| Compound ID |
Compound Name |
Compound Formula |
|
CP0386901
|
(8S,11R,13S,14S,17S)-17-butyl-11-[4-(dimethylamino)phenyl]-17-hydroxy-13-methyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one
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|
C30H41NO2
|
1
|
| 1 |
EC50 = 1.5 nM
|
|
|
|
CP0035186
|
(10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]-14-hydroxy-15-methyl-14-(prop-1-yn-1-yl)tetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-1,6-dien-5-one
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|
C29H35NO2
|
1
|
| 1 |
EC50 = 11.9 nM
|
|
|
|
CP0386913
|
(8S,11R,13S,14S,17S)-17-hydroxy-13-methyl-11-(4-propan-2-ylphenyl)-17-prop-1-ynyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one
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|
C30H36O2
|
1
|
| 1 |
EC50 = 13 nM
|
|
|
|
CP0427247
|
(8S,11R,13S,14S,17S)-17-but-1-ynyl-11-[4-(dimethylamino)phenyl]-17-hydroxy-13-methyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one
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|
C30H37NO2
|
1
|
| 1 |
EC50 = 30 nM
|
|
|
|
CP0466627
|
(8S,11R,13S,14S,17S)-11-[4-(dimethylamino)phenyl]-17-hydroxy-13-methyl-17-(3,3,3-trifluoroprop-1-ynyl)-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one
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|
C29H32F3NO2
|
1
|
| 1 |
EC50 = 54 nM
|
|
|
|
CP0095953
|
ENZALUTAMIDE
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|
C21H16F4N4O2S
|
12
|
| 1 |
EC50 = 180 nM
|
|
|
| 2 |
IC50 = 14 nM
|
|
|
| 3 |
IC50 = 36 nM
|
|
|
| 4 |
IC50 = 38 nM
|
|
|
| 5 |
IC50 = 50 nM
|
|
|
| 6 |
IC50 = 70 nM
|
|
|
| 7 |
IC50 = 75 nM
|
|
|
| 8 |
IC50 = 90 nM
|
|
|
| 9 |
IC50 = 117 nM
|
|
|
| 10 |
IC50 = 480 nM
|
|
|
| 11 |
IC50 > 100000 nM
|
|
|
| 12 |
Ki = 17 nM
|
|
|
|
CP0364506
|
1-[(3S,8R,9S,10R,13S,14S)-3-imidazol-1-yl-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15-decahydro-1H-cyclopenta[a]phenanthren-17-yl]benzimidazole
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|
C29H34N4
|
1
|
| 1 |
EC50 = 190 nM
|
|
|
|
CP0412317
|
(8R,9S,10R,11S,13S,14S,17S)-11-[4-(dimethylamino)phenyl]-17-(3,3-dimethylbut-1-ynyl)-17-hydroxy-13-methyl-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one
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|
C32H43NO2
|
2
|
| 1 |
EC50 = 224 nM
|
|
|
| 2 |
IC50 = 165 nM
|
|
|
|
CP0572169
|
1-[(1S,2R,8R,10R,11S,15S)-8-imidazol-1-yl-2,15-dimethyl-14-pentacyclo[8.7.0.02,7.05,7.011,15]heptadec-13-enyl]benzimidazole
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|
C29H34N4
|
1
|
| 1 |
EC50 = 470 nM
|
|
|
|
CP0485770
|
(8S,9R,10R,11S,13S,14S,17S)-17-hydroxy-10,13-dimethyl-11-[4-[methyl(propan-2-yl)amino]phenyl]-17-prop-1-ynyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
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|
C32H43NO2
|
2
|
| 1 |
EC50 = 1142 nM
|
|
|
| 2 |
IC50 = 2246 nM
|
|
|
|
CP0451131
|
1-[(3S,8R,9S,10R,13S,14S)-10,13-dimethyl-3-(pyridin-4-ylmethoxy)-2,3,4,7,8,9,11,12,14,15-decahydro-1H-cyclopenta[a]phenanthren-17-yl]benzimidazole
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|
C32H37N3O
|
1
|
| 1 |
EC50 = 1650 nM
|
|
|
|
CP0434728
|
(8S,9S,10R,11S,13S,14S,17S)-11-[(4-chlorophenyl)methoxy]-17-hydroxy-10,13-dimethyl-17-prop-1-ynyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
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|
C29H35ClO3
|
2
|
| 1 |
EC50 = 1885 nM
|
|
|
| 2 |
IC50 = 85 nM
|
|
|
|
CP0483514
|
O-[(3S,8R,9S,10R,13S,14S)-17-(benzimidazol-1-yl)-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15-decahydro-1H-cyclopenta[a]phenanthren-3-yl] imidazole-1-carbothioate
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|
C30H34N4OS
|
1
|
| 1 |
EC50 > 100 nM
|
|
|
|
CP0068675
|
(8R,9S,10R,11S,13S,14S,17S)-17-(3,3-dimethylbut-1-ynyl)-17-hydroxy-13-methyl-11-[4-[methyl(propan-2-yl)amino]phenyl]-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one
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|
C34H47NO2
|
2
|
| 1 |
EC50 > 2500 nM
|
|
|
| 2 |
IC50 = 484 nM
|
|
|
|
CP0343817
|
(8S,11R,13S,14S,17S)-11-[4-(dimethylamino)phenyl]-17-(3,3-dimethylbut-1-ynyl)-17-hydroxy-13-methyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one
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|
C32H41NO2
|
2
|
| 1 |
EC50 > 2500 nM
|
|
|
| 2 |
IC50 = 129 nM
|
|
|
|
CP0386902
|
(8S,11R,13S,14S,17S)-17-(3,3-dimethylbut-1-ynyl)-17-hydroxy-13-methyl-11-(4-pyrrolidin-1-ylphenyl)-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one
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|
C34H43NO2
|
1
|
| 1 |
EC50 > 2500 nM
|
|
|
|
CP0386904
|
(8S,11R,13S,14S,17S)-17-(3,3-dimethylbut-1-ynyl)-17-hydroxy-13-methyl-11-[4-[methyl(propan-2-yl)amino]phenyl]-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one
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|
C34H45NO2
|
1
|
| 1 |
EC50 > 2500 nM
|
|
|
|
CP0386905
|
(8S,11S,13S,14S,17S)-11-[4-(dimethylamino)-2,6-difluorophenyl]-17-(3,3-dimethylbut-1-ynyl)-17-hydroxy-13-methyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one
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|
C32H39F2NO2
|
1
|
| 1 |
EC50 > 2500 nM
|
|
|
|
CP0386907
|
(8S,11R,13S,14S,17S)-17-hydroxy-13-methyl-11-phenyl-17-prop-1-ynyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one
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|
C27H30O2
|
1
|
| 1 |
EC50 > 2500 nM
|
|
|
|
CP0386908
|
(8S,11R,13S,14S,17S)-11-[4-(dimethylamino)phenyl]-17-hydroxy-13-methyl-17-(3-methylbut-1-ynyl)-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one
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|
C31H39NO2
|
1
|
| 1 |
EC50 > 2500 nM
|
|
|
|
CP0386909
|
(8S,11R,13S,14S,17S)-11-[3-(dimethylamino)phenyl]-17-(3,3-dimethylbut-1-ynyl)-17-hydroxy-13-methyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one
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|
C32H41NO2
|
1
|
| 1 |
EC50 > 2500 nM
|
|
|
|
CP0386911
|
(8S,11R,13S,14S,17S)-17-(3,3-dimethylbut-1-ynyl)-17-hydroxy-13-methyl-11-(4-morpholin-4-ylphenyl)-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one
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|
C34H43NO3
|
1
|
| 1 |
EC50 > 2500 nM
|
|
|
|
CP0393878
|
(8S,11R,13S,14S,17S)-17-(3,3-dimethylbut-1-ynyl)-17-hydroxy-11-(4-methoxyphenyl)-13-methyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one
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|
C31H38O3
|
1
|
| 1 |
EC50 > 2500 nM
|
|
|
|
CP0393887
|
(8S,11R,13S,14S,17S)-17-(3,3-dimethylbut-1-ynyl)-17-hydroxy-13-methyl-11-(4-propan-2-ylphenyl)-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one
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|
C33H42O2
|
1
|
| 1 |
EC50 > 2500 nM
|
|
|
|
CP0412314
|
(8R,9S,10R,11S,13S,14S,17S)-11-[4-(dimethylamino)phenyl]-17-hydroxy-17-(3-methoxy-3-methylbut-1-ynyl)-13-methyl-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one
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|
C32H43NO3
|
1
|
| 1 |
EC50 > 2500 nM
|
|
|
|
CP0412315
|
(8S,11R,13S,14S,17S)-17-(3,3-dimethylbut-1-ynyl)-11-[4-(1,1-dioxo-1,4-thiazinan-4-yl)phenyl]-17-hydroxy-13-methyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one
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|
C34H43NO4S
|
1
|
| 1 |
EC50 > 2500 nM
|
|
|
|
CP0412319
|
(8S,11R,13S,14S,17S)-17-(3,3-dimethylbut-1-ynyl)-11-(4-ethylphenyl)-17-hydroxy-13-methyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one
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|
C32H40O2
|
1
|
| 1 |
EC50 > 2500 nM
|
|
|
|
CP0412323
|
(8S,11R,13S,14S,17S)-11-[4-(dimethylamino)-3,5-difluorophenyl]-17-(3,3-dimethylbut-1-ynyl)-17-hydroxy-13-methyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one
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|
C32H39F2NO2
|
1
|
| 1 |
EC50 > 2500 nM
|
|
|
|
CP0422768
|
(8S,11R,13S,14S,17S)-11-cyclohexyl-17-hydroxy-13-methyl-17-prop-1-ynyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one
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|
C27H36O2
|
1
|
| 1 |
EC50 > 2500 nM
|
|
|
|
CP0427235
|
(8S,11R,13S,14S,17S)-11-[3-(dimethylamino)phenyl]-17-hydroxy-13-methyl-17-prop-1-ynyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one
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|
C29H35NO2
|
1
|
| 1 |
EC50 > 2500 nM
|
|
|
|
CP0427239
|
(8S,11R,13S,14S,17S)-11-[4-(dimethylamino)-3-methylphenyl]-17-(3,3-dimethylbut-1-ynyl)-17-hydroxy-13-methyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one
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|
C33H43NO2
|
1
|
| 1 |
EC50 > 2500 nM
|
|
|
|
CP0435333
|
(8S,11R,13S,14S,17S)-17-(3,3-dimethylbut-1-ynyl)-17-hydroxy-13-methyl-11-[4-(3-methyloxetan-3-yl)phenyl]-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one
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|
C34H42O3
|
1
|
| 1 |
EC50 > 2500 nM
|
|
|
|
CP0438419
|
(8S,11R,13S,14S,17S)-17-(3,3-dimethylbut-1-ynyl)-17-hydroxy-13-methyl-11-(4-methylphenyl)-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one
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|
C31H38O2
|
1
|
| 1 |
EC50 > 2500 nM
|
|
|
|
CP0466439
|
(8S,11S,13S,14S,17S)-11-ethyl-17-hydroxy-13-methyl-17-prop-1-ynyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one
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|
C23H30O2
|
1
|
| 1 |
EC50 > 2500 nM
|
|
|
|
CP0474730
|
(8S,11R,13S,14S,17S)-11-[4-(dimethylamino)-3-methoxyphenyl]-17-(3,3-dimethylbut-1-ynyl)-17-hydroxy-13-methyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one
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|
C33H43NO3
|
1
|
| 1 |
EC50 > 2500 nM
|
|
|
|
CP0343816
|
(8S,9R,10R,11S,13S,14S,17S)-17-(2-cyclopropylethynyl)-11-[4-(dimethylamino)phenyl]-17-hydroxy-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
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|
C32H41NO2
|
2
|
| 1 |
EC50 > 2500 nM
|
|
|
| 2 |
IC50 = 1452 nM
|
|
|
|
CP0396796
|
(8R,9S,10R,11S,13S,14S,17S)-17-(3,3-dimethylbut-1-ynyl)-17-hydroxy-13-methyl-11-(4-morpholin-4-ylphenyl)-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one
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|
C34H45NO3
|
2
|
| 1 |
EC50 > 2500 nM
|
|
|
| 2 |
IC50 = 208 nM
|
|
|
|
CP0396797
|
(8R,9S,10R,11S,13S,14S,17S)-11-[4-(diethylamino)phenyl]-17-(3,3-dimethylbut-1-ynyl)-17-hydroxy-13-methyl-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one
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|
C34H47NO2
|
2
|
| 1 |
EC50 > 2500 nM
|
|
|
| 2 |
IC50 = 263 nM
|
|
|
|
CP0396799
|
(8R,9S,10R,11S,13S,14S,17S)-11-[4-(dimethylamino)phenyl]-17-(3,3-dimethylpent-1-ynyl)-17-hydroxy-13-methyl-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one
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|
C33H45NO2
|
2
|
| 1 |
EC50 > 2500 nM
|
|
|
| 2 |
IC50 = 175 nM
|
|
|
|
CP0396800
|
(8S,9R,10R,11S,13S,14S,17S)-11-[4-(dimethylamino)phenyl]-17-hydroxy-10,13-dimethyl-17-(3-methylbut-1-ynyl)-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
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|
C32H43NO2
|
2
|
| 1 |
EC50 > 2500 nM
|
|
|
| 2 |
IC50 > 5000 nM
|
|
|
|
CP0421753
|
(8S,9R,10R,11S,13S,14S,17S)-11-[4-(dimethylamino)phenyl]-17-(3,3-dimethylbut-1-ynyl)-17-hydroxy-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
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|
C33H45NO2
|
2
|
| 1 |
EC50 > 2500 nM
|
|
|
| 2 |
IC50 > 5000 nM
|
|
|
|
CP0421754
|
(8S,9R,10R,11S,13S,14S,17S)-11-[4-(dimethylamino)phenyl]-17-hydroxy-10,13-dimethyl-17-prop-1-ynyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
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|
C30H39NO2
|
2
|
| 1 |
EC50 > 2500 nM
|
|
|
| 2 |
IC50 = 912 nM
|
|
|
|
CP0434729
|
(8S,9R,10R,11S,13S,14S,17S)-17-but-1-ynyl-11-[4-(dimethylamino)phenyl]-17-hydroxy-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
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|
C31H41NO2
|
2
|
| 1 |
EC50 > 2500 nM
|
|
|
| 2 |
IC50 = 2955 nM
|
|
|
|
CP0438094
|
(8S,9R,10R,11S,13S,14S,17S)-17-hydroxy-11-[4-[2-methoxyethyl(methyl)amino]phenyl]-10,13-dimethyl-17-prop-1-ynyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
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|
C32H43NO3
|
2
|
| 1 |
EC50 > 2500 nM
|
|
|
| 2 |
IC50 = 1295 nM
|
|
|
|
CP0438095
|
(8R,9S,10R,11S,13S,14S,17S)-17-(3,3-dimethylbut-1-ynyl)-17-hydroxy-13-methyl-11-[4-(4-methylsulfonylpiperazin-1-yl)phenyl]-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one
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|
C35H48N2O4S
|
2
|
| 1 |
EC50 > 2500 nM
|
|
|
| 2 |
IC50 = 359 nM
|
|
|
|
CP0470985
|
(8S,9R,10R,11S,13S,14S,17S)-17-hydroxy-11-(4-methoxyphenyl)-10,13-dimethyl-17-prop-1-ynyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
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|
C29H36O3
|
2
|
| 1 |
EC50 > 2500 nM
|
|
|
| 2 |
IC50 = 561 nM
|
|
|
|
CP0471010
|
(8S,9R,10R,11S,13S,14S,17S)-17-hydroxy-10,13-dimethyl-17-prop-1-ynyl-11-(4-pyrrolidin-1-ylphenyl)-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
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|
C32H41NO2
|
2
|
| 1 |
EC50 > 2500 nM
|
|
|
| 2 |
IC50 = 3146 nM
|
|
|
|
CP0527812
|
(8S,9R,10R,11S,13S,14S,17S)-11-[4-(dimethylamino)phenyl]-17-hydroxy-17-(3-methoxyprop-1-ynyl)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
Show/Hide
|
C31H41NO3
|
2
|
| 1 |
EC50 > 2500 nM
|
|
|
| 2 |
IC50 > 5000 nM
|
|
|
|
CP0529951
|
(8S,9R,10R,11S,13S,14S,17S)-17-hydroxy-10,13-dimethyl-17-prop-1-ynyl-11-(4-pyrrol-1-ylphenyl)-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
Show/Hide
|
C32H37NO2
|
2
|
| 1 |
EC50 > 2500 nM
|
|
|
| 2 |
IC50 = 354 nM
|
|
|
|
CP0529952
|
(8R,9S,10R,11S,13S,14S,17S)-17-(3,3-dimethylbut-1-ynyl)-17-hydroxy-13-methyl-11-[4-(4-methylpiperazin-1-yl)phenyl]-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one
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|
C35H48N2O2
|
2
|
| 1 |
EC50 > 2500 nM
|
|
|
| 2 |
IC50 = 1005 nM
|
|
|
|
CP0531036
|
(8S,9R,10R,11S,13S,14S,17S)-11-[4-(dimethylamino)phenyl]-17-hydroxy-10,13-dimethyl-17-(3,3,3-trifluoroprop-1-ynyl)-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
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|
C30H36F3NO2
|
2
|
| 1 |
EC50 > 2500 nM
|
|
|
| 2 |
IC50 = 642 nM
|
|
|
|
CP0037412
|
(2R)-N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorobenzene)sulfonyl]-2-hydroxy-2-methylpropanamide
Show/Hide
|
C18H14F4N2O4S
|
4
|
| 1 |
GI50 = 1800 nM
|
|
|
| 2 |
IC50 = 850 nM
|
|
|
| 3 |
IC50 = 27710 nM
|
|
|
| 4 |
Ki = 10 nM
|
|
|
|
CP0959638
|
N-(4-chloro-3-(trifluoromethyl)phenyl)-2-(4-((4-cyanophenoxy)methyl)-1H-1,2,3-triazol-1-yl)acetamide
Show/Hide
|
C19H13ClF3N5O2
|
2
|
| 1 |
GI50 = 5090 nM
|
|
|
| 2 |
GI50 = 15700 nM
|
|
|
|
CP0949660
|
N-(4-cyano-3-(trifluoromethyl)phenyl)-2-(4-((4-cyanophenoxy)methyl)-1H-1,2,3-triazol-1-yl)acetamide
Show/Hide
|
C20H13F3N6O2
|
1
|
| 1 |
GI50 = 6420 nM
|
|
|
|
CP0891225
|
4-(4-(((4-fluorophenyl)thio)methyl)-1H-1,2,3-triazol-1-yl)-2-(trifluoromethyl)benzonitrile
Show/Hide
|
C17H10F4N4S
|
1
|
| 1 |
GI50 = 16750 nM
|
|
|
|
CP0891224
|
4-(4-((4-fluorophenoxy)methyl)-1H-1,2,3-triazol-1-yl)-2-(trifluoromethyl)benzonitrile
Show/Hide
|
C17H10F4N4O
|
1
|
| 1 |
GI50 = 19230 nM
|
|
|
|
CP0359162
|
3-[3-(3-Chloro-4-cyanophenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl]propane-1-sulfonamide
Show/Hide
|
C15H17ClN4O3S2
|
3
|
| 1 |
IC50 = 10 nM
|
|
|
| 2 |
IC50 = 12 nM
|
|
|
| 3 |
IC50 = 410 nM
|
|
|
|
CP0389793
|
N-[3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl]imidazo[1,2-a]pyrimidine-3-carboxamide
Show/Hide
|
C22H22ClN5O2
|
1
|
| 1 |
IC50 = 16 nM
|
|
|
|
CP0383542
|
3-[3-(4-Cyano-3-trifluoromethylphenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl]propane-1-sulfonamide
Show/Hide
|
C16H17F3N4O3S2
|
2
|
| 1 |
IC50 = 18 nM
|
|
|
| 2 |
IC50 = 160 nM
|
|
|
|
CP0479428
|
5-[5-[4-(1-methylpiperidin-4-yl)oxyphenyl]-8-oxo-6-sulfanylidene-5,7-diazaspiro[3.4]octan-7-yl]-3-(trifluoromethyl)pyridine-2-carbonitrile
Show/Hide
|
C25H24F3N5O2S
|
4
|
| 1 |
IC50 = 19 nM
|
|
|
| 2 |
IC50 = 98 nM
|
|
|
| 3 |
IC50 = 191 nM
|
|
|
| 4 |
Ki = 8.4 nM
|
|
|
|
CP0405940
|
