| 2 |
IC50 = 15.8 nM
|
|
|
| 3 |
Ki = 0.02 nM
|
|
|
| 4 |
Ki = 0.3 nM
|
|
|
| 5 |
Ki = 2.22 nM
|
|
|
| 6 |
Ki = 7.9 nM
|
|
|
|
CP0543320
|
(2S)-2-(5-phenyl-1,3-thiazol-2-yl)-N-(3-propan-2-ylphenyl)pyrrolidine-1-carboxamide
Show/Hide
|
C23H25N3OS
|
1
|
| 1 |
IC50 = 2.66 nM
|
|
|
|
CP0372742
|
8-chloro-5-[[6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl]amino]-3,4-dihydro-2H-chromen-3-ol
Show/Hide
|
C20H15ClF3N3O2
|
1
|
| 1 |
IC50 = 2.9 nM
|
|
|
|
CP0360597
|
N-[4-(trifluoromethyl)phenyl]-4-[3-(trifluoromethyl)pyridin-2-yl]benzamide
Show/Hide
|
C20H12F6N2O
|
2
|
| 1 |
IC50 = 3 nM
|
|
|
| 2 |
IC50 = 13 nM
|
|
|
|
CP0512595
|
4-chloro-3-(4-chloro-3-fluorophenyl)-N-[(1R,3S)-3-hydroxycyclohexyl]-1,2-oxazole-5-carboxamide
Show/Hide
|
C16H15Cl2FN2O3
|
1
|
| 1 |
IC50 = 3.162 nM
|
|
|
|
CP0511428
|
1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(2-chloro-7-hydroxynaphthalen-1-yl)urea
Show/Hide
|
C18H11Cl2F3N2O2
|
1
|
| 1 |
IC50 = 3.4 nM
|
|
|
|
CP0441341
|
1-(7-hydroxynaphthalen-1-yl)-3-(3-(trifluoromethyl)phenyl)urea
Show/Hide
|
C18H13F3N2O2
|
1
|
| 1 |
IC50 = 3.5 nM
|
|
|
|
CP0255650
|
3-(7-hydroxynaphthalen-1-yl)-1-[3-(methylsulfanyl)phenyl]urea
Show/Hide
|
C18H16N2O2S
|
2
|
| 1 |
IC50 = 3.9 nM
|
|
|
| 2 |
IC50 = 13 nM
|
|
|
|
CP0376005
|
4-chloro-N-[(1R,3S)-3-hydroxycyclohexyl]-3-[4-(trifluoromethyl)phenyl]-1,2-oxazole-5-carboxamide
Show/Hide
|
C17H16ClF3N2O3
|
1
|
| 1 |
IC50 = 3.981 nM
|
|
|
|
CP0441833
|
2-(4-(trifluoromethyl)phenyl)-6-(3-(trifluoromethyl)pyridin-2-yl)-1,2-dihydroindazol-3-one
Show/Hide
|
C20H11F6N3O
|
2
|
| 1 |
IC50 = 4 nM
|
|
|
| 2 |
IC50 = 35 nM
|
|
|
|
CP0498937
|
1-(3,4-dichlorophenyl)-3-(7-hydroxynaphthalen-1-yl)urea
Show/Hide
|
C17H12Cl2N2O2
|
1
|
| 1 |
IC50 = 4.9 nM
|
|
|
|
CP0527176
|
4-chloro-5-(4-chlorophenyl)-N-[(1R,3S)-3-hydroxycyclohexyl]-1,2-oxazole-3-carboxamide
Show/Hide
|
C16H16Cl2N2O3
|
1
|
| 1 |
IC50 = 5.012 nM
|
|
|
|
CP0568294
|
(2S)-2-(5-phenyl-1,3-thiazol-2-yl)-N-(2-propan-2-ylphenyl)pyrrolidine-1-carboxamide
Show/Hide
|
C23H25N3OS
|
1
|
| 1 |
IC50 = 5.32 nM
|
|
|
|
CP0504375
|
1-(7-hydroxynaphthalen-1-yl)-3-(4-(trifluoromethyl)phenyl)urea
Show/Hide
|
C18H13F3N2O2
|
1
|
| 1 |
IC50 = 5.4 nM
|
|
|
|
CP0460670
|
1-(3-bromophenyl)-3-(7-hydroxynaphthalen-1-yl)urea
Show/Hide
|
C17H13BrN2O2
|
1
|
| 1 |
IC50 = 5.7 nM
|
|
|
|
CP0579096
|
(2S)-2-[4-(4-fluorophenyl)-1,3-thiazol-2-yl]-N-(2-methoxyphenyl)pyrrolidine-1-carboxamide
Show/Hide
|
C21H20FN3O2S
|
1
|
| 1 |
IC50 = 5.71 nM
|
|
|
|
CP0483443
|
1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(2,3-dichloro-7-hydroxynaphthalen-1-yl)urea
Show/Hide
|
C18H10Cl3F3N2O2
|
1
|
| 1 |
IC50 = 5.9 nM
|
|
|
|
CP0513959
|
1-(3-chlorophenyl)-3-(7-hydroxynaphthalen-1-yl)urea
Show/Hide
|
C17H13ClN2O2
|
1
|
| 1 |
IC50 = 6.1 nM
|
|
|
|
CP0453195
|
(E)-3-(4-tert-Butyl-phenyl)-N-(3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl)-acrylamide
Show/Hide
|
C21H22N2O3
|
2
|
| 1 |
IC50 = 6.5 nM
|
|
|
| 2 |
IC50 > 4000 nM
|
|
|
|
CP0498939
|
1-(3-bromo-2-chloro-7-hydroxynaphthalen-1-yl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea
Show/Hide
|
C18H10BrCl2F3N2O2
|
1
|
| 1 |
IC50 = 6.8 nM
|
|
|
|
CP0411646
|
N-[[2-butoxy-6-[chloro(difluoro)methyl]pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C21H25ClF3N3O4S
|
4
|
| 1 |
IC50 = 7 nM
|
|
|
| 2 |
IC50 = 8.3 nM
|
|
|
| 3 |
Ki = 0.02 nM
|
|
|
| 4 |
Ki = 0.3 nM
|
|
|
|
CP0443337
|
(2S)-N-[[2-cyclohexylsulfanyl-4-(trifluoromethyl)phenyl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C24H28F4N2O3S2
|
4
|
| 1 |
IC50 = 7.3 nM
|
|
|
| 2 |
IC50 = 20.4 nM
|
|
|
| 3 |
Ki = 0.03 nM
|
|
|
| 4 |
Ki = 0.3 nM
|
|
|
|
CP0460716
|
1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(2,3-dibromo-7-hydroxynaphthalen-1-yl)urea
Show/Hide
|
C18H10Br2ClF3N2O2
|
1
|
| 1 |
IC50 = 7.5 nM
|
|
|
|
CP0476848
|
1-(7-hydroxynaphthalen-1-yl)-3-(3-nitrophenyl)urea
Show/Hide
|
C17H13N3O4
|
1
|
| 1 |
IC50 = 7.5 nM
|
|
|
|
CP0524477
|
1-(7-hydroxynaphthalen-1-yl)-3-(3-methoxyphenyl)urea
Show/Hide
|
C18H16N2O3
|
1
|
| 1 |
IC50 = 8 nM
|
|
|
|
CP0451014
|
US9120756, 26
Show/Hide
|
C21H19ClF4N4O3S
|
4
|
| 1 |
IC50 = 8 nM
|
|
|
| 2 |
IC50 = 8.1 nM
|
|
|
| 3 |
Ki = 0.1 nM
|
|
|
| 4 |
Ki = 0.3 nM
|
|
|
|
CP0362623
|
1-(2-bromophenyl)-3-[(3R)-1-[5-(trifluoromethyl)pyridin-2-yl]pyrrolidin-3-yl]urea
Show/Hide
|
C17H16BrF3N4O
|
1
|
| 1 |
IC50 = 9.24 nM
|
|
|
|
CP0412687
|
5-[[6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl]amino]-3,4-dihydro-2H-chromen-3-ol
Show/Hide
|
C20H16F3N3O2
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0569423
|
(2S)-N-(4-chlorophenyl)-2-[4-(4-fluorophenyl)-1,3-thiazol-2-yl]pyrrolidine-1-carboxamide
Show/Hide
|
C20H17ClFN3OS
|
1
|
| 1 |
IC50 = 10.65 nM
|
|
|
|
CP0459181
|
1-(7-hydroxynaphthalen-1-yl)-3-m-tolylurea
Show/Hide
|
C18H16N2O2
|
1
|
| 1 |
IC50 = 11 nM
|
|
|
|
CP0486659
|
1-(4-chlorophenyl)-3-(7-hydroxynaphthalen-1-yl)urea
Show/Hide
|
C17H13ClN2O2
|
1
|
| 1 |
IC50 = 12 nM
|
|
|
|
CP0498644
|
1-(3,5-dichlorophenyl)-3-(7-hydroxynaphthalen-1-yl)urea
Show/Hide
|
C17H12Cl2N2O2
|
1
|
| 1 |
IC50 = 12 nM
|
|
|
|
CP0524603
|
1-(2,4-dichlorophenyl)-3-(7-hydroxynaphthalen-1-yl)urea
Show/Hide
|
C17H12Cl2N2O2
|
1
|
| 1 |
IC50 = 12 nM
|
|
|
|
CP0550343
|
(2S)-N-(2-nitrophenyl)-2-(5-phenyl-1,3-thiazol-2-yl)pyrrolidine-1-carboxamide
Show/Hide
|
C20H18N4O3S
|
1
|
| 1 |
IC50 = 12.36 nM
|
|
|
|
CP0494487
|
5-(4-chloro-2-ethoxyphenyl)-N-[(1R,3S)-3-hydroxycyclohexyl]-4-methyl-1,2-oxazole-3-carboxamide
Show/Hide
|
C19H23ClN2O4
|
1
|
| 1 |
IC50 = 12.59 nM
|
|
|
|
CP0505271
|
5-(4-chloro-2-ethoxyphenyl)-4-methyl-N-(oxan-4-yl)-1,2-oxazole-3-carboxamide
Show/Hide
|
C18H21ClN2O4
|
1
|
| 1 |
IC50 = 12.59 nM
|
|
|
|
CP0498938
|
1-(2-chloro-5-(trifluoromethyl)phenyl)-3-(7-hydroxynaphthalen-1-yl)urea
Show/Hide
|
C18H12ClF3N2O2
|
1
|
| 1 |
IC50 = 13 nM
|
|
|
|
CP0391569
|
(E)-3-(4-tert-Butyl-phenyl)-4-phenyl-but-2-enoic acid (2,3-dihydro-benzo[1,4]dioxin-6-yl)-amide
Show/Hide
|
C28H29NO3
|
2
|
| 1 |
IC50 = 14 nM
|
|
|
| 2 |
IC50 = 110 nM
|
|
|
|
CP0494406
|
1-(3-fluorophenyl)-3-(7-hydroxynaphthalen-1-yl)urea
Show/Hide
|
C17H13FN2O2
|
1
|
| 1 |
IC50 = 14 nM
|
|
|
|
CP0374739
|
N-[[2-cyclohexyl-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C23H27F4N3O3S
|
4
|
| 1 |
IC50 = 14.1 nM
|
|
|
| 2 |
IC50 = 43.4 nM
|
|
|
| 3 |
Ki = 0.2 nM
|
|
|
| 4 |
Ki = 0.6 nM
|
|
|
|
CP0578811
|
(2S)-2-(5-phenyl-1,3-thiazol-2-yl)-N-[3-(trifluoromethyl)phenyl]pyrrolidine-1-carboxamide
Show/Hide
|
C21H18F3N3OS
|
1
|
| 1 |
IC50 = 14.52 nM
|
|
|
|
CP0428429
|
5-tert-Butyl-2-[(E)-2-(2,3-dihydro-benzo[1,4]dioxin-6-ylcarbamoyl)-vinyl]-benzoic acid ethyl ester
Show/Hide
|
C24H27NO5
|
2
|
| 1 |
IC50 = 15 nM
|
|
|
| 2 |
IC50 = 26 nM
|
|
|
|
CP0461569
|
(E)-N-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-3-(2-morpholin-4-yl-6-trifluoromethyl-pyridin-3-yl)-acrylamide
Show/Hide
|
C21H20F3N3O4
|
2
|
| 1 |
IC50 = 15 nM
|
|
|
| 2 |
IC50 = 40 nM
|
|
|
|
CP0543409
|
4-chloro-N-cyclopentyl-5-(4-(trifluoromethyl)phenyl)isoxazole-3-carboxamide
Show/Hide
|
C16H14ClF3N2O2
|
1
|
| 1 |
IC50 = 15 nM
|
|
|
|
CP0431225
|
(E)-3-(4-tert-Butyl-phenyl)-N-(3,4-dihydro-2H-benzo[1,4]oxazin-7-yl)-acrylamide
Show/Hide
|
C21H24N2O2
|
2
|
| 1 |
IC50 = 16 nM
|
|
|
| 2 |
IC50 = 57 nM
|
|
|
|
CP0495244
|
(E)-3-(4-tert-Butyl-phenyl)-5-methyl-hex-2-enoic acid (2,3-dihydro-benzo[1,4]dioxin-6-yl)-amide
Show/Hide
|
C25H31NO3
|
2
|
| 1 |
IC50 = 16 nM
|
|
|
| 2 |
IC50 = 94 nM
|
|
|
|
CP0412035
|
US9120756, 28
Show/Hide
|
C22H22ClF3N4O4S
|
2
|
| 1 |
IC50 = 16 nM
|
|
|
| 2 |
Ki = 0.4 nM
|
|
|
|
CP0411648
|
N-[[6-[chloro(difluoro)methyl]-2-cyclopentyloxypyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C22H25ClF3N3O4S
|
4
|
| 1 |
IC50 = 18.5 nM
|
|
|
| 2 |
IC50 = 19.3 nM
|
|
|
| 3 |
Ki = 0.04 nM
|
|
|
| 4 |
Ki = 0.5 nM
|
|
|
|
CP0375082
|
5-[3-fluoro-4-(trifluoromethyl)phenyl]-4-(hydroxymethyl)-N-[(2S)-3-methylbutan-2-yl]-1,2-oxazole-3-carboxamide
Show/Hide
|
C17H18F4N2O3
|
1
|
| 1 |
IC50 = 19.95 nM
|
|
|
|
CP0378858
|
(E)-3-(4-tert-Butyl-phenyl)-N-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-3-phenyl-acrylamide
Show/Hide
|
C27H27NO3
|
2
|
| 1 |
IC50 = 20 nM
|
|
|
| 2 |
IC50 = 120 nM
|
|
|
|
CP0498115
|
(E)-3-(4-tert-Butyl-phenyl)-N-(3-methoxy-phenyl)-acrylamide
Show/Hide
|
C20H23NO2
|
2
|
| 1 |
IC50 = 21 nM
|
|
|
| 2 |
IC50 > 4000 nM
|
|
|
|
CP0403277
|
2-(4-(trifluoromethyl)phenyl)-6-(3-(trifluoromethyl)pyridin-2-yl)-1H-benzo[d]imidazole
Show/Hide
|
C20H11F6N3
|
1
|
| 1 |
IC50 = 22 nM
|
|
|
|
CP0376928
|
(1R,3S)-4-chloro-N-(3-hydroxycyclopentyl)-5-(4-(trifluoromethyl)phenyl)isoxazole-3-carboxamide
Show/Hide
|
C16H14ClF3N2O3
|
1
|
| 1 |
IC50 = 23 nM
|
|
|
|
CP0569199
|
(2S)-N-(4-methyl-2-nitrophenyl)-2-(5-phenyl-1,3-thiazol-2-yl)pyrrolidine-1-carboxamide
Show/Hide
|
C21H20N4O3S
|
1
|
| 1 |
IC50 = 23.92 nM
|
|
|
|
CP0526275
|
4-(trifluoromethyl)-N-(4-(3-(trifluoromethyl)pyridin-2-yl)phenyl)benzamide
Show/Hide
|
C20H12F6N2O
|
2
|
| 1 |
IC50 = 24 nM
|
|
|
| 2 |
IC50 = 33 nM
|
|
|
|
CP0494347
|
1-(2,5-dichlorophenyl)-3-(7-hydroxynaphthalen-1-yl)urea
Show/Hide
|
C17H12Cl2N2O2
|
1
|
| 1 |
IC50 = 24 nM
|
|
|
|
CP0546896
|
(2S)-2-[4-(4-fluorophenyl)-1,3-thiazol-2-yl]-N-isoquinolin-5-ylpyrrolidine-1-carboxamide
Show/Hide
|
C23H19FN4OS
|
1
|
| 1 |
IC50 = 24.28 nM
|
|
|
|
CP0570204
|
(2S)-N-(4-fluorophenyl)-2-[4-(4-fluorophenyl)-1,3-thiazol-2-yl]pyrrolidine-1-carboxamide
Show/Hide
|
C20H17F2N3OS
|
1
|
| 1 |
IC50 = 24.56 nM
|
|
|
|
CP0425373
|
(Z)-3-(4-tert-Butyl-phenyl)-N-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-3-(4-trifluoromethyl-phenyl)-acrylamide
Show/Hide
|
C28H26F3NO3
|
2
|
| 1 |
IC50 = 25 nM
|
|
|
| 2 |
IC50 = 180 nM
|
|
|
|
CP0431001
|
(E)-N-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-3-(6''-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,2'']bipyridinyl-3''-yl)-acrylamide
Show/Hide
|
C22H22F3N3O3
|
2
|
| 1 |
IC50 = 27 nM
|
|
|
| 2 |
IC50 = 54 nM
|
|
|
|
CP0502615
|
1-(3-acetylphenyl)-3-(7-hydroxynaphthalen-1-yl)urea
Show/Hide
|
C19H16N2O3
|
1
|
| 1 |
IC50 = 28 nM
|
|
|
|
CP0476847
|
3-(7-hydroxynaphthalen-1-yl)-1-phenylurea
Show/Hide
|
C17H14N2O2
|
1
|
| 1 |
IC50 = 29 nM
|
|
|
|
CP0453194
|
(E)-3-(4-tert-Butyl-phenyl)-N-(3-hydroxy-4-methoxy-phenyl)-acrylamide
Show/Hide
|
C20H23NO3
|
2
|
| 1 |
IC50 = 30 nM
|
|
|
| 2 |
IC50 > 4000 nM
|
|
|
|
CP0504350
|
1-(4-chloro-2-(trifluoromethyl)phenyl)-3-(7-hydroxynaphthalen-1-yl)urea
Show/Hide
|
C18H12ClF3N2O2
|
1
|
| 1 |
IC50 = 31 nM
|
|
|
|
CP0568345
|
(2S)-N-(4-fluorophenyl)-2-(4-phenyl-1,3-thiazol-2-yl)pyrrolidine-1-carboxamide
Show/Hide
|
C20H18FN3OS
|
1
|
| 1 |
IC50 = 31.63 nM
|
|
|
|
CP0395180
|
1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(7-methoxynaphthalen-1-yl)urea
Show/Hide
|
C19H14ClF3N2O2
|
1
|
| 1 |
IC50 = 32 nM
|
|
|
|
CP0374759
|
N-[[2-cyclopentylsulfanyl-4-(trifluoromethyl)phenyl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C23H26F4N2O3S2
|
4
|
| 1 |
IC50 = 32 nM
|
|
|
| 2 |
IC50 = 37.2 nM
|
|
|
| 3 |
Ki = 0.03 nM
|
|
|
| 4 |
Ki = 0.3 nM
|
|
|
|
CP0524604
|
N-[4-chloro-3-(trifluoromethyl)phenyl]-2-(7-hydroxynaphthalen-1-yl)acetamide
Show/Hide
|
C19H13ClF3NO2
|
1
|
| 1 |
IC50 = 34 nM
|
|
|
|
CP0421248
|
(E)-3-(4-tert-Butyl-phenyl)-N-(1,2,3,4-tetrahydro-quinolin-7-yl)-acrylamide
Show/Hide
|
C22H26N2O
|
2
|
| 1 |
IC50 = 36 nM
|
|
|
| 2 |
IC50 = 160 nM
|
|
|
|
CP0421257
|
(E)-4-(4-tert-Butyl-phenyl)-5-(2,3-dihydro-benzo[1,4]dioxin-6-ylcarbamoyl)-pent-4-enoic acid ethyl ester
Show/Hide
|
C26H31NO5
|
2
|
| 1 |
IC50 = 36 nM
|
|
|
| 2 |
IC50 = 290 nM
|
|
|
|
CP0529424
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-2-(3-methylphenyl)-N-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]acetamide
Show/Hide
|
C29H32F4N4O3S
|
4
|
| 1 |
IC50 = 36.2 nM
|
|
|
| 2 |
IC50 = 86.7 nM
|
|
|
| 3 |
Ki = 0.1 nM
|
|
|
| 4 |
Ki = 0.25 nM
|
|
|
|
CP0404821
|
(E)-3-(4-tert-Butyl-phenyl)-but-2-enoic acid (2,3-dihydro-benzo[1,4]dioxin-6-yl)-amide
Show/Hide
|
C22H25NO3
|
2
|
| 1 |
IC50 = 39 nM
|
|
|
| 2 |
IC50 = 430 nM
|
|
|
|
CP0419389
|
US9120756, 24
Show/Hide
|
C21H19ClF4N4O3S
|
2
|
| 1 |
IC50 = 39.2 nM
|
|
|
| 2 |
Ki = 0.3 nM
|
|
|
|
CP0465984
|
N-cyclopentyl-5-[3-fluoro-4-(trifluoromethyl)phenyl]-4-(hydroxymethyl)-1,2-oxazole-3-carboxamide
Show/Hide
|
C17H16F4N2O3
|
1
|
| 1 |
IC50 = 39.81 nM
|
|
|
|
CP0502884
|
4-chloro-N-(tetrahydro-2H-pyran-4-yl)-5-(4-(trifluoromethyl)phenyl)isoxazole-3-carboxamide
Show/Hide
|
C16H14ClF3N2O3
|
1
|
| 1 |
IC50 = 43 nM
|
|
|
|
CP0425374
|
(Z)-3-(4-tert-Butyl-phenyl)-N-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-3-pyridin-4-yl-acrylamide
Show/Hide
|
C26H26N2O3
|
2
|
| 1 |
IC50 = 44 nM
|
|
|
| 2 |
IC50 = 660 nM
|
|
|
|
CP0460671
|
3-(4-chloro-3-(trifluoromethyl)phenyl)-1-(7-hydroxynaphthalen-1-yl)-1-methylurea
Show/Hide
|
C19H14ClF3N2O2
|
1
|
| 1 |
IC50 = 44 nM
|
|
|
|
CP0545152
|
(2S)-N-(2,5-dimethylphenyl)-2-(4-phenyl-1,3-thiazol-2-yl)pyrrolidine-1-carboxamide
Show/Hide
|
C22H23N3OS
|
1
|
| 1 |
IC50 = 44.42 nM
|
|
|
|
CP0486012
|
(E)-N-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-3-(4-trifluoromethyl-phenyl)-acrylamide
Show/Hide
|
C18H14F3NO3
|
2
|
| 1 |
IC50 = 46 nM
|
|
|
| 2 |
IC50 = 100 nM
|
|
|
|
CP0506089
|
4-bromo-N-cyclopentyl-5-(4-(trifluoromethyl)phenyl)isoxazole-3-carboxamide
Show/Hide
|
C16H14BrF3N2O2
|
1
|
| 1 |
IC50 = 46 nM
|
|
|
|
CP0119888
|
US9120756, 23
Show/Hide
|
C21H19ClF4N4O3S
|
2
|
| 1 |
IC50 = 47.1 nM
|
|
|
| 2 |
Ki = 0.3 nM
|
|
|
|
CP0506086
|
4-chloro-N-[(1R,2S)-2-(hydroxymethyl)cyclohexyl]-5-[4-(trifluoromethyl)phenyl]-1,2-oxazole-3-carboxamide
Show/Hide
|
C18H18ClF3N2O3
|
1
|
| 1 |
IC50 = 48 nM
|
|
|
|
CP0469060
|
(1R,3S)-4-chloro-5-(4-fluorophenyl)-N-(3-hydroxycyclohexyl)isoxazole-3-carboxamide
Show/Hide
|
C16H16ClFN2O3
|
2
|
| 1 |
IC50 = 50.12 nM
|
|
|
| 2 |
IC50 = 141 nM
|
|
|
|
CP0459180
|
1-(2-chlorophenyl)-3-(7-hydroxynaphthalen-1-yl)urea
Show/Hide
|
C17H13ClN2O2
|
1
|
| 1 |
IC50 = 52 nM
|
|
|
|
CP0409347
|
(E)-N-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-3-(4-isopropyl-phenyl)-acrylamide
Show/Hide
|
C20H21NO3
|
2
|
| 1 |
IC50 = 55 nM
|
|
|
| 2 |
IC50 = 82 nM
|
|
|
|
CP0502885
|
(1S,3R)-4-chloro-N-(3-hydroxycyclopentyl)-5-(4-(trifluoromethyl)phenyl)isoxazole-3-carboxamide
Show/Hide
|
C16H14ClF3N2O3
|
1
|
| 1 |
IC50 = 55 nM
|
|
|
|
CP0428428
|
(E)-3-(2-Bromo-4-tert-butyl-phenyl)-N-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-acrylamide
Show/Hide
|
C21H22BrNO3
|
2
|
| 1 |
IC50 = 60 nM
|
|
|
| 2 |
IC50 = 470 nM
|
|
|
|
CP0391843
|
(E)-3-(4-tert-Butyl-phenyl)-N-(5,6,7,8-tetrahydro-naphthalen-2-yl)-acrylamide
Show/Hide
|
C23H27NO
|
2
|
| 1 |
IC50 = 61 nM
|
|
|
| 2 |
IC50 = 960 nM
|
|
|
|
CP0160739
|
N-[(1R,3S)-3-hydroxycyclohexyl]-4-[(propan-2-ylamino)methyl]-5-[4-(trifluoromethyl)phenyl]-1,2-oxazole-3-carboxamide
Show/Hide
|
C21H26F3N3O3
|
1
|
| 1 |
IC50 = 63.1 nM
|
|
|
|
CP0473831
|
N-[(2S)-3-methylbutan-2-yl]-4-[(propan-2-ylamino)methyl]-5-[4-(trifluoromethyl)phenyl]-1,2-oxazole-3-carboxamide
Show/Hide
|
C20H26F3N3O2
|
1
|
| 1 |
IC50 = 63.1 nM
|
|
|
|
CP0549054
|
4-chloro-N-[(1S,2R)-2-hydroxycyclohexyl]-5-[4-(trifluoromethyl)phenyl]-1,2-oxazole-3-carboxamide
Show/Hide
|
C17H16ClF3N2O3
|
1
|
| 1 |
IC50 = 65 nM
|
|
|
|
CP0572807
|
(2S)-N-isoquinolin-5-yl-2-(4-phenyl-1,3-thiazol-2-yl)pyrrolidine-1-carboxamide
Show/Hide
|
C23H20N4OS
|
1
|
| 1 |
IC50 = 67.61 nM
|
|
|
|
CP0466939
|
(Z)-3-(4-tert-Butyl-phenyl)-N-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-3-pyridin-3-yl-acrylamide
Show/Hide
|
C26H26N2O3
|
2
|
| 1 |
IC50 = 78 nM
|
|
|
| 2 |
IC50 = 510 nM
|
|
|
|
CP0378441
|
(1R,3S)-4-chloro-5-(3,4-difluorophenyl)-N-(3-hydroxycyclohexyl)isoxazole-3-carboxamide
Show/Hide
|
C16H15ClF2N2O3
|
1
|
| 1 |
IC50 = 79 nM
|
|
|
|
CP0050824
|
N-[(1R,3S)-3-hydroxycyclohexyl]-4-(hydroxymethyl)-5-[4-(trifluoromethyl)phenyl]-1,2-oxazole-3-carboxamide
