General Information of the Compound
Compound ID
CP0495244
Compound Name
(E)-3-(4-tert-Butyl-phenyl)-5-methyl-hex-2-enoic acid (2,3-dihydro-benzo[1,4]dioxin-6-yl)-amide
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Structure
Formula
C25H31NO3
Molecular Weight
393.527
Canonical SMILES
CC(C)C\C(=C/C(=O)Nc1ccc2OCCOc2c1)c1ccc(cc1)C(C)(C)C
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InChI
InChI=1S/C25H31NO3/c1-17(2)14-19(18-6-8-20(9-7-18)25(3,4)5)15-24(27)26-21-10-11-22-23(16-21)29-13-12-28-22/h6-11,15-17H,12-14H2,1-5H3,(H,26,27)/b19-15+
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InChIKey
SHGJSGCAJRTIIG-XDJHFCHBSA-N
Physicochemical Property
logP
5.8235
Rotatable Bonds
5
Heavy Atom Count
29
Polar Areas
47.56
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
3
Complexity
29

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 10309581
SID: 15317307
ChEMBL ID
CHEMBL192205
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02183, Transient receptor potential cation channel subfamily V member 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  2
1
IC50 = 16 nM
   TI
   LI
   LO
   TS
2
IC50 = 94 nM
   TI
   LI
   LO
   TS