General Information of the Compound
Compound ID
CP0568992
Compound Name
N-[[5-tert-butyl-2-(3-chlorophenyl)pyrazol-3-yl]methyl]-2-[4-fluoro-3-(trifluoromethyl)phenyl]propanamide
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Formula
C24H24ClF4N3O
Molecular Weight
481.921
Canonical SMILES
CC(C(=O)NCc1cc(nn1-c1cccc(Cl)c1)C(C)(C)C)c1ccc(F)c(c1)C(F)(F)F
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InChI
InChI=1S/C24H24ClF4N3O/c1-14(15-8-9-20(26)19(10-15)24(27,28)29)22(33)30-13-18-12-21(23(2,3)4)31-32(18)17-7-5-6-16(25)11-17/h5-12,14H,13H2,1-4H3,(H,30,33)
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InChIKey
MVFFNEPGXHEWJT-UHFFFAOYSA-N
Physicochemical Property
logP
6.401
Rotatable Bonds
5
Heavy Atom Count
33
Polar Areas
46.92
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
3
Complexity
33

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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ChEMBL ID
CHEMBL4870003
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02183, Transient receptor potential cation channel subfamily V member 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 59 nM
   TI
   LI
   LO
   TS