Show/Hide
|
C18H19F3N2O4
|
1
|
| 1 |
IC50 = 79.43 nM
|
|
|
|
CP0569197
|
(2S)-2-[4-(3-fluorophenyl)-1,3-thiazol-2-yl]-N-isoquinolin-5-ylpyrrolidine-1-carboxamide
Show/Hide
|
C23H19FN4OS
|
1
|
| 1 |
IC50 = 80.57 nM
|
|
|
|
CP0475822
|
4-chloro-N-cyclobutyl-5-(4-(trifluoromethyl)phenyl)isoxazole-3-carboxamide
Show/Hide
|
C15H12ClF3N2O2
|
1
|
| 1 |
IC50 = 87 nM
|
|
|
|
CP0494405
|
1-(7-hydroxynaphthalen-1-yl)-3-(2-(trifluoromethyl)phenyl)urea
Show/Hide
|
C18H13F3N2O2
|
1
|
| 1 |
IC50 = 87 nM
|
|
|
|
CP0475823
|
4-chloro-N-cyclohexyl-5-(4-(trifluoromethyl)phenyl)isoxazole-3-carboxamide
Show/Hide
|
C17H16ClF3N2O2
|
1
|
| 1 |
IC50 = 92 nM
|
|
|
|
CP0404819
|
(E)-3-(4-tert-Butyl-phenyl)-N-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-2-methyl-acrylamide
Show/Hide
|
C22H25NO3
|
2
|
| 1 |
IC50 = 100 nM
|
|
|
| 2 |
IC50 = 600 nM
|
|
|
|
CP0461568
|
(E)-3-(6-tert-Butyl-pyridin-3-yl)-N-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-acrylamide
Show/Hide
|
C20H22N2O3
|
2
|
| 1 |
IC50 = 100 nM
|
|
|
| 2 |
IC50 = 2400 nM
|
|
|
|
CP0513224
|
N-ethyl-N-(2-hydroxyethyl)-7-[3-(trifluoromethyl)phenyl]pyrrolo[1,2-b]pyridazine-6-carboxamide
Show/Hide
|
C19H18F3N3O2
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0404814
|
(E)-3-(4-tert-Butyl-phenyl)-N-(3,4-dihydro-2H-benzo[1,4]oxazin-6-yl)-acrylamide
Show/Hide
|
C21H24N2O2
|
2
|
| 1 |
IC50 = 110 nM
|
|
|
| 2 |
IC50 > 4000 nM
|
|
|
|
CP0510346
|
(E)-3-(4-Bromo-phenyl)-N-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-acrylamide
Show/Hide
|
C17H14BrNO3
|
2
|
| 1 |
IC50 = 110 nM
|
|
|
| 2 |
IC50 = 370 nM
|
|
|
|
CP0471809
|
N-cyclopentyl-4-fluoro-5-[4-(trifluoromethyl)phenyl]-1,2-oxazole-3-carboxamide
Show/Hide
|
C16H14F4N2O2
|
1
|
| 1 |
IC50 = 112 nM
|
|
|
|
CP0506087
|
4-chloro-N-(3-hydroxyphenyl)-5-(4-(trifluoromethyl)phenyl)isoxazole-3-carboxamide
Show/Hide
|
C17H10ClF3N2O3
|
1
|
| 1 |
IC50 = 118 nM
|
|
|
|
CP0517361
|
4-chloro-N-[(3S,5R)-3,5-dihydroxycyclohexyl]-5-[4-(trifluoromethyl)phenyl]-1,2-oxazole-3-carboxamide
Show/Hide
|
C17H16ClF3N2O4
|
1
|
| 1 |
IC50 = 120 nM
|
|
|
|
CP0501672
|
4-(hydroxymethyl)-N-[(2S)-3-methylbutan-2-yl]-5-[4-(trifluoromethyl)phenyl]-1,2-oxazole-3-carboxamide
Show/Hide
|
C17H19F3N2O3
|
1
|
| 1 |
IC50 = 125.89 nM
|
|
|
|
CP0453266
|
(E)-3-(4-tert-Butyl-phenyl)-N-(4-methoxy-phenyl)-acrylamide
Show/Hide
|
C20H23NO2
|
2
|
| 1 |
IC50 = 140 nM
|
|
|
| 2 |
IC50 > 4000 nM
|
|
|
|
CP0504555
|
4-chloro-N-[(1S,3S)-3-hydroxycyclohexyl]-5-[4-(trifluoromethyl)phenyl]-1,2-oxazole-3-carboxamide
Show/Hide
|
C17H16ClF3N2O3
|
1
|
| 1 |
IC50 = 149 nM
|
|
|
|
CP0404818
|
3-(4-tert-Butyl-phenyl)-N-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-propionamide
Show/Hide
|
C21H25NO3
|
2
|
| 1 |
IC50 = 150 nM
|
|
|
| 2 |
IC50 = 660 nM
|
|
|
|
CP0455212
|
5-[3-fluoro-4-(trifluoromethyl)phenyl]-N-[(2R)-1-hydroxybutan-2-yl]-4-(hydroxymethyl)-1,2-oxazole-3-carboxamide
Show/Hide
|
C16H16F4N2O4
|
1
|
| 1 |
IC50 = 158.49 nM
|
|
|
|
CP0465983
|
N-cyclopentyl-4-(hydroxymethyl)-5-[4-(trifluoromethyl)phenyl]-1,2-oxazole-3-carboxamide
Show/Hide
|
C17H17F3N2O3
|
1
|
| 1 |
IC50 = 158.49 nM
|
|
|
|
CP0487969
|
N-ethyl-N-(2-hydroxyethyl)-3-(3-methylphenyl)indolizine-2-carboxamide
Show/Hide
|
C20H22N2O2
|
1
|
| 1 |
IC50 = 158.49 nM
|
|
|
|
CP0403276
|
N-[4-(3-methylpyridin-2-yl)phenyl]-4-(trifluoromethyl)benzamide
Show/Hide
|
C20H15F3N2O
|
1
|
| 1 |
IC50 = 160 nM
|
|
|
|
CP0391571
|
(E)-N-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-3-(4-ethyl-phenyl)-acrylamide
Show/Hide
|
C19H19NO3
|
2
|
| 1 |
IC50 = 170 nM
|
|
|
| 2 |
IC50 = 220 nM
|
|
|
|
CP0404809
|
(E)-3-(4-tert-Butyl-phenyl)-N-(3,4-dimethoxy-phenyl)-acrylamide
Show/Hide
|
C21H25NO3
|
2
|
| 1 |
IC50 = 170 nM
|
|
|
| 2 |
IC50 > 4000 nM
|
|
|
|
CP0442312
|
2-p-tolyl-6-(3-(trifluoromethyl)pyridin-2-yl)-1H-benzo[d]imidazole
Show/Hide
|
C20H14F3N3
|
1
|
| 1 |
IC50 = 170 nM
|
|
|
|
CP0503360
|
6-(2-methoxyphenyl)-2-(4-(trifluoromethyl)phenyl)-1,2-dihydroindazol-3-one
Show/Hide
|
C21H15F3N2O2
|
1
|
| 1 |
IC50 = 170 nM
|
|
|
|
CP0512068
|
US9120756, 21
Show/Hide
|
C21H19ClF4N4O3S
|
3
|
| 1 |
IC50 = 179 nM
|
|
|
| 2 |
Ki = 0.3 nM
|
|
|
| 3 |
Ki = 0.4 nM
|
|
|
|
CP0465126
|
6-(3-methylpyridin-2-yl)-2-(4-(trifluoromethyl)phenyl)-1,2-dihydroindazol-3-one
Show/Hide
|
C20H14F3N3O
|
1
|
| 1 |
IC50 = 180 nM
|
|
|
|
CP0502256
|
(E)-N-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-3-(4-nitro-phenyl)-acrylamide
Show/Hide
|
C17H14N2O5
|
2
|
| 1 |
IC50 = 190 nM
|
|
|
| 2 |
IC50 = 440 nM
|
|
|
|
CP0504554
|
(1R,3R)-4-chloro-N-(3-hydroxycyclopentyl)-5-(4-(trifluoromethyl)phenyl)isoxazole-3-carboxamide
Show/Hide
|
C16H14ClF3N2O3
|
1
|
| 1 |
IC50 = 197 nM
|
|
|
|
CP0375590
|
5-(4-chloro-2-ethoxyphenyl)-N-(4-hydroxycyclohexyl)-4-methyl-1,2-oxazole-3-carboxamide
Show/Hide
|
C19H23ClN2O4
|
1
|
| 1 |
IC50 = 199.53 nM
|
|
|
|
CP0486605
|
[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]-[7-[3-(trifluoromethyl)phenyl]pyrrolo[1,2-b]pyridazin-6-yl]methanone
Show/Hide
|
C20H18F3N3O2
|
1
|
| 1 |
IC50 = 199.53 nM
|
|
|
|
CP0489133
|
N-cyclopentyl-5-[4-(trifluoromethyl)phenyl]-1,2-oxazole-3-carboxamide
Show/Hide
|
C16H15F3N2O2
|
1
|
| 1 |
IC50 = 201 nM
|
|
|
|
CP0409352
|
2-(4-tert-butylbenzylidene)-N-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)butanamide
Show/Hide
|
C23H27NO3
|
2
|
| 1 |
IC50 = 210 nM
|
|
|
| 2 |
IC50 = 800 nM
|
|
|
|
CP0421258
|
(E)-N-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-3-p-tolyl-acrylamide
Show/Hide
|
C18H17NO3
|
2
|
| 1 |
IC50 = 210 nM
|
|
|
| 2 |
IC50 = 1100 nM
|
|
|
|
CP0375226
|
(4S)-8-chloro-4-hydroxy-N-[4-(trifluoromethoxy)phenyl]spiro[3,4-dihydrochromene-2,4'-piperidine]-1'-carboxamide
Show/Hide
|
C21H20ClF3N2O4
|
1
|
| 1 |
IC50 = 217.8 nM
|
|
|
|
CP0464704
|
2-(4-tert-butylphenyl)-6-(3-(trifluoromethyl)pyridin-2-yl)-1H-benzo[d]imidazole
Show/Hide
|
C23H20F3N3
|
1
|
| 1 |
IC50 = 224 nM
|
|
|
|
CP0549053
|
4-chloro-N-(4-hydroxybutyl)-5-(4-(trifluoromethyl)phenyl)isoxazole-3-carboxamide
Show/Hide
|
C15H14ClF3N2O3
|
1
|
| 1 |
IC50 = 238 nM
|
|
|
|
CP0404803
|
(E)-3-(4-Chloro-phenyl)-N-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-acrylamide
Show/Hide
|
C17H14ClNO3
|
2
|
| 1 |
IC50 = 250 nM
|
|
|
| 2 |
IC50 = 320 nM
|
|
|
|
CP0410428
|
N-ethyl-N-(2-hydroxyethyl)-7-(3-methylphenyl)pyrrolo[1,2-b]pyridazine-6-carboxamide
Show/Hide
|
C19H21N3O2
|
1
|
| 1 |
IC50 = 251.19 nM
|
|
|
|
CP0395179
|
1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(7-hydroxy-1,2,3,4-tetrahydronaphthalen-1-yl)urea
Show/Hide
|
C18H16ClF3N2O2
|
1
|
| 1 |
IC50 = 260 nM
|
|
|
|
CP0506088
|
(4-chloro-5-(4-(trifluoromethyl)phenyl)isoxazol-3-yl)(4-hydroxypiperidin-1-yl)methanone
Show/Hide
|
C16H14ClF3N2O3
|
1
|
| 1 |
IC50 = 263 nM
|
|
|
|
CP0375228
|
(4S)-8-fluoro-4-hydroxy-N-[4-(trifluoromethoxy)phenyl]spiro[3,4-dihydrochromene-2,4'-piperidine]-1'-carboxamide
Show/Hide
|
C21H20F4N2O4
|
1
|
| 1 |
IC50 = 266.3 nM
|
|
|
|
CP0456497
|
(E)-3-(4-tert-Butyl-phenyl)-N-(3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-7-yl)-acrylamide
Show/Hide
|
C21H22N2O3
|
2
|
| 1 |
IC50 = 270 nM
|
|
|
| 2 |
IC50 > 4000 nM
|
|
|
|
CP0500593
|
6-(3-methylpyridin-2-yl)-2-(4-(trifluoromethyl)phenyl)-1,2-dihydropyrazolo[3,4-b]pyridin-3-one
Show/Hide
|
C19H13F3N4O
|
1
|
| 1 |
IC50 = 270 nM
|
|
|
|
CP0385971
|
(2E)-3-(4-chlorophenyl)-N-(3-methoxyphenyl)prop-2-enamide
Show/Hide
|
C16H14ClNO2
|
1
|
| 1 |
IC50 = 270 nM
|
|
|
|
CP0503846
|
(E)-3-(4-tert-Butyl-phenyl)-N-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-thioacrylamide
Show/Hide
|
C21H23NO2S
|
2
|
| 1 |
IC50 = 280 nM
|
|
|
| 2 |
IC50 = 1400 nM
|
|
|
|
CP0941052
|
2-(4-(trifluoromethyl)phenyl)-6-(3-(trifluoromethyl)pyridin-2-yl)-1,2,4,5,6,7-hexahydropyrazolo[3,4-b]pyridin-3-one
Show/Hide
|
C19H14F6N4O
|
1
|
| 1 |
IC50 = 290 nM
|
|
|
|
CP0473832
|
N-cyclopentyl-4-[(propan-2-ylamino)methyl]-5-[4-(trifluoromethyl)phenyl]-1,2-oxazole-3-carboxamide
Show/Hide
|
C20H24F3N3O2
|
1
|
| 1 |
IC50 = 316.23 nM
|
|
|
|
CP0526273
|
2-(4-fluorophenyl)-6-(3-(trifluoromethyl)pyridin-2-yl)-1H-benzo[d]imidazole
Show/Hide
|
C19H11F4N3
|
1
|
| 1 |
IC50 = 320 nM
|
|
|
|
CP0425366
|
(E)-3-(4-tert-Butyl-phenyl)-N-phenyl-acrylamide
Show/Hide
|
C19H21NO
|
2
|
| 1 |
IC50 = 330 nM
|
|
|
| 2 |
IC50 > 4000 nM
|
|
|
|
CP0541357
|
2-(4-(trifluoromethyl)phenyl)-1,2-dihydroindazol-3-one
Show/Hide
|
C14H9F3N2O
|
1
|
| 1 |
IC50 = 340 nM
|
|
|
|
CP0483442
|
1-(4-chloro-3-(trifluoromethyl)phenyl)-2-cyano-3-(7-hydroxynaphthalen-1-yl)guanidine
Show/Hide
|
C19H12ClF3N4O
|
1
|
| 1 |
IC50 = 340 nM
|
|
|
|
CP0378876
|
(E)-N-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-3-(2-methyl-6-trifluoromethyl-pyridin-3-yl)-acrylamide
Show/Hide
|
C18H15F3N2O3
|
2
|
| 1 |
IC50 = 360 nM
|
|
|
| 2 |
IC50 = 870 nM
|
|
|
|
CP0461564
|
(E)-3-(4-Butyl-phenyl)-N-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-acrylamide
Show/Hide
|
C21H23NO3
|
2
|
| 1 |
IC50 = 360 nM
|
|
|
| 2 |
IC50 = 2700 nM
|
|
|
|
CP0486011
|
(E)-N-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-3-(4-isobutyl-phenyl)-acrylamide
Show/Hide
|
C21H23NO3
|
2
|
| 1 |
IC50 = 360 nM
|
|
|
| 2 |
IC50 = 860 nM
|
|
|
|
CP0503361
|
2-(4-(trifluoromethyl)phenyl)-5-(3-(trifluoromethyl)pyridin-2-yl)-1,2-dihydroindazol-3-one
Show/Hide
|
C20H11F6N3O
|
1
|
| 1 |
IC50 = 370 nM
|
|
|
|
CP0517363
|
4-bromo-5-(4-chlorophenyl)-N-cyclopentylisoxazole-3-carboxamide
Show/Hide
|
C15H14BrClN2O2
|
1
|
| 1 |
IC50 = 370 nM
|
|
|
|
CP0471808
|
4-bromo-N-cyclopentyl-5-(4-fluorophenyl)isoxazole-3-carboxamide
Show/Hide
|
C15H14BrFN2O2
|
1
|
| 1 |
IC50 = 377 nM
|
|
|
|
CP0437147
|
4-chloro-N-(4-hydroxycyclohexyl)-5-[4-(trifluoromethyl)phenyl]-1,2-oxazole-3-carboxamide
Show/Hide
|
C17H16ClF3N2O3
|
1
|
| 1 |
IC50 = 392 nM
|
|
|
|
CP0549056
|
(1R,3S)-4-chloro-5-(3,4-difluorophenyl)-N-(3-hydroxycyclopentyl)isoxazole-3-carboxamide
Show/Hide
|
C15H13ClF2N2O3
|
1
|
| 1 |
IC50 = 404 nM
|
|
|
|
CP0437307
|
4-bromo-5-(4-bromophenyl)-N-cyclopentylisoxazole-3-carboxamide
Show/Hide
|
C15H14Br2N2O2
|
1
|
| 1 |
IC50 = 410 nM
|
|
|
|
CP0375225
|
(4S)-8-bromo-4-hydroxy-N-[4-(trifluoromethoxy)phenyl]spiro[3,4-dihydrochromene-2,4'-piperidine]-1'-carboxamide
Show/Hide
|
C21H20BrF3N2O4
|
1
|
| 1 |
IC50 = 412.9 nM
|
|
|
|
CP0050997
|
N-[2-(4-chlorophenyl)ethyl]-7,8-dihydroxy-1,3,4,5-tetrahydro-2-benzazepine-2-carbothioamide
Show/Hide
|
C19H21ClN2O2S
|
1
|
| 1 |
IC50 = 420 nM
|
|
|
|
CP0549055
|
(1R,3S)-4-chloro-5-(4-fluorophenyl)-N-(3-hydroxycyclopentyl)isoxazole-3-carboxamide
Show/Hide
|
C15H14ClFN2O3
|
1
|
| 1 |
IC50 = 434 nM
|
|
|
|
CP0394221
|
4-tert-butyl-N-(4-(3-(trifluoromethyl)pyridin-2-yl)phenyl)benzamide
Show/Hide
|
C23H21F3N2O
|
1
|
| 1 |
IC50 = 470 nM
|
|
|
|
CP0498265
|
(E)-3-(5-tert-Butyl-pyridin-2-yl)-N-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-acrylamide
Show/Hide
|
C20H22N2O3
|
2
|
| 1 |
IC50 = 500 nM
|
|
|
| 2 |
IC50 = 2900 nM
|
|
|
|
CP0486606
|
[2-(hydroxymethyl)piperidin-1-yl]-[3-(3-methoxyphenyl)indolizin-2-yl]methanone
Show/Hide
|
C22H24N2O3
|
1
|
| 1 |
IC50 = 501.19 nM
|
|
|
|
CP0493885
|
N-ethyl-N-(2-hydroxyethyl)-3-[6-(trifluoromethyl)pyridin-2-yl]indolizine-2-carboxamide
Show/Hide
|
C19H18F3N3O2
|
1
|
| 1 |
IC50 = 501.19 nM
|
|
|
|
CP0513223
|
N-ethyl-N-(2-hydroxyethyl)-3-[3-(trifluoromethyl)phenyl]furo[3,2-b]pyridine-2-carboxamide
Show/Hide
|
C19H17F3N2O3
|
1
|
| 1 |
IC50 = 501.19 nM
|
|
|
|
CP0395177
|
3-(3-(7-hydroxynaphthalen-1-yl)ureido)benzoic acid
Show/Hide
|
C18H14N2O4
|
1
|
| 1 |
IC50 = 520 nM
|
|
|
|
CP0421246
|
(E)-3-(4-tert-Butyl-phenyl)-N-(2-methoxy-phenyl)-acrylamide
Show/Hide
|
C20H23NO2
|
2
|
| 1 |
IC50 = 550 nM
|
|
|
| 2 |
IC50 > 4000 nM
|
|
|
|
CP0495233
|
(E)-N-Benzo[1,3]dioxol-5-yl-3-(4-tert-butyl-phenyl)-acrylamide
Show/Hide
|
C20H21NO3
|
2
|
| 1 |
IC50 = 570 nM
|
|
|
| 2 |
IC50 > 4000 nM
|
|
|
|
CP0469059
|
4-chloro-N-(3-hydroxypropyl)-5-(4-(trifluoromethyl)phenyl)isoxazole-3-carboxamide
Show/Hide
|
C14H12ClF3N2O3
|
1
|
| 1 |
IC50 = 595 nM
|
|
|
|
CP0508597
|
(E)-3-(3-tert-Butyl-phenyl)-N-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-acrylamide
Show/Hide
|
C21H23NO3
|
2
|
| 1 |
IC50 = 620 nM
|
|
|
| 2 |
IC50 > 4000 nM
|
|
|
|
CP0377616
|
N-ethyl-N-(2-hydroxyethyl)-4-methyl-7-[3-(trifluoromethyl)phenyl]pyrrolo[1,2-b]pyridazine-6-carboxamide
Show/Hide
|
C20H20F3N3O2
|
1
|
| 1 |
IC50 = 630.96 nM
|
|
|
|
CP0503363
|
N-[4-(3-methylpyridin-2-yl)phenyl]-3-(trifluoromethyl)benzamide
Show/Hide
|
C20H15F3N2O
|
1
|
| 1 |
IC50 = 640 nM
|
|
|
|
CP0431226
|
(E)-3-(4-tert-Butyl-phenyl)-acrylic acid 2,3-dihydro-benzo[1,4]dioxin-6-yl ester
Show/Hide
|
C21H22O4
|
2
|
| 1 |
IC50 = 670 nM
|
|
|
| 2 |
IC50 = 3200 nM
|
|
|
|
CP0499539
|
(1S,3S)-4-chloro-N-(3-hydroxycyclopentyl)-5-(4-(trifluoromethyl)phenyl)isoxazole-3-carboxamide
Show/Hide
|
C16H14ClF3N2O3
|
1
|
| 1 |
IC50 = 762 nM
|
|
|
|
CP0455210
|
4-chloro-3-(4-fluorophenyl)-N-[(1R,3S)-3-hydroxycyclohexyl]-1,2-oxazole-5-carboxamide
Show/Hide
|
C16H16ClFN2O3
|
1
|
| 1 |
IC50 = 794.33 nM
|
|
|
|
CP0528896
|
N-[(2R)-3-methylbutan-2-yl]-4-[(propan-2-ylamino)methyl]-5-[4-(trifluoromethyl)phenyl]-1,2-oxazole-3-carboxamide
Show/Hide
|
C20H26F3N3O2
|
1
|
| 1 |
IC50 = 794.33 nM
|
|
|
|
CP0453577
|
N-ethyl-N-(2-hydroxyethyl)-2-methyl-7-[3-(trifluoromethyl)phenyl]pyrrolo[1,2-b]pyridazine-6-carboxamide
Show/Hide
|
C20H20F3N3O2
|
1
|
| 1 |
IC50 = 794.33 nM
|
|
|
|
CP0375227
|
(4R)-8-fluoro-4-hydroxy-N-[4-(trifluoromethoxy)phenyl]spiro[3,4-dihydrochromene-2,4'-piperidine]-1'-carboxamide
Show/Hide
|
C21H20F4N2O4
|
1
|
| 1 |
IC50 = 841.6 nM
|
|
|
|
CP0404805
|
(E)-N-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-3-(6-trifluoromethyl-pyridin-3-yl)-acrylamide
Show/Hide
|
C17H13F3N2O3
|
2
|
| 1 |
IC50 = 870 nM
|
|
|
| 2 |
IC50 = 1290 nM
|
|
|
|
CP0378871
|
(E)-N-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-3-(4-fluoro-phenyl)-acrylamide
Show/Hide
|
C17H14FNO3
|
2
|
| 1 |
IC50 = 1000 nM
|
|
|
| 2 |
IC50 > 4000 nM
|
|
|
|
CP0473828
|
N-cyclopentyl-4-(1-hydroxyethyl)-5-[4-(trifluoromethyl)phenyl]-1,2-oxazole-3-carboxamide
Show/Hide
|
C18H19F3N2O3
|
1
|
| 1 |
IC50 = 1000 nM
|
|
|
|
CP0377615
|
N-ethyl-N-(2-hydroxyethyl)-3-(3-methoxyphenyl)indolizine-2-carboxamide
Show/Hide
|
C20H22N2O3
|
1
|
| 1 |
IC50 = 1000 nM
|
|
|
|
CP0410429
|
N-ethyl-N-(2-hydroxyethyl)-1-[3-(trifluoromethyl)phenyl]pyrrolo[2,3-b]pyridine-2-carboxamide
Show/Hide
|
C19H18F3N3O2
|
1
|
| 1 |
IC50 = 1000 nM
|
|
|
|
CP0486539
|
4-methyl-N-(4-(3-(trifluoromethyl)pyridin-2-yl)phenyl)benzamide
Show/Hide
|
C20H15F3N2O
|
1
|
| 1 |
IC50 = 1100 nM
|
|
|
|
CP0377963
|
4-bromo-N-cyclopentyl-5-(4-(trifluoromethoxy)phenyl)isoxazole-3-carboxamide
Show/Hide
|
C16H14BrF3N2O3
|
1
|
| 1 |
IC50 = 1252 nM
|
|
|
|
CP0493886
|
N-ethyl-N-(2-hydroxyethyl)-3-(6-methoxypyridin-2-yl)indolizine-2-carboxamide
Show/Hide
|
C19H21N3O3
|
1
|
| 1 |
IC50 = 1258.93 nM
|
|
|
|
CP0513221
|
N-ethyl-N-(2-hydroxyethyl)-7-(3-methoxyphenyl)pyrrolo[1,2-b]pyridazine-6-carboxamide
Show/Hide
|
C19H21N3O3
|
1
|
| 1 |
IC50 = 1258.93 nM
|
|
|
|
CP0486541
|
N-(4-pyridin-2-ylphenyl)-4-(trifluoromethyl)benzamide
Show/Hide
|
C19H13F3N2O
|
1
|
| 1 |
IC50 = 1500 nM
|
|
|
|
CP0473830
|
3-(cyclopentylcarbamoyl)-5-[4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxylic acid
Show/Hide
|
C17H15F3N2O4
|
1
|
| 1 |
IC50 = 1584.89 nM
|
|
|
|
CP0478526
|
N-[(2R)-1-hydroxybutan-2-yl]-4-(hydroxymethyl)-5-[4-(trifluoromethyl)phenyl]-1,2-oxazole-3-carboxamide
Show/Hide
|
C16H17F3N2O4
|
1
|
| 1 |
IC50 = 1584.89 nM
|
|
|
|
CP0502767
|
N-(4-hydroxycyclohexyl)-4-(hydroxymethyl)-5-[4-(trifluoromethyl)phenyl]-1,2-oxazole-3-carboxamide
Show/Hide
|
C18H19F3N2O4
|
1
|
| 1 |
IC50 = 1584.89 nM
|
|
|
|
CP0499975
|
1-[(2R)-2-(hydroxymethyl)pyrrolidin-1-yl]-2-[7-[3-(trifluoromethyl)phenyl]pyrrolo[1,2-b]pyridazin-6-yl]ethanone
Show/Hide
|
C21H20F3N3O2
|
1
|
| 1 |
IC50 = 1584.89 nM
