General Information of the Compound
Compound ID
CP0561946
Compound Name
(2S)-2-(2,5-dichlorophenoxy)-N-[2-oxo-4-(trifluoromethyl)chromen-7-yl]propanamide
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Structure
Formula
C19H12Cl2F3NO4
Molecular Weight
446.208
Canonical SMILES
C[C@H](Oc1cc(Cl)ccc1Cl)C(=O)Nc1ccc2c(cc(=O)oc2c1)C(F)(F)F
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InChI
InChI=1S/C19H12Cl2F3NO4/c1-9(28-16-6-10(20)2-5-14(16)21)18(27)25-11-3-4-12-13(19(22,23)24)8-17(26)29-15(12)7-11/h2-9H,1H3,(H,25,27)/t9-/m0/s1
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InChIKey
ONYYOXQBBGVBPH-VIFPVBQESA-N
Physicochemical Property
logP
5.5246
Rