General Information of the Compound
Compound ID
CP0469587
Compound Name
2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-[(4-fluorophenyl)sulfonyl-[(4-methylphenyl)methyl]amino]-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
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Structure
Formula
C31H29F5N4O5S2
Molecular Weight
696.72
Canonical SMILES
CC(C(=O)NCc1ccc(nc1N(Cc1ccc(C)cc1)S(=O)(=O)c1ccc(F)cc1)C(F)(F)F)c1ccc(NS(C)(=O)=O)c(F)c1
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InChI
InChI=1S/C31H29F5N4O5S2/c1-19-4-6-21(7-5-19)18-40(47(44,45)25-12-10-24(32)11-13-25)29-23(9-15-28(38-29)31(34,35)36)17-37-30(41)20(2)22-8-14-27(26(33)16-22)39-46(3,42)43/h4-16,20,39H,17-18H2,1-3H3,(H,37,41)
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InChIKey
WSRVBKYIHBHJIK-UHFFFAOYSA-N
Physicochemical Property
logP
5.87392
Rotatable Bonds
11
Heavy Atom Count
47
Polar Areas
125.54
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
6
Complexity
47

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 127026253
ChEMBL ID
CHEMBL3770685
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02183, Transient receptor potential cation channel subfamily V member 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  2
1
Ki = 3.28 nM
   TI
   LI
   LO
   TS
2
Ki = 7.08 nM
   TI
   LI
   LO
   TS