|
|
|
|
CP0378872
|
(E)-N-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-3-(4-methoxy-phenyl)-acrylamide
Show/Hide
|
C18H17NO4
|
2
|
| 1 |
IC50 = 1800 nM
|
|
|
| 2 |
IC50 > 4000 nM
|
|
|
|
CP0421252
|
2-(4-tert-Butyl-phenyl)-cyclopropanecarboxylic acid (2,3-dihydro-benzo[1,4]dioxin-6-yl)-amide
Show/Hide
|
C22H25NO3
|
2
|
| 1 |
IC50 = 1800 nM
|
|
|
| 2 |
IC50 > 4000 nM
|
|
|
|
CP0528895
|
3-N-cyclopentyl-4-N,4-N-dimethyl-5-[4-(trifluoromethyl)phenyl]-1,2-oxazole-3,4-dicarboxamide
Show/Hide
|
C19H20F3N3O3
|
1
|
| 1 |
IC50 = 1995.26 nM
|
|
|
|
CP0513222
|
N-(2-hydroxyethyl)-3-phenyl-N-propylindolizine-2-carboxamide
Show/Hide
|
C20H22N2O2
|
1
|
| 1 |
IC50 = 1995.26 nM
|
|
|
|
CP0446965
|
4-chloro-N-(3-methoxypropyl)-5-(4-(trifluoromethyl)phenyl)isoxazole-3-carboxamide
Show/Hide
|
C15H14ClF3N2O3
|
1
|
| 1 |
IC50 = 2212 nM
|
|
|
|
CP0541705
|
N-[4-[3-(trifluoromethyl)pyridin-2-yl]phenyl]benzamide
Show/Hide
|
C19H13F3N2O
|
1
|
| 1 |
IC50 = 2400 nM
|
|
|
|
CP0410426
|
N-ethyl-N-(2-hydroxyethyl)-7-[4-(trifluoromethyl)phenyl]pyrrolo[1,2-b]pyridazine-6-carboxamide
Show/Hide
|
C19H18F3N3O2
|
1
|
| 1 |
IC50 = 2511.89 nM
|
|
|
|
CP0527238
|
US9120756, 25
Show/Hide
|
C21H19ClF4N4O3S
|
2
|
| 1 |
IC50 = 2585 nM
|
|
|
| 2 |
Ki = 26.5 nM
|
|
|
|
CP0441887
|
3,3-Bis-(4-tert-butyl-phenyl)-N-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-acrylamide
Show/Hide
|
C31H35NO3
|
2
|
| 1 |
IC50 = 2700 nM
|
|
|
| 2 |
IC50 > 4000 nM
|
|
|
|
CP0505873
|
4-(hydroxymethyl)-N-(oxan-4-yl)-5-[4-(trifluoromethyl)phenyl]-1,2-oxazole-3-carboxamide
Show/Hide
|
C17H17F3N2O4
|
1
|
| 1 |
IC50 = 3162.28 nM
|
|
|
|
CP0544535
|
[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]-[7-(4-methoxyphenyl)pyrrolo[1,2-b]pyridazin-6-yl]methanone
Show/Hide
|
C20H21N3O3
|
1
|
| 1 |
IC50 = 3162.28 nM
|
|
|
|
CP0500567
|
(E)-3-(4-tert-Butyl-phenyl)-6-dimethylamino-hex-2-enoic acid (2,3-dihydro-benzo[1,4]dioxin-6-yl)-amide
Show/Hide
|
C26H34N2O3
|
2
|
| 1 |
IC50 = 3900 nM
|
|
|
| 2 |
IC50 > 4000 nM
|
|
|
|
CP0482451
|
3-[2-[2-(hydroxymethyl)piperidine-1-carbonyl]indolizin-3-yl]benzonitrile
Show/Hide
|
C22H21N3O2
|
1
|
| 1 |
IC50 = 3981.07 nM
|
|
|
|
CP0504556
|
4-bromo-5-(3-chlorophenyl)-N-cyclopentylisoxazole-3-carboxamide
Show/Hide
|
C15H14BrClN2O2
|
1
|
| 1 |
IC50 = 4222 nM
|
|
|
|
CP0473829
|
3-N-cyclopentyl-4-N-ethyl-5-[4-(trifluoromethyl)phenyl]-1,2-oxazole-3,4-dicarboxamide
Show/Hide
|
C19H20F3N3O3
|
1
|
| 1 |
IC50 = 5011.87 nM
|
|
|
|
CP0526849
|
N-cyclopentyl-4-(2-hydroxypropan-2-yl)-5-[4-(trifluoromethyl)phenyl]-1,2-oxazole-3-carboxamide
Show/Hide
|
C19H21F3N2O3
|
1
|
| 1 |
IC50 = 5011.87 nM
|
|
|
|
CP0487970
|
N-ethyl-N-(2-hydroxyethyl)-3-methyl-7-[3-(trifluoromethyl)phenyl]pyrrolo[1,2-b]pyridazine-6-carboxamide
Show/Hide
|
C20H20F3N3O2
|
1
|
| 1 |
IC50 = 5011.87 nM
|
|
|
|
CP0534524
|
N-ethyl-N-(2-hydroxyethyl)-3-methoxy-7-[3-(trifluoromethyl)phenyl]pyrrolo[1,2-b]pyridazine-6-carboxamide
Show/Hide
|
C20H20F3N3O3
|
1
|
| 1 |
IC50 = 5011.87 nM
|
|
|
|
CP0497845
|
N-ethyl-N-(2-hydroxyethyl)-7-[[3-(trifluoromethyl)phenyl]methyl]pyrrolo[1,2-b]pyridazine-6-carboxamide
Show/Hide
|
C20H20F3N3O2
|
1
|
| 1 |
IC50 = 7943.28 nM
|
|
|
|
CP0516825
|
US9186360, 76
Show/Hide
|
C21H15F5N4O4S
|
1
|
| 1 |
IC50 = 8010 nM
|
|
|
|
CP0180290
|
9-[6-[[4-(2,4-dimethyl-1,3-thiazol-5-yl)-1,3-thiazol-2-yl]amino]pyridine-3-carbonyl]-3-oxa-9-azabicyclo[3.3.1]nonan-7-one
Show/Hide
|
C21H21N5O3S2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0019489
|
US9108905, 1
Show/Hide
|
C12H14FNO
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0262006
|
4-[3-(3-methoxypropoxy)phenyl]-2-sulfanylidene-3,4-dihydro-1H-indeno[1,2-d]pyrimidin-5-one
Show/Hide
|
C21H20N2O3S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0402704
|
US9186360, 85
Show/Hide
|
C21H15F4N5O3S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0402705
|
US9186360, 24
Show/Hide
|
C21H16ClFN4O3S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0412454
|
US9186360, 22
Show/Hide
|
C26H28N4O4S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0412575
|
US9186360, 49
Show/Hide
|
C23H19F5N4O4S2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0412578
|
US9186360, 70
Show/Hide
|
C21H16F4N4O5S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0412582
|
US9186360, 18
Show/Hide
|
C22H16F4N4O3S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0412583
|
US9186360, 30
Show/Hide
|
C22H17ClF2N4O4S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0412586
|
US9186360, 75
Show/Hide
|
C24H24Cl2N4O5S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0412587
|
US9186360, 82
Show/Hide
|
C19H13F4N5O4S2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0412588
|
US9186360, 11
Show/Hide
|
C22H17F3N4O3S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0412589
|
US9186360, 14
Show/Hide
|
C24H24N4O3S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0412592
|
US9186360, 56
Show/Hide
|
C22H17F5N4O4S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0412617
|
US9186360, 17
Show/Hide
|
C23H22N4O3S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0412618
|
US9186360, 28
Show/Hide
|
C22H15F5N4O3S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0412619
|
US9186360, 39
Show/Hide
|
C20H17F3N6O3S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0413535
|
US9186360, 58
Show/Hide
|
C20H14F4N4O4S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0413536
|
US9186360, 77
Show/Hide
|
C19H12F5N5O3S2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0413540
|
US9186360, 69
Show/Hide
|
C21H16F4N4O4S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0413541
|
US9186360, 87
Show/Hide
|
C21H14F5N5O3S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0419511
|
US9186360, 31
Show/Hide
|
C22H15F5N4O3S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0419512
|
US9186360, 73
Show/Hide
|
C21H16ClF3N4O5S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0419513
|
US9186360, 94
Show/Hide
|
C21H18F5N6O7PS
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0419515
|
US9186360, 6
Show/Hide
|
C22H20N4O3S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0419516
|
US9186360, 20
Show/Hide
|
C22H16F4N4O3S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0423872
|
US9186360, 27
Show/Hide
|
C21H16F2N4O3S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0441106
|
US9186360, 86
Show/Hide
|
C22H16F5N5O4S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0441108
|
US9186360, 95
Show/Hide
|
C27H27ClF3N5O7S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0441109
|
US9186360, 1
Show/Hide
|
C19H16BrN7O2S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0441110
|
US9186360, 4
Show/Hide
|
C21H16Cl2N4O3S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0441111
|
US9186360, 9
Show/Hide
|
C21H17ClN4O3S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0441112
|
US9186360, 19
Show/Hide
|
C22H16F4N4O3S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0441113
|
US9186360, 23
Show/Hide
|
C25H26N4O4S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0441114
|
US9186360, 25
Show/Hide
|
C21H16ClFN4O3S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0441115
|
US9186360, 41
Show/Hide
|
C20H16F4N6O4S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0441116
|
US9186360, 62
Show/Hide
|
C22H17F5N4O5S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0463397
|
US9186360, 3
Show/Hide
|
C21H17BrN4O3S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0463398
|
US9186360, 12
Show/Hide
|
C25H26N4O3S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0463399
|
US9186360, 15
Show/Hide
|
C21H16ClFN4O3S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0463400
|
US9186360, 16
Show/Hide
|
C22H18F3N5O3
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0463403
|
US9186360, 60
Show/Hide
|
C21H15ClF4N4O5S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0463405
|
US9186360, 48
Show/Hide
|
C22H18F4N4O4S2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0470141
|
US9186360, 67
Show/Hide
|
C21H16F4N4O4S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0470143
|
US9186360, 92
Show/Hide
|
C19H12F5N5O4S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0470699
|
US9186360, 68
Show/Hide
|
C21H16F4N4O5S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0470719
|
US9186360, 47
Show/Hide
|
C20H16Cl2N4O3S2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0472819
|
US9186360, 38
Show/Hide
|
C20H16F4N6O3S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0478201
|
US9186360, 34
Show/Hide
|
C20H16F3N5O4S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0478205
|
US9186360, 54
Show/Hide
|
C20H14F4N4O4S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0478206
|
US9186360, 63
Show/Hide
|
C21H16ClF3N4O5S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0478207
|
US9186360, 71
Show/Hide
|
C21H16ClF3N4O4S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0478208
|
US9186360, 79
Show/Hide
|
C19H13F4N5O3S2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0478209
|
US9186360, 83
Show/Hide
|
C19H13F4N5O3S2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0479347
|
US9186360, 32
Show/Hide
|
C23H17F5N4O4S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0479348
|
US9186360, 36
Show/Hide
|
C20H15F4N5O3S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0479349
|
US9186360, 37
Show/Hide
|
C23H24Cl2N6O4S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0479354
|
US9186360, 50
Show/Hide
|
C22H18F4N4O3S2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0482710
|
US9186360, 65
Show/Hide
|
C21H16F4N4O4S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0482711
|
US9186360, 62
Show/Hide
|
C25H26F2N4O5S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0482713
|
US9186360, 35
Show/Hide
|
C22H18Cl2F3N5O4S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0483920
|
US9186360, 33
Show/Hide
|
C22H15F5N4O3S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0485488
|
US9186360, 81
Show/Hide
|
C19H13F4N5O3S2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0489890
|
US9186360, 10
Show/Hide
|
C27H28N4O3S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0490192
|
US9186360, 88
Show/Hide
|
C21H15F4N5O4S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0490193
|
US9186360, 16
Show/Hide
|
C22H17F3N4O3S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0495054
|
US9186360, 26
Show/Hide
|
C22H17F3N4O4S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0495055
|
US9186360, 29
Show/Hide
|
C22H16F4N4O4S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0499846
|
US9186360, 78
Show/Hide
|
C19H13F4N5O3S2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0512070
|
US9186360, 57
Show/Hide
|
C21H15Cl2F3N4O5S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0512071
|
US9186360, 72
Show/Hide
|
C21H15F5N4O4S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0512072
|
US9186360, 61
Show/Hide
|
C21H16F4N4O4S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0512088
|
US9186360, 5
Show/Hide
|
C21H17IN4O3S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0512093
|
US9186360, 8
Show/Hide
|
C21H18ClN5O3
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0516824
|
US9186360, 93
Show/Hide
|
C22H19ClF3N4O9PS
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0516826
|
US9186360, 53
Show/Hide
|
C23H22F2N4O5S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0518910
|
US9186360, 55
Show/Hide
|
C20H14F4N4O4S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0518928
|
US9186360, 59
Show/Hide
|
C20H14F4N4O4S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0518929
|
US9186360, 74
Show/Hide
|
C22H18ClF3N4O5S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0518944
|
US9186360, 2
Show/Hide
|
C23H25N7O2S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0519543
|
US9186360, 13
Show/Hide
|
C21H16F2N4O3S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0521618
|
US9186360, 46
Show/Hide
|
C23H20F4N4O3S2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0544901
|
US9186360, 64
Show/Hide
|
C21H15F5N4O4S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0548934
|
US9186360, 80
Show/Hide
|
C19H13ClF3N5O4S2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0140132
|
[6-[[4-(2,4-dimethyl-1,3-thiazol-5-yl)-1,3-thiazol-2-yl]amino]pyridin-3-yl]-[3-[5-(trifluoromethyl)pyrimidin-2-yl]-3,8-diazabicyclo[3.2.1]octan-8-yl]methanone
Show/Hide
|
C25H23F3N8OS2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0468867
|
[6-[[4-(2,4-dimethyl-1,3-thiazol-5-yl)-1,3-thiazol-2-yl]amino]pyridin-3-yl]-[7-[5-(trifluoromethyl)pyrimidin-2-yl]-3-oxa-7,9-diazabicyclo[3.3.1]nonan-9-yl]methanone
Show/Hide
|
C25H23F3N8O2S2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0544902
|
US9186360, 84
Show/Hide
|
C19H12F5N5O3S2
|
1
|
| 1 |
IC50 = 17660 nM
|
|
|
|
CP0385690
|
N-[2-[4-(difluoromethoxy)phenyl]ethyl]-2-(8-methyl-4-oxoquinazolin-3-yl)acetamide
Show/Hide
|
C20H19F2N3O3
|
1
|
| 1 |
IC50 > 20000 nM
|
|
|
|
CP0395178
|
2-(3-fluorophenyl)-N-(7-hydroxynaphthalen-1-yl)acetamide
Show/Hide
|
C18H14FNO2
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0460715
|
1-(3-(1-hydroxyethyl)phenyl)-3-(7-hydroxynaphthalen-1-yl)urea
Show/Hide
|
C19H18N2O3
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0498645
|
1-(3-fluorophenyl)-3-(3-hydroxybenzyl)urea
Show/Hide
|
C14H13FN2O2
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0502616
|
1-(3-(hydroxymethyl)phenyl)-3-(7-hydroxynaphthalen-1-yl)urea
Show/Hide
|
C18H16N2O3
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0503177
|
1-(2,6-dichlorophenyl)-3-(7-hydroxynaphthalen-1-yl)urea
Show/Hide
|
C17H12Cl2N2O2
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0365159
|
(4R)-8-chloro-4-hydroxy-N-[4-(trifluoromethoxy)phenyl]spiro[3,4-dihydrochromene-2,4'-piperidine]-1'-carboxamide
Show/Hide
|
C21H20ClF3N2O4
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0375224
|
(4R)-8-bromo-4-hydroxy-N-[4-(trifluoromethoxy)phenyl]spiro[3,4-dihydrochromene-2,4'-piperidine]-1'-carboxamide
Show/Hide
|
C21H20BrF3N2O4
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0412557
|
US9186360, 21
Show/Hide
|
C22H16ClF3N4O3S
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0047443
|
(E)-N-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-3-phenyl-acrylamide
Show/Hide
|
C17H15NO3
|
1
|
| 1 |
IC50 > 4000 nM
|
|
|
|
CP0404797
|
(E)-4-(4-tert-Butyl-phenyl)-5-(2,3-dihydro-benzo[1,4]dioxin-6-ylcarbamoyl)-pent-4-enoic acid
Show/Hide
|
C24H27NO5
|
1
|
| 1 |
IC50 > 4000 nM
|
|
|
|
CP0404820
|
(E)-3-(4-tert-Butyl-phenyl)-N-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-2-phenyl-acrylamide
Show/Hide
|
C27H27NO3
|
1
|
| 1 |
IC50 > 4000 nM
|
|
|
|
CP0502254
|
(E)-3-Biphenyl-4-yl-N-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-acrylamide
Show/Hide
|
C23H19NO3
|
1
|
| 1 |
IC50 > 4000 nM
|
|
|
|
CP0404816
|
(E)-3-(4-tert-Butyl-phenyl)-N-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-N-methyl-acrylamide
Show/Hide
|
C22H25NO3
|
1
|
| 1 |
IC50 > 4000 nM
|
|
|
|
CP0428427
|
(E)-N-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-3-(4-hydroxy-phenyl)-acrylamide
Show/Hide
|
C17H15NO4
|
1
|
| 1 |
IC50 > 4000 nM
|
|
|
|
CP0494839
|
5-tert-Butyl-2-[(E)-2-(2,3-dihydro-benzo[1,4]dioxin-6-ylcarbamoyl)-vinyl]-benzoic acid
Show/Hide
|
C22H23NO5
|
1
|
| 1 |
IC50 > 4000 nM
|
|
|
|
CP0503848
|
N-[(E)-3-(4-tert-butylphenyl)prop-2-enyl]-2,3-dihydro-1,4-benzodioxin-6-amine
Show/Hide
|
C21H25NO2
|
1
|
| 1 |
IC50 > 4000 nM
|
|
|
|
CP0469889
|
1-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]-3-(3-oxo-4H-1,4-benzoxazin-8-yl)urea
Show/Hide
|
C22H24F3N5O3
|
2
|
| 1 |
Kd = 0.589 nM
|
|
|
| 2 |
Ki = 0.63 nM
|
|
|
|
CP0547839
|
1-[(1R)-5-tert-butyl-2,3-dihydro-1H-inden-1-yl]-3-isoquinolin-5-ylurea
Show/Hide
|
C23H25N3O
|
1
|
| 1 |
Kd = 3.4 nM
|
|
|
|
