General Information of the Compound
Compound ID
CP0579466
Compound Name
7-[(4-propan-2-ylphenyl)methoxy]-4-(trifluoromethyl)chromen-2-one
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Structure
Formula
C20H17F3O3
Molecular Weight
362.347
Canonical SMILES
CC(C)c1ccc(COc2ccc3c(cc(=O)oc3c2)C(F)(F)F)cc1
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InChI
InChI=1S/C20H17F3O3/c1-12(2)14-5-3-13(4-6-14)11-25-15-7-8-16-17(20(21,22)23)10-19(24)26-18(16)9-15/h3-10,12H,11H2,1-2H3
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InChIKey
CSQGJLMQFIKUGT-UHFFFAOYSA-N
Physicochemical Property
logP
5.5142
Rotatable Bonds
4
Heavy Atom Count
26
Polar Areas
39.44
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
3
Complexity
26

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 166634065
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00894, Androgen receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000141 LNCaP Homo sapiens (Human)  1
1
IC50 = 9260 nM
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