General Information of the Compound
Compound ID
CP0381904
Compound Name
N-[[2-[N-(benzenesulfonyl)anilino]-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
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Structure
Formula
C29H26F4N4O5S2
Molecular Weight
650.676
Canonical SMILES
CC(C(=O)NCc1ccc(nc1N(c1ccccc1)S(=O)(=O)c1ccccc1)C(F)(F)F)c1ccc(NS(C)(=O)=O)c(F)c1
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InChI
InChI=1S/C29H26F4N4O5S2/c1-19(20-13-15-25(24(30)17-20)36-43(2,39)40)28(38)34-18-21-14-16-26(29(31,32)33)35-27(21)37(22-9-5-3-6-10-22)44(41,42)23-11-7-4-8-12-23/h3-17,19,36H,18H2,1-2H3,(H,34,38)
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InChIKey
OJJWHKGWQZJHPO-UHFFFAOYSA-N
Physicochemical Property
logP
5.5579
Rotatable Bonds
10
Heavy Atom Count
44
Polar Areas
125.54
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
6
Complexity
44

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 127026007
ChEMBL ID
CHEMBL3771342
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02183, Transient receptor potential cation channel subfamily V member 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  2
1
Ki = 6 nM
   TI
   LI
   LO
   TS
2
Ki = 18.3 nM
   TI
   LI
   LO
   TS