CP0312254
|
US9120756, 17
Show/Hide
|
C24H28ClFN4O3S
|
3
|
| 1 |
Ki = 0.04 nM
|
|
|
| 2 |
Ki = 0.1 nM
|
|
|
| 3 |
Ki = 0.3 nM
|
|
|
|
CP0379261
|
(2S)-N-[[2-(4-tert-butylcyclohexen-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C27H33F4N3O3S
|
1
|
| 1 |
Ki = 0.1 nM
|
|
|
|
CP0494292
|
N-[[2-(4-ethylcyclohexen-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C25H29F4N3O3S
|
1
|
| 1 |
Ki = 0.1 nM
|
|
|
|
CP0551428
|
(2S)-N-[[2-(4,4-dimethylcyclohexen-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C25H29F4N3O3S
|
1
|
| 1 |
Ki = 0.1 nM
|
|
|
|
CP0555279
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-[(3R)-3-methylcyclohexen-1-yl]-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
|
C24H27F4N3O3S
|
1
|
| 1 |
Ki = 0.1 nM
|
|
|
|
CP0471721
|
(2S)-N-[[5-tert-butyl-2-(3-chloro-4-fluorophenyl)pyrazol-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C24H27ClF2N4O3S
|
1
|
| 1 |
Ki = 0.1 nM
|
|
|
|
CP0550925
|
(2S)-N-[[2-(4-ethylcyclohexyl)-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C25H31F4N3O3S
|
1
|
| 1 |
Ki = 0.2 nM
|
|
|
|
CP0551424
|
N-[[2-chloro-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C17H16ClF4N3O3S
|
1
|
| 1 |
Ki = 0.2 nM
|
|
|
|
CP0551427
|
N-[[2-(4,4-dimethylcyclohexen-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C25H29F4N3O3S
|
1
|
| 1 |
Ki = 0.2 nM
|
|
|
|
CP0554583
|
(2S)-2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-(4-methylcyclohexen-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
|
C24H27F4N3O3S
|
1
|
| 1 |
Ki = 0.2 nM
|
|
|
|
CP0555278
|
N-[[2-(4-tert-butylcyclohexen-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C27H33F4N3O3S
|
1
|
| 1 |
Ki = 0.2 nM
|
|
|
|
CP0557810
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-(3-methylcyclohexen-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
|
C24H27F4N3O3S
|
1
|
| 1 |
Ki = 0.2 nM
|
|
|
|
CP0489324
|
N-[[2-(3-chloro-4-fluorophenyl)-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C23H19ClF5N3O3S
|
2
|
| 1 |
Ki = 0.2 nM
|
|
|
| 2 |
Ki = 0.6 nM
|
|
|
|
CP0374736
|
N-[[2-(4-benzylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C29H32F4N4O3S
|
1
|
| 1 |
Ki = 0.2 nM
|
|
|
|
CP0400486
|
N-[[2-(dipropylamino)-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C23H30F4N4O3S
|
1
|
| 1 |
Ki = 0.2 nM
|
|
|
|
CP0381415
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-(4-methylcyclohexen-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
|
C24H27F4N3O3S
|
1
|
| 1 |
Ki = 0.3 nM
|
|
|
|
CP0410645
|
N-[[2-(4-tert-butylcyclohexyl)-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C27H35F4N3O3S
|
1
|
| 1 |
Ki = 0.3 nM
|
|
|
|
CP0536769
|
N-[[2-(4-ethylcyclohexyl)-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C25H31F4N3O3S
|
1
|
| 1 |
Ki = 0.3 nM
|
|
|
|
CP0544650
|
(2S)-N-[[2-cyclohexyl-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C23H27F4N3O3S
|
1
|
| 1 |
Ki = 0.3 nM
|
|
|
|
CP0544652
|
N-[[2-(4-tert-butylcyclohexyl)-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C27H35F4N3O3S
|
1
|
| 1 |
Ki = 0.3 nM
|
|
|
|
CP0544653
|
(2S)-N-[[2-(4,4-dimethylcyclohexyl)-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C25H31F4N3O3S
|
1
|
| 1 |
Ki = 0.3 nM
|
|
|
|
CP0489322
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-thiophen-2-yl-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
|
C21H19F4N3O3S2
|
1
|
| 1 |
Ki = 0.3 nM
|
|
|
|
CP0398141
|
N-[[6-[chloro(difluoro)methyl]-2-(4-methylpiperidin-1-yl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C23H28ClF3N4O3S
|
1
|
| 1 |
Ki = 0.3 nM
|
|
|
|
CP0484593
|
N-[[2-(dipropylamino)-4-(trifluoromethyl)phenyl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C24H31F4N3O3S
|
1
|
| 1 |
Ki = 0.3 nM
|
|
|
|
CP0097608
|
US9120756, 16
Show/Hide
|
C24H28ClFN4O3S
|
1
|
| 1 |
Ki = 0.3 nM
|
|
|
|
CP0396763
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-(4-methylcyclohexyl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
|
C24H29F4N3O3S
|
1
|
| 1 |
Ki = 0.4 nM
|
|
|
|
CP0415802
|
N-[[2-(4,4-dimethylcyclohexyl)-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C25H31F4N3O3S
|
1
|
| 1 |
Ki = 0.4 nM
|
|
|
|
CP0489319
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-(4-fluorophenyl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
|
C23H20F5N3O3S
|
4
|
| 1 |
Ki = 0.4 nM
|
|
|
| 2 |
Ki = 0.84 nM
|
|
|
| 3 |
Ki = 25.9 nM
|
|
|
| 4 |
Ki = 130.8 nM
|
|
|
|
CP0529533
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-(4-fluoro-3-methylphenyl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
|
C24H22F5N3O3S
|
1
|
| 1 |
Ki = 0.4 nM
|
|
|
|
CP0431547
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[4-(trifluoromethyl)-2-[4-(trifluoromethyl)piperidin-1-yl]phenyl]methyl]propanamide
Show/Hide
|
C24H26F7N3O3S
|
1
|
| 1 |
Ki = 0.4 nM
|
|
|
|
CP0441779
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[6-(trifluoromethyl)-2-[4-(trifluoromethyl)piperidin-1-yl]pyridin-3-yl]methyl]propanamide
Show/Hide
|
C23H25F7N4O3S
|
1
|
| 1 |
Ki = 0.4 nM
|
|
|
|
CP0470390
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-[4-[(3-fluorophenyl)methyl]piperidin-1-yl]-4-(trifluoromethyl)phenyl]methyl]propanamide
Show/Hide
|
C30H32F5N3O3S
|
1
|
| 1 |
Ki = 0.4 nM
|
|
|
|
CP0471621
|
(2S)-N-[[2-cyclohexylsulfanyl-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C23H27F4N3O3S2
|
1
|
| 1 |
Ki = 0.4 nM
|
|
|
|
CP0543243
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-[4-[(4-fluorophenyl)methyl]piperidin-1-yl]-4-(trifluoromethyl)phenyl]methyl]propanamide
Show/Hide
|
C30H32F5N3O3S
|
1
|
| 1 |
Ki = 0.4 nM
|
|
|
|
CP0545699
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-pentyl-4-(trifluoromethyl)phenyl]methyl]propanamide
Show/Hide
|
C23H28F4N2O3S
|
1
|
| 1 |
Ki = 0.4 nM
|
|
|
|
CP0409393
|
(2S)-N-[(4-tert-butylphenyl)methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C21H27FN2O3S
|
3
|
| 1 |
Ki = 0.49 nM
|
|
|
| 2 |
Ki = 8.3 nM
|
|
|
| 3 |
Ki = 15.8 nM
|
|
|
|
CP0530689
|
N-[[2-(4-tert-butylphenyl)-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C27H29F4N3O3S
|
1
|
| 1 |
Ki = 0.5 nM
|
|
|
|
CP0533021
|
N-[[2-(3-chlorophenyl)-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C23H20ClF4N3O3S
|
1
|
| 1 |
Ki = 0.5 nM
|
|
|
|
CP0559300
|
N-[[2-(azepan-1-yl)-6-[chloro(difluoro)methyl]pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C23H28ClF3N4O3S
|
1
|
| 1 |
Ki = 0.5 nM
|
|
|
|
CP0374735
|
N-[[2-benzylsulfanyl-4-(trifluoromethyl)phenyl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C25H24F4N2O3S2
|
1
|
| 1 |
Ki = 0.5 nM
|
|
|
|
CP0406474
|
N-[[2-cyclohexylsulfanyl-4-(trifluoromethyl)phenyl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C24H28F4N2O3S2
|
1
|
| 1 |
Ki = 0.5 nM
|
|
|
|
CP0539683
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-[(4-fluorophenyl)methoxy]-4-(trifluoromethyl)phenyl]methyl]propanamide
Show/Hide
|
C25H23F5N2O4S
|
1
|
| 1 |
Ki = 0.5 nM
|
|
|
|
CP0573528
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-(3-methylbutoxy)-4-(trifluoromethyl)phenyl]methyl]propanamide
Show/Hide
|
C23H28F4N2O4S
|
1
|
| 1 |
Ki = 0.5 nM
|
|
|
|
CP0539784
|
US9120756, 18
Show/Hide
|
C24H27ClF2N4O3S
|
1
|
| 1 |
Ki = 0.5 nM
|
|
|
|
CP0385450
|
(2S)-N-[[2-[benzenesulfonyl(benzyl)amino]-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C30H28F4N4O5S2
|
2
|
| 1 |
Ki = 0.54 nM
|
|
|
| 2 |
Ki = 1.81 nM
|
|
|
|
CP0472491
|
1-(1-methyl-2-oxoquinolin-5-yl)-3-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]urea
Show/Hide
|
C24H26F3N5O2
|
2
|
| 1 |
Ki = 0.57 nM
|
|
|
| 2 |
Ki = 2.59 nM
|
|
|
|
CP0551426
|
N-[[2-(3,3-dimethylbutyl)-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C23H29F4N3O3S
|
1
|
| 1 |
Ki = 0.6 nM
|
|
|
|
CP0539106
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-[2-(4-methylphenyl)ethyl]-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
|
C26H27F4N3O3S
|
1
|
| 1 |
Ki = 0.6 nM
|
|
|
|
CP0539586
|
N-[[6-[chloro(difluoro)methyl]-2-(dipropylamino)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C23H30ClF3N4O3S
|
1
|
| 1 |
Ki = 0.6 nM
|
|
|
|
CP0559299
|
N-[[6-[chloro(difluoro)methyl]-2-(2-methylpropoxy)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C21H25ClF3N3O4S
|
1
|
| 1 |
Ki = 0.6 nM
|
|
|
|
CP0384879
|
N-[[2-cyclohexyl-4-(trifluoromethyl)phenyl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C24H28F4N2O3S
|
1
|
| 1 |
Ki = 0.6 nM
|
|
|
|
CP0406471
|
N-[[2-cyclopentyloxy-4-(trifluoromethyl)phenyl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C23H26F4N2O4S
|
1
|
| 1 |
Ki = 0.6 nM
|
|
|
|
CP0443290
|
N-[[2-(3-chloro-4-fluorophenyl)-4-(trifluoromethyl)phenyl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C24H20ClF5N2O3S
|
1
|
| 1 |
Ki = 0.6 nM
|
|
|
|
CP0396766
|
N-[[2-(cyclohexen-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C23H25F4N3O3S
|
1
|
| 1 |
Ki = 0.7 nM
|
|
|
|
CP0410644
|
N-[[2-[(E)-2-cyclohexylethenyl]-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C25H29F4N3O3S
|
1
|
| 1 |
Ki = 0.7 nM
|
|
|
|
CP0547526
|
N-[[2-[(E)-3,3-dimethylbut-1-enyl]-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C23H27F4N3O3S
|
1
|
| 1 |
Ki = 0.7 nM
|
|
|
|
CP0489326
|
N-[[2-(4-chlorophenyl)-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C23H20ClF4N3O3S
|
1
|
| 1 |
Ki = 0.7 nM
|
|
|
|
CP0443291
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-pentoxy-4-(trifluoromethyl)phenyl]methyl]propanamide
Show/Hide
|
C23H28F4N2O4S
|
1
|
| 1 |
Ki = 0.7 nM
|
|
|
|
CP0468570
|
N-[[2-cyclohexyloxy-4-(trifluoromethyl)phenyl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C24H28F4N2O4S
|
1
|
| 1 |
Ki = 0.7 nM
|
|
|
|
CP0530356
|
N-[[2-(4-ethylpiperidin-1-yl)-4-(trifluoromethyl)phenyl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C25H31F4N3O3S
|
1
|
| 1 |
Ki = 0.7 nM
|
|
|
|
CP0573527
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-[4-(4-methylphenyl)piperazin-1-yl]-4-(trifluoromethyl)phenyl]methyl]propanamide
Show/Hide
|
C29H32F4N4O3S
|
1
|
| 1 |
Ki = 0.7 nM
|
|
|
|
CP0409235
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-[(4-fluorophenyl)methyl-(4-fluorophenyl)sulfonylamino]-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
|
C30H26F6N4O5S2
|
2
|
| 1 |
Ki = 0.71 nM
|
|
|
| 2 |
Ki = 2.99 nM
|
|
|
|
CP0472490
|
1-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]-3-(2-oxo-1H-quinolin-5-yl)urea
Show/Hide
|
C23H24F3N5O2
|
2
|
| 1 |
Ki = 0.72 nM
|
|
|
| 2 |
Ki = 3.94 nM
|
|
|
|
CP0467982
|
N-[[2-[benzyl-(4-chlorophenyl)sulfonylamino]-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C30H27ClF4N4O5S2
|
2
|
| 1 |
Ki = 0.76 nM
|
|
|
| 2 |
Ki = 8.5 nM
|
|
|
|
CP0379306
|
(2S)-N-[[2-(2-bicyclo[2.2.1]heptanyl)-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C24H27F4N3O3S
|
1
|
| 1 |
Ki = 0.8 nM
|
|
|
|
CP0566875
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-(2-phenylethynyl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
|
C25H21F4N3O3S
|
1
|
| 1 |
Ki = 0.8 nM
|
|
|
|
CP0462158
|
N-[[6-[chloro(difluoro)methyl]-2-hexoxypyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C23H29ClF3N3O4S
|
1
|
| 1 |
Ki = 0.8 nM
|
|
|
|
CP0539585
|
N-[[6-[chloro(difluoro)methyl]-2-(4-phenylpiperazin-1-yl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C27H29ClF3N5O3S
|
1
|
| 1 |
Ki = 0.8 nM
|
|
|
|
CP0380138
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-(2-methylpropoxy)-4-(trifluoromethyl)phenyl]methyl]propanamide
Show/Hide
|
C22H26F4N2O4S
|
1
|
| 1 |
Ki = 0.8 nM
|
|
|
|
CP0380139
|
N-[[4-(1,1-difluoroethyl)-2-hexoxyphenyl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C25H33F3N2O4S
|
1
|
| 1 |
Ki = 0.8 nM
|
|
|
|
CP0380275
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-(3-methylbutoxy)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
|
C22H27F4N3O4S
|
1
|
| 1 |
Ki = 0.8 nM
|
|
|
|
CP0443289
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-(4-methoxyphenyl)-4-(trifluoromethyl)phenyl]methyl]propanamide
Show/Hide
|
C25H24F4N2O4S
|
1
|
| 1 |
Ki = 0.8 nM
|
|
|
|
CP0470309
|
US9120756, 40
Show/Hide
|
C27H21ClF4N4O2
|
1
|
| 1 |
Ki = 0.8 nM
|
|
|
|
CP0492741
|
1-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]-3-(2-oxo-1H-quinolin-7-yl)urea
Show/Hide
|
C23H24F3N5O2
|
2
|
| 1 |
Ki = 0.83 nM
|
|
|
| 2 |
Ki = 2.95 nM
|
|
|
|
CP0415801
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-(4-methylpentyl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
|
C23H29F4N3O3S
|
1
|
| 1 |
Ki = 0.9 nM
|
|
|
|
CP0554582
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-[(E)-pent-1-enyl]-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
|
C22H25F4N3O3S
|
1
|
| 1 |
Ki = 0.9 nM
|
|
|
|
CP0568983
|
N-[[2-(3,4-dichlorophenyl)-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C23H19Cl2F4N3O3S
|
1
|
| 1 |
Ki = 0.9 nM
|
|
|
|
CP0398140
|
N-[[6-[chloro(difluoro)methyl]-2-phenylmethoxypyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C24H23ClF3N3O4S
|
1
|
| 1 |
Ki = 0.9 nM
|
|
|
|
CP0530906
|
N-[[6-[chloro(difluoro)methyl]-2-cyclohexyloxypyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C23H27ClF3N3O4S
|
1
|
| 1 |
Ki = 0.9 nM
|
|
|
|
CP0530908
|
N-[[6-cyclopropyl-2-(4-methylpiperidin-1-yl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C25H33FN4O3S
|
1
|
| 1 |
Ki = 0.9 nM
|
|
|
|
CP0384886
|
N-[[2-cyclohexylsulfanyl-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C23H27F4N3O3S2
|
1
|
| 1 |
Ki = 0.9 nM
|
|
|
|
CP0380648
|
N-[[2-cyclopentyloxy-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C22H25F4N3O4S
|
1
|
| 1 |
Ki = 0.9 nM
|
|
|
|
CP0384880
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-(4-methylpiperidin-1-yl)-4-(trifluoromethyl)phenyl]methyl]propanamide
Show/Hide
|
C24H29F4N3O3S
|
1
|
| 1 |
Ki = 0.9 nM
|
|
|
|
CP0406475
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-phenylmethoxy-4-(trifluoromethyl)phenyl]methyl]propanamide
Show/Hide
|
C25H24F4N2O4S
|
1
|
| 1 |
Ki = 0.9 nM
|
|
|
|
CP0417285
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-[4-(4-fluorophenyl)piperidin-1-yl]-4-(trifluoromethyl)phenyl]methyl]propanamide
Show/Hide
|
C29H30F5N3O3S
|
1
|
| 1 |
Ki = 0.9 nM
|
|
|
|
CP0573530
|
N-[[2-[(2-chlorophenyl)methylsulfanyl]-4-(trifluoromethyl)phenyl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C25H23ClF4N2O3S2
|
1
|
| 1 |
Ki = 0.9 nM
|
|
|
|
CP0452040
|
N-[[2-[(4-chlorophenyl)methyl-(4-fluorophenyl)sulfonylamino]-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C30H26ClF5N4O5S2
|
2
|
| 1 |
Ki = 0.9 nM
|
|
|
| 2 |
Ki = 6 nM
|
|
|
|
CP0544648
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-pentyl-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
|
C22H27F4N3O3S
|
1
|
| 1 |
Ki = 1 nM
|
|
|
|
CP0508241
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-(4-methoxyphenyl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
|
C24H23F4N3O4S
|
1
|
| 1 |
Ki = 1 nM
|
|
|
|
CP0539032
|
N-[[2-(1-benzothiophen-2-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C25H21F4N3O3S2
|
1
|
| 1 |
Ki = 1 nM
|
|
|
|
CP0441774
|
N-[[6-(difluoromethyl)-2-(4-methylpiperidin-1-yl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C23H29F3N4O3S
|
1
|
| 1 |
Ki = 1 nM
|
|
|
|
CP0530907
|
N-[[6-[chloro(difluoro)methyl]-2-(3,5-dimethylpiperidin-1-yl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C24H30ClF3N4O3S
|
1
|
| 1 |
Ki = 1 nM
|
|
|
|
CP0374757
|
N-[[2-(3-chlorophenyl)-4-(trifluoromethyl)phenyl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C24H21ClF4N2O3S
|
1
|
| 1 |
Ki = 1 nM
|
|
|
|
CP0539682
|
N-[[2-butoxy-4-(trifluoromethyl)phenyl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C22H26F4N2O4S
|
1
|
| 1 |
Ki = 1 nM
|
|
|
|
CP0539587
|
N-[(6-cyclopropyl-2-piperidin-1-ylpyridin-3-yl)methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C24H31FN4O3S
|
1
|
| 1 |
Ki = 1.1 nM
|
|
|
|
CP0449643
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-2-(4-methylphenyl)-N-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]acetamide
