General Information of the Compound
Compound ID
CP0378872
Compound Name
(E)-N-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-3-(4-methoxy-phenyl)-acrylamide
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Structure
Formula
C18H17NO4
Molecular Weight
311.337
Canonical SMILES
COc1ccc(\C=C\C(=O)Nc2ccc3OCCOc3c2)cc1
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InChI
InChI=1S/C18H17NO4/c1-21-15-6-2-13(3-7-15)4-9-18(20)19-14-5-8-16-17(12-14)23-11-10-22-16/h2-9,12H,10-11H2,1H3,(H,19,20)/b9-4+
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InChIKey
XEZJVUZBHGOCAD-RUDMXATFSA-N
Physicochemical Property
logP
3.1183
Rotatable Bonds
4
Heavy Atom Count
23
Polar Areas
56.79
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Complexity
23

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 6029870
SID: 16573025
ChEMBL ID
CHEMBL195374
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02183, Transient receptor potential cation channel subfamily V member 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  2
1
IC50 = 1800 nM
   TI
   LI
   LO
   TS
2
IC50 > 4000 nM
   TI
   LI
   LO
   TS