General Information of the Compound
Compound ID
CP0564395
Compound Name
US9120756, 134
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Structure
Formula
C23H23ClF4N4O3S
Molecular Weight
546.974
Canonical SMILES
CC(C(=O)NCc1c(C)c(nn1-c1cccc(Cl)c1)C(F)(F)F)c1ccc(CNS(C)(=O)=O)c(F)c1
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InChI
InChI=1S/C23H23ClF4N4O3S/c1-13(15-7-8-16(19(25)9-15)11-30-36(3,34)35)22(33)29-12-20-14(2)21(23(26,27)28)31-32(20)18-6-4-5-17(24)10-18/h4-10,13,30H,11-12H2,1-3H3,(H,29,33)
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InChIKey
GYIPJSXLAKWECL-UHFFFAOYSA-N
Physicochemical Property
logP
4.46112
Rotatable Bonds
8
Heavy Atom Count
36
Polar Areas
93.09
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
5
Complexity
36

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 66644220
ChEMBL ID
CHEMBL3689065
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02183, Transient receptor potential cation channel subfamily V member 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 2.5 nM
   TI
   LI
   LO
   TS