Show/Hide
|
C29H32F4N4O3S
|
1
|
| 1 |
Ki = 1.1 nM
|
|
|
|
CP0406473
|
N-[[2-[(4-chlorophenyl)methylsulfanyl]-4-(trifluoromethyl)phenyl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C25H23ClF4N2O3S2
|
1
|
| 1 |
Ki = 1.1 nM
|
|
|
|
CP0487275
|
N-[[2-(4-tert-butylphenyl)-4-(trifluoromethyl)phenyl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C28H30F4N2O3S
|
1
|
| 1 |
Ki = 1.1 nM
|
|
|
|
CP0380274
|
N-[[2-[butyl(methyl)amino]-4-(trifluoromethyl)phenyl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C23H29F4N3O3S
|
1
|
| 1 |
Ki = 1.2 nM
|
|
|
|
CP0468571
|
N-[[2-cyclopentylsulfanyl-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C22H25F4N3O3S2
|
1
|
| 1 |
Ki = 1.2 nM
|
|
|
|
CP0470308
|
US9120756, 29
Show/Hide
|
C24H27ClF2N4O3S
|
1
|
| 1 |
Ki = 1.2 nM
|
|
|
|
CP0549440
|
N-[[2-[benzenesulfonyl-[(4-chlorophenyl)methyl]amino]-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C30H27ClF4N4O5S2
|
2
|
| 1 |
Ki = 1.29 nM
|
|
|
| 2 |
Ki = 5.77 nM
|
|
|
|
CP0544651
|
N-[[2-(4-tert-butylcyclohexyl)-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C27H35F4N3O3S
|
1
|
| 1 |
Ki = 1.3 nM
|
|
|
|
CP0433264
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-(3-fluorophenyl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
|
C23H20F5N3O3S
|
1
|
| 1 |
Ki = 1.3 nM
|
|
|
|
CP0519880
|
N-[[6-[chloro(difluoro)methyl]-2-piperidin-1-ylpyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C22H26ClF3N4O3S
|
1
|
| 1 |
Ki = 1.3 nM
|
|
|
|
CP0529430
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-phenylacetamide
Show/Hide
|
C28H30F4N4O3S
|
1
|
| 1 |
Ki = 1.3 nM
|
|
|
|
CP0472631
|
N-[[2-(4,4-dimethylpiperidin-1-yl)-4-(trifluoromethyl)phenyl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C25H31F4N3O3S
|
1
|
| 1 |
Ki = 1.3 nM
|
|
|
|
CP0481351
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-(furan-3-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
|
C21H19F4N3O4S
|
1
|
| 1 |
Ki = 1.4 nM
|
|
|
|
CP0568982
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-(2-phenylethyl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
|
C25H25F4N3O3S
|
1
|
| 1 |
Ki = 1.4 nM
|
|
|
|
CP0384884
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-(3-methylbutylsulfanyl)-4-(trifluoromethyl)phenyl]methyl]propanamide
Show/Hide
|
C23H28F4N2O3S2
|
1
|
| 1 |
Ki = 1.4 nM
|
|
|
|
CP0417284
|
N-[[2-(4-benzylpiperidin-1-yl)-4-(trifluoromethyl)phenyl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C30H33F4N3O3S
|
1
|
| 1 |
Ki = 1.4 nM
|
|
|
|
CP0396764
|
N-[[2-(2-bicyclo[2.2.1]heptanyl)-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C24H27F4N3O3S
|
1
|
| 1 |
Ki = 1.5 nM
|
|
|
|
CP0415803
|
N-[[2-(4,4-difluorocyclohexyl)-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C23H25F6N3O3S
|
1
|
| 1 |
Ki = 1.5 nM
|
|
|
|
CP0398834
|
N-[[2-[benzyl-(4-fluorophenyl)sulfonylamino]-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C30H27F5N4O5S2
|
2
|
| 1 |
Ki = 1.56 nM
|
|
|
| 2 |
Ki = 3.87 nM
|
|
|
|
CP0551425
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-hexyl-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
|
C23H29F4N3O3S
|
1
|
| 1 |
Ki = 1.6 nM
|
|
|
|
CP0543074
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]butanamide
Show/Hide
|
C24H30F4N4O3S
|
1
|
| 1 |
Ki = 1.6 nM
|
|
|
|
CP0374733
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-[4-(4-methoxyphenyl)piperazin-1-yl]-4-(trifluoromethyl)phenyl]methyl]propanamide
Show/Hide
|
C29H32F4N4O4S
|
1
|
| 1 |
Ki = 1.6 nM
|
|
|
|
CP0384882
|
N-[[2-(azepan-1-yl)-4-(trifluoromethyl)phenyl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C24H29F4N3O3S
|
1
|
| 1 |
Ki = 1.6 nM
|
|
|
|
CP0381845
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-[(4-fluorophenyl)sulfonyl-[(4-methoxyphenyl)methyl]amino]-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
|
C31H29F5N4O6S2
|
2
|
| 1 |
Ki = 1.65 nM
|
|
|
| 2 |
Ki = 7.9 nM
|
|
|
|
CP0384883
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-piperidin-1-yl-4-(trifluoromethyl)phenyl]methyl]propanamide
Show/Hide
|
C23H27F4N3O3S
|
1
|
| 1 |
Ki = 1.7 nM
|
|
|
|
CP0433262
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-[2-(4-fluorophenyl)ethyl]-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
|
C25H24F5N3O3S
|
1
|
| 1 |
Ki = 1.8 nM
|
|
|
|
CP0470392
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-hexylsulfanyl-4-(trifluoromethyl)phenyl]methyl]propanamide
Show/Hide
|
C24H30F4N2O3S2
|
1
|
| 1 |
Ki = 1.8 nM
|
|
|
|
CP0573529
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-[4-(3-methylphenyl)piperazin-1-yl]-4-(trifluoromethyl)phenyl]methyl]propanamide
Show/Hide
|
C29H32F4N4O3S
|
1
|
| 1 |
Ki = 1.8 nM
|
|
|
|
CP0508841
|
N-[[2-[benzenesulfonyl-[(4-methylphenyl)methyl]amino]-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
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C31H30F4N4O5S2
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2
|
| 1 |
Ki = 1.85 nM
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| 2 |
Ki = 5.54 nM
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CP0443336
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2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-(3-fluorophenyl)-4-(trifluoromethyl)phenyl]methyl]propanamide
Show/Hide
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C24H21F5N2O3S
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1
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| 1 |
Ki = 1.9 nM
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CP0472632
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N-[[2-butylsulfanyl-4-(trifluoromethyl)phenyl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
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C22H26F4N2O3S2
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1
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| 1 |
Ki = 1.9 nM
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CP0385449
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N-[[2-[benzenesulfonyl(benzyl)amino]-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
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C30H28F4N4O5S2
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2
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| 1 |
Ki = 1.99 nM
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| 2 |
Ki = 5.9 nM
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CP0529532
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2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-thiophen-3-yl-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
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C21H19F4N3O3S2
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1
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| 1 |
Ki = 2 nM
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CP0417286
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2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-propoxy-4-(trifluoromethyl)phenyl]methyl]propanamide
Show/Hide
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C21H24F4N2O4S
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1
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| 1 |
Ki = 2 nM
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CP0468569
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2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-(4-phenylpiperazin-1-yl)-4-(trifluoromethyl)phenyl]methyl]propanamide
Show/Hide
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C28H30F4N4O3S
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1
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| 1 |
Ki = 2 nM
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CP0550924
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2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-[(Z)-pent-1-enyl]-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
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C22H25F4N3O3S
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1
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| 1 |
Ki = 2.1 nM
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CP0312253
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US9120756, 15
Show/Hide
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C24H28ClFN4O3S
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1
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| 1 |
Ki = 2.1 nM
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CP0381902
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N-[[2-[benzenesulfonyl-[(4-methoxyphenyl)methyl]amino]-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
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C31H30F4N4O6S2
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2
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| 1 |
Ki = 2.14 nM
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| 2 |
Ki = 7.5 nM
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CP0566111
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2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-[(E)-2-phenylethenyl]-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
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C25H23F4N3O3S
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1
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| 1 |
Ki = 2.2 nM
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CP0561485
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US9120756, 27
Show/Hide
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C25H31ClN4O4S
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1
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| 1 |
Ki = 2.2 nM
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CP0384885
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2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-pentylsulfanyl-4-(trifluoromethyl)phenyl]methyl]propanamide
Show/Hide
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C23H28F4N2O3S2
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1
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| 1 |
Ki = 2.3 nM
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CP0543244
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2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-pyrrolidin-1-yl-4-(trifluoromethyl)phenyl]methyl]propanamide
Show/Hide
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C22H25F4N3O3S
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1
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| 1 |
Ki = 2.3 nM
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CP0552365
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2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-[(4-methoxyphenyl)methylsulfanyl]-4-(trifluoromethyl)phenyl]methyl]propanamide
Show/Hide
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C26H26F4N2O4S2
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1
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| 1 |
Ki = 2.3 nM
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CP0459535
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N-[[2-[benzenesulfonyl(cyclohexylmethyl)amino]-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
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C30H34F4N4O5S2
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2
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| 1 |
Ki = 2.3 nM
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| 2 |
Ki = 10 nM
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CP0398835
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N-[[2-[benzenesulfonyl-[(4-fluorophenyl)methyl]amino]-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
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C30H27F5N4O5S2
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2
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| 1 |
Ki = 2.32 nM
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| 2 |
Ki = 7.37 nM
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CP0566652
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2-[3-fluoro-4-(methanesulfonamido)phenyl]-2-(3-fluorophenyl)-N-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]acetamide
Show/Hide
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C28H29F5N4O3S
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1
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| 1 |
Ki = 2.4 nM
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CP0449861
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2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-[(4-fluorophenyl)methoxy]-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
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C24H22F5N3O4S
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1
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| 1 |
Ki = 2.5 nM
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CP0564395
|
US9120756, 134
Show/Hide
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C23H23ClF4N4O3S
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1
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| 1 |
Ki = 2.5 nM
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CP0573637
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2-(2-chloro-6-fluorophenyl)-N-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]acetamide
Show/Hide
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C21H22ClF4N3O
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1
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| 1 |
Ki = 2.6 nM
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CP0384881
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N-[[2-(azocan-1-yl)-4-(trifluoromethyl)phenyl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
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C25H31F4N3O3S
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1
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| 1 |
Ki = 2.8 nM
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CP0559298
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N-[[6-[chloro(difluoro)methyl]-2-cyclohexylsulfanylpyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
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C23H27ClF3N3O3S2
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1
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| 1 |
Ki = 3 nM
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CP0414756
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N-[[2-[benzyl(propylsulfonyl)amino]-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
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C27H30F4N4O5S2
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2
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| 1 |
Ki = 3.13 nM
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| 2 |
Ki = 8.8 nM
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CP0481353
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N-[[2-[4-(dimethylamino)phenyl]-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
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C25H26F4N4O3S
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1
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| 1 |
Ki = 3.2 nM
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CP0470391
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2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-(furan-2-ylmethylsulfanyl)-4-(trifluoromethyl)phenyl]methyl]propanamide
Show/Hide
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C23H22F4N2O4S2
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1
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| 1 |
Ki = 3.2 nM