N-[3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl]-1-methylpyrazole-4-carboxamide
Show/Hide
|
C20H23ClN4O2
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0880496
|
(2S,6R)-4-(3-Trifluoromethyl-phenyl)-4-aza-tricyclo[5.3.2.0*2,6*]dodecane-3,5-dione
Show/Hide
|
C18H18F3NO2
|
2
|
| 1 |
IC50 = 23 nM
|
|
|
| 2 |
Ki = 20 nM
|
|
|
|
CP0871744
|
4-((1S,2S,6R,7R)-1,7-Dimethyl-3,5-dioxo-9-propyl-11-oxa-4,9-diaza-tricyclo[5.3.1.0*2,6*]undec-4-yl)-2-trifluoromethyl-benzonitrile
Show/Hide
|
C21H22F3N3O3
|
1
|
| 1 |
IC50 = 25 nM
|
|
|
|
CP0848003
|
(2R,6S,8S,10R)-4-[3-(trifluoromethyl)phenyl]-4-azatetracyclo[5.3.2.0^{2,6}.0^{8,10}]dodec-11-ene-3,5-dione
Show/Hide
|
C18H14F3NO2
|
2
|
| 1 |
IC50 = 30 nM
|
|
|
| 2 |
Ki = 9 nM
|
|
|
|
CP0372331
|
3-[3-(4-Cyano-3-trifluoromethylphenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl]propane-1-sulfonic acidmethylamide
Show/Hide
|
C17H19F3N4O3S2
|
2
|
| 1 |
IC50 = 30 nM
|
|
|
| 2 |
IC50 = 190 nM
|
|
|
|
CP0243191
|
5-[3-(4-Cyano-3-trifluoromethylphenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl]pyridine-3-sulfonic acid amide
Show/Hide
|
C18H14F3N5O3S2
|
1
|
| 1 |
IC50 = 30 nM
|
|
|
|
CP0459011
|
N-[3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl]-5-methyl-1,3,4-oxadiazole-2-carboxamide
Show/Hide
|
C19H21ClN4O3
|
1
|
| 1 |
IC50 = 30 nM
|
|
|
|
CP0547450
|
2-(5,7-difluoro-1H-indol-3-yl)quinoline
Show/Hide
|
C17H10F2N2
|
1
|
| 1 |
IC50 = 30 nM
|
|
|
|
CP0573250
|
2-(7-chloro-6-fluoro-1H-indol-3-yl)quinoline
Show/Hide
|
C17H10ClFN2
|
1
|
| 1 |
IC50 = 30 nM
|
|
|
|
CP0476322
|
N-[3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl]acetamide
Show/Hide
|
C17H21ClN2O2
|
1
|
| 1 |
IC50 = 32 nM
|
|
|
|
CP0479432
|
5-[5-oxo-8-[6-(4-piperidyloxy)- 3-pyridyl]-7-thioxo-6,8- diazaspiro[3.4]octan-6-yl]-3- (trifluoromethyl)pyridine-2- carbonitrile
Show/Hide
|
C23H21F3N6O2S
|
2
|
| 1 |
IC50 = 37 nM
|
|
|
| 2 |
IC50 = 54 nM
|
|
|
|
CP0549132
|
3-chloro-5-[8-oxo-5-(4-piperidin-4-yloxyphenyl)-6-sulfanylidene-5,7-diazaspiro[3.4]octan-7-yl]pyridine-2-carbonitrile
Show/Hide
|
C23H22ClN5O2S
|
2
|
| 1 |
IC50 = 37 nM
|
|
|
| 2 |
IC50 = 76 nM
|
|
|
|
CP0559091
|
N-(2,2-difluoroethyl)-2-(5,6,7-trifluoro-1H-indol-3-yl)quinoline-5-carboxamide
Show/Hide
|
C20H12F5N3O
|
1
|
| 1 |
IC50 = 40 nM
|
|
|
|
CP0917601
|
(2R,6S)-4-(3,4-Dichloro-phenyl)-4-aza-tricyclo[5.2.1.0*2,6*]dec-8-ene-3,5-dione
Show/Hide
|
C15H11Cl2NO2
|
2
|
| 1 |
IC50 = 41 nM
|
|
|
| 2 |
Ki = 6 nM
|
|
|
|
CP0433246
|
N-[3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl]-1H-pyrazole-4-carboxamide
Show/Hide
|
C19H21ClN4O2
|
1
|
| 1 |
IC50 = 42 nM
|
|
|
|
CP0408556
|
N-[4-(4-hydroxyphenoxy)-3-methylphenyl]-3-methoxybenzamide
Show/Hide
|
C21H19NO4
|
1
|
| 1 |
IC50 = 43 nM
|
|
|
|
CP0479438
|
3-chloro-5-[8-oxo-5-(6-piperidin-4-yloxypyridin-3-yl)-6-sulfanylidene-5,7-diazaspiro[3.4]octan-7-yl]pyridine-2-carbonitrile
Show/Hide
|
C22H21ClN6O2S
|
2
|
| 1 |
IC50 = 47 nM
|
|
|
| 2 |
IC50 = 50 nM
|
|
|
|
CP0359227
|
5-[3-(3-Chloro-4-cyanophenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl]pyridine-3-sulfonic acid amide
Show/Hide
|
C17H14ClN5O3S2
|
1
|
| 1 |
IC50 = 50 nM
|
|
|
|
CP0372323
|
3-[3-(4-Cyano-3-methylphenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl]propane-1-sulfonamide
Show/Hide
|
C16H20N4O3S2
|
2
|
| 1 |
IC50 = 51 nM
|
|
|
| 2 |
IC50 = 300 nM
|
|
|
|
CP0844856
|
(1S,2S,6R,7R)-4-(4-Cyano-3-trifluoromethyl-phenyl)-1,7-dimethyl-3,5-dioxo-11-oxa-4,9-diaza-tricyclo[5.3.1.0*2,6*]undecane-9-carboxylic acid propyl ester
Show/Hide
|
C22H22F3N3O5
|
1
|
| 1 |
IC50 = 54 nM
|
|
|
|
CP0506047
|
N-[3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl]-1,5-dimethylpyrazole-3-carboxamide
Show/Hide
|
C21H25ClN4O2
|
1
|
| 1 |
IC50 = 54 nM
|
|
|
|
CP0374238
|
4-[3-(4-Cyano-3-trifluoromethylphenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl]butyramide
Show/Hide
|
C17H17F3N4O2S
|
2
|
| 1 |
IC50 = 55 nM
|
|
|
| 2 |
IC50 = 400 nM
|
|
|
|
CP0848004
|
(2R,6S,10R,11S)-4-(4-Bromo-3-methyl-phenyl)-10,11-dihydroxy-4-aza-tricyclo[5.2.2.0*2,6*]undec-8-ene-3,5-dione
Show/Hide
|
C17H16BrNO4
|
2
|
| 1 |
IC50 = 59 nM
|
|
|
| 2 |
Ki = 33 nM
|
|
|
|
CP0405942
|
N-[3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl]-1-(2-hydroxyethyl)pyrazole-4-carboxamide
Show/Hide
|
C21H25ClN4O3
|
1
|
| 1 |
IC50 = 59 nM
|
|
|
|
CP0561987
|
2-(7-methyl-1H-indol-3-yl)quinoline
Show/Hide
|
C18H14N2
|
1
|
| 1 |
IC50 = 60 nM
|
|
|
|
CP0494205
|
(2R)-1'-[6-cyano-5-(trifluoromethyl)pyridin-3-yl]-6-fluoro-N-methyl-5'-oxo-3'-propan-2-yl-2'-sulfanylidenespiro[1,3-dihydroindene-2,4'-imidazolidine]-5-carboxamide
Show/Hide
|
C23H19F4N5O2S
|
1
|
| 1 |
IC50 = 65 nM
|
|
|
|
CP0862669
|
(2R,6S)-4-(3-Trifluoromethyl-phenyl)-4-aza-tricyclo[5.2.2.0*2,6*]undec-8-ene-3,5-dione
Show/Hide
|
C17H14F3NO2
|
2
|
| 1 |
IC50 = 66 nM
|
|
|
| 2 |
Ki = 19 nM
|
|
|
|
CP0844851
|
(1S,2S,6R,7R)-4-(4-Cyano-3-trifluoromethyl-phenyl)-1,7-dimethyl-3,5-dioxo-11-oxa-4,9-diaza-tricyclo[5.3.1.0*2,6*]undecane-9-carboxylic acid isopropyl ester
Show/Hide
|
C22H22F3N3O5
|
1
|
| 1 |
IC50 = 69 nM
|
|
|
|
CP0495788
|
N-[3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl]-2-methylimidazo[1,2-a]pyrimidine-3-carboxamide
Show/Hide
|
C23H24ClN5O2
|
1
|
| 1 |
IC50 = 69 nM
|
|
|
|
CP0506046
|
N-[3-(4-cyano-3-methylphenoxy)-2,2,4,4-tetramethylcyclobutyl]acetamide
Show/Hide
|
C18H24N2O2
|
1
|
| 1 |
IC50 = 70 nM
|
|
|
|
CP0559092
|
5-[2-(5,6,7-trifluoro-1H-indol-3-yl)quinolin-5-yl]-1,3-thiazole
Show/Hide
|
C20H10F3N3S
|
1
|
| 1 |
IC50 = 70 nM
|
|
|
|
CP0574826
|
N-cyclopropyl-2-(5,6,7-trifluoro-1H-indol-3-yl)quinoline-5-carboxamide
Show/Hide
|
C21H14F3N3O
|
1
|
| 1 |
IC50 = 70 nM
|
|
|
|
CP0475156
|
N-[3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl]-1H-pyrazole-5-carboxamide
Show/Hide
|
C19H21ClN4O2
|
1
|
| 1 |
IC50 = 75 nM
|
|
|
|
CP0563608
|
(2R)-1'-[4-cyano-3-(trifluoromethyl)phenyl]-6-fluoro-N-methyl-5'-oxo-3'-propan-2-yl-2'-sulfanylidenespiro[1,3-dihydroindene-2,4'-imidazolidine]-5-carboxamide
Show/Hide
|
C24H20F4N4O2S
|
1
|
| 1 |
IC50 = 78 nM
|
|
|
|
CP0372169
|
2-[3-(4-Cyano-3-trifluoromethylphenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl]ethanesulfonamide
Show/Hide
|
C15H15F3N4O3S2
|
2
|
| 1 |
IC50 = 79 nM
|
|
|
| 2 |
IC50 = 750 nM
|
|
|
|
CP0344451
|
4-[3-(4-Cyano-3-trifluoromethylphenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl]pyridine-2-sulfonic acid amide
Show/Hide
|
C18H14F3N5O3S2
|
1
|
| 1 |
IC50 = 80 nM
|
|
|
|
CP0491419
|
3-methyl-5-[8-oxo-5-(6-piperidin-4-yloxypyridin-3-yl)-6-sulfanylidene-5,7-diazaspiro[3.4]octan-7-yl]pyridine-2-carbonitrile
Show/Hide
|
C23H24N6O2S
|
2
|
| 1 |
IC50 = 81 nM
|
|
|
| 2 |
IC50 = 120 nM
|
|
|
|
CP0440338
|
N-[3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl]pyrazine-2-carboxamide
Show/Hide
|
C20H21ClN4O2
|
1
|
| 1 |
IC50 = 82 nM
|
|
|
|
CP0479448
|
5-[5-[6-(1-methylpiperidin-4-yl)oxypyridin-3-yl]-8-oxo-6-sulfanylidene-5,7-diazaspiro[3.4]octan-7-yl]-3-(trifluoromethyl)pyridine-2-carbonitrile
Show/Hide
|
C24H23F3N6O2S
|
2
|
| 1 |
IC50 = 85 nM
|
|
|
| 2 |
IC50 = 115 nM
|
|
|
|
CP0372325
|
3-[3-(4-Cyano-3-trifluoromethylphenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl]propylsulfamide
Show/Hide
|
C16H18F3N5O3S2
|
2
|
| 1 |
IC50 = 89 nM
|
|
|
| 2 |
IC50 = 780 nM
|
|
|
|
CP0395359
|
N-[3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl]-1-(2-cyanoethyl)pyrazole-3-carboxamide
Show/Hide
|
C22H24ClN5O2
|
1
|
| 1 |
IC50 = 90 nM
|
|
|
|
CP0573249
|
2-(5,6,7-trifluoro-1H-indol-3-yl)quinoline
Show/Hide
|
C17H9F3N2
|
1
|
| 1 |
IC50 = 90 nM
|
|
|
|
CP0538881
|
US9126941, RD131
Show/Hide
|
C25H23F3N4O2S
|
1
|
| 1 |
IC50 = 92 nM
|
|
|
|
CP0550766
|
1'-[4-cyano-3-(trifluoromethyl)phenyl]-6-fluoro-N-methyl-5'-oxo-3'-propan-2-yl-2'-sulfanylidenespiro[1,3-dihydroindene-2,4'-imidazolidine]-5-carboxamide
Show/Hide
|
C24H20F4N4O2S
|
1
|
| 1 |
IC50 = 93 nM
|
|
|
|
CP0076394
|
6-[3-(4-Cyano-3-trifluoromethylphenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl]pyridine-2-sulfonic acid amide
Show/Hide
|
C18H14F3N5O3S2
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0163140
|
6-[3-(3-Chloro-4-cyanophenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl]pyridine-2-sulfonic acid amide
Show/Hide
|
C17H14ClN5O3S2
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0195890
|
3-[3-(4-Cyano-3-trifluoromethylphenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl]benzenesulfonamide
Show/Hide
|
C19H15F3N4O3S2
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0296445
|
3-[3-(3-Chloro-4-cyanophenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl]benzenesulfonamide
Show/Hide
|
C18H15ClN4O3S2
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0344449
|
4-(3-Phenyl-4,4-dimethyl-5-oxo-2-thioxoimidazolidin-1-yl)-2-trifluoromethylbenzonitrile
Show/Hide
|
C19H14F3N3OS
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0313967
|
4-[4-(4,5-dibromoimidazol-1-yl)-1,3-thiazol-2-yl]morpholine
Show/Hide
|
C10H10Br2N4OS
|
2
|
| 1 |
IC50 = 100 nM
|
|
|
| 2 |
IC50 = 170 nM
|
|
|
|
CP0386610
|
10-[(2-hydroxy-4-methoxyphenyl)methylidene]anthracen-9-one
Show/Hide
|
C22H16O3
|
2
|
| 1 |
IC50 = 100 nM
|
|
|
| 2 |
IC50 = 231.8 nM
|
|
|
|
CP0533999
|
2-(7-chloro-5-fluoro-1H-indol-3-yl)quinoline
Show/Hide
|
C17H10ClFN2
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0561986
|
2-(7-chloro-1H-indol-3-yl)quinoline
Show/Hide
|
C17H11ClN2
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0562648
|
8-fluoro-2-(7-methyl-1H-indol-3-yl)quinoline
Show/Hide
|
C18H13FN2
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0479433
|
3-methoxy-5-[5-[6-(1-methylpiperidin-4-yl)oxypyridin-3-yl]-8-oxo-6-sulfanylidene-5,7-diazaspiro[3.4]octan-7-yl]pyridine-2-carbonitrile
Show/Hide
|
C24H26N6O3S
|
2
|
| 1 |
IC50 = 102 nM
|
|
|
| 2 |
IC50 = 162 nM
|
|
|
|
CP0570300
|
1'-[6-cyano-5-(trifluoromethyl)pyridin-3-yl]-6-fluoro-N-methyl-3'-(2-methylpropyl)-5'-oxo-2'-sulfanylidenespiro[1,3-dihydroindene-2,4'-imidazolidine]-5-carboxamide
Show/Hide
|
C24H21F4N5O2S
|
1
|
| 1 |
IC50 = 102 nM
|
|
|
|
CP0844858
|
4-[(1S,2S,6R,7R)-9-(6-Chloro-pyrimidin-4-yl)-1,7-dimethyl-3,5-dioxo-11-oxa-4,9-diaza-tricyclo[5.3.1.0*2,6*]undec-4-yl]-2-trifluoromethyl-benzonitrile
Show/Hide
|
C22H17ClF3N5O3
|
1
|
| 1 |
IC50 = 104 nM
|
|
|
|
CP0859768
|
(1S,2S,6R,7R)-4-(4-Cyano-3-trifluoromethyl-phenyl)-1,7-dimethyl-3,5-dioxo-11-oxa-4,9-diaza-tricyclo[5.3.1.0*2,6*]undecane-9-carboxylic acid(4-fluoro-phenyl)-amide
Show/Hide
|
C25H20F4N4O4
|
1
|
| 1 |
IC50 = 104 nM
|
|
|
|
CP0374239
|
4-[3-(4-Cyano-3-trifluoromethylphenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl]butane-1-sulfonamide
Show/Hide
|
C17H19F3N4O3S2
|
2
|
| 1 |
IC50 = 110 nM
|
|
|
| 2 |
IC50 = 1400 nM
|
|
|
|
CP0572509
|
N-methyl-2-(5,6,7-trifluoro-1H-indol-3-yl)quinoline-5-carboxamide
Show/Hide
|
C19H12F3N3O
|
1
|
| 1 |
IC50 = 110 nM
|
|
|
|
CP0496367
|
N-(4-phenylmethoxyphenyl)benzenesulfonamide
Show/Hide
|
C19H17NO3S
|
1
|
| 1 |
IC50 = 110 nM
|
|
|
|
CP0513412
|
US9126941, RD130
Show/Hide
|
C24H21F3N4O2S
|
1
|
| 1 |
IC50 = 112 nM
|
|
|
|
CP0420014
|
(2S)-1'-[6-cyano-5-(trifluoromethyl)pyridin-3-yl]-6-fluoro-N-methyl-5'-oxo-3'-propan-2-yl-2'-sulfanylidenespiro[1,3-dihydroindene-2,4'-imidazolidine]-5-carboxamide
Show/Hide
|
C23H19F4N5O2S
|
1
|
| 1 |
IC50 = 112 nM
|
|
|
|
CP0902636
|
(1S,2S,6R,7R)-4-(4-Cyano-3-trifluoromethyl-phenyl)-1,7-dimethyl-3,5-dioxo-11-oxa-4,9-diaza-tricyclo[5.3.1.0*2,6*]undecane-9-carboxylic acid phenylamide
Show/Hide
|
C25H21F3N4O4
|
1
|
| 1 |
IC50 = 123 nM
|
|
|
|
CP0534095
|
1'-[4-cyano-3-(trifluoromethyl)phenyl]-6-fluoro-N-methyl-3'-(2-methylpropyl)-5'-oxo-2'-sulfanylidenespiro[1,3-dihydroindene-2,4'-imidazolidine]-5-carboxamide
Show/Hide
|
C25H22F4N4O2S
|
1
|
| 1 |
IC50 = 123 nM
|
|
|
|
CP0474678
|
US9126941, RD37
Show/Hide
|
C21H16F3N3OS
|
1
|
| 1 |
IC50 = 124 nM
|
|
|
|
CP0904024
|
4-((1S,2S,6R,7R)-9-Isopropyl-1,7-dimethyl-3,5,8,10-tetraoxo-11-oxa-4,9-diaza-tricyclo[5.3.1.0*2,6*]undec-4-yl)-2-trifluoromethyl-benzonitrile
Show/Hide
|
C21H18F3N3O5
|
1
|
| 1 |
IC50 = 125 nM
|
|
|
|
CP0461551
|
US9126941, RD7
Show/Hide
|
C20H16F3N3OS
|
1
|
| 1 |
IC50 = 125 nM
|
|
|
|
CP0440337
|
N-[3-[4-cyano-3-(trifluoromethyl)phenoxy]-2,2,4,4-tetramethylcyclobutyl]acetamide
Show/Hide
|
C18H21F3N2O2
|
1
|
| 1 |
IC50 = 126 nM
|
|
|
|
CP0500063
|
US9126941, RD68
Show/Hide
|
C20H15F4N3OS
|
1
|
| 1 |
IC50 = 126 nM
|
|
|
|
CP0906735
|
3-[(1S,2S,6R,7R)-4-(4-Cyano-3-trifluoromethyl-phenyl)-1,7-dimethyl-3,5-dioxo-11-oxa-4,9-diaza-tricyclo[5.3.1.0*2,6*]undec-9-yl]-benzamide
Show/Hide
|
C25H21F3N4O4
|
1
|
| 1 |
IC50 = 127 nM
|
|
|
|
CP0559398
|
2-(5-chloro-7-fluoro-1H-indol-3-yl)quinoline
Show/Hide
|
C17H10ClFN2
|
1
|
| 1 |
IC50 = 130 nM
|
|
|
|
CP0500055
|
US9126941, RD13
Show/Hide
|
C21H15ClF3N3O3S
|
1
|
| 1 |
IC50 = 131 nM
|
|
|
|
CP0527561
|
1'-[6-cyano-5-(trifluoromethyl)pyridin-3-yl]-3'-cyclopentyl-6-fluoro-N-methyl-5'-oxo-2'-sulfanylidenespiro[1,3-dihydroindene-2,4'-imidazolidine]-5-carboxamide
Show/Hide
|
C25H21F4N5O2S
|
1
|
| 1 |
IC50 = 132 nM
|
|
|
|
CP0433245
|
N-[3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl]-1-(2-hydroxyethyl)pyrazole-3-carboxamide
Show/Hide
|
C21H25ClN4O3
|
1
|
| 1 |
IC50 = 136 nM
|
|
|
|
CP0500451
|
N-[3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl]-1-(2-methoxyethyl)pyrazole-3-carboxamide
Show/Hide
|
C22H27ClN4O3
|
1
|
| 1 |
IC50 = 136 nM
|
|
|
|
CP0466643
|
US9126941, RD8
Show/Hide
|
C19H14F3N3O2S
|
1
|
| 1 |
IC50 = 137 nM
|
|
|
|
CP0468376
|
US9126941, RD138
Show/Hide
|
C25H24F3N5O3S2
|
1
|
| 1 |
IC50 = 138 nM
|
|
|
|
CP0500062
|
US9126941, RD66
Show/Hide
|
C20H13F6N3OS
|
1
|
| 1 |
IC50 = 143 nM
|
|
|
|
CP0405943
|
N-[3-(5-cyano-6-methylpyridin-2-yl)oxy-2,2,4,4-tetramethylcyclobutyl]imidazo[1,2-a]pyrimidine-3-carboxamide
Show/Hide
|
C22H24N6O2
|
1
|
| 1 |
IC50 = 144 nM
|
|
|
|
CP0930031
|
US9126941, RD93
Show/Hide
|
C30H20F6N6S2
|
1
|
| 1 |
IC50 = 144 nM
|
|
|
|
CP0567476
|
5-[8-oxo-5-(4-piperidin-4-yloxyphenyl)-6-sulfanylidene-5,7-diazaspiro[3.4]octan-7-yl]-3-(trifluoromethyl)pyridine-2-carbonitrile
Show/Hide
|
C24H22F3N5O2S
|
2
|
| 1 |
IC50 = 145 nM
|
|
|
| 2 |
IC50 = 240 nM
|
|
|
|
CP0539746
|
1'-[6-cyano-5-(trifluoromethyl)pyridin-3-yl]-6-fluoro-N-methyl-5'-oxo-3'-propan-2-yl-2'-sulfanylidenespiro[1,3-dihydroindene-2,4'-imidazolidine]-5-carboxamide
Show/Hide
|
C23H19F4N5O2S
|
1
|
| 1 |
IC50 = 145 nM
|
|
|
|
CP0500056
|
US9126941, RD35
Show/Hide
|
C22H18F3N3OS
|
1
|
| 1 |
IC50 = 147 nM
|
|
|
|
CP0461550
|
US9126941, RD10
Show/Hide
|
C19H14F3N3OS
|
1
|
| 1 |
IC50 = 149 nM
|
|
|
|
CP0902637
|
4-[(1S,2S,6R,7R)-9-(3-Methanesulfonyl-phenyl)-1,7-dimethyl-3,5-dioxo-11-oxa-4,9-diaza-tricyclo[5.3.1.0*2,6*]undec-4-yl]-2-trifluoromethyl-benzonitrile
Show/Hide
|
C25H22F3N3O5S
|
1
|
| 1 |
IC50 = 150 nM
|
|
|
|
CP0375186
|
2-fluoro-6-(2-morpholin-4-yl-1,3-thiazol-4-yl)phenol
Show/Hide
|
C13H13FN2O2S
|
2
|
| 1 |
IC50 = 150 nM
|
|
|
| 2 |
IC50 = 270 nM
|
|
|
|
CP0274308
|
12-(4-bromophenyl)-11-azatetracyclo[8.7.0.02,7.013,17]heptadeca-1(10),2,4,6,8,15-hexaene
Show/Hide
|
C22H18BrN
|
1
|
| 1 |
IC50 = 150 nM
|
|
|
|
CP0485650
|
(2S)-1'-[4-cyano-3-(trifluoromethyl)phenyl]-6-fluoro-N-methyl-5'-oxo-3'-propan-2-yl-2'-sulfanylidenespiro[1,3-dihydroindene-2,4'-imidazolidine]-5-carboxamide
Show/Hide
|
C24H20F4N4O2S
|
1
|
| 1 |
IC50 = 151 nM
|
|
|
|
CP0952445
|
US9126941, RD91
Show/Hide
|
C23H22F3N5S2
|
1
|
| 1 |
IC50 = 157 nM
|
|
|
|
CP0550760
|
(2R)-4-(4-phenyl-1,3-thiazol-2-yl)-2-(trifluoromethyl)morpholine
Show/Hide
|
C14H13F3N2OS
|
2
|
| 1 |
IC50 = 160 nM
|
|
|
| 2 |
IC50 = 1650 nM
|
|
|
|
CP0559090
|
8-bromo-2-(7-methyl-1H-indol-3-yl)quinoline
Show/Hide
|
C18H13BrN2
|
1
|
| 1 |
IC50 = 160 nM
|
|
|
|
CP0418886
|
N-propan-2-yl-2-(5,6,7-trifluoro-1H-indol-3-yl)quinoline-5-carboxamide
Show/Hide
|
C21H16F3N3O
|
2
|
| 1 |
IC50 = 160 nM
|
|
|
| 2 |
IC50 = 190 nM
|
|
|
|
CP0506048
|
N-[3-(2-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl]acetamide
Show/Hide
|
C17H21ClN2O2
|
1
|
| 1 |
IC50 = 161 nM
|
|
|
|
CP0500059
|
US9126941, RD58
Show/Hide
|
C20H14F3N3O2S
|
1
|
| 1 |
IC50 = 162 nM
|
|
|
|
CP0517670
|
N-[3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl]-1-[2-(methylamino)-2-oxoethyl]pyrazole-3-carboxamide
Show/Hide
|
C22H26ClN5O3
|
1
|
| 1 |
IC50 = 163 nM
|
|
|
|
CP0415536
|
