Brief Information of the Compound and Protein
Compound Name
 Compound Info 
2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
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 PubChem ID
CID: 16225451
SID: 24907966
Canonical SMILES
CC(C(=O)NCc1ccc(nc1N1CCC(C)CC1)C(F)(F)F)c1ccc(NS(C)(=O)=O)c(F)c1
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Compound Formula C23H28F4N4O3S
Compound Structure
Protein Name
 Protein Info 
Transient receptor potential cation channel subfamily V member 1
Protein Classification
Ion channel
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Voltage-gated ion channel
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Transient receptor potential channel
Uniprot ID
Q8NER1
Gene Name
TRPV1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  6
1
IC50 = 2.56 nM
   TI
   LI
   LO
   TS
2
IC50 = 15.8 nM
   TI
   LI
   LO
   TS
3
Ki = 0.02 nM
   TI
   LI
   LO
   TS
4
Ki = 0.3 nM
   TI
   LI
   LO
   TS
5
Ki = 2.22 nM
   TI
   LI
   LO
   TS
6
Ki = 7.9 nM
   TI
   LI
   LO
   TS
CL000026 CHO-K1
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  4
1
IC50 = 4.5 nM
   TI
   LI
   LO
   TS
2
IC50 = 8.4 nM
   TI
   LI
   LO
   TS
3
Ki = 0.23 nM
   TI
   LI
   LO
   TS
4
Ki = 0.3 nM
   TI
   LI
   LO
   TS