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CP0469587
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2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-[(4-fluorophenyl)sulfonyl-[(4-methylphenyl)methyl]amino]-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
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C31H29F5N4O5S2
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2
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| 1 |
Ki = 3.28 nM
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| 2 |
Ki = 7.08 nM
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CP0566112
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N-[[2-(1,3-benzodioxol-5-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C24H21F4N3O5S
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1
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| 1 |
Ki = 3.4 nM
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CP0566651
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-2-(4-fluorophenyl)-N-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]acetamide
Show/Hide
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C28H29F5N4O3S
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1
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| 1 |
Ki = 3.4 nM
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CP0321970
|
US9120756, 14
Show/Hide
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C24H28ClFN4O3S
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1
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| 1 |
Ki = 3.7 nM
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CP0573206
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N-[[2-(3-chlorophenyl)-5-(trifluoromethyl)pyrazol-3-yl]methyl]-2-(3,4-dichlorophenyl)acetamide
Show/Hide
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C19H13Cl3F3N3O
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1
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| 1 |
Ki = 3.8 nM
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CP0552364
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2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[4-(trifluoromethyl)-2-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]phenyl]methyl]propanamide
Show/Hide
|
C29H29F7N4O3S
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1
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| 1 |
Ki = 3.9 nM
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CP0545740
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N-[[2-chloro-4-(trifluoromethyl)phenyl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C18H17ClF4N2O3S
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1
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| 1 |
Ki = 4 nM
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CP0561074
|
US9120756, 33
Show/Hide
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C25H30ClFN4O3S
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1
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| 1 |
Ki = 4 nM
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CP0579309
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N-[[5-tert-butyl-2-(3-chlorophenyl)pyrazol-3-yl]methyl]-2-(2,3-dichlorophenyl)acetamide
Show/Hide
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C22H22Cl3N3O
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1
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| 1 |
Ki = 4 nM
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CP0481352
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2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-(3-fluoro-4-methoxyphenyl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
|
C24H22F5N3O4S
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1
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| 1 |
Ki = 4.2 nM
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CP0411647
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N-[[6-[chloro(difluoro)methyl]-2-(pyridin-2-ylmethoxy)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C23H22ClF3N4O4S
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1
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| 1 |
Ki = 4.2 nM
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CP0505257
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N-[[2-[(2-chlorophenyl)methylsulfanyl]-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C24H22ClF4N3O3S2
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1
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| 1 |
Ki = 4.9 nM
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CP0538372
|
2-(2,3-dichlorophenyl)-N-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]acetamide
Show/Hide
|
C21H22Cl2F3N3O
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1
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| 1 |
Ki = 4.9 nM
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CP0489323
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N-[[2-(2,3-dihydro-1,4-benzodioxin-6-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C25H23F4N3O5S
|
1
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| 1 |
Ki = 5 nM
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CP0394930
|
N-[(4-tert-butylphenyl)methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
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C21H27FN2O3S
|
3
|
| 1 |
Ki = 5.1 nM
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| 2 |
Ki = 12.7 nM
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| 3 |
Ki = 89 nM
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CP0470176
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N-[[5-tert-butyl-2-[(E)-pent-1-enyl]pyrazol-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C23H33FN4O3S
|
1
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| 1 |
Ki = 5.1 nM
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CP0533051
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-(furan-2-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
|
C21H19F4N3O4S
|
1
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| 1 |
Ki = 5.8 nM
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CP0431888
|
N-[[2-(3,5-dimethoxyphenyl)-4-(trifluoromethyl)phenyl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C26H26F4N2O5S
|
1
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| 1 |
Ki = 5.8 nM
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CP0407829
|
[(1R,2R,6R,10S,11R,13S,15R,17R)-13-benzyl-6-hydroxy-4,17-dimethyl-5-oxo-15-prop-1-en-2-yl-12,14,18-trioxapentacyclo[11.4.1.01,10.02,6.011,15]octadeca-3,8-dien-8-yl]methyl 2-(4-hydroxy-3-iodo-5-methoxyphenyl)acetate
Show/Hide
|
C37H39IO9
|
3
|
| 1 |
Ki = 5.87 nM
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| 2 |
Ki = 5.9 nM
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| 3 |
Ki = 11.8 nM
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CP0381904
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N-[[2-[N-(benzenesulfonyl)anilino]-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C29H26F4N4O5S2
|
2
|
| 1 |
Ki = 6 nM
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| 2 |
Ki = 18.3 nM
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CP0563488
|
2-(3-chlorophenyl)-N-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]acetamide
Show/Hide
|
C21H23ClF3N3O
|
1
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| 1 |
Ki = 6.1 nM
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CP0455152
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N-[[2-[benzyl(propan-2-ylsulfonyl)amino]-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C27H30F4N4O5S2
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2
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| 1 |
Ki = 6.19 nM
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| 2 |
Ki = 18.1 nM
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CP0573207
|
2-(3-chlorophenyl)-N-[[2-(3-chlorophenyl)-5-(trifluoromethyl)pyrazol-3-yl]methyl]acetamide
Show/Hide
|
C19H14Cl2F3N3O
|
1
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| 1 |
Ki = 6.2 nM
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CP0462926
|
US9120756, 30
Show/Hide
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C20H15ClF5N3O
|
1
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| 1 |
Ki = 6.3 nM
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CP0570992
|
2-(4-chlorophenyl)-N-[[2-(3-chlorophenyl)-5-(trifluoromethyl)pyrazol-3-yl]methyl]acetamide
Show/Hide
|
C19H14Cl2F3N3O
|
1
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| 1 |
Ki = 6.3 nM
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CP0489327
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-phenyl-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
|
C23H21F4N3O3S
|
1
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| 1 |
Ki = 6.4 nM
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CP0572535
|
2-(3,4-dichlorophenyl)-N-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]acetamide
Show/Hide
|
C21H22Cl2F3N3O
|
1
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| 1 |
Ki = 6.7 nM
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CP0448736
|
US8765733, 24
Show/Hide
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C22H27F4N5O3S
|
3
|
| 1 |
Ki = 6.77 nM
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|
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| 2 |
Ki = 11.5 nM
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| 3 |
Ki = 12.5 nM
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CP0573609
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N-[[5-tert-butyl-2-(3-chlorophenyl)pyrazol-3-yl]methyl]-2-(2,3-difluorophenyl)acetamide
Show/Hide
|
C22H22ClF2N3O
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1
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| 1 |
Ki = 6.9 nM
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CP0431548
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-morpholin-4-yl-4-(trifluoromethyl)phenyl]methyl]propanamide
Show/Hide
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C22H25F4N3O4S
|
1
|
| 1 |
Ki = 7.2 nM
|
|
|
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CP0540980
|
US9120756, 39
Show/Hide
|
C27H21ClF4N4O2
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1
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| 1 |
Ki = 7.2 nM
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CP0452291
|
N-[[2-[N-(benzenesulfonyl)-4-fluoroanilino]-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C29H25F5N4O5S2
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2
|
| 1 |
Ki = 7.3 nM
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| 2 |
Ki = 11.8 nM
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CP0499803
|
N-[[2-cyclohexylsulfanyl-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]-2-(4-methylphenyl)acetamide
Show/Hide
|
C29H31F4N3O3S2
|
1
|
| 1 |
Ki = 7.5 nM
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|
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CP0573635
|
N-[[2-(3-chlorophenyl)-5-(trifluoromethyl)pyrazol-3-yl]methyl]-2-(3,4-dichlorophenyl)propanamide
Show/Hide
|
C20H15Cl3F3N3O
|
1
|
| 1 |
Ki = 7.6 nM
|
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CP0568459
|
N-[[5-tert-butyl-2-(3-chlorophenyl)pyrazol-3-yl]methyl]-2-(2-chlorophenyl)acetamide
Show/Hide
|
C22H23Cl2N3O
|
1
|
| 1 |
Ki = 7.7 nM
|
|
|
|
CP0326694
|
US9120756, 12
Show/Hide
|
C25H31FN4O3S
|
1
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| 1 |
Ki = 8 nM
|
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|
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CP0470177
|
N-[(5-tert-butyl-2-phenylpyrazol-3-yl)methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C24H29FN4O3S
|
1
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| 1 |
Ki = 8 nM
|
|
|
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CP0374758
|
N-[[2-(3,4-dimethoxyphenyl)-4-(trifluoromethyl)phenyl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C26H26F4N2O5S
|
1
|
| 1 |
Ki = 8.6 nM
|
|
|
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CP0572041
|
N-[[5-tert-butyl-2-(3-chlorophenyl)pyrazol-3-yl]methyl]-2-[4-fluoro-3-(trifluoromethyl)phenyl]acetamide
Show/Hide
|
C23H22ClF4N3O
|
1
|
| 1 |
Ki = 8.8 nM
|
|
|
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CP0569466
|
2-(2-chlorophenyl)-N-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]acetamide
Show/Hide
|
C21H23ClF3N3O
|
1
|
| 1 |
Ki = 9.1 nM
|
|
|
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CP0441773
|
N-[[2-(4-benzylpiperidin-1-yl)-4-methyl-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C30H34F4N4O3S
|
1
|
| 1 |
Ki = 9.2 nM
|
|
|
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CP0569008
|
2-(2,3-difluorophenyl)-N-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]acetamide
Show/Hide
|
C21H22F5N3O
|
1
|
| 1 |
Ki = 9.4 nM
|
|
|
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CP0569455
|
2-(4-chloro-3-fluorophenyl)-N-[[2-(3-chlorophenyl)-5-(trifluoromethyl)pyrazol-3-yl]methyl]propanamide
Show/Hide
|
C20H15Cl2F4N3O
|
1
|
| 1 |
Ki = 9.5 nM
|
|
|
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CP0564875
|
2-[4-fluoro-3-(trifluoromethyl)phenyl]-N-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]acetamide
Show/Hide
|
C22H22F7N3O
|
1
|
| 1 |
Ki = 9.8 nM
|
|
|
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CP0569009
|
2-(2-fluorophenyl)-N-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]acetamide
Show/Hide
|
C21H23F4N3O
|
1
|
| 1 |
Ki = 9.9 nM
|
|
|
|
CP0567796
|
2-(3,5-difluorophenyl)-N-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]acetamide
Show/Hide
|
C21H22F5N3O
|
1
|
| 1 |
Ki = 10.3 nM
|
|
|
|
CP0568994
|
2-[4-fluoro-3-(trifluoromethyl)phenyl]-N-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
|
C23H24F7N3O
|
1
|
| 1 |
Ki = 10.8 nM
|
|
|
|
CP0544649
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-(2-methylprop-1-enyl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
|
C21H23F4N3O3S
|
1
|
| 1 |
Ki = 11.5 nM
|
|
|
|
CP0569829
|
N-[[2-(3-chlorophenyl)-5-(trifluoromethyl)pyrazol-3-yl]methyl]-2-(2,3-difluorophenyl)acetamide
Show/Hide
|
C19H13ClF5N3O
|
1
|
| 1 |
Ki = 11.5 nM
|
|
|
|
CP0385452
|
N-[[2-[benzyl(ethylsulfonyl)amino]-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C26H28F4N4O5S2
|
2
|
| 1 |
Ki = 11.9 nM
|
|
|
| 2 |
Ki = 38 nM
|
|
|
|
CP0558998
|
N-[[2-(3-chlorophenyl)-5-(trifluoromethyl)pyrazol-3-yl]methyl]-2-[4-fluoro-3-(trifluoromethyl)phenyl]acetamide
Show/Hide
|
C20H13ClF7N3O
|
1
|
| 1 |
Ki = 11.9 nM
|
|
|
|
CP0559006
|
2-(3-chloro-4-fluorophenyl)-N-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]acetamide
Show/Hide
|
C21H22ClF4N3O
|
1
|
| 1 |
Ki = 12.9 nM
|
|
|
|
CP0579310
|
N-[[2-(3-chlorophenyl)-5-(trifluoromethyl)pyrazol-3-yl]methyl]-2-(2,3-dichlorophenyl)propanamide
Show/Hide
|
C20H15Cl3F3N3O
|
1
|
| 1 |
Ki = 13.2 nM
|
|
|
|
CP0119890
|
US9120756, 141
Show/Hide
|
C21H15ClF7N3O
|
1
|
| 1 |
Ki = 13.6 nM
|
|
|
|
CP0566373
|
N-[[2-(3-chlorophenyl)-5-(trifluoromethyl)pyrazol-3-yl]methyl]-2-(3,5-difluorophenyl)acetamide
Show/Hide
|
C19H13ClF5N3O
|
1
|
| 1 |
Ki = 13.7 nM
|
|
|
|
CP0540360
|
N-[[2-(4-cyclohexylpiperazin-1-yl)-4-(trifluoromethyl)phenyl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C28H36F4N4O3S
|
1
|
| 1 |
Ki = 13.8 nM
|
|
|
|
CP0551891
|
2-(3-chlorophenyl)-N-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
|
C22H25ClF3N3O
|
1
|
| 1 |
Ki = 13.8 nM
|
|
|
|
CP0530355
|
(2R)-N-[[2-cyclohexylsulfanyl-4-(trifluoromethyl)phenyl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C24H28F4N2O3S2
|
1
|
| 1 |
Ki = 13.9 nM
|
|
|
|
CP0571001
|
2-(2-chloro-4-fluorophenyl)-N-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]acetamide
Show/Hide
