General Information of the Compound
Compound ID
CP0375082
Compound Name
5-[3-fluoro-4-(trifluoromethyl)phenyl]-4-(hydroxymethyl)-N-[(2S)-3-methylbutan-2-yl]-1,2-oxazole-3-carboxamide
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Structure
Formula
C17H18F4N2O3
Molecular Weight
374.334
Canonical SMILES
CC(C)[C@H](C)NC(=O)c1noc(c1CO)-c1ccc(c(F)c1)C(F)(F)F
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InChI
InChI=1S/C17H18F4N2O3/c1-8(2)9(3)22-16(25)14-11(7-24)15(26-23-14)10-4-5-12(13(18)6-10)17(19,20)21/h4-6,8-9,24H,7H2,1-3H3,(H,22,25)/t9-/m0/s1
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InChIKey
NIUFMTYBABSXHC-VIFPVBQESA-N
Physicochemical Property
logP
3.7661
Rotatable Bonds
5
Heavy Atom Count
26
Polar Areas
75.36
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
4
Complexity
26

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 46865593
SID: 99304556
ChEMBL ID
CHEMBL1807958
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02183, Transient receptor potential cation channel subfamily V member 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 19.95 nM
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   LI
   LO
   TS