1,8-dichloro-10-[(3-hydroxy-2,4-dimethoxyphenyl)methylidene]anthracen-9-one
Show/Hide
|
C23H16Cl2O4
|
2
|
| 1 |
IC50 = 170 nM
|
|
|
| 2 |
IC50 = 1135 nM
|
|
|
|
CP0487257
|
2-(6-fluoro-7-methyl-1H-indol-3-yl)quinoline
Show/Hide
|
C18H13FN2
|
1
|
| 1 |
IC50 = 170 nM
|
|
|
|
CP0570285
|
1'-[6-cyano-5-(trifluoromethyl)pyridin-3-yl]-3'-cyclobutyl-6-fluoro-N-methyl-5'-oxo-2'-sulfanylidenespiro[1,3-dihydroindene-2,4'-imidazolidine]-5-carboxamide
Show/Hide
|
C24H19F4N5O2S
|
1
|
| 1 |
IC50 = 170 nM
|
|
|
|
CP0109735
|
7-[(4-bromophenyl)methoxy]-4-(trifluoromethyl)chromen-2-one
Show/Hide
|
C17H10BrF3O3
|
1
|
| 1 |
IC50 = 170 nM
|
|
|
|
CP0523437
|
N-[3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl]-1-[2-(dimethylamino)-2-oxoethyl]pyrazole-3-carboxamide
Show/Hide
|
C23H28ClN5O3
|
1
|
| 1 |
IC50 = 174 nM
|
|
|
|
CP0490449
|
1'-[6-cyano-5-(trifluoromethyl)pyridin-3-yl]-3'-cyclohexyl-6-fluoro-N-methyl-5'-oxo-2'-sulfanylidenespiro[1,3-dihydroindene-2,4'-imidazolidine]-5-carboxamide
Show/Hide
|
C26H23F4N5O2S
|
1
|
| 1 |
IC50 = 174 nM
|
|
|
|
CP0405941
|
N-[3-(3,4-dicyanophenoxy)-2,2,4,4-tetramethylcyclobutyl]acetamide
Show/Hide
|
C18H21N3O2
|
1
|
| 1 |
IC50 = 175 nM
|
|
|
|
CP0924227
|
US9126941, RD92
Show/Hide
|
C28H22F3N5S2
|
1
|
| 1 |
IC50 = 176 nM
|
|
|
|
CP0914809
|
4-((1S,2S,6R,7R)-9-Benzoyl-1,7-dimethyl-3,5-dioxo-11-oxa-4,9-diaza-tricyclo[5.3.1.0*2,6*]undec-4-yl)-2-trifluoromethyl-benzonitrile
Show/Hide
|
C25H20F3N3O4
|
1
|
| 1 |
IC50 = 177 nM
|
|
|
|
CP0550765
|
5-(3'-methyl-5'-oxo-5-piperidin-4-yloxy-2'-sulfanylidenespiro[1,3-dihydroindene-2,4'-imidazolidine]-1'-yl)-3-(trifluoromethyl)pyridine-2-carbonitrile
Show/Hide
|
C24H22F3N5O2S
|
1
|
| 1 |
IC50 = 178 nM
|
|
|
|
CP0867205
|
4-((1S,2S,6R,7R)-9-Methoxy-1,7-dimethyl-3,5-dioxo-11-oxa-4,9-diaza-tricyclo[5.3.1.0*2,6*]undec-4-yl)-2-trifluoromethyl-benzonitrile
Show/Hide
|
C19H18F3N3O4
|
1
|
| 1 |
IC50 = 179 nM
|
|
|
|
CP0547510
|
4-[4-(3,4-difluoro-2-methoxyphenyl)-1,3-thiazol-2-yl]morpholine
Show/Hide
|
C14H14F2N2O2S
|
2
|
| 1 |
IC50 = 180 nM
|
|
|
| 2 |
IC50 = 250 nM
|
|
|
|
CP0559093
|
N-(cyclopropylmethyl)-2-(5,6,7-trifluoro-1H-indol-3-yl)quinoline-5-carboxamide
Show/Hide
|
C22H16F3N3O
|
1
|
| 1 |
IC50 = 180 nM
|
|
|
|
CP0561988
|
8-methyl-2-(7-methyl-1H-indol-3-yl)quinoline
Show/Hide
|
C19H16N2
|
1
|
| 1 |
IC50 = 180 nM
|
|
|
|
CP0561687
|
5-[5-(4-hydroxyphenyl)-8-oxo-6-sulfanylidene-5,7-diazaspiro[3.4]octan-7-yl]-3-(trifluoromethyl)pyridine-2-carbonitrile
Show/Hide
|
C19H13F3N4O2S
|
2
|
| 1 |
IC50 = 182 nM
|
|
|
| 2 |
IC50 = 204 nM
|
|
|
|
CP0573217
|
2-(6,7-difluoro-1H-indol-3-yl)quinoline
Show/Hide
|
C17H10F2N2
|
1
|
| 1 |
IC50 = 190 nM
|
|
|
|
CP0513410
|
US9126941, RD48
Show/Hide
|
C23H20F3N3OS
|
1
|
| 1 |
IC50 = 194 nM
|
|
|
|
CP0504249
|
3-[3-(4-Cyano-3-trifluoromethylphenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl]propylurea
Show/Hide
|
C17H18F3N5O2S
|
2
|
| 1 |
IC50 = 200 nM
|
|
|
| 2 |
IC50 = 1600 nM
|
|
|
|
CP0418885
|
8-chloro-2-(7-methyl-1H-indol-3-yl)quinoline
Show/Hide
|
C18H13ClN2
|
1
|
| 1 |
IC50 = 200 nM
|
|
|
|
CP0514805
|
5-[8-oxo-5-[4-(piperazin-1-ylmethyl)phenyl]-6-sulfanylidene-5,7-diazaspiro[3.4]octan-7-yl]-3-(trifluoromethyl)pyridine-2-carbonitrile
Show/Hide
|
C24H23F3N6OS
|
2
|
| 1 |
IC50 = 204 nM
|
|
|
| 2 |
IC50 = 355 nM
|
|
|
|
CP0479429
|
3-methoxy-5-[5-[4-(1-methylpiperidin-4-yl)oxyphenyl]-8-oxo-6-sulfanylidene-5,7-diazaspiro[3.4]octan-7-yl]pyridine-2-carbonitrile
Show/Hide
|
C25H27N5O3S
|
2
|
| 1 |
IC50 = 214 nM
|
|
|
| 2 |
IC50 = 302 nM
|
|
|
|
CP0547518
|
4-(4-thiophen-3-yl-1,3-thiazol-2-yl)morpholine
Show/Hide
|
C11H12N2OS2
|
2
|
| 1 |
IC50 = 220 nM
|
|
|
| 2 |
IC50 = 260 nM
|
|
|
|
CP0577610
|
12-(2-fluorophenyl)-11-azatetracyclo[8.7.0.02,7.013,17]heptadeca-1(10),2,4,6,8,15-hexaene
Show/Hide
|
C22H18FN
|
1
|
| 1 |
IC50 = 220 nM
|
|
|
|
CP0952444
|
US9126941, RD90
Show/Hide
|
C22H19F3N4S
|
1
|
| 1 |
IC50 = 222 nM
|
|
|
|
CP0518251
|
US9126941, RD133
Show/Hide
|
C23H19F3N4O2S
|
1
|
| 1 |
IC50 = 224 nM
|
|
|
|
CP0381382
|
4-[4-(4-fluoro-2-methoxyphenyl)-1,3-thiazol-2-yl]morpholine
Show/Hide
|
C14H15FN2O2S
|
2
|
| 1 |
IC50 = 230 nM
|
|
|
| 2 |
IC50 = 300 nM
|
|
|
|
CP0418884
|
2-(5-fluoro-7-methyl-1H-indol-3-yl)quinoline
Show/Hide
|
C18H13FN2
|
1
|
| 1 |
IC50 = 230 nM
|
|
|
|
CP0487258
|
N-methyl-2-(7-methyl-1H-indol-3-yl)quinoline-5-carboxamide
Show/Hide
|
C20H17N3O
|
1
|
| 1 |
IC50 = 230 nM
|
|
|
|
CP0538879
|
US9126941, RD49
Show/Hide
|
C24H22F3N3OS
|
1
|
| 1 |
IC50 = 232 nM
|
|
|
|
CP0461575
|
US9126941, RD134
Show/Hide
|
C24H21F3N4O2S
|
1
|
| 1 |
IC50 = 234 nM
|
|
|
|
CP0731051
|
6-(4-{4-[2-(1-Methyl-1H-pyrazol-5-yl)ethoxy]phenyl}piperidin-1-yl)-3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazine
Show/Hide
|
C23H24F3N7O
|
1
|
| 1 |
IC50 = 234.42 nM
|
|
|
|
CP0547992
|
2-(7-methyl-1H-indol-3-yl)-5-(trifluoromethyl)quinoline
Show/Hide
|
C19H13F3N2
|
1
|
| 1 |
IC50 = 240 nM
|
|
|
|
CP0546195
|
4-[4-(4,5-dimethylthiophen-3-yl)-1,3-thiazol-2-yl]morpholine
Show/Hide
|
C13H16N2OS2
|
2
|
| 1 |
IC50 = 250 nM
|
|
|
| 2 |
IC50 = 430 nM
|
|
|
|
CP0550310
|
1'-[6-cyano-5-(trifluoromethyl)pyridin-3-yl]-3'-cyclopropyl-6-fluoro-N-methyl-5'-oxo-2'-sulfanylidenespiro[1,3-dihydroindene-2,4'-imidazolidine]-5-carboxamide
Show/Hide
|
C23H17F4N5O2S
|
1
|
| 1 |
IC50 = 257 nM
|
|
|
|
CP0545643
|
US9126941, RD71
Show/Hide
|
C21H16F3N3OS
|
1
|
| 1 |
IC50 = 258 nM
|
|
|
|
CP0146696
|
Bicalutamide
Show/Hide
|
C18H14F4N2O4S
|
9
|
| 1 |
IC50 = 270 nM
|
|
|
| 2 |
IC50 = 400 nM
|
|
|
| 3 |
IC50 = 550 nM
|
|
|
| 4 |
IC50 = 600 nM
|
|
|
| 5 |
IC50 = 889 nM
|
|
|
| 6 |
IC50 = 940 nM
|
|
|
| 7 |
IC50 = 44260 nM
|
|
|
| 8 |
IC50 > 100000 nM
|
|
|
| 9 |
Ki = 35 nM
|
|
|
|
CP0545641
|
US9126941, RD9
Show/Hide
|
C19H15F3N4OS
|
1
|
| 1 |
IC50 = 273 nM
|
|
|
|
CP0500060
|
US9126941, RD59
Show/Hide
|
C19H14F3N3OS2
|
1
|
| 1 |
IC50 = 278 nM
|
|
|
|
CP0057435
|
4-(4-phenyl-1,3-thiazol-2-yl)morpholine
Show/Hide
|
C13H14N2OS
|
2
|
| 1 |
IC50 = 280 nM
|
|
|
| 2 |
IC50 = 330 nM
|
|
|
|
CP0500058
|
US9126941, RD57
Show/Hide
|
C26H18F3N3OS
|
1
|
| 1 |
IC50 = 283 nM
|
|
|
|
CP0435121
|
N-[4-(4-hydroxyphenoxy)phenyl]-3-methoxybenzamide
Show/Hide
|
C20H17NO4
|
1
|
| 1 |
IC50 = 290 nM
|
|
|
|
CP0559069
|
7-fluoro-2-(7-methyl-1H-indol-3-yl)quinoline
Show/Hide
|
C18H13FN2
|
1
|
| 1 |
IC50 = 300 nM
|
|
|
|
CP0491435
|
5-[8-oxo-5-(2-piperidin-4-yloxypyrimidin-5-yl)-6-sulfanylidene-5,7-diazaspiro[3.4]octan-7-yl]-3-(trifluoromethyl)pyridine-2-carbonitrile
Show/Hide
|
C22H20F3N7O2S
|
2
|
| 1 |
IC50 = 309 nM
|
|
|
| 2 |
IC50 = 501 nM
|
|
|
|
CP0466645
|
US9126941, RD110
Show/Hide
|
C21H16F3N3O2S
|
1
|
| 1 |
IC50 = 311 nM
|
|
|
|
CP0415495
|
10-[(3-hydroxyphenyl)methylidene]anthracen-9-one
Show/Hide
|
C21H14O2
|
2
|
| 1 |
IC50 = 316.2 nM
|
|
|
| 2 |
IC50 = 350 nM
|
|
|
|
CP0249897
|
1-[4-[2-[4-[1-[3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperidin-4-yl]phenoxy]ethyl]piperazin-1-yl]ethanone
Show/Hide
|
C25H30F3N7O2
|
1
|
| 1 |
IC50 = 323.59 nM
|
|
|
|
CP0396742
|
4-[4-(5-bromo-4-chloroimidazol-1-yl)-1,3-thiazol-2-yl]morpholine
Show/Hide
|
C10H10BrClN4OS
|
2
|
| 1 |
IC50 = 330 nM
|
|
|
| 2 |
IC50 = 440 nM
|
|
|
|
CP0860897
|
3-[(1S,2S,6R,7R)-4-(4-Cyano-3-trifluoromethyl-phenyl)-1,7-dimethyl-3,5-dioxo-11-oxa-4,9-diaza-tricyclo[5.3.1.0*2,6*]undec-9-yl]-benzenesulfonamide
Show/Hide
|
C24H21F3N4O5S
|
1
|
| 1 |
IC50 = 337 nM
|
|
|
|
CP0550309
|
1'-[4-cyano-3-(trifluoromethyl)phenyl]-6-fluoro-N,3'-dimethyl-5'-oxo-2'-sulfanylidenespiro[1,3-dihydroindene-2,4'-imidazolidine]-5-carboxamide
Show/Hide
|
C22H16F4N4O2S
|
1
|
| 1 |
IC50 = 339 nM
|
|
|
|
CP0386608
|
1,8-dichloro-10-[(3-hydroxy-4-methoxyphenyl)methylidene]anthracen-9-one
Show/Hide
|
C22H14Cl2O3
|
2
|
| 1 |
IC50 = 340 nM
|
|
|
| 2 |
IC50 = 1886 nM
|
|
|
|
CP0474679
|
US9126941, RD60
Show/Hide
|
C19H14F3N3O3
|
1
|
| 1 |
IC50 = 369 nM
|
|
|
|
CP0859770
|
4-((1S,2S,6R,7R)-1,7-Dimethyl-3,5-dioxo-9-pyrimidin-2-yl-11-oxa-4,9-diaza-tricyclo[5.3.1.0*2,6*]undec-4-yl)-2-trifluoromethyl-benzonitrile
Show/Hide
|
C22H18F3N5O3
|
1
|
| 1 |
IC50 = 377 nM
|
|
|
|
CP0372170
|
4-[3-(4-cyano-3-trifluoromethylphenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl]butyric acid
Show/Hide
|
C17H16F3N3O3S
|
2
|
| 1 |
IC50 = 400 nM
|
|
|
| 2 |
IC50 = 2000 nM
|
|
|
|
CP0738520
|
SID56463155
Show/Hide
|
C49H43N3O6
|
1
|
| 1 |
IC50 = 400 nM
|
|
|
|
CP0859765
|
4-((1S,2S,6R,7R)-9-Cyclopropanecarbonyl-1,7-dimethyl-3,5-dioxo-11-oxa-4,9-diaza-tricyclo[5.3.1.0*2,6*]undec-4-yl)-2-trifluoromethyl-benzonitrile
Show/Hide
|
C22H20F3N3O4
|
1
|
| 1 |
IC50 = 404 nM
|
|
|
|
CP0410620
|
4-[4-(4-fluorophenyl)-1,3-thiazol-2-yl]morpholine
Show/Hide
|
C13H13FN2OS
|
2
|
| 1 |
IC50 = 410 nM
|
|
|
| 2 |
IC50 = 650 nM
|
|
|
|
CP0579462
|
7-[(2-chlorophenyl)methoxy]-4-(trifluoromethyl)chromen-2-one
Show/Hide
|
C17H10ClF3O3
|
1
|
| 1 |
IC50 = 410 nM
|
|
|
|
CP0549145
|
5-[5-[2-(1-methylpiperidin-4-yl)oxypyrimidin-5-yl]-8-oxo-6-sulfanylidene-5,7-diazaspiro[3.4]octan-7-yl]-3-(trifluoromethyl)pyridine-2-carbonitrile
Show/Hide
|
C23H22F3N7O2S
|
2
|
| 1 |
IC50 = 417 nM
|
|
|
| 2 |
IC50 = 427 nM
|
|
|
|
CP0090138
|
6-fluoro-N-(furan-2-ylmethyl)-N-propan-2-yl-1H-indole-2-carboxamide
Show/Hide
|
C17H17FN2O2
|
2
|
| 1 |
IC50 = 430 nM
|
|
|
| 2 |
IC50 = 530 nM
|
|
|
|
CP0461552
|
US9126941, RD129
Show/Hide
|
C25H22F3N3O3S
|
1
|
| 1 |
IC50 = 432 nM
|
|
|
|
CP0518250
|
US9126941, RD83
Show/Hide
|
C19H15F3N4OS
|
1
|
| 1 |
IC50 = 457 nM
|
|
|
|
CP0468374
|
US9126941, RD54
Show/Hide
|
C22H15F3N4OS
|
1
|
| 1 |
IC50 = 469 nM
|
|
|
|
CP0544565
|
1-(dimethylsulfamoylamino)-4-phenylmethoxybenzene
Show/Hide
|
C15H18N2O3S
|
1
|
| 1 |
IC50 = 470 nM
|
|
|
|
CP0527932
|
7-[(4-fluorophenyl)methoxy]-4-(trifluoromethyl)chromen-2-one
Show/Hide
|
C17H10F4O3
|
1
|
| 1 |
IC50 = 470 nM
|
|
|
|
CP0500057
|
US9126941, RD55
Show/Hide
|
C21H15F3N4O3S
|
1
|
| 1 |
IC50 = 498 nM
|
|
|
|
CP0440696
|
(3aS,4S,9bR)-4-(4-bromophenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide
Show/Hide
|
C18H17BrN2O2S
|
1
|
| 1 |
IC50 = 500 nM
|
|
|
|
CP0314021
|
5-fluoro-N-(furan-2-ylmethyl)-N-propan-2-yl-1H-indole-2-carboxamide
Show/Hide
|
C17H17FN2O2
|
2
|
| 1 |
IC50 = 500 nM
|
|
|
| 2 |
IC50 = 600 nM
|
|
|
|
CP0507535
|
N-[4-[[4-[2-[3-chloro-4-(2-chloroethoxy)-5-fluorophenyl]propan-2-yl]phenoxy]methyl]pyrimidin-2-yl]methanesulfonamide
Show/Hide
|
C23H24Cl2FN3O4S
|
1
|
| 1 |
IC50 = 500 nM
|
|
|
|
CP0517348
|
N-[4-[[4-[2-[3-chloro-4-(2-chloroethoxy)-5-cyanophenyl]propan-2-yl]phenoxy]methyl]-1,3-oxazol-2-yl]propane-2-sulfonamide
Show/Hide
|
C25H27Cl2N3O5S
|
1
|
| 1 |
IC50 = 500 nM
|
|
|
|
CP0576518
|
2-[2-(5,6,7-trifluoro-1H-indol-3-yl)quinolin-5-yl]-1,3-thiazole
Show/Hide
|
C20H10F3N3S
|
1
|
| 1 |
IC50 = 500 nM
|
|
|
|
CP0547519
|
4-(5-phenylthiophen-2-yl)morpholine
Show/Hide
|
C14H15NOS
|
2
|
| 1 |
IC50 = 510 nM
|
|
|
| 2 |
IC50 = 520 nM
|
|
|
|
CP0523713
|
N-[3-(5-cyano-6-methylpyridin-2-yl)oxy-2,2,4,4-tetramethylcyclobutyl]acetamide
Show/Hide
|
C17H23N3O2
|
1
|
| 1 |
IC50 = 519 nM
|
|
|
|
CP0375187
|
4-[4-(2,5-dimethylphenyl)-1,3-thiazol-2-yl]morpholine
Show/Hide
|
C15H18N2OS
|
2
|
| 1 |
IC50 = 520 nM
|
|
|
| 2 |
IC50 = 620 nM
|
|
|
|
CP0513411
|
US9126941, RD67
Show/Hide
|
C20H14Cl2F3N3OS
|
1
|
| 1 |
IC50 = 521 nM
|
|
|
|
CP0545642
|
US9126941, RD65
Show/Hide
|
C20H14F3N3O3S
|
1
|
| 1 |
IC50 = 523 nM
|
|
|
|
CP0490462
|
1'-[4-cyano-3-(trifluoromethyl)phenyl]-N,3'-dimethyl-5'-oxo-2'-sulfanylidenespiro[1,3-dihydroindene-2,4'-imidazolidine]-5-carboxamide
Show/Hide
|
C22H17F3N4O2S
|
1
|
| 1 |
IC50 = 525 nM
|
|
|
|
CP0902635
|
4-[(1R,2R,6S,7S)-3,5-dioxo-9-propionyl-11-oxa-4,9-diazatricyclo[5.3.1.02,6]undec-4-yl]-2-(trifluoromethyl)benzonitrile
Show/Hide
|
C21H20F3N3O4
|
1
|
| 1 |
IC50 = 549 nM
|
|
|
|
CP0474868
|
4-[(2,6-dichlorophenyl)methyl]-2H-phthalazin-1-one
Show/Hide
|
C15H10Cl2N2O
|
1
|
| 1 |
IC50 = 550 nM
|
|
|
|
CP0564986
|
2-(5,6,7-trifluoro-1H-indol-3-yl)-5-(trifluoromethyl)quinoline
Show/Hide
|
C18H8F6N2
|
1
|
| 1 |
IC50 = 550 nM
|
|
|
|
CP0410425
|
4-[4-(4,5-dichloroimidazol-1-yl)-1,3-thiazol-2-yl]morpholine
Show/Hide
|
C10H10Cl2N4OS
|
2
|
| 1 |
IC50 = 570 nM
|
|
|
| 2 |
IC50 = 680 nM
|
|
|
|
CP0381379
|
4-[4-[3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]morpholine
Show/Hide
|
C14H13F3N2OS
|
2
|
| 1 |
IC50 = 580 nM
|
|
|
| 2 |
IC50 = 610 nM
|
|
|
|
CP0844848
|
(1S,2S,6R,7R)-4-(4-Cyano-3-trifluoromethyl-phenyl)-1,7-dimethyl-3,5-dioxo-11-oxa-4,9-diaza-tricyclo[5.3.1.0*2,6*]undecane-9-carboxylic acid ethyl ester
Show/Hide
|
C21H20F3N3O5
|
1
|
| 1 |
IC50 = 590 nM
|
|
|
|
CP0913170
|
4-((1S,2S,6R,7R)-9-Ethanesulfonyl-1,7-dimethyl-3,5-dioxo-11-oxa-4,9-diaza-tricyclo[5.3.1.0*2,6*]undec-4-yl)-2-trifluoromethyl-benzonitrile
Show/Hide
|
C20H20F3N3O5S
|
1
|
| 1 |
IC50 = 600 nM
|
|
|
|
CP0561947
|
7-[(4-methylphenyl)methoxy]-4-(trifluoromethyl)chromen-2-one
Show/Hide
|
C18H13F3O3
|
1
|
| 1 |
IC50 = 610 nM
|
|
|
|
CP0301197
|
4-(4-phenyl-1,3-thiazol-2-yl)thiomorpholine
Show/Hide
|
C13H14N2S2
|
1
|
| 1 |
IC50 = 620 nM
|
|
|
|
CP0111654
|
4-phenyl-2-(4-pyridyl)thiazole
Show/Hide
|
C14H10N2S
|
2
|
| 1 |
IC50 = 630 nM
|
|
|
| 2 |
IC50 = 1200 nM
|
|
|
|
CP0876327
|
(2R,6R)-8-Methyl-4-(4-nitro-naphthalen-1-yl)-4,8-diaza-tricyclo[5.2.2.0*2,6*]undec-10-ene-3,5,9-trione
Show/Hide
|
C20H15N3O5
|
2
|
| 1 |
IC50 = 631 nM
|
|
|
| 2 |
Ki = 115 nM
|
|
|
|
CP0466644
|
US9126941, RD53
Show/Hide
|
C23H21F3N4OS
|
1
|
| 1 |
IC50 = 638 nM
|
|
|
|
CP0547451
|
disodium;[5,6,7-trifluoro-3-[5-(propan-2-ylcarbamoyl)quinolin-2-yl]indol-1-yl]methyl phosphate
Show/Hide
|
C22H17F3N3Na2O5P
|
1
|
| 1 |
IC50 = 660 nM
|
|
|
|
CP0485585
|
1'-[6-cyano-5-(trifluoromethyl)pyridin-3-yl]-N,3'-dimethyl-5'-oxo-2'-sulfanylidenespiro[1,3-dihydroindene-2,4'-imidazolidine]-5-carboxamide
Show/Hide
|
C21H16F3N5O2S
|
1
|
| 1 |
IC50 = 676 nM
|
|
|
|
CP0845618
|
4-[(1S,2S,6R,7R)-9-(4-Fluoro-benzenesulfonyl)-1,7-dimethyl-3,5-dioxo-11-oxa-4,9-diaza-tricyclo[5.3.1.0*2,6*]undec-4-yl]-2-trifluoromethyl-benzonitrile
Show/Hide
|
C24H19F4N3O5S
|
1
|
| 1 |
IC50 = 685 nM
|
|
|
|
CP0546198
|
4-phenyl-2-piperidin-1-yl-1,3-thiazole
Show/Hide
|
C14H16N2S
|
2
|
| 1 |
IC50 = 690 nM
|
|
|
| 2 |
IC50 = 1030 nM
|
|
|
|
CP0199696
|
6-fluoro-N-[(5-methylfuran-2-yl)methyl]-N-propan-2-yl-1H-indole-2-carboxamide
Show/Hide
|
C18H19FN2O2
|
2
|
| 1 |
IC50 = 700 nM
|
|
|
| 2 |
IC50 = 840 nM
|
|
|
|
CP0527838
|
2,3-difluoro-6-(2-morpholin-4-yl-1,3-thiazol-4-yl)phenol
Show/Hide
|
C13H12F2N2O2S
|
2
|
| 1 |
IC50 = 700 nM
|
|
|
| 2 |
IC50 = 800 nM
|
|
|
|
CP0566765
|
US9126941, RD137
Show/Hide
|
C24H22F3N5OS
|
1
|
| 1 |
IC50 = 718 nM
|
|
|
|
CP0490051
|
4-[4-(4-chloroimidazol-1-yl)-1,3-thiazol-2-yl]morpholine
Show/Hide
|
C10H11ClN4OS
|
2
|
| 1 |
IC50 = 720 nM
|
|
|
| 2 |
IC50 = 960 nM
|
|
|
|
CP0518249
|
US9126941, RD82
Show/Hide
|
C18H13F3N4OS
|
1
|
| 1 |
IC50 = 723 nM
|
|
|
|
CP0466409
|
1,8-dichloro-10-[(2-hydroxy-3-methoxyphenyl)methylidene]anthracen-9-one
Show/Hide
|
C22H14Cl2O3
|
2
|
| 1 |
IC50 = 730 nM
|
|
|
| 2 |
IC50 = 1480 nM
|
|
|
|
CP0538880
|
US9126941, RD135
Show/Hide
|
C25H23F3N4O3S
|
1
|
| 1 |
IC50 = 732 nM
|
|
|
|
CP0572510
|
N-tert-butyl-2-(5,6,7-trifluoro-1H-indol-3-yl)quinoline-5-carboxamide
Show/Hide
|
C22H18F3N3O
|
1
|
| 1 |
IC50 = 740 nM
|
|
|
|
CP0568037
|
1'-[6-cyano-5-(trifluoromethyl)pyridin-3-yl]-6-fluoro-N,3'-dimethyl-5'-oxo-2'-sulfanylidenespiro[1,3-dihydroindene-2,4'-imidazolidine]-5-carboxamide
Show/Hide
|
C21H15F4N5O2S
|
1
|
| 1 |
IC50 = 759 nM
|
|
|
|
CP0579461
|
7-[(2-chloro-6-fluorophenyl)methoxy]-4-(trifluoromethyl)chromen-2-one
Show/Hide
|
C17H9ClF4O3
|
1
|
| 1 |
IC50 = 780 nM
|
|
|
|
CP0513067
|
5-fluoro-2-(2-morpholin-4-yl-1,3-thiazol-4-yl)phenol
Show/Hide
|
C13H13FN2O2S
|
2
|
| 1 |
IC50 = 810 nM
|
|
|
| 2 |
IC50 = 1190 nM
|
|
|
|
CP0577987
|
ethyl 11-azatetracyclo[8.7.0.02,7.013,17]heptadeca-1(10),2,4,6,8,15-hexaene-12-carboxylate
Show/Hide
|
C19H19NO2
|
1
|
| 1 |
IC50 = 820 nM
|
|
|
|
CP0550761
|
4-(5-phenylthiophen-3-yl)morpholine
Show/Hide
|
C14H15NOS
|
2
|
| 1 |
IC50 = 840 nM
|
|
|
| 2 |
IC50 = 1240 nM
|
|
|
|
CP0133659
|
N-(furan-2-ylmethyl)-6-methyl-N-propan-2-yl-1H-indole-2-carboxamide
Show/Hide
|
C18H20N2O2
|
2
|
| 1 |
IC50 = 850 nM
|
|
|
| 2 |
IC50 = 1020 nM
|
|
|
|
CP0407252
|
4-(2-chlorobenzyl)phthalazin-1(2H)-one
Show/Hide