|
C21H22ClF4N3O
|
1
|
| 1 |
Ki = 14.2 nM
|
|
|
|
CP0530905
|
N-[[6-[chloro(difluoro)methyl]-2-(pyridin-3-ylmethoxy)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C23H22ClF3N4O4S
|
1
|
| 1 |
Ki = 14.6 nM
|
|
|
|
CP0527236
|
US9120756, 128
Show/Hide
|
C24H25ClFN3O3S
|
1
|
| 1 |
Ki = 16.3 nM
|
|
|
|
CP0572532
|
N-[[5-tert-butyl-2-(3-chlorophenyl)pyrazol-3-yl]methyl]-2-(2,4-dichlorophenyl)acetamide
Show/Hide
|
C22H22Cl3N3O
|
1
|
| 1 |
Ki = 16.7 nM
|
|
|
|
CP0495829
|
US9120756, 47
Show/Hide
|
C21H17ClF5N3O2
|
1
|
| 1 |
Ki = 17 nM
|
|
|
|
CP0434047
|
[(2R)-2-[(4-tert-butylphenyl)methyl]-3-[[3-fluoro-4-(methanesulfonamido)phenyl]methylcarbamothioylamino]propyl] 2,2-dimethylpropanoate
Show/Hide
|
C28H40FN3O4S2
|
2
|
| 1 |
Ki = 17.2 nM
|
|
|
| 2 |
Ki = 94 nM
|
|
|
|
CP0539584
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[4-methyl-2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
|
C24H30F4N4O3S
|
1
|
| 1 |
Ki = 17.5 nM
|
|
|
|
CP0573172
|
2-(3-chloro-4-fluorophenyl)-N-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
|
C22H24ClF4N3O
|
1
|
| 1 |
Ki = 17.7 nM
|
|
|
|
CP0579311
|
N-[[2-(3-chlorophenyl)-5-(trifluoromethyl)pyrazol-3-yl]methyl]-2-(2,3-difluorophenyl)propanamide
Show/Hide
|
C20H15ClF5N3O
|
1
|
| 1 |
Ki = 18.4 nM
|
|
|
|
CP0407650
|
1-[[3-fluoro-4-(methanesulfonamido)phenyl]methyl]-3-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]urea
Show/Hide
|
C22H27F4N5O3S
|
2
|
| 1 |
Ki = 18.7 nM
|
|
|
| 2 |
Ki = 59 nM
|
|
|
|
CP0567780
|
N-[[5-tert-butyl-2-(3-chlorophenyl)pyrazol-3-yl]methyl]-2-(2-chloro-6-fluorophenyl)acetamide
Show/Hide
|
C22H22Cl2FN3O
|
1
|
| 1 |
Ki = 19 nM
|
|
|
|
CP0572040
|
N-[[5-tert-butyl-2-(3-chlorophenyl)pyrazol-3-yl]methyl]-2-(2-chloro-4-fluorophenyl)acetamide
Show/Hide
|
C22H22Cl2FN3O
|
1
|
| 1 |
Ki = 19.9 nM
|
|
|
|
CP0489321
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-(1H-indol-6-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
|
C25H22F4N4O3S
|
1
|
| 1 |
Ki = 20.3 nM
|
|
|
|
CP0573205
|
2-(4-chloro-3-fluorophenyl)-N-[[2-(3-chlorophenyl)-5-(trifluoromethyl)pyrazol-3-yl]methyl]acetamide
Show/Hide
|
C19H13Cl2F4N3O
|
1
|
| 1 |
Ki = 20.9 nM
|
|
|
|
CP0512630
|
US9120756, 7
Show/Hide
|
C24H35FN4O3S
|
1
|
| 1 |
Ki = 21.6 nM
|
|
|
|
CP0566375
|
N-[[2-(3-chlorophenyl)-5-(trifluoromethyl)pyrazol-3-yl]methyl]-2-(2,3-dichlorophenyl)acetamide
Show/Hide
|
C19H13Cl3F3N3O
|
1
|
| 1 |
Ki = 22.6 nM
|
|
|
|
CP0544647
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-propyl-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
|
C20H23F4N3O3S
|
1
|
| 1 |
Ki = 22.7 nM
|
|
|
|
CP0434048
|
2-[(4-tert-butylphenyl)methyl]-3-({[(3-fluoro-4-methanesulfonamidophenyl)methyl]carbamothioyl}amino)propyl 2,2-dimethylpropanoate
Show/Hide
|
C28H40FN3O4S2
|
2
|
| 1 |
Ki = 23 nM
|
|
|
| 2 |
Ki = 122 nM
|
|
|
|
CP0570169
|
US8791268, 10
Show/Hide
|
C22H24F5N3O
|
1
|
| 1 |
Ki = 24.7 nM
|
|
|
|
CP0474204
|
N-[[2-[benzyl(methylsulfonyl)amino]-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C25H26F4N4O5S2
|
2
|
| 1 |
Ki = 25 nM
|
|
|
| 2 |
Ki = 101 nM
|
|
|
|
CP0433263
|
N-[[2-(3,4-dimethoxyphenyl)-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C25H25F4N3O5S
|
1
|
| 1 |
Ki = 25.6 nM
|
|
|
|
CP0512067
|
US9120756, 147
Show/Hide
|
C19H13ClF5N3O2
|
1
|
| 1 |
Ki = 26 nM
|
|
|
|
CP0579308
|
N-[[5-tert-butyl-2-(3-chlorophenyl)pyrazol-3-yl]methyl]-2-(2-chloro-4-fluorophenyl)propanamide
Show/Hide
|
C23H24Cl2FN3O
|
1
|
| 1 |
Ki = 26 nM
|
|
|
|
CP0572534
|
2-(2-chlorophenyl)-N-[[2-(3-chlorophenyl)-5-(trifluoromethyl)pyrazol-3-yl]methyl]acetamide
Show/Hide
|
C19H14Cl2F3N3O
|
1
|
| 1 |
Ki = 26.2 nM
|
|
|
|
CP0567940
|
2-(3-chloro-4-fluorophenyl)-N-[[2-(3-chlorophenyl)-5-(trifluoromethyl)pyrazol-3-yl]methyl]acetamide
Show/Hide
|
C19H13Cl2F4N3O
|
1
|
| 1 |
Ki = 26.9 nM
|
|
|
|
CP0397944
|
N-[[2-[benzenesulfonyl(propan-2-yl)amino]-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C26H28F4N4O5S2
|
2
|
| 1 |
Ki = 27.6 nM
|
|
|
| 2 |
Ki = 410 nM
|
|
|
|
CP0429307
|
2-[3-fluoro-4-(methanesulfonamidomethyl)phenyl]-N-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
|
C24H30F4N4O3S
|
2
|
| 1 |
Ki = 27.6 nM
|
|
|
| 2 |
Ki = 230 nM
|
|
|
|
CP0519527
|
US9120756, 6
Show/Hide
|
C24H37FN4O3S
|
1
|
| 1 |
Ki = 27.7 nM
|
|
|
|
CP0413268
|
US9120756, 5
Show/Hide
|
C24H37FN4O3S
|
2
|
| 1 |
Ki = 27.7 nM
|
|
|
| 2 |
Ki = 50.2 nM
|
|
|
|
CP0459457
|
1-[1-[3-fluoro-4-(methanesulfonamido)phenyl]ethyl]-3-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]urea
Show/Hide
|
C23H29F4N5O3S
|
2
|
| 1 |
Ki = 28.1 nM
|
|
|
| 2 |
Ki = 31.6 nM
|
|
|
|
CP0441772
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[3-piperidin-1-yl-5-(trifluoromethyl)pyridin-2-yl]methyl]propanamide
Show/Hide
|
C22H26F4N4O3S
|
1
|
| 1 |
Ki = 28.6 nM
|
|
|
|
CP0576108
|
US8791268, 7
Show/Hide
|
C21H22F5N3O
|
1
|
| 1 |
Ki = 30 nM
|
|
|
|
CP0448184
|
2-cyclohexyl-2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]acetamide
Show/Hide
|
C28H36F4N4O3S
|
1
|
| 1 |
Ki = 31.1 nM
|
|
|
|
CP0564394
|
US9120756, 126
Show/Hide
|
C21H17ClF4N4O
|
1
|
| 1 |
Ki = 31.4 nM
|
|
|
|
CP0573636
|
2-(2,3-difluorophenyl)-N-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
|
C22H24F5N3O
|
1
|
| 1 |
Ki = 31.4 nM
|
|
|
|
CP0312255
|
US9120756, 22
Show/Hide
|
C21H19ClF4N4O3S
|
1
|
| 1 |
Ki = 31.7 nM
|
|
|
|
CP0559297
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[4-phenyl-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
|
C23H21F4N3O3S
|
1
|
| 1 |
Ki = 32.7 nM
|
|
|
|
CP0396016
|
[(1R,2R,6R,10S,11R,13S,15R,17R)-13-benzyl-6-hydroxy-4,17-dimethyl-5-oxo-15-prop-1-en-2-yl-12,14,18-trioxapentacyclo[11.4.1.01,10.02,6.011,15]octadeca-3,8-dien-8-yl]methyl (3-bromo-4-hydroxy-5-methoxyphenyl) carbonate
Show/Hide
|
C36H37BrO10
|
2
|
| 1 |
Ki = 33.3 nM
|
|
|
| 2 |
Ki = 512 nM
|
|
|
|
CP0527711
|
N-[[2-(3-chlorophenyl)-5-(trifluoromethyl)pyrazol-3-yl]methyl]-2-(2,6-difluorophenyl)propanamide
Show/Hide
|
C20H15ClF5N3O
|
1
|
| 1 |
Ki = 33.6 nM
|
|
|
|
CP0567482
|
US8791268, 4
Show/Hide
|
C21H23F4N3O
|
1
|
| 1 |
Ki = 34 nM
|
|
|
|
CP0558997
|
2-(2-chloro-6-fluorophenyl)-N-[[2-(3-chlorophenyl)-5-(trifluoromethyl)pyrazol-3-yl]methyl]acetamide
Show/Hide
|
C19H13Cl2F4N3O
|
1
|
| 1 |
Ki = 35.7 nM
|
|
|
|
CP0483752
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-imidazol-1-yl-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
|
C20H19F4N5O3S
|
1
|
| 1 |
Ki = 36.1 nM
|
|
|
|
CP0441768
|
N-[[2-cyclohexylsulfanyl-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]-2-(4-fluorophenyl)acetamide
Show/Hide
|
C28H28F5N3O3S2
|
1
|
| 1 |
Ki = 37.6 nM
|
|
|
|
CP0566374
|
US8791268, 6
Show/Hide
|
C21H22F5N3O
|
1
|
| 1 |
Ki = 38 nM
|
|
|
|
CP0570168
|
2-(2-chloro-4-fluorophenyl)-N-[[2-(3-chlorophenyl)-5-(trifluoromethyl)pyrazol-3-yl]methyl]acetamide
Show/Hide
|
C19H13Cl2F4N3O
|
1
|
| 1 |
Ki = 38.8 nM
|
|
|
|
CP0579312
|
2-(2,6-dichlorophenyl)-N-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]acetamide
Show/Hide
|
C21H22Cl2F3N3O
|
1
|
| 1 |
Ki = 39.7 nM
|
|
|
|
CP0487430
|
1-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]-3-(2-oxo-1H-quinolin-6-yl)urea
Show/Hide
|
C23H24F3N5O2
|
1
|
| 1 |
Ki = 39.9 nM
|
|
|
|
CP0529425
|
N-[[2-cyclohexylsulfanyl-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]-3-(4-methylphenyl)propanamide
Show/Hide
|
C30H33F4N3O3S2
|
1
|
| 1 |
Ki = 40.3 nM
|
|
|
|
CP0572533
|
2-(2-chlorophenyl)-N-[[2-(3-chlorophenyl)-5-(trifluoromethyl)pyrazol-3-yl]methyl]propanamide
Show/Hide
|
C20H16Cl2F3N3O
|
1
|
| 1 |
Ki = 41.9 nM
|
|
|
|
CP0398119
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-2-(2-methylphenyl)-N-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]acetamide
Show/Hide
|
C29H32F4N4O3S
|
1
|
| 1 |
Ki = 42.9 nM
|
|
|
|
CP0573610
|
N-[[2-(3-chlorophenyl)-5-(trifluoromethyl)pyrazol-3-yl]methyl]-2-(2,4-difluorophenyl)acetamide
Show/Hide
|
C19H13ClF5N3O
|
1
|
| 1 |
Ki = 43.3 nM
|
|
|
|
CP0462156
|
N-[[2-cyclopentyloxy-4-methyl-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C23H27F4N3O4S
|
1
|
| 1 |
Ki = 44 nM
|
|
|
|
CP0551892
|
2-(2,4-dichlorophenyl)-N-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]acetamide
Show/Hide
|
C21H22Cl2F3N3O
|
1
|
| 1 |
Ki = 46 nM
|
|
|
|
CP0529429
|
N-[[2-cyclohexylsulfanyl-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]-2-(3-fluorophenyl)acetamide
Show/Hide
|
C28H28F5N3O3S2
|
1
|
| 1 |
Ki = 48.7 nM
|
|
|
|
CP0386210
|
[(1R,2R,6R,10S,11R,13S,15R,17R)-13-benzyl-6-hydroxy-4,17-dimethyl-5-oxo-15-prop-1-en-2-yl-12,14,18-trioxapentacyclo[11.4.1.01,10.02,6.011,15]octadeca-3,8-dien-8-yl]methyl (4-hydroxy-3-iodo-5-methoxyphenyl) carbonate
Show/Hide
|
C36H37IO10
|
2
|
| 1 |
Ki = 49 nM
|
|
|
| 2 |
Ki = 189 nM
|
|
|
|
CP0556749
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-2-methyl-N-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
|
C24H30F4N4O3S
|
1
|
| 1 |
Ki = 49 nM
|
|
|
|
CP0448183
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-3-(4-fluorophenyl)-N-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
|
C29H31F5N4O3S
|
1
|
| 1 |
Ki = 49.3 nM
|
|
|
|
CP0533475
|
N-[[5-tert-butyl-2-(3-chlorophenyl)pyrazol-3-yl]methyl]-2-(2,6-difluorophenyl)acetamide
Show/Hide
|
C22H22ClF2N3O
|
1
|
| 1 |
Ki = 49.6 nM
|
|
|
|
CP0530697
|
N-[(5-tert-butyl-2-pentylpyrazol-3-yl)methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C23H35FN4O3S
|
1
|
| 1 |
Ki = 50.2 nM
|
|
|
|
CP0474527
|
US9120756, 74
Show/Hide
|
C19H14ClF4N3O
|
1
|
| 1 |
Ki = 51.8 nM
|
|
|
|
CP0472257
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[2-[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]ethyl]propanamide
Show/Hide
|
C24H30F4N4O3S
|
2
|
| 1 |
Ki = 54 nM
|
|
|
| 2 |
Ki = 95 nM
|
|
|
|
CP0561075
|
US9120756, 117
Show/Hide
|
C21H18ClF4N3O
|
1
|
| 1 |
Ki = 56 nM
|
|
|
|
CP0529427
|
N-[[2-cyclohexylsulfanyl-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]-2-(3-methylphenyl)acetamide
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C29H31F4N3O3S2
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1
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| 1 |
Ki = 56.4 nM
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CP0568993
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N-[[2-(3-chlorophenyl)-5-(trifluoromethyl)pyrazol-3-yl]methyl]-2-(2,5-difluorophenyl)propanamide
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C20H15ClF5N3O
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1
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| 1 |
Ki = 56.7 nM
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CP0508240
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N-[[2-(3,5-dimethoxyphenyl)-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
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C25H25F4N3O5S
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1
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| 1 |
Ki = 58 nM
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CP0531459
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US9120756, 127
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C24H30FN5O3S
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1
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| 1 |
Ki = 58.1 nM
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CP0538371
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N-[[2-(3-chlorophenyl)-5-(trifluoromethyl)pyrazol-3-yl]methyl]-2-(2,5-difluorophenyl)acetamide
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C19H13ClF5N3O
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1
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| 1 |
Ki = 58.9 nM
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CP0411649
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2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[6-(4-fluorophenyl)-2-(4-methylpiperidin-1-yl)pyridin-3-yl]methyl]propanamide
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C28H32F2N4O3S
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1
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| 1 |
Ki = 59 nM
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CP0447634
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1-[3-fluoro-4-(methanesulfonamido)phenyl]-1-methyl-3-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]urea
Show/Hide
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C22H27F4N5O3S
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2
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| 1 |
Ki = 59 nM
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| 2 |
Ki = 1160 nM
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CP0568992
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N-[[5-tert-butyl-2-(3-chlorophenyl)pyrazol-3-yl]methyl]-2-[4-fluoro-3-(trifluoromethyl)phenyl]propanamide
Show/Hide
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C24H24ClF4N3O
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1
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| 1 |
Ki = 59 nM
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CP0543242
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2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-pyridin-3-yl-4-(trifluoromethyl)phenyl]methyl]propanamide
Show/Hide
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C23H21F4N3O3S
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1
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| 1 |
Ki = 59.4 nM
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CP0578590
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2-(2,5-difluorophenyl)-N-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
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C22H24F5N3O
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1
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| 1 |
Ki = 59.6 nM
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CP0573173
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2-(2-fluorophenyl)-N-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
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C22H25F4N3O
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1
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| 1 |
Ki = 60.4 nM
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CP0459662
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N-[[2-cyclohexylsulfanyl-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]-2-phenylacetamide
Show/Hide
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C28H29F4N3O3S2
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1
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| 1 |
Ki = 62.5 nM
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CP0434046
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[(2S)-2-[(4-tert-butylphenyl)methyl]-3-[[3-fluoro-4-(methanesulfonamido)phenyl]methylcarbamothioylamino]propyl] 2,2-dimethylpropanoate
Show/Hide
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C28H40FN3O4S2
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2
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| 1 |
Ki = 63 nM
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| 2 |
Ki = 161 nM
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CP0481354
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2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-(2-fluorophenyl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
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C23H20F5N3O3S
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1
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| 1 |
Ki = 63.3 nM
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CP0561076
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US9120756, 129
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C22H24F4N6O3S
