General Information of the Compound
Compound ID
CP0558442
Compound Name
14-(4-chlorophenyl)-13-azapentacyclo[14.2.1.02,15.03,12.04,9]nonadeca-3(12),4,6,8,10-pentaene
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Formula
C24H22ClN
Molecular Weight
359.9
Canonical SMILES
Clc1ccc(cc1)C1Nc2ccc3ccccc3c2C2C3CCC(C3)C12
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InChI
InChI=1S/C24H22ClN/c25-18-10-7-15(8-11-18)24-22-17-6-5-16(13-17)21(22)23-19-4-2-1-3-14(19)9-12-20(23)26-24/h1-4,7-12,16-17,21-22,24,26H,5-6,13H2
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InChIKey
WNHWHMBSPFMPPM-UHFFFAOYSA-N
Physicochemical Property
logP
6.7897
Rotatable Bonds
1
Heavy Atom Count
26
Polar Areas
12.03
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
1
Complexity
26

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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ChEMBL ID
CHEMBL4782786
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00894, Androgen receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000141 LNCaP Homo sapiens (Human)  1
1
IC50 = 7450 nM
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