General Information of the Compound
Compound ID
CP0512067
Compound Name
US9120756, 147
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Structure
Formula
C19H13ClF5N3O2
Molecular Weight
445.775
Canonical SMILES
Oc1c(F)cc(CC(=O)NCc2cc(nn2-c2cccc(Cl)c2)C(F)(F)F)cc1F
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InChI
InChI=1S/C19H13ClF5N3O2/c20-11-2-1-3-12(7-11)28-13(8-16(27-28)19(23,24)25)9-26-17(29)6-10-4-14(21)18(30)15(22)5-10/h1-5,7-8,30H,6,9H2,(H,26,29)
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InChIKey
CSRRUYYNTUIVGK-UHFFFAOYSA-N
Physicochemical Property
logP
4.3872
Rotatable Bonds
5
Heavy Atom Count
30
Polar Areas
67.15
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
4
Complexity
30

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 87087896
ChEMBL ID
CHEMBL3689068
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02183, Transient receptor potential cation channel subfamily V member 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 26 nM
   TI
   LI
   LO
   TS