|
C15H11ClN2O
|
1
|
| 1 |
IC50 = 860 nM
|
|
|
|
CP0513078
|
4-(5-morpholin-4-ylthiophen-2-yl)benzonitrile
Show/Hide
|
C15H14N2OS
|
2
|
| 1 |
IC50 = 890 nM
|
|
|
| 2 |
IC50 = 1440 nM
|
|
|
|
CP0578442
|
4-(trifluoromethyl)-7-[[4-(trifluoromethyl)phenyl]methoxy]chromen-2-one
Show/Hide
|
C18H10F6O3
|
1
|
| 1 |
IC50 = 890 nM
|
|
|
|
CP0456413
|
ethyl (3aS,4S,9bS)-4-phenyl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-carboxylate
Show/Hide
|
C21H21NO2
|
1
|
| 1 |
IC50 = 900 nM
|
|
|
|
CP0431862
|
4-[(2,3,6-trichlorophenyl)methyl]-2H-phthalazin-1-one
Show/Hide
|
C15H9Cl3N2O
|
1
|
| 1 |
IC50 = 920 nM
|
|
|
|
CP0578446
|
7-[(2-fluorophenyl)methoxy]-4-(trifluoromethyl)chromen-2-one
Show/Hide
|
C17H10F4O3
|
1
|
| 1 |
IC50 = 920 nM
|
|
|
|
CP0549338
|
7-[(2-bromophenyl)methoxy]-4-(trifluoromethyl)chromen-2-one
Show/Hide
|
C17H10BrF3O3
|
1
|
| 1 |
IC50 = 940 nM
|
|
|
|
CP0916497
|
4-[(1R,2R,6S,7S)-3,5-dioxo-9-(phenylsulfonyl)-11-oxa-4,9-diazatricyclo[5.3.1.0 2,6]undec-4-yl]-2-(trifluoromethyl)benzonitrile
Show/Hide
|
C24H20F3N3O5S
|
1
|
| 1 |
IC50 = 979 nM
|
|
|
|
CP0374749
|
4-[(2-aminophenyl)methyl]-2H-phthalazin-1-one
Show/Hide
|
C15H13N3O
|
1
|
| 1 |
IC50 = 990 nM
|
|
|
|
CP0205224
|
7-fluoro-N-[(5-methylfuran-2-yl)methyl]-N-propan-2-yl-1H-indole-2-carboxamide
Show/Hide
|
C18H19FN2O2
|
2
|
| 1 |
IC50 = 1000 nM
|
|
|
| 2 |
IC50 = 1200 nM
|
|
|
|
CP0548107
|
5-[8-oxo-5-(6-oxo-1H-pyridin-3-yl)-6-sulfanylidene-5,7-diazaspiro[3.4]octan-7-yl]-3-(trifluoromethyl)pyridine-2-carbonitrile
Show/Hide
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C18H12F3N5O2S
|
2
|
| 1 |
IC50 = 1000 nM
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| 2 |
IC50 = 2239 nM
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CP0542355
|
7-[(4-chlorophenyl)methoxy]-4-(trifluoromethyl)chromen-2-one
Show/Hide
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C17H10ClF3O3
|
1
|
| 1 |
IC50 = 1040 nM
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CP0898234
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4-{4-[2-(4-Acetylpiperazin-1-yl)ethoxy]phenyl}-1-[3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperidin-4-ol
Show/Hide
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C25H30F3N7O3
|
1
|
| 1 |
IC50 = 1047.13 nM
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CP0372171
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3-[3-(4-Cyano-2-methyl-3-trifluoromethylphenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl]propane-1-sulfonamide
Show/Hide
|
C17H19F3N4O3S2
|
1
|
| 1 |
IC50 = 1100 nM
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CP0205223
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5-fluoro-N-[(5-methylfuran-2-yl)methyl]-N-propan-2-yl-1H-indole-2-carboxamide
Show/Hide
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C18H19FN2O2
|
2
|
| 1 |
IC50 = 1100 nM
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| 2 |
IC50 = 1380 nM
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CP0185212
|
7-(benzyloxy)-4-(trifluoromethyl)-2H-chromen-2-one
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C17H11F3O3
|
1
|
| 1 |
IC50 = 1180 nM
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CP0390760
|
methyl 4-[(3aR,4S,9bS)-8-acetyl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-4-yl]benzoate
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|
C22H21NO3
|
1
|
| 1 |
IC50 = 1200 nM
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CP0114174
|
N-(furan-2-ylmethyl)-5-methyl-N-propan-2-yl-1H-indole-2-carboxamide
Show/Hide
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C18H20N2O2
|
2
|
| 1 |
IC50 = 1200 nM
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| 2 |
IC50 = 1300 nM
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CP0844849
|
4-[(1S,2S,6R,7R)-1,7-Dimethyl-3,5-dioxo-9-(pyridine-2-sulfonyl)-11-oxa-4,9-diaza-tricyclo[5.3.1.0*2,6*]undec-4-yl]-2-trifluoromethyl-benzonitrile
Show/Hide
|
C23H19F3N4O5S
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1
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| 1 |
IC50 = 1241 nM
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CP0381384
|
4-(4-fluorophenyl)-2-(4-pyridyl)thiazole
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C14H9FN2S
|
1
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| 1 |
IC50 = 1270 nM
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CP0906734
|
4-((1S,2S,6R,7R)-9-Hydroxy-1,7-dimethyl-3,5-dioxo-11-oxa-4,9-diaza-tricyclo[5.3.1.0*2,6*]undec-4-yl)-2-trifluoromethyl-benzonitrile
Show/Hide
|
C18H16F3N3O4
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1
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| 1 |
IC50 = 1280 nM
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CP0375185
|
4-[4-(4-bromo-5-chloroimidazol-1-yl)-1,3-thiazol-2-yl]morpholine
Show/Hide
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C10H10BrClN4OS
|
2
|
| 1 |
IC50 = 1280 nM
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| 2 |
IC50 = 1450 nM
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CP0537753
|
4-[4-(2,4-dichlorophenyl)-1,3-thiazol-2-yl]morpholine
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C13H12Cl2N2OS
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2
|
| 1 |
IC50 = 1320 nM
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| 2 |
IC50 = 1660 nM
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CP0476042
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2-(2-morpholin-4-yl-1,3-thiazol-4-yl)aniline
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C13H15N3OS
|
2
|
| 1 |
IC50 = 1380 nM
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| 2 |
IC50 = 2030 nM
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CP0573710
|
7-[(3-methylphenyl)methoxy]-4-(trifluoromethyl)chromen-2-one
Show/Hide
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C18H13F3O3
|
1
|
| 1 |
IC50 = 1400 nM
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CP0390781
|
(E)-1-(5-fluoro-2-hydroxyphenyl)-3-(2-hydroxyphenyl)prop-2-en-1-one
Show/Hide
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C15H11FO3
|
1
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| 1 |
IC50 = 1420 nM
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CP0860896
|
(1S,2S,6R,7R)-4-(4-Cyano-3-trifluoromethyl-phenyl)-1,7-dimethyl-3,5-dioxo-11-oxa-4,9-diaza-tricyclo[5.3.1.0*2,6*]undecane-9-carboxylic acid ethylamide
Show/Hide
|
C21H21F3N4O4
|
1
|
| 1 |
IC50 = 1456 nM
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CP0547372
|
4-(5-methyl-4-phenyl-1,3-thiazol-2-yl)morpholine
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|
C14H16N2OS
|
1
|
| 1 |
IC50 = 1460 nM
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CP0388128
|
4-[(2-nitrophenyl)methyl]-2H-phthalazin-1-one
Show/Hide
|
C15H11N3O3
|
1
|
| 1 |
IC50 = 1460 nM
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CP0575293
|
7-[(6-chloro-1,3-benzodioxol-5-yl)methoxy]-4-(trifluoromethyl)chromen-2-one
Show/Hide
|
C18H10ClF3O5
|
1
|
| 1 |
IC50 = 1470 nM
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CP0427005
|
2-(2-phenoxyethylsulfanyl)-1H-indole-7-sulfonamide
Show/Hide
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C16H16N2O3S2
|
3
|
| 1 |
IC50 = 1500 nM
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|
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| 2 |
IC50 = 1600 nM
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| 3 |
IC50 = 6400 nM
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CP0574825
|
2-(5,7-dichloro-1H-indol-3-yl)quinoline
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C17H10Cl2N2
|
1
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| 1 |
IC50 = 1500 nM
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CP0368254
|
Chalcone, 10
Show/Hide
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C15H11ClO2
|
1
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| 1 |
IC50 = 1510 nM
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CP0316053
|
4-[[4-[3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperazin-1-yl]methyl]benzonitrile
Show/Hide
|
C18H16F3N7
|
1
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| 1 |
IC50 = 1513.56 nM
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CP0551494
|
4-bromo-N-(4-phenylmethoxyphenyl)benzenesulfonamide
Show/Hide
|
C19H16BrNO3S
|
1
|
| 1 |
IC50 = 1550 nM
|
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CP0805369
|
6-[4-(4-Fluorobenzyl)piperazin-1-yl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazine
Show/Hide
|
C17H16F4N6
|
1
|
| 1 |
IC50 = 1584.89 nM
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CP0090441
|
4-[4-(4-fluorophenyl)-1,3-thiazol-2-yl]thiomorpholine
Show/Hide
|
C13H13FN2S2
|
1
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| 1 |
IC50 = 1590 nM
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CP0572507
|
2-(5,7-dimethyl-1H-indol-3-yl)quinoline
Show/Hide
|
C19H16N2
|
1
|
| 1 |
IC50 = 1590 nM
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|
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CP0549913
|
3-nitro-N-(4-phenylmethoxyphenyl)benzenesulfonamide
Show/Hide
|
C19H16N2O5S
|
1
|
| 1 |
IC50 = 1590 nM
|
|
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CP0844854
|
4-((1S,2S,6R,7R)-9-Isobutyryl-1,7-dimethyl-3,5-dioxo-11-oxa-4,9-diaza-tricyclo[5.3.1.0*2,6*]undec-4-yl)-2-trifluoromethyl-benzonitrile
Show/Hide
|
C22H22F3N3O4
|
1
|
| 1 |
IC50 = 1610 nM
|
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CP0527933
|
7-[(4-methoxyphenyl)methoxy]-4-(trifluoromethyl)chromen-2-one
Show/Hide
|
C18H13F3O4
|
1
|
| 1 |
IC50 = 1620 nM
|
|
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CP0551282
|
(E)-1-(2-hydroxy-5-iodophenyl)-3-(2-hydroxyphenyl)prop-2-en-1-one
Show/Hide
|
C15H11IO3
|
1
|
| 1 |
IC50 = 1640 nM
|
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CP0334305
|
6-methyl-N-[(5-methylfuran-2-yl)methyl]-N-propan-2-yl-1H-indole-2-carboxamide
Show/Hide
|
C19H22N2O2
|
2
|
| 1 |
IC50 = 1650 nM
|
|
|
| 2 |
IC50 = 2890 nM
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CP0572508
|
7-chloro-2-(7-methyl-1H-indol-3-yl)quinoline
Show/Hide
|
C18H13ClN2
|
1
|
| 1 |
IC50 = 1650 nM
|
|
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CP0494204
|
1'-[4-cyano-3-(trifluoromethyl)phenyl]-N,3'-dimethyl-2',5'-dioxospiro[1,3-dihydroindene-2,4'-imidazolidine]-5-carboxamide
Show/Hide
|
C22H17F3N4O3
|
1
|
| 1 |
IC50 = 1660 nM
|
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CP0386607
|
6-chloro-2-(2-hydroxyphenyl)-2,3-dihydrochromen-4-one
Show/Hide
|
C15H11ClO3
|
1
|
| 1 |
IC50 = 1680 nM
|
|
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CP0537460
|
(E)-1-(2-hydroxy-5-iodophenyl)-3-(2-methoxyphenyl)prop-2-en-1-one
Show/Hide
|
C16H13IO3
|
1
|
| 1 |
IC50 = 1720 nM
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CP0381381
|
4-[4-(4,5-diiodoimidazol-1-yl)-1,3-thiazol-2-yl]morpholine
Show/Hide
|
C10H10I2N4OS
|
2
|
| 1 |
IC50 = 1730 nM
|
|
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| 2 |
IC50 = 1810 nM
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CP0547509
|
4-[4-(4-bromoimidazol-1-yl)-1,3-thiazol-2-yl]morpholine
Show/Hide
|
C10H11BrN4OS
|
2
|
| 1 |
IC50 = 1740 nM
|
|
|
| 2 |
IC50 = 2800 nM
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CP0329253
|
5-methyl-N-[(5-methylfuran-2-yl)methyl]-N-propan-2-yl-1H-indole-2-carboxamide
Show/Hide
|
C19H22N2O2
|
2
|
| 1 |
IC50 = 1770 nM
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| 2 |
IC50 = 2670 nM
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CP0415533
|
6-bromo-2-(2-hydroxyphenyl)-2,3-dihydrochromen-4-one
Show/Hide
|
C15H11BrO3
|
1
|
| 1 |
IC50 = 1770 nM
|
|
|
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CP0575031
|
N-(4-phenylmethoxyphenyl)-4-(trifluoromethyl)benzenesulfonamide
Show/Hide
|
C20H16F3NO3S
|
1
|
| 1 |
IC50 = 1770 nM
|
|
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CP0284899
|
1-[4-[2-[4-[1-[3-(trifluoromethyl)-7,8-dihydro-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperidin-4-yl]phenoxy]ethyl]piperazin-1-yl]ethanone
Show/Hide
|
C25H32F3N7O2
|
2
|
| 1 |
IC50 = 1778.28 nM
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| 2 |
Ki = 2200 nM
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CP0362893
|
2-[2-(3-methylphenoxy)ethylsulfanyl]-1H-benzimidazole
Show/Hide
|
C16H16N2OS
|
3
|
| 1 |
IC50 = 1800 nM
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|
|
| 2 |
IC50 = 3300 nM
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|
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| 3 |
IC50 = 13000 nM
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CP0883546
|
(1S,6R,7S)-4-(4-Cyano-naphthalen-1-yl)-3,5-dioxo-2,4,8-triaza-tricyclo[5.2.1.0*2,6*]decane-8-carboxylic acid 4-fluoro-phenyl ester
Show/Hide
|
C25H17FN4O4
|
1
|
| 1 |
IC50 = 1870 nM
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CP0372324
|
3-[3-(4-Cyano-3-methoxyphenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl]propane-1-sulfonamide
Show/Hide
|
C16H20N4O4S2
|
1
|
| 1 |
IC50 = 1900 nM
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CP0124307
|
2-[2-(2,6-dimethylphenoxy)ethylsulfanyl]-1H-benzimidazole
Show/Hide
|
C17H18N2OS
|
3
|
| 1 |
IC50 = 1900 nM
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|
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| 2 |
IC50 = 2700 nM
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|
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| 3 |
IC50 = 6800 nM
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CP0531375
|
2-(7-chloro-5-methyl-1H-indol-3-yl)quinoline
Show/Hide
|
C18H13ClN2
|
1
|
| 1 |
IC50 = 1900 nM
|
|
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CP0542356
|
7-(pyridin-4-ylmethoxy)-4-(trifluoromethyl)chromen-2-one
Show/Hide
|
C16H10F3NO3
|
1
|
| 1 |
IC50 = 1900 nM
|
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CP0274309
|
12-(4-chlorophenyl)-11-azatetracyclo[8.7.0.02,7.013,17]heptadeca-1(10),2,4,6,8,15-hexaene
Show/Hide
|
C22H18ClN
|
1
|
| 1 |
IC50 = 1920 nM
|
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CP0781788
|
6-[4-(2,3-Difluorobenzyl)piperazin-1-yl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazine
Show/Hide
|
C17H15F5N6
|
1
|
| 1 |
IC50 = 2089.3 nM
|
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CP0573218
|
2-(7-fluoro-6-methyl-1H-indol-3-yl)quinoline
Show/Hide
|
C18H13FN2
|
1
|
| 1 |
IC50 = 2170 nM
|
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CP0542962
|
4-cyano-N-(4-phenylmethoxyphenyl)benzenesulfonamide
Show/Hide
|
C20H16N2O3S
|
1
|
| 1 |
IC50 = 2250 nM
|
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|
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CP0191382
|
2-pyridin-4-ylquinoline
Show/Hide
|
C14H10N2
|
2
|
| 1 |
IC50 = 2260 nM
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|
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| 2 |
IC50 = 4200 nM
|
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CP0496366
|
4-fluoro-N-(4-phenylmethoxyphenyl)benzenesulfonamide
Show/Hide
|
C19H16FNO3S
|
1
|
| 1 |
IC50 = 2270 nM
|
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CP0579465
|
7-[(3-bromophenyl)methoxy]-4-(trifluoromethyl)chromen-2-one
Show/Hide
|
C17H10BrF3O3
|
1
|
| 1 |
IC50 = 2280 nM
|
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CP0897703
|
(1R,6S,7R)-4-(4-Nitro-phenyl)-3,5-dioxo-2,4,8-triaza-tricyclo[5.2.1.0*2,6*]decane-8-carboxylic acid tert-butyl ester
Show/Hide
|
C18H20N4O6
|
1
|
| 1 |
IC50 = 2390 nM
|
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CP0461442
|
N-[4-(4-hydroxyphenoxy)-3,5-dimethylphenyl]-3-methoxybenzamide
Show/Hide
|
C22H21NO4
|
1
|
| 1 |
IC50 = 2400 nM
|
|
|
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CP0557355
|
12-(2-chlorophenyl)-11-azatetracyclo[8.7.0.02,7.013,17]heptadeca-1(10),2,4,6,8,15-hexaene
Show/Hide
|
C22H18ClN
|
1
|
| 1 |
IC50 = 2400 nM
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CP0398857
|
4-[4-(4,5-dimethylimidazol-1-yl)-1,3-thiazol-2-yl]morpholine
Show/Hide
|
C12H16N4OS
|
2
|
| 1 |
IC50 = 2420 nM
|
|
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| 2 |
IC50 = 3560 nM
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CP0883980
|
