General Information of the Compound
Compound ID
CP0381902
Compound Name
N-[[2-[benzenesulfonyl-[(4-methoxyphenyl)methyl]amino]-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
    Show/Hide
Structure
Formula
C31H30F4N4O6S2
Molecular Weight
694.729
Canonical SMILES
COc1ccc(CN(c2nc(ccc2CNC(=O)C(C)c2ccc(NS(C)(=O)=O)c(F)c2)C(F)(F)F)S(=O)(=O)c2ccccc2)cc1
    Show/Hide
InChI
InChI=1S/C31H30F4N4O6S2/c1-20(22-11-15-27(26(32)17-22)38-46(3,41)42)30(40)36-18-23-12-16-28(31(33,34)35)37-29(23)39(19-21-9-13-24(45-2)14-10-21)47(43,44)25-7-5-4-6-8-25/h4-17,20,38H,18-19H2,1-3H3,(H,36,40)
    Show/Hide
InChIKey
HSFMUBAUTKMLLS-UHFFFAOYSA-N
Physicochemical Property
logP
5.435
Rotatable Bonds
12
Heavy Atom Count
47
Polar Areas
134.77
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
7
Complexity
47

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 127026928
ChEMBL ID
CHEMBL3770852
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02183, Transient receptor potential cation channel subfamily V member 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  2
1
Ki = 2.14 nM
   TI
   LI
   LO
   TS
2
Ki = 7.5 nM
   TI
   LI
   LO
   TS