General Information of the Compound
Compound ID
CP0552364
Compound Name
2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[4-(trifluoromethyl)-2-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]phenyl]methyl]propanamide
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Structure
Formula
C29H29F7N4O3S
Molecular Weight
646.629
Canonical SMILES
CC(C(=O)NCc1ccc(cc1N1CCN(CC1)c1cccc(c1)C(F)(F)F)C(F)(F)F)c1ccc(NS(C)(=O)=O)c(F)c1
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InChI
InChI=1S/C29H29F7N4O3S/c1-18(19-7-9-25(24(30)14-19)38-44(2,42)43)27(41)37-17-20-6-8-22(29(34,35)36)16-26(20)40-12-10-39(11-13-40)23-5-3-4-21(15-23)28(31,32)33/h3-9,14-16,18,38H,10-13,17H2,1-2H3,(H,37,41)
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InChIKey
UQGTYRFJDKOVEQ-UHFFFAOYSA-N
Physicochemical Property
logP
5.9813
Rotatable Bonds
8
Heavy Atom Count
44
Polar Areas
81.75
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
5
Complexity
44

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 122193011
ChEMBL ID
CHEMBL3627932
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02183, Transient receptor potential cation channel subfamily V member 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 3.9 nM
   TI
   LI
   LO
   TS