(1S,6R,7S)-8-Benzoyl-4-(4-nitro-phenyl)-2,4,8-triaza-tricyclo[5.2.1.0*2,6*]decane-3,5-dione
Show/Hide
|
C20H16N4O5
|
1
|
| 1 |
IC50 = 2540 nM
|
|
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CP0398858
|
4-(4-pyridin-2-yl-1,3-thiazol-2-yl)morpholine
Show/Hide
|
C12H13N3OS
|
1
|
| 1 |
IC50 = 2580 nM
|
|
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CP0860542
|
4-((1S,6R,7S)-8-Benzoyl-3,5-dioxo-2,4,8-triaza-tricyclo[5.2.1.0*2,6*]dec-4-yl)-2-trifluoromethyl-benzonitrile
Show/Hide
|
C22H15F3N4O3
|
1
|
| 1 |
IC50 = 2600 nM
|
|
|
|
CP0410424
|
4-[4-(4-chloro-5-iodoimidazol-1-yl)-1,3-thiazol-2-yl]morpholine
Show/Hide
|
C10H10ClIN4OS
|
2
|
| 1 |
IC50 = 2610 nM
|
|
|
| 2 |
IC50 = 4020 nM
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CP0108724
|
N-[3-[1-(3,4-dichlorophenyl)-3-methyl-6-oxopyridazin-4-yl]phenyl]ethanesulfonamide
Show/Hide
|
C19H17Cl2N3O3S
|
1
|
| 1 |
IC50 = 2650 nM
|
|
|
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CP0096296
|
6,2''-Dihydroxyflavanone
Show/Hide
|
C15H12O4
|
1
|
| 1 |
IC50 = 2730 nM
|
|
|
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CP0450689
|
(E)-1-(3,5-dibromo-2-hydroxyphenyl)-3-(2-hydroxyphenyl)prop-2-en-1-one
Show/Hide
|
C15H10Br2O3
|
1
|
| 1 |
IC50 = 2870 nM
|
|
|
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CP0546194
|
4-(4-pyridin-4-yl-1,3-thiazol-2-yl)morpholine
Show/Hide
|
C12H13N3OS
|
1
|
| 1 |
IC50 = 2940 nM
|
|
|
|
CP0381383
|
4-[4-(3,4-dichlorophenyl)-1,3-thiazol-2-yl]morpholine
Show/Hide
|
C13H12Cl2N2OS
|
2
|
| 1 |
IC50 = 2960 nM
|
|
|
| 2 |
IC50 = 3320 nM
|
|
|
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CP0490052
|
3-fluoro-4-methoxy-5-(2-morpholin-4-yl-1,3-thiazol-4-yl)phenol
Show/Hide
|
C14H15FN2O3S
|
1
|
| 1 |
IC50 = 3020 nM
|
|
|
|
CP0147607
|
N-[(5-bromothiophen-2-yl)methyl]-6-fluoro-N-methyl-1H-indole-2-carboxamide
Show/Hide
|
C15H12BrFN2OS
|
2
|
| 1 |
IC50 = 3060 nM
|
|
|
| 2 |
IC50 = 3530 nM
|
|
|
|
CP0545791
|
N-methyl-4-naphthalen-2-yl-1,3-thiazol-2-amine
Show/Hide
|
C14H12N2S
|
2
|
| 1 |
IC50 = 3170 nM
|
|
|
| 2 |
IC50 = 3910 nM
|
|
|
|
CP0205227
|
N-[(5-methylfuran-2-yl)methyl]-N-propan-2-yl-1H-indole-2-carboxamide
Show/Hide
|
C18H20N2O2
|
2
|
| 1 |
IC50 = 3320 nM
|
|
|
| 2 |
IC50 = 3420 nM
|
|
|
|
CP0859767
|
4-((1S,2S,6R,7R)-9-Cyclopropylmethyl-1,7-dimethyl-3,5,8,10-tetraoxo-11-oxa-4,9-diaza-tricyclo[5.3.1.0*2,6*]undec-4-yl)-2-trifluoromethyl-benzonitrile
Show/Hide
|
C22H18F3N3O5
|
1
|
| 1 |
IC50 = 3329 nM
|
|
|
|
CP0571539
|
2,5-dichloro-N-(4-phenylmethoxyphenyl)benzenesulfonamide
Show/Hide
|
C19H15Cl2NO3S
|
1
|
| 1 |
IC50 = 3370 nM
|
|
|
|
CP0205226
|
6-fluoro-N-methyl-N-(thiophen-2-ylmethyl)-1H-indole-2-carboxamide
Show/Hide
|
C15H13FN2OS
|
2
|
| 1 |
IC50 = 3380 nM
|
|
|
| 2 |
IC50 = 5450 nM
|
|
|
|
CP0474867
|
4-[(2,6-dimethylphenyl)methyl]-2H-phthalazin-1-one
Show/Hide
|
C17H16N2O
|
1
|
| 1 |
IC50 = 3420 nM
|
|
|
|
CP0386606
|
(E)-1-(2-hydroxyphenyl)-3-(2-methoxyphenyl)prop-2-en-1-one
Show/Hide
|
C16H14O3
|
1
|
| 1 |
IC50 = 3500 nM
|
|
|
|
CP0897704
|
(1S,6S,7S)-4-(4-Cyano-phenyl)-3,5-dioxo-2,4,8-triaza-tricyclo[5.2.1.0*2,6*]decane-8-carboxylic acid tert-butyl ester
Show/Hide
|
C19H20N4O4
|
1
|
| 1 |
IC50 = 3510 nM
|
|
|
|
CP0860898
|
4-((1S,2S,6R,7R)-9-Methanesulfonyl-1,7-dimethyl-3,5-dioxo-11-oxa-4,9-diaza-tricyclo[5.3.1.0*2,6*]undec-4-yl)-2-trifluoromethyl-benzonitrile
Show/Hide
|
C19H18F3N3O5S
|
1
|
| 1 |
IC50 = 3511 nM
|
|
|
|
CP0381380
|
4-[4-(3-fluoro-2-methylsulfonylphenyl)-1,3-thiazol-2-yl]morpholine
Show/Hide
|
C14H15FN2O3S2
|
1
|
| 1 |
IC50 = 3560 nM
|
|
|
|
CP0554387
|
6,8-dibromo-2-(2-hydroxyphenyl)-2,3-dihydrochromen-4-one
Show/Hide
|
C15H10Br2O3
|
1
|
| 1 |
IC50 = 3570 nM
|
|
|
|
CP0383543
|
3-[3-(4-Cyano-3-trifluoromethylphenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl]propane-1-sulfonic aciddimethylamide
Show/Hide
|
C18H21F3N4O3S2
|
1
|
| 1 |
IC50 = 3700 nM
|
|
|
|
CP0527931
|
7-[(2-hydroxyphenyl)methylideneamino]-4-(trifluoromethyl)chromen-2-one
Show/Hide
|
C17H10F3NO3
|
2
|
| 1 |
IC50 = 3710 nM
|
|
|
| 2 |
IC50 = 5570 nM
|
|
|
|
CP0827344
|
4-(4-Fluorophenyl)-1-[3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperidin-4-ol
Show/Hide
|
C17H15F4N5O
|
1
|
| 1 |
IC50 = 3715.35 nM
|
|
|
|
CP0368253
|
(E)-1-(5-chloro-2-hydroxyphenyl)-3-(2-hydroxyphenyl)prop-2-en-1-one
Show/Hide
|
C15H11ClO3
|
2
|
| 1 |
IC50 = 3740 nM
|
|
|
| 2 |
IC50 < 1000 nM
|
|
|
|
CP0886325
|
4-fluorophenyl (5S,8S,8aR)-2-(4-cyano-3-(trifluoromethyl)phenyl)-1,3-dioxohexahydro-5,8-methanoimidazo[1,5-a]pyrazine-7(1H)-carboxylate
Show/Hide
|
C22H14F4N4O4
|
1
|
| 1 |
IC50 = 3920 nM
|
|
|
|
CP0538495
|
(E)-1-(5-bromo-2-hydroxyphenyl)-3-(2-propoxyphenyl)prop-2-en-1-one
Show/Hide
|
C18H17BrO3
|
1
|
| 1 |
IC50 = 3960 nM
|
|
|
|
CP0510910
|
2-[2-(4-chlorophenoxy)ethylsulfanyl]-1H-benzimidazole
Show/Hide
|
C15H13ClN2OS
|
1
|
| 1 |
IC50 = 4000 nM
|
|
|
|
CP0199695
|
6-fluoro-N,N-bis(furan-2-ylmethyl)-1H-indole-2-carboxamide
Show/Hide
|
C19H15FN2O3
|
2
|
| 1 |
IC50 = 4040 nM
|
|
|
| 2 |
IC50 = 5480 nM
|
|
|
|
CP0571504
|
2-nitro-N-(4-phenylmethoxyphenyl)benzenesulfonamide
Show/Hide
|
C19H16N2O5S
|
1
|
| 1 |
IC50 = 4160 nM
|
|
|
|
CP0144360
|
2-(2-Phenoxy-ethylsulfanyl)-1H-benzoimidazole
Show/Hide
|
C15H14N2OS
|
3
|
| 1 |
IC50 = 4200 nM
|
|
|
| 2 |
IC50 = 4300 nM
|
|
|
| 3 |
IC50 = 21000 nM
|
|
|
|
CP0513329
|
2-(2-hydroxyphenyl)-6-iodo-2,3-dihydrochromen-4-one
Show/Hide
|
C15H11IO3
|
1
|
| 1 |
IC50 = 4260 nM
|
|
|
|
CP0482555
|
(E)-3-(1,3-benzodioxol-5-yl)-1-(5-chloro-2-hydroxyphenyl)prop-2-en-1-one
Show/Hide
|
C16H11ClO4
|
1
|
| 1 |
IC50 = 4360 nM
|
|
|
|
CP0891250
|
(1S,6R,7S)-4-(4-Cyano-3-trifluoromethyl-phenyl)-3,5-dioxo-2,4,8-triaza-tricyclo[5.2.1.0*2,6*]decane-8-carboxylic acid tert-butyl ester
Show/Hide
|
C20H19F3N4O4
|
1
|
| 1 |
IC50 = 4380 nM
|
|
|
|
CP0897702
|
(1S,6R,7S)-4-(4-Nitro-naphthalen-1-yl)-3,5-dioxo-2,4,8-triaza-tricyclo[5.2.1.0*2,6*]decane-8-carboxylic acid tert-butyl ester
Show/Hide
|
C22H22N4O6
|
1
|
| 1 |
IC50 = 4430 nM
|
|
|
|
CP0199692
|
N-benzyl-N-(2-cyanoethyl)-1H-indole-2-carboxamide
Show/Hide
|
C19H17N3O
|
2
|
| 1 |
IC50 = 4580 nM
|
|
|
| 2 |
IC50 = 7510 nM
|
|
|
|
CP0858358
|
(1S,2S,6R,7R)-4-(4-Cyano-3-trifluoromethyl-phenyl)-1,7-dimethyl-3,5-dioxo-11-oxa-4,9-diaza-tricyclo[5.3.1.0*2,6*]undecane-9-carboxylic acid isopropylamide
Show/Hide
|
C22H23F3N4O4
|
1
|
| 1 |
IC50 = 4600 nM
|
|
|
|
CP0044019
|
4-(2,3-dihydro-1H-perimidin-2-yl)-2-methoxyphenol
Show/Hide
|
C18H16N2O2
|
1
|
| 1 |
IC50 = 4600 nM
|
|
|
|
CP0891249
|
(1S,6R,7S)-8-(4-Butyl-benzoyl)-4-(4-nitro-phenyl)-2,4,8-triaza-tricyclo[5.2.1.0*2,6*]decane-3,5-dione
Show/Hide
|
C24H24N4O5
|
1
|
| 1 |
IC50 = 4750 nM
|
|
|
|
CP0386603
|
(E)-1-(5-bromo-2-hydroxyphenyl)-3-(2-methoxyphenyl)prop-2-en-1-one
Show/Hide
|
C16H13BrO3
|
2
|
| 1 |
IC50 = 4870 nM
|
|
|
| 2 |
IC50 < 1000 nM
|
|
|
|
CP0871275
|
(1S,6R,7S)-4-(4-Cyano-phenyl)-3,5-dioxo-2,4,8-triaza-tricyclo[5.2.1.0*2,6*]decane-8-carboxylic acid tert-butyl ester
Show/Hide
|
C19H20N4O4
|
1
|
| 1 |
IC50 = 4970 nM
|
|
|
|
CP0859764
|
4-((1S,2S,6R,7R)-9-Isopropyl-1,7-dimethyl-3,5,8,10-tetraoxo-9-oxy-11-oxa-4,9-diaza-tricyclo[5.3.1.0*2,6*]undec-4-yl)-2-trifluoromethyl-benzonitrile
Show/Hide
|
C21H18F3N3O6
|
1
|
| 1 |
IC50 = 5000 nM
|
|
|
|
CP0418492
|
2-[2-(3-chlorophenoxy)ethylsulfanyl]-1H-benzimidazole
Show/Hide
|
C15H13ClN2OS
|
1
|
| 1 |
IC50 = 5000 nM
|
|
|
|
CP0390780
|
(E)-1-(5-fluoro-2-hydroxyphenyl)-3-(2-methoxyphenyl)prop-2-en-1-one
Show/Hide
|
C16H13FO3
|
1
|
| 1 |
IC50 = 5010 nM
|
|
|
|
CP0539872
|
1'-[4-cyano-3-(trifluoromethyl)phenyl]-N-methyl-5'-oxo-2'-sulfanylidenespiro[1,3-dihydroindene-2,4'-imidazolidine]-5-carboxamide
Show/Hide
|
C21H15F3N4O2S
|
1
|
| 1 |
IC50 = 5012 nM
|
|
|
|
CP0578026
|
4-chloro-N-(4-phenylmethoxyphenyl)benzenesulfonamide
Show/Hide
|
C19H16ClNO3S
|
1
|
| 1 |
IC50 = 5020 nM
|
|
|
|
CP0546196
|
(2-morpholin-4-yl-4-phenyl-1,3-thiazol-5-yl)methanol
Show/Hide
|
C14H16N2O2S
|
1
|
| 1 |
IC50 = 5040 nM
|
|
|
|
CP0398859
|
4-[4-(1H-indol-3-yl)-1,3-thiazol-2-yl]phenol
Show/Hide
|
C17H12N2OS
|
2
|
| 1 |
IC50 = 5050 nM
|
|
|
| 2 |
IC50 = 6460 nM
|
|
|
|
CP0553402
|
N-[3-[1-(3-chloro-4-fluorophenyl)-3-methyl-6-oxopyridazin-4-yl]phenyl]ethanesulfonamide
Show/Hide
|
C19H17ClFN3O3S
|
1
|
| 1 |
IC50 = 5070 nM
|
|
|
|
CP0314019
|
N-(furan-2-ylmethyl)-N-propan-2-yl-5-(trifluoromethyl)-1H-indole-2-carboxamide
Show/Hide
|
C18H17F3N2O2
|
2
|
| 1 |
IC50 = 5200 nM
|
|
|
| 2 |
IC50 = 5290 nM
|
|
|
|
CP0137496
|
(E)-1-(5-chloro-2-hydroxyphenyl)-3-(3,4-dimethoxyphenyl)prop-2-en-1-one
Show/Hide
|
C17H15ClO4
|
1
|
| 1 |
IC50 = 5250 nM
|
|
|
|
CP0537461
|
(E)-1-(5-bromo-2-hydroxyphenyl)-3-(2-ethoxyphenyl)prop-2-en-1-one
Show/Hide
|
C17H15BrO3
|
1
|
| 1 |
IC50 = 5270 nM
|
|
|
|
CP0510909
|
2-(2-phenoxyethylsulfanyl)-1H-indole
Show/Hide
|
C16H15NOS
|
1
|
| 1 |
IC50 = 5400 nM
|
|
|
|
CP0565082
|
14-phenyl-13-azapentacyclo[14.2.1.02,15.03,12.04,9]nonadeca-3(12),4,6,8,10-pentaene
Show/Hide
|
C24H23N
|
1
|
| 1 |
IC50 = 5600 nM
|
|
|
|
CP0567311
|
1-phenyl-N-(4-phenylmethoxyphenyl)methanesulfonamide
Show/Hide
|
C20H19NO3S
|
1
|
| 1 |
IC50 = 5730 nM
|
|
|
|
CP0483416
|
4-(5-ethyl-4-phenyl-1,3-thiazol-2-yl)morpholine
Show/Hide
|
C15H18N2OS
|
2
|
| 1 |
IC50 = 5800 nM
|
|
|
| 2 |
IC50 = 8430 nM
|
|
|
|
CP0874437
|
(1S,6S,7S)-4-(4-Nitro-naphthalen-1-yl)-3,5-dioxo-2,4,8-triaza-tricyclo[5.2.1.0*2,6*]decane-8-carboxylic acid tert-butyl ester
Show/Hide
|
C22H22N4O6
|
1
|
| 1 |
IC50 = 5860 nM
|
|
|
|
CP0827343
|
6-[4-(4-Fluorobenzyl)piperazin-1-yl]-3-(trifluoromethyl)-7,8-dihydro[1,2,4]triazolo[4,3-b]pyridazine
Show/Hide
|
C17H18F4N6
|
1
|
| 1 |
IC50 = 5888.44 nM
|
|
|
|
CP0241989
|
4-(2,3-dihydro-1H-perimidin-2-yl)phenol
Show/Hide
|
C17H14N2O
|
1
|
| 1 |
IC50 = 5900 nM
|
|
|
|
CP0551284
|
(E)-1-(5-chloro-2-hydroxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one
Show/Hide
|
C15H11ClO3
|
1
|
| 1 |
IC50 = 5920 nM
|
|
|
|
CP0483869
|
(E)-1-(5-chloro-2-hydroxyphenyl)-3-(4-hydroxy-3-methoxyphenyl)prop-2-en-1-one
Show/Hide
|
C16H13ClO4
|
1
|
| 1 |
IC50 = 5950 nM
|
|
|
|
CP0865415
|
4-(2-(5-fluoro-1,3-dioxoisoindolin-2-yl)thiazol-4-yl)benzonitrile
Show/Hide
|
C18H8FN3O2S
|
1
|
| 1 |
IC50 = 5960 nM
|
|
|
|
CP0061018
|
N-(4-phenylmethoxyphenyl)methanesulfonamide
Show/Hide
|
C14H15NO3S
|
1
|
| 1 |
IC50 = 6110 nM
|
|
|
|
CP0450690
|
6-methoxy-2-(2-methoxyphenyl)chromen-4-one
Show/Hide
|
C17H14O4
|
1
|
| 1 |
IC50 = 6190 nM
|
|
|
|
CP0397168
|
N-[3-[1-(4-cyanophenyl)-3-methyl-6-oxopyridazin-4-yl]phenyl]ethanesulfonamide
Show/Hide
|
C20H18N4O3S
|
1
|
| 1 |
IC50 = 6260 nM
|
|
|
|
CP0042218
|
2'-Hydroxyflavanone
Show/Hide
|
C15H12O3
|
2
|
| 1 |
IC50 = 6400 nM
|
|
|
| 2 |
IC50 < 1000 nM
|
|
|
|
CP0199693
|
5-fluoro-N-(furan-2-ylmethyl)-N-(2-methoxyethyl)-1H-indole-2-carboxamide
Show/Hide
|
C17H17FN2O3
|
2
|
| 1 |
IC50 = 6470 nM
|
|
|
| 2 |
IC50 = 6620 nM
|
|
|
|
CP0205225
|
5-fluoro-N-methyl-N-[(5-methylfuran-2-yl)methyl]-1H-indole-2-carboxamide
Show/Hide
|
C16H15FN2O2
|
2
|
| 1 |
IC50 = 6560 nM
|
|
|
| 2 |
IC50 = 9440 nM
|
|
|
|
CP0860543
|
4-[(1S,6R,7S)-8-(4-Butyl-benzoyl)-3,5-dioxo-2,4,8-triaza-tricyclo[5.2.1.0*2,6*]dec-4-yl]-benzonitrile
Show/Hide
|
C25H24N4O3
|
1
|
| 1 |
IC50 = 6800 nM
|
|
|
|
CP0510911
|
2-[2-(4-methylphenoxy)ethylsulfanyl]-1H-benzimidazole
Show/Hide
|
C16H16N2OS
|
1
|
| 1 |
IC50 = 7000 nM
|
|
|
|
CP0573867
|
N-(4-phenylmethoxyphenyl)butane-1-sulfonamide
Show/Hide
|
C17H21NO3S
|
1
|
| 1 |
IC50 = 7050 nM
|
|
|
|
CP0511125
|
2-(2-phenylethylsulfanyl)-1H-benzimidazole
Show/Hide
|
C15H14N2S
|
1
|
| 1 |
IC50 = 7400 nM
|
|
|
|
CP0527837
|
2-morpholin-4-yl-1,3-benzothiazol-6-ol
Show/Hide
|
C11H12N2O2S
|
2
|
| 1 |
IC50 = 7410 nM
|
|
|
| 2 |
IC50 = 8080 nM
|
|
|
|
CP0558442
|
14-(4-chlorophenyl)-13-azapentacyclo[14.2.1.02,15.03,12.04,9]nonadeca-3(12),4,6,8,10-pentaene
Show/Hide
|
C24H22ClN
|
1
|
| 1 |
IC50 = 7450 nM
|
|
|
|
CP0961896
|
5-fluoro-2-(4-(4-nitrophenyl)thiazol-2-yl)isoindoline-1,3-dione
Show/Hide
|
C17H8FN3O4S
|
1
|
| 1 |
IC50 = 7780 nM
|
|
|
|
CP0546327
|
N-(4-phenylmethoxyphenyl)ethanesulfonamide
Show/Hide
|
C15H17NO3S
|
1
|
| 1 |
IC50 = 7900 nM
|
|
|
|
CP0199694
|
N-[(5-bromofuran-2-yl)methyl]-6-fluoro-N-methyl-1H-indole-2-carboxamide
Show/Hide
|
C15H12BrFN2O2
|
2
|
| 1 |
IC50 = 8090 nM
|
|
|
| 2 |
IC50 = 15670 nM
|
|
|
|
CP0907003
|
5-fluoro-2-(4-(4-methoxyphenyl)thiazol-2-yl)isoindoline-1,3-dione
Show/Hide
|
C18H11FN2O3S
|
1
|
| 1 |
IC50 = 8170 nM
|
|
|
|
CP0478546
|
(E)-1-(5-bromo-2-hydroxyphenyl)-3-(2-hydroxyphenyl)prop-2-en-1-one
Show/Hide
|
C15H11BrO3
|
1
|
| 1 |
IC50 = 8690 nM
|
|
|
|
CP0386600
|
(E)-1-(5-bromo-2-hydroxyphenyl)-3-(2-propan-2-yloxyphenyl)prop-2-en-1-one
Show/Hide
|
C18H17BrO3
|
2
|
| 1 |
IC50 = 9110 nM
|
|
|
| 2 |
IC50 < 1000 nM
|
|
|
|
CP0211845
|
4-(2-naphthalenyl)-2-thiazolamine
Show/Hide
|
C13H10N2S
|
2
|
| 1 |
IC50 = 9160 nM
|
|
|
| 2 |
IC50 = 10600 nM
|
|
|
|
CP0579466
|
7-[(4-propan-2-ylphenyl)methoxy]-4-(trifluoromethyl)chromen-2-one
Show/Hide
|
C20H17F3O3
|
1
|
| 1 |
IC50 = 9260 nM
|
|
|
|
CP0579468
|
7-(1,3-benzodioxol-5-ylmethoxy)-4-(trifluoromethyl)chromen-2-one
Show/Hide
|
C18H11F3O5
|
1
|
| 1 |
IC50 = 9370 nM
|
|
|
|
CP0489119
|
N-[3-(3-methyl-1-naphthalen-2-yl-6-oxopyridazin-4-yl)phenyl]ethanesulfonamide
Show/Hide
|
C23H21N3O3S
|
1
|
| 1 |
IC50 = 9760 nM
|
|
|
|
CP0550762
|
4-quinolin-2-ylphenol
Show/Hide
|
C15H11NO
|
1
|
| 1 |
IC50 = 9840 nM
|
|
|
|
CP0415535
|
6-methoxy-2-(2-methoxyphenyl)-2,3-dihydrochromen-4-one
Show/Hide
|
C17H16O4
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0478786
|
5,7-dihydroxy-2-(2-hydroxyphenyl)-2,3-dihydrochromen-4-one
Show/Hide
|
C15H12O5
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0537463
|
2-(2-hydroxyphenyl)-7-methoxy-2,3-dihydrochromen-4-one
Show/Hide
|
C16H14O4
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0542366
|
(E)-1-(5-fluoro-2-hydroxyphenyl)-3-[2-(methoxymethoxy)phenyl]prop-2-en-1-one
Show/Hide
|
C17H15FO4
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0542367
|
7-hydroxy-2-(2-hydroxyphenyl)-2,3-dihydrochromen-4-one
Show/Hide
|
C15H12O4
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0558831
|
(E)-1-(5-chloro-2-hydroxyphenyl)-3-(2-methoxyphenyl)prop-2-en-1-one
Show/Hide
|
C16H13ClO3
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0415532
|
(E)-1-(2-hydroxy-5-methoxyphenyl)-3-(2-methoxyphenyl)prop-2-en-1-one
Show/Hide
|
C17H16O4
|
2
|
| 1 |
IC50 > 10000 nM
|
|
|
| 2 |
IC50 < 1000 nM
|
|
|
|
CP0450691
|
2-(2-Hydroxyphenyl)-4H-chromen-4-one (3d)
Show/Hide
|
C15H10O3
|
2
|
| 1 |
IC50 > 10000 nM
|
|
|
| 2 |
IC50 < 1000 nM
|
|
|
|
CP0386609
|
1,8-dichloro-10-[(4-hydroxy-3,5-dimethoxyphenyl)methylidene]anthracen-9-one
Show/Hide
|
C23H16Cl2O4
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0464462
|
(1S,6R,7S)-4-(4-Cyano-3-trifluoromethyl-phenyl)-6-methyl-3,5-dioxo-2,4,8-triaza-tricyclo[5.2.1.0*2,6*]decane-8-carboxylic acid tert-butyl ester
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C21H21F3N4O4
|
1
|
| 1 |
IC50 = 10400 nM
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CP0925213
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4-Pyridin-3-yl-1-[3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperidin-4-ol
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C16H15F3N6O
|
1
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| 1 |
IC50 = 10715.19 nM
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CP0928928
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4-(2-(1,3-dioxoisoindolin-2-yl)thiazol-4-yl)benzonitrile
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C18H9N3O2S
|
1
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| 1 |
IC50 = 10960 nM
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CP0038692
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4-(2,3-dihydro-1H-perimidin-2-yl)-2-ethoxy-phenol
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C19H18N2O2
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1
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| 1 |
IC50 = 11100 nM
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CP0500807
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propan-2-yl 2-[2-[2-(4-methylphenoxy)ethylsulfanyl]benzimidazol-1-yl]acetate
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C21H24N2O3S