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1
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| 1 |
Ki = 63.6 nM
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CP0474528
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US9120756, 137
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C22H28F4N4O3S
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1
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| 1 |
Ki = 65.1 nM
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CP0566648
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N-[[2-cyclohexylsulfanyl-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]-2-methylpropanamide
Show/Hide
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C24H29F4N3O3S2
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1
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| 1 |
Ki = 65.7 nM
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CP0398118
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2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]-3-phenylpropanamide
Show/Hide
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C29H32F4N4O3S
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1
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| 1 |
Ki = 65.9 nM
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CP0406472
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2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-fluoro-4-(trifluoromethyl)phenyl]methyl]propanamide
Show/Hide
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C18H17F5N2O3S
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1
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| 1 |
Ki = 68.7 nM
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CP0413539
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2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[6-methyl-2-(4-methylpiperidin-1-yl)pyridin-3-yl]methyl]propanamide
Show/Hide
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C23H31FN4O3S
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1
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| 1 |
Ki = 72.1 nM
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CP0563487
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2-(2-chlorophenyl)-N-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
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C22H25ClF3N3O
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1
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| 1 |
Ki = 72.8 nM
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CP0326695
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US9120756, 13
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C28H37FN4O3S
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1
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| 1 |
Ki = 75.2 nM
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CP0567481
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2-(2,3-dichlorophenyl)-N-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
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C22H24Cl2F3N3O
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1
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| 1 |
Ki = 75.3 nM
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CP0567480
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N-[[2-(3-chlorophenyl)-5-(trifluoromethyl)pyrazol-3-yl]methyl]-2-(2-fluorophenyl)acetamide
Show/Hide
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C19H14ClF4N3O
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1
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| 1 |
Ki = 80.7 nM
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CP0459459
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1-[3-fluoro-4-(methanesulfonamido)phenyl]-3-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]urea
Show/Hide
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C21H25F4N5O3S
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2
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| 1 |
Ki = 83 nM
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| 2 |
Ki = 149 nM
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CP0425513
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US9120756, 41
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C28H21ClF6N4O2
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1
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| 1 |
Ki = 85 nM
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CP0449644
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2-cyclopentyl-2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]acetamide
Show/Hide
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C27H34F4N4O3S
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1
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| 1 |
Ki = 88.7 nM
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CP0444207
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1-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]-3-(1-oxo-2H-isoquinolin-7-yl)urea
Show/Hide
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C23H24F3N5O2
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2
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| 1 |
Ki = 90.7 nM
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| 2 |
Ki = 215 nM
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CP0519879
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2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-hexoxy-4-methyl-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
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C24H31F4N3O4S
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1
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| 1 |
Ki = 100 nM
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CP0452041
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N-[[2-[benzenesulfonyl(methyl)amino]-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
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C24H24F4N4O5S2
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2
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| 1 |
Ki = 100 nM
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| 2 |
Ki = 698 nM
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CP0529432
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N-[[2-cyclohexylsulfanyl-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-cyclopentyl-2-[3-fluoro-4-(methanesulfonamido)phenyl]acetamide
Show/Hide
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C27H33F4N3O3S2
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1
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| 1 |
Ki = 103 nM
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CP0412037
|
US9120756, 119
Show/Hide
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C22H18ClF4N3O
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1
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| 1 |
Ki = 107 nM
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CP0570170
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2-(2,6-difluorophenyl)-N-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
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C22H24F5N3O
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1
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| 1 |
Ki = 110 nM
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CP0460026
|
US9120756, 130
Show/Hide
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C20H16ClF4N3O
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1
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| 1 |
Ki = 112 nM
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CP0468241
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US9120756, 55
Show/Hide
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C26H30ClFN4O3S
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1
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| 1 |
Ki = 114 nM
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CP0449642
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2-[3-fluoro-4-(methanesulfonamido)phenyl]-2-methyl-N-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]butanamide
Show/Hide
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C25H32F4N4O3S
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1
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| 1 |
Ki = 124 nM
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CP0489320
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N-[[2-benzyl-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
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C24H23F4N3O3S
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1
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| 1 |
Ki = 141 nM
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CP0544646
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N-[[2-bromo-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
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C17H16BrF4N3O3S
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1
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| 1 |
Ki = 169 nM
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CP0447625
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1-[[3-fluoro-4-(methanesulfonamidomethyl)phenyl]methyl]-3-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]urea
Show/Hide
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C23H29F4N5O3S
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2
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| 1 |
Ki = 199 nM
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| 2 |
Ki = 410 nM
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CP0451861
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1-[3-fluoro-4-(methanesulfonamido)phenyl]-3-[2-[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]ethyl]urea
Show/Hide
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C22H27F4N5O3S
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1
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| 1 |
Ki = 210 nM
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CP0386211
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(4-amino-3-bromo-5-methoxyphenyl) [(1R,2R,6R,10S,11R,13S,15R,17R)-13-benzyl-6-hydroxy-4,17-dimethyl-5-oxo-15-prop-1-en-2-yl-12,14,18-trioxapentacyclo[11.4.1.01,10.02,6.011,15]octadeca-3,8-dien-8-yl]methyl carbonate
Show/Hide
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C36H38BrNO9
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2
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| 1 |
Ki = 212 nM
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| 2 |
Ki = 666 nM
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CP0426680
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(2R)-N-[(4-tert-butylphenyl)methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
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C21H27FN2O3S
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3
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| 1 |
Ki = 217 nM
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| 2 |
Ki = 440 nM
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| 3 |
Ki = 2590 nM
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CP0533906
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1-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]-3-(1-oxo-2H-isoquinolin-8-yl)urea
Show/Hide
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C23H24F3N5O2
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1
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| 1 |
Ki = 239 nM
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CP0397471
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(4-amino-3-chloro-5-methoxyphenyl) [(1R,2R,6R,10S,11R,13S,15R,17R)-13-benzyl-6-hydroxy-4,17-dimethyl-5-oxo-15-prop-1-en-2-yl-12,14,18-trioxapentacyclo[11.4.1.01,10.02,6.011,15]octadeca-3,8-dien-8-yl]methyl carbonate
Show/Hide
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C36H38ClNO9
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2
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| 1 |
Ki = 330 nM
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| 2 |
Ki = 1400 nM
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CP0410643
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2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-methyl-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
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C18H19F4N3O3S
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1
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| 1 |
Ki = 387 nM
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CP0533904
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1-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]-3-(2-oxo-1H-quinolin-8-yl)urea
Show/Hide
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C23H24F3N5O2
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2
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| 1 |
Ki = 441 nM
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| 2 |
Ki = 492 nM
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CP0420072
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1-[3-fluoro-4-(methanesulfonamido)phenyl]-1-(3-methylphenyl)-3-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]urea
Show/Hide
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C28H31F4N5O3S
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3
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| 1 |
Ki = 490 nM
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| 2 |
Ki = 860 nM
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| 3 |
Ki = 2200 nM
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CP0567956
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1-(2-methyl-1-oxoisoquinolin-5-yl)-3-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]urea
Show/Hide
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C24H26F3N5O2
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1
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| 1 |
Ki = 589 nM
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CP0482223
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N-[[5-tert-butyl-2-[4-[(E)-2-(4-methylphenyl)ethenyl]phenyl]pyrazol-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
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C33H37FN4O3S
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1
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| 1 |
Ki = 819 nM
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CP0406395
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(4-amino-3-iodo-5-methoxyphenyl) [(1R,2R,6R,10S,11R,13S,15R,17R)-13-benzyl-6-hydroxy-4,17-dimethyl-5-oxo-15-prop-1-en-2-yl-12,14,18-trioxapentacyclo[11.4.1.01,10.02,6.011,15]octadeca-3,8-dien-8-yl]methyl carbonate
Show/Hide
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C36H38INO9
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2
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| 1 |
Ki = 990 nM
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| 2 |
Ki = 1800 nM
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CP0437983
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1-[[2-[4-benzyl-4-(dimethylamino)piperidin-1-yl]-4-(trifluoromethyl)phenyl]methyl]-3-[3-fluoro-4-(methanesulfonamido)phenyl]urea
Show/Hide
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C30H35F4N5O3S
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1
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| 1 |
Ki = 1159 nM
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