General Information of the Compound
Compound ID
CP0569199
Compound Name
(2S)-N-(4-methyl-2-nitrophenyl)-2-(5-phenyl-1,3-thiazol-2-yl)pyrrolidine-1-carboxamide
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Structure
Formula
C21H20N4O3S
Molecular Weight
408.483
Canonical SMILES
Cc1ccc(NC(=O)N2CCC[C@H]2c2ncc(s2)-c2ccccc2)c(c1)[N+]([O-])=O
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InChI
InChI=1S/C21H20N4O3S/c1-14-9-10-16(18(12-14)25(27)28)23-21(26)24-11-5-8-17(24)20-22-13-19(29-20)15-6-3-2-4-7-15/h2-4,6-7,9-10,12-13,17H,5,8,11H2,1H3,(H,23,26)/t17-/m0/s1
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InChIKey
FGDPMXRJRHRZPX-KRWDZBQOSA-N
Physicochemical Property
logP
5.39572
Rotatable Bonds
4
Heavy Atom Count
29
Polar Areas
88.37
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
5
Complexity
29

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 154636977
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02183, Transient receptor potential cation channel subfamily V member 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 23.92 nM
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