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1
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| 1 |
IC50 = 11100 nM
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CP0549911
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4-methyl-N-(4-phenylmethoxyphenyl)benzenesulfonamide
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C20H19NO3S
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1
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| 1 |
IC50 = 11520 nM
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CP0474096
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2-(3-phenylpropylsulfanyl)-1H-benzimidazole
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C16H16N2S
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1
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| 1 |
IC50 = 12000 nM
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CP0488888
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1-ethyl-2-(2-phenoxyethylsulfanyl)benzimidazole
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C17H18N2OS
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1
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| 1 |
IC50 = 12000 nM
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CP0488891
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1-(2-methoxyethyl)-2-[2-(4-methylphenoxy)ethylsulfanyl]benzimidazole
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C19H22N2O2S
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1
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| 1 |
IC50 = 12700 nM
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CP0391752
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1-[2-(4-methylphenoxy)ethyl]-2-(2-phenoxyethylsulfanyl)benzimidazole
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C24H24N2O2S
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1
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| 1 |
IC50 = 13100 nM
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CP0865414
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2-(4-(4-nitrophenyl)thiazol-2-yl)isoindoline-1,3-dione
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C17H9N3O4S
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1
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| 1 |
IC50 = 13170 nM
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CP0500882
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N-[3-[1-(3,5-dichlorophenyl)-3-methyl-6-oxopyridazin-4-yl]phenyl]ethanesulfonamide
Show/Hide
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C19H17Cl2N3O3S
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1
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| 1 |
IC50 = 13190 nM
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CP0905184
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2-(4-(4-methoxyphenyl)thiazol-2-yl)isoindoline-1,3-dione
Show/Hide
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C18H12N2O3S
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1
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| 1 |
IC50 = 13670 nM
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CP0521697
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propan-2-yl 2-[2-[2-(3-methylphenoxy)ethylsulfanyl]benzimidazol-1-yl]acetate
Show/Hide
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C21H24N2O3S
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1
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| 1 |
IC50 = 13700 nM
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CP0438543
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ethyl 2-[2-[2-(3-methylphenoxy)ethylsulfanyl]benzimidazol-1-yl]acetate
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C20H22N2O3S
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1
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| 1 |
IC50 = 14100 nM
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CP0548331
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1'-[6-cyano-5-(trifluoromethyl)pyridin-3-yl]-N-methyl-5'-oxo-2'-sulfanylidenespiro[1,3-dihydroindene-2,4'-imidazolidine]-5-carboxamide
Show/Hide
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C20H14F3N5O2S
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1
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| 1 |
IC50 > 15000 nM
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CP0294278
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4-(2,3-dihydro-1H-perimidin-2-yl)benzene-1,2-diol
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C17H14N2O2
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1
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| 1 |
IC50 = 18640 nM
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CP0510912
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2-[2-(2-methylphenoxy)ethylsulfanyl]-1H-benzimidazole
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C16H16N2OS
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1
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| 1 |
IC50 = 19000 nM
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CP0568110
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8-(2,4-dichlorophenyl)-3-oxa-9-azatetracyclo[8.8.0.02,7.013,18]octadeca-1(10),11,13,15,17-pentaene
Show/Hide
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C22H19Cl2NO
|
1
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| 1 |
IC50 = 20350 nM
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CP0854922
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5-fluoro-2-(4-(4-fluorophenyl)thiazol-2-yl)isoindoline-1,3-dione
Show/Hide
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C17H8F2N2O2S
|
1
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| 1 |
IC50 = 21510 nM
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CP0906652
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5-fluoro-2-(4-phenylthiazol-2-yl)isoindoline-1,3-dione
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C17H9FN2O2S
|
1
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| 1 |
IC50 = 22590 nM
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CP0488890
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2-[2-(3-ethoxyphenoxy)ethylsulfanyl]-1-[2-(4-methylphenoxy)ethyl]benzimidazole
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C26H28N2O3S
|
1
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| 1 |
IC50 = 22800 nM
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CP0524675
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1-(2-methoxyethyl)-2-[2-(3-methylphenoxy)ethylsulfanyl]benzimidazole
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C19H22N2O2S
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1
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| 1 |
IC50 = 24100 nM
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CP0527934
|
7-[[4-(trifluoromethoxy)phenyl]methoxy]-4-(trifluoromethyl)chromen-2-one
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C18H10F6O4
|
1
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| 1 |
IC50 = 25060 nM
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CP0907004
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5-fluoro-2-(4-p-tolylthiazol-2-yl)isoindoline-1,3-dione
Show/Hide
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C18H11FN2O2S
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1
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| 1 |
IC50 = 25820 nM
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CP0928930
|
SID124894379
Show/Hide
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C17H9ClN2O2S
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1
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| 1 |
IC50 = 26240 nM
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CP0912415
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2-(4-(4-chlorophenyl)thiazol-2-yl)-5-fluoroisoindoline-1,3-dione
Show/Hide
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C17H8ClFN2O2S
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1
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| 1 |
IC50 = 27960 nM
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CP0961897
|
SID124894408
Show/Hide
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C17H9FN2O2S
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1
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| 1 |
IC50 = 28560 nM
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CP0928929
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2-(4-p-tolylthiazol-2-yl)isoindoline-1,3-dione
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C18H12N2O2S
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1
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| 1 |
IC50 = 29040 nM
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CP0883970
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(1S,6R,7S)-4-(4-Nitro-naphthalen-1-yl)-3,5-dioxo-2,4,8-triaza-tricyclo[5.2.1.0*2,6*]decane-8-carboxylic acid 4-fluoro-phenyl ester
Show/Hide
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C24H17FN4O6
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1
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| 1 |
IC50 = 30000 nM
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CP0524674
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propan-2-yl 2-[2-[2-(3,4-dimethylphenoxy)ethylsulfanyl]benzimidazol-1-yl]acetate
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C22H26N2O3S
|
1
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| 1 |
IC50 = 30600 nM
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CP0527935
|
methyl 4-[[2-oxo-4-(trifluoromethyl)chromen-7-yl]oxymethyl]benzoate
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C19H13F3O5
|
1
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| 1 |
IC50 = 30740 nM
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CP0868528
|
2,2,2-trifluoro-1-(2-(5,6,7-trifluoro-1H-indol-3-yl)quinolin-5-yl)ethanol
Show/Hide
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C19H10F6N2O
|
1
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| 1 |
IC50 = 32000 nM
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CP0438542
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methyl 2-[2-[2-(4-methylphenoxy)ethylsulfanyl]benzimidazol-1-yl]acetate
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C19H20N2O3S
|
1
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| 1 |
IC50 = 32900 nM
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CP0787472
|
2-hydroxy-4-(2-(3-methyl-5-oxo-1-phenyl-1H-pyrazol-4(5H)-ylidene)hydrazinyl)benzoic acid
Show/Hide
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C17H14N4O4
|
1
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| 1 |
IC50 = 33400 nM
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CP0914361
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4-[(1S,6R,7S)-8-(4-Butyl-benzoyl)-3,5-dioxo-2,4,8-triaza-tricyclo[5.2.1.0*2,6*]dec-4-yl]-2-trifluoromethyl-benzonitrile
Show/Hide
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C26H23F3N4O3
|
1
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| 1 |
IC50 = 33700 nM
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CP0047174
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(1S,2R,10S,11S,14R,15S,17S)-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-dien-5-one
Show/Hide
|
C21H28O5
|
1
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| 1 |
IC50 = 34000 nM
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CP0044103
|
5-(2,3-dihydro-1H-perimidin-2-yl)-2-methoxyphenol
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C18H16N2O2
|
1
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| 1 |
IC50 = 34400 nM
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CP0024380
|
2-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]acetic acid
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C14H9I3O4
|
1
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| 1 |
IC50 = 34800 nM
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CP0438541
|
1-ethyl-2-[2-(3-methylphenoxy)ethylsulfanyl]benzimidazole
Show/Hide
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C18H20N2OS
|
1
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| 1 |
IC50 = 35000 nM
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CP0890835
|
2-(4-phenylthiazol-2-yl)isoindoline-1,3-dione
Show/Hide
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C17H10N2O2S
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1
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| 1 |
IC50 = 36840 nM
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CP0033569
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4-[4-(3,4-dihydroxyphenyl)-2,3-dimethyl-butyl]pyrocatechol
Show/Hide
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C18H22O4
|
1
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| 1 |
IC50 = 38800 nM
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CP0510915
|
ethyl 2-[2-[2-(3,4-dimethylphenoxy)ethylsulfanyl]benzimidazol-1-yl]acetate
Show/Hide
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C21H24N2O3S
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1
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| 1 |
IC50 = 40300 nM
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CP0511128
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1-methyl-2-[2-(3-methylphenoxy)ethylsulfanyl]benzimidazole
Show/Hide
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C17H18N2OS
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1
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| 1 |
IC50 = 45000 nM
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CP0026502
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(2R)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoic acid
Show/Hide
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C15H12I3NO4
|
1
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| 1 |
IC50 > 50000 nM
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CP0036697
|
2-{[3-(trifluoromethyl)phenyl]amino}benzoic acid
Show/Hide
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C14H10F3NO2
|
1
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| 1 |
IC50 > 50000 nM
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CP0042725
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2-[2-(3,4-dihydroxyphenyl)-2-oxoethyl]sulfanyl-1H-quinazolin-4-one
Show/Hide
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C16H12N2O4S
|
1
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| 1 |
IC50 = 50000 nM
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CP0440694
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3-[1-[2-(4-methylphenoxy)ethyl]benzimidazol-2-yl]sulfanylpropanoic acid
Show/Hide
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C19H20N2O3S
|
1
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| 1 |
IC50 = 50000 nM
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CP0440695
|
3-[(2,4-dichlorophenyl)sulfanylmethyl]benzoic acid
Show/Hide
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C14H10Cl2O2S
|
1
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| 1 |
IC50 = 50000 nM
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CP0475664
|
(E)-3-[1-(1,3-benzodioxol-5-yl)-2,5-dimethylpyrrol-3-yl]prop-2-enoic acid
Show/Hide
|
C16H15NO4
|
1
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| 1 |
IC50 = 50000 nM
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CP0491734
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1,3-dimethyl-2-oxo-N-(4-phenylmethoxyphenyl)benzimidazole-5-sulfonamide
Show/Hide
|
C22H21N3O4S
|
1
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| 1 |
IC50 > 50000 nM
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CP0491740
|
1-(4-chlorophenyl)-N-(4-phenylmethoxyphenyl)methanesulfonamide
Show/Hide
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C20H18ClNO3S
|
1
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| 1 |
IC50 > 50000 nM
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CP0491741
|
2,4,6-trimethyl-N-(4-phenylmethoxyphenyl)benzenesulfonamide
Show/Hide
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C22H23NO3S
|
1
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| 1 |
IC50 > 50000 nM
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CP0567312
|
1-(4-nitrophenyl)-N-(4-phenylmethoxyphenyl)methanesulfonamide
Show/Hide
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C20H18N2O5S
|
1
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| 1 |
IC50 > 50000 nM
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CP0571541
|
N-[4-[(4-phenylmethoxyphenyl)sulfamoyl]phenyl]acetamide
Show/Hide
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C21H20N2O4S
|
1
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| 1 |
IC50 > 50000 nM
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CP0573866
|
4-methyl-2,6-dioxo-N-(4-phenylmethoxyphenyl)-1,3-diazinane-5-sulfonamide
Show/Hide
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C18H19N3O5S
|
1
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| 1 |
IC50 > 50000 nM
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CP0574201
|
ethyl 5-[(4-phenylmethoxyphenyl)sulfamoyl]-1H-pyrazole-4-carboxylate
Show/Hide
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C19H19N3O5S
|
1
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| 1 |
IC50 > 50000 nM
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CP0575032
|
2-methyl-N-(4-phenylmethoxyphenyl)propane-1-sulfonamide
Show/Hide
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C17H21NO3S
|
1
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| 1 |
IC50 > 50000 nM
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CP0577035
|
4-acetyl-N-(4-phenylmethoxyphenyl)benzenesulfonamide
Show/Hide
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C21H19NO4S
|
1
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| 1 |
IC50 > 50000 nM
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CP0577455
|
methyl 3-[(4-phenylmethoxyphenyl)sulfamoyl]thiophene-2-carboxylate
Show/Hide
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C19H17NO5S2
|
1
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| 1 |
IC50 > 50000 nM
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CP0577937
|
1-(4-methoxyphenyl)-N-(4-phenylmethoxyphenyl)methanesulfonamide
Show/Hide
|
C21H21NO4S
|
1
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| 1 |
IC50 > 50000 nM
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CP0577938
|
1-acetyl-5-bromo-2-methyl-N-(4-phenylmethoxyphenyl)-2,3-dihydroindole-6-sulfonamide
Show/Hide
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C24H23BrN2O4S
|
1
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| 1 |
IC50 > 50000 nM
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CP0488437
|
1-methyl-N-[2-oxo-4-(trifluoromethyl)chromen-7-yl]pyrazole-4-carboxamide
Show/Hide
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C15H10F3N3O3
|
1
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| 1 |
IC50 > 50000 nM
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CP0527929
|
3-methyl-N-[2-oxo-4-(trifluoromethyl)chromen-7-yl]benzamide
Show/Hide
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C18H12F3NO3
|
1
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| 1 |
IC50 > 50000 nM
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CP0527930
|
3-bromo-1-methyl-N-[2-oxo-4-(trifluoromethyl)chromen-7-yl]pyrazole-4-carboxamide
Show/Hide
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C15H9BrF3N3O3
|
1
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| 1 |
IC50 > 50000 nM
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CP0542357
|
7-(pyridin-2-ylmethoxy)-4-(trifluoromethyl)chromen-2-one
Show/Hide
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C16H10F3NO3
|
1
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| 1 |
IC50 > 50000 nM
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CP0543044
|
7-[(4-acetylphenyl)methoxy]-4-(trifluoromethyl)chromen-2-one
Show/Hide
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C19H13F3O4
|
1
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| 1 |
IC50 > 50000 nM
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CP0545533
|
2-[(2-phenyl-1,3-benzoxazol-5-yl)iminomethyl]phenol
Show/Hide
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C20H14N2O2
|
1
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| 1 |
IC50 > 50000 nM
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CP0545786
|
methyl 4-methyl-2-[2-oxo-4-(trifluoromethyl)chromen-7-yl]oxypentanoate
Show/Hide
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C17H17F3O5
|
1
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| 1 |
IC50 > 50000 nM
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CP0549336
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2-chloro-N-[2-oxo-4-(trifluoromethyl)chromen-7-yl]benzamide
Show/Hide
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C17H9ClF3NO3
|
1
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| 1 |
IC50 > 50000 nM
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CP0549337
|
2-[(3,4-dichlorophenyl)iminomethyl]phenol
Show/Hide
|
C13H9Cl2NO
|
1
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| 1 |
IC50 > 50000 nM
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CP0561942
|
N-[2-oxo-4-(trifluoromethyl)chromen-7-yl]benzamide
Show/Hide
|
C17H10F3NO3
|
1
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| 1 |
IC50 > 50000 nM
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CP0561943
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1-ethyl-3-methyl-N-[2-oxo-4-(trifluoromethyl)chromen-7-yl]pyrazole-4-carboxamide
Show/Hide
|
C17H14F3N3O3
|
1
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| 1 |
IC50 > 50000 nM
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CP0561944
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3-iodo-1-methyl-N-[2-oxo-4-(trifluoromethyl)chromen-7-yl]pyrazole-4-carboxamide
Show/Hide
|
C15H9F3IN3O3
|
1
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| 1 |
IC50 > 50000 nM
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CP0561945
|
N-[2-oxo-4-(trifluoromethyl)chromen-7-yl]-[1,2,4]triazolo[1,5-a]pyrimidine-2-carboxamide
Show/Hide
|
C16H8F3N5O3
|
1
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| 1 |
IC50 > 50000 nM
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CP0561946
|
(2S)-2-(2,5-dichlorophenoxy)-N-[2-oxo-4-(trifluoromethyl)chromen-7-yl]propanamide
Show/Hide
|
C19H12Cl2F3NO4
|
1
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| 1 |
IC50 > 50000 nM
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CP0561958
|
7-[(2-methoxy-5-nitrophenyl)methoxy]-4-(trifluoromethyl)chromen-2-one
Show/Hide
|
C18H12F3NO6
|
1
|
| 1 |
IC50 > 50000 nM
|
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CP0569967
|
[4-[(2-hydroxyphenyl)methylideneamino]phenyl]-phenylmethanone
Show/Hide
|
C20H15NO2
|
1
|
| 1 |
IC50 > 50000 nM
|
|
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CP0569969
|
7-[(4-nitrophenyl)methoxy]-4-(trifluoromethyl)chromen-2-one
Show/Hide
|
C17H10F3NO5
|
1
|
| 1 |
IC50 > 50000 nM
|
|
|
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CP0573582
|
4-[[2-oxo-4-(trifluoromethyl)chromen-7-yl]oxymethyl]benzamide
Show/Hide
|
C18H12F3NO4
|
1
|
| 1 |
IC50 > 50000 nM
|
|
|
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CP0573584
|
2-fluoro-N-[2-oxo-4-(trifluoromethyl)chromen-7-yl]benzamide
Show/Hide
|
C17H9F4NO3
|
1
|
| 1 |
IC50 > 50000 nM
|
|
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CP0573711
|
(2,4-dimethylphenyl) N-[2-oxo-4-(trifluoromethyl)chromen-7-yl]carbamate
Show/Hide
|
C19H14F3NO4
|
1
|
| 1 |
IC50 > 50000 nM
|
|
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CP0575294
|
7-(pyridin-3-ylmethoxy)-4-(trifluoromethyl)chromen-2-one
Show/Hide
|
C16H10F3NO3
|
1
|
| 1 |
IC50 > 50000 nM
|
|
|
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CP0576182
|
ethyl 2-[2-oxo-4-(trifluoromethyl)chromen-7-yl]oxybutanoate
Show/Hide
|
C16H15F3O5
|
1
|
| 1 |
IC50 > 50000 nM
|
|
|
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CP0576183
|
2-[(3-bromo-4-methylphenyl)iminomethyl]phenol
Show/Hide
|
C14H12BrNO
|
1
|
| 1 |
IC50 > 50000 nM
|
|
|
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CP0576184
|
3-[(2-hydroxyphenyl)methylideneamino]benzonitrile
Show/Hide
|
C14H10N2O
|
1
|
| 1 |
IC50 > 50000 nM
|
|
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CP0578443
|
7-[(4-phenylphenyl)methoxy]-4-(trifluoromethyl)chromen-2-one
Show/Hide
|
C23H15F3O3
|
1
|
| 1 |
IC50 > 50000 nM
|
|
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CP0578444
|
7-(naphthalen-2-ylmethoxy)-4-(trifluoromethyl)chromen-2-one
Show/Hide
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C21H13F3O3
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1
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| 1 |
IC50 > 50000 nM
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CP0579463
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[2-oxo-4-(trifluoromethyl)chromen-7-yl] cyclohexanecarboxylate
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C17H15F3O4
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1
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| 1 |
IC50 > 50000 nM
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CP0579464
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3-chloro-N-[2-oxo-4-(trifluoromethyl)chromen-7-yl]benzamide
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C17H9ClF3NO3
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1
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| 1 |
IC50 > 50000 nM
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CP0474099
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ethyl 2-[2-[2-(3-ethylphenoxy)ethylsulfanyl]benzimidazol-1-yl]acetate
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C21H24N2O3S
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1
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| 1 |
IC50 = 55000 nM
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CP0438537
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4-[2-(1H-benzimidazol-2-ylsulfanyl)ethoxy]benzenesulfonamide
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C15H15N3O3S2
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1
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| 1 |
IC50 = 62000 nM
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CP0063115
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US10196374, Example 1
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C27H28F2N4O3
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1
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| 1 |
IC50 > 100000 nM
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CP0466279
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N-[4-[[4-[2-[3,5-dichloro-4-(2-chloroethoxy)phenyl]propan-2-yl]phenoxy]methyl]pyrimidin-2-yl]methanesulfonamide
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C23H24Cl3N3O4S
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1
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| 1 |
IC50 < 500 nM
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CP0532815
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N-[2-[[4-[2-[3-chloro-4-(2-chloroethoxy)-5-cyanophenyl]propan-2-yl]phenoxy]methyl]-1,3-thiazol-5-yl]methanesulfonamide
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C23H23Cl2N3O4S2
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1
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| 1 |
IC50 < 500 nM
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CP0546803
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N-[5-[[4-[2-[3-chloro-4-(2-chloroethoxy)-5-cyanophenyl]propan-2-yl]phenoxy]methyl]pyrimidin-2-yl]methanesulfonamide
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C24H24Cl2N4O4S
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1
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| 1 |
IC50 < 500 nM
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CP0553273
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3-chloro-2-(2-chloroethoxy)-5-[2-[4-[(2-propan-2-ylsulfonyl-1,3-oxazol-4-yl)methoxy]phenyl]propan-2-yl]benzonitrile
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C25H26Cl2N2O5S
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1
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| 1 |
IC50 < 500 nM
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CP0555906
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N-[2-[[4-[2-[3-chloro-4-(2-chloroethoxy)-5-cyanophenyl]propan-2-yl]phenoxy]methyl]-1,3-thiazol-4-yl]methanesulfonamide
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C23H23Cl2N3O4S2
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1
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| 1 |
IC50 < 500 nM
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CP0565132
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3-chloro-2-(2-chloroethoxy)-5-[2-[4-[(4-methyl-2-methylsulfanyl-1,3-oxazol-5-yl)methoxy]phenyl]propan-2-yl]benzonitrile
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C24H24Cl2N2O3S
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1
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| 1 |
IC50 < 500 nM
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CP0565443
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N-[4-[[4-[2-[3-chloro-4-(2-chloroethoxy)-5-cyanophenyl]propan-2-yl]phenoxy]methyl]-5-methylpyrimidin-2-yl]methanesulfonamide
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C25H26Cl2N4O4S
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1
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| 1 |
IC50 < 500 nM
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CP0568300
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N-[4-[[4-[2-[3-chloro-4-(2-chloroethoxy)-5-cyanophenyl]propan-2-yl]phenoxy]methyl]-5,6-dimethylpyrimidin-2-yl]methanesulfonamide
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C26H28Cl2N4O4S
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1
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| 1 |
IC50 < 500 nM
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CP0569279
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N-[5-[[4-[2-[3-chloro-4-(2-chloroethoxy)-5-cyanophenyl]propan-2-yl]phenoxy]methyl]-1,3-oxazol-2-yl]methanesulfonamide
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C23H23Cl2N3O5S
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1
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| 1 |
IC50 < 500 nM
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CP0571865
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3-chloro-2-(2-chloroethoxy)-5-[2-[4-[(2-chloro-1,3-oxazol-5-yl)methoxy]phenyl]propan-2-yl]benzonitrile
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C22H19Cl3N2O3
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1
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| 1 |
IC50 < 500 nM
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CP0468375
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US9126941, RD84
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C18H14F3N5OS
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1
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| 1 |
IC50 > 1000 nM
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CP0545644
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US9126941, RD85
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C24H16F3N3OS
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1
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| 1 |
IC50 > 1000 nM
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CP0874415
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(1R,2R,6S,7S)-4-(4-Nitro-3-trifluoromethyl-phenyl)-4-aza-tricyclo[5.2.1.0*2,6*]decane-3,5-dione
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C16H13F3N2O4
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1
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| 1 |
IC50 > 5000 nM
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CP0883977
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(1R,6S,7R)-4-(4-Cyano-3-trifluoromethyl-phenyl)-3,5-dioxo-2,4,8-triaza-tricyclo[5.2.1.0*2,6*]decane-8-carboxylic acid tert-butyl ester
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C20H19F3N4O4
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1
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| 1 |
IC50 > 5000 nM
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CP0901877
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(1R,6R,7S)-4-(4-Nitro-naphthalen-1-yl)-2,4-diaza-tricyclo[5.2.1.0*2,6*]decane-3,5-dione
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C18H15N3O4
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1
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| 1 |
IC50 > 5000 nM
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CP0910886
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(1S,6S,7S)-4-(4-Cyano-3-trifluoromethyl-phenyl)-3,5-dioxo-2,4,8-triaza-tricyclo[5.2.1.0*2,6*]decane-8-carboxylic acid tert-butyl ester
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C20H19F3N4O4
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1
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| 1 |
IC50 > 5000 nM
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CP0844850
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2-Trifluoromethyl-4-((1S,2S,6R,7R)-1,7,9-trimethyl-3,5,8,10-tetraoxo-11-oxa-4,9-diaza-tricyclo[5.3.1.0*2,6*]undec-4-yl)-benzonitrile
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C19H14F3N3O5
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1
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| 1 |
IC50 > 5000 nM
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CP0859766
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4-((1S,2S,6R,7R)-1,7-Dimethyl-3,5-dioxo-11-oxa-4,9-diaza-tricyclo[5.3.1.0*2,6*]undec-4-yl)-2-trifluoromethyl-benzonitrile
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C18H16F3N3O3
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1
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| 1 |
IC50 > 5000 nM
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CP0881224
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(2R,6S)-4-(4-Bromo-3-methyl-phenyl)-4-aza-tricyclo[5.2.2.0*2,6*]undec-8-ene-3,5-dione
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C17H16BrNO2
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1
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| 1 |
Ki = 0.01 nM
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CP0853961
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(2S,6R)-4-(4-Nitro-naphthalen-1-yl)-4-aza-tricyclo[5.2.2.0*2,6*]undec-8-ene-3,5-dione
Show/Hide
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C20H16N2O4
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1
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| 1 |
Ki = 0.5 nM
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CP0860627
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(2S,6R)-4-(4-Nitro-naphthalen-1-yl)-4-aza-tricyclo[5.2.1.0*2,6*]dec-8-ene-3,5-dione
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C19H14N2O4
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1
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| 1 |
Ki = 0.5 nM
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CP0874496
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(2S,6R)-4-(4-Bromo-3-trifluoromethyl-phenyl)-4-aza-tricyclo[5.2.1.0*2,6*]dec-8-ene-3,5-dione
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C16H11BrF3NO2
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1
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| 1 |
Ki = 0.6 nM
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CP0040191
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2-Hydroxy-2-methyl-N-(4-nitro-3-trifluoromethyl-phenyl)-propionamide
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C11H11F3N2O4
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2
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| 1 |
Ki = 2 nM
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| 2 |
Ki = 3 nM
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CP0853960
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(2S,6R)-4-(4-Nitro-3-trifluoromethyl-phenyl)-4-aza-tricyclo[5.2.1.0*2,6*]decane-3,5-dione
Show/Hide
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C16H13F3N2O4
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1
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| 1 |
Ki = 2 nM
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CP0855754
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(2S,6R)-4-(3-Chloro-4-fluoro-phenyl)-4-aza-tricyclo[5.2.1.0*2,6*]dec-8-ene-3,5-dione
Show/Hide
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C15H11ClFNO2
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1
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| 1 |
Ki = 2 nM
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CP0169826
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4-[(Benzyl)(4-nitrophenyl)amino]-1-methylpyrrole-2-carboxylic acid
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C19H17N3O4
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1
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| 1 |
Ki = 3 nM
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CP0274814
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4-(N-benzyl-4-nitroanilino)-N,N-diethyl-1-methylpyrrole-2-carboxamide
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C23H26N4O3
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1
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| 1 |
Ki = 3 nM
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CP0860626
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(2S,6R)-4-(3,4-Dimethyl-phenyl)-4-aza-tricyclo[5.2.1.0*2,6*]dec-8-ene-3,5-dione
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C17H17NO2
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1
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| 1 |
Ki = 3.4 nM
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CP0874497
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(2S,6R)-4-(4-Bromo-3-methyl-phenyl)-4-aza-tricyclo[5.2.1.0*2,6*]dec-8-ene-3,5-dione
Show/Hide
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C16H14BrNO2
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1
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| 1 |
Ki = 3.6 nM
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CP0883935
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(2S,6R)-4-(4-Nitro-3-trifluoromethyl-phenyl)-4-aza-tricyclo[5.2.1.0*2,6*]dec-8-ene-3,5-dione
Show/Hide
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C16H11F3N2O4
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1
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| 1 |
Ki = 5 nM
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CP0235287
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[4-(N-benzyl-4-nitroanilino)-1-methylpyrrol-2-yl]-pyrrolidin-1-ylmethanone
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C23H24N4O3
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1
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| 1 |
Ki = 5 nM
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CP0855770
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(2S,6R)-4-(3,5-Dichloro-phenyl)-4-aza-tricyclo[5.2.1.0*2,6*]dec-8-ene-3,5-dione
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C15H11Cl2NO2
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1
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| 1 |
Ki = 6 nM
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CP0474563
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4-[benzyl-[1-methyl-5-(pyrrolidine-1-carbonyl)pyrrol-3-yl]amino]benzonitrile
Show/Hide
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C24H24N4O
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1
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| 1 |
Ki = 6 nM
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CP0897803
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(2S,6R)-4-(3-Trifluoromethyl-phenyl)-4-aza-tricyclo[5.2.1.0*2,6*]dec-8-ene-3,5-dione
Show/Hide
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C16H12F3NO2
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1
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| 1 |
Ki = 7 nM
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CP0091013
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methyl 4-[benzyl-[1-methyl-5-(pyrrolidine-1-carbonyl)pyrrol-3-yl]amino]benzoate
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C25H27N3O3
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1
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| 1 |
Ki = 7 nM
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CP0881223
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(2S,6R)-4-(4-Nitro-naphthalen-1-yl)-4-aza-tricyclo[5.3.2.0*2,6*]dodec-11-ene-3,5-dione
Show/Hide
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C21H18N2O4
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1
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| 1 |
Ki = 9 nM
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CP0169830
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[4-(N-benzyl-4-nitroanilino)-1-methylpyrrol-2-yl]-(2,3-dihydroindol-1-yl)methanone
Show/Hide
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C27H24N4O3
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1
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| 1 |
Ki = 9 nM
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CP0855812
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(2S,6R)-4-Naphthalen-2-yl-4-aza-tricyclo[5.2.1.0*2,6*]dec-8-ene-3,5-dione
Show/Hide
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C19H15NO2
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1
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| 1 |
Ki = 11 nM
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CP0897800
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(2S,6R)-4-Naphthalen-2-yl-4-aza-tricyclo[5.2.1.0*2,6*]decane-3,5-dione
Show/Hide
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C19H17NO2
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1
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| 1 |
Ki = 11 nM
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CP0883915
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(2R,6S)-4-(4-nitrophenyl)-4-azatricyclo[5.2.1.0~2,6~]dec-8-ene-3,5-dione
Show/Hide
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C15H12N2O4
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1
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| 1 |
Ki = 12 nM
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CP0855510
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(2S,6R)-4-Quinolin-7-yl-4-aza-tricyclo[5.2.1.0*2,6*]dec-8-ene-3,5-dione
Show/Hide
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C18H14N2O2
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1
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| 1 |
Ki = 13 nM
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CP0870105
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(2S,6R)-4-(3,5-Bis-trifluoromethyl-phenyl)-4-aza-tricyclo[5.2.1.0*2,6*]dec-8-ene-3,5-dione
Show/Hide
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C17H11F6NO2
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1
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| 1 |
Ki = 24 nM
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CP0128114
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[4-(N-benzyl-4-nitroanilino)-1-methylpyrrol-2-yl]-piperidin-1-ylmethanone
Show/Hide
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C24H26N4O3
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1
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| 1 |
Ki = 27 nM
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CP0871049
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(2R,6S)-4-(3,4-Dichloro-phenyl)-4-aza-tricyclo[5.2.2.0*2,6*]undec-8-ene-3,5-dione
Show/Hide
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C16H13Cl2NO2
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1
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| 1 |
Ki = 28 nM
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CP0855813
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(2S,6R)-4-(8-Hydroxy-quinolin-5-yl)-4-aza-tricyclo[5.2.1.0*2,6*]dec-8-ene-3,5-dione
Show/Hide
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C18H14N2O3
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1
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| 1 |
Ki = 32 nM
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CP0156817
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[4-[N-benzyl-4-(trifluoromethyl)anilino]-1-methylpyrrol-2-yl]-pyrrolidin-1-ylmethanone
Show/Hide
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C24H24F3N3O
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1
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| 1 |
Ki = 36 nM
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CP0176851
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[4-[N-benzyl-4-nitro-3-(trifluoromethyl)anilino]-1-methylpyrrol-2-yl]-pyrrolidin-1-ylmethanone
Show/Hide
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C24H23F3N4O3
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1
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| 1 |
Ki = 49 nM
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CP0317471
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ethyl 4-(N-benzyl-4-nitroanilino)-1-methylpyrrole-2-carboxylate
Show/Hide
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C21H21N3O4
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1
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| 1 |
Ki = 100 nM
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CP0265037
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1-[4-[benzyl-[1-methyl-5-(pyrrolidine-1-carbonyl)pyrrol-3-yl]amino]phenyl]ethanone
Show/Hide
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C25H27N3O2
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1
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| 1 |
Ki = 130 nM
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CP0288759
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[1-methyl-4-[N-[(4-methylphenyl)methyl]-4-nitroanilino]pyrrol-2-yl]-pyrrolidin-1-ylmethanone
Show/Hide
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C24H26N4O3
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1
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| 1 |
Ki = 130 nM
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CP0235286
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[4-[N-[(4-fluorophenyl)methyl]-4-nitroanilino]-1-methylpyrrol-2-yl]-pyrrolidin-1-ylmethanone
Show/Hide
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C23H23FN4O3
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1
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| 1 |
Ki = 140 nM
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CP0176849
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[4-[N-[(4-hydroxyphenyl)methyl]-4-nitroanilino]-1-methylpyrrol-2-yl]-pyrrolidin-1-ylmethanone
Show/Hide
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C23H24N4O4
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1
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| 1 |
Ki = 330 nM
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CP0332399
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[4-[N-[[4-(hydroxymethyl)phenyl]methyl]-4-nitroanilino]-1-methylpyrrol-2-yl]-pyrrolidin-1-ylmethanone
Show/Hide
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C24H26N4O4
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1
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| 1 |
Ki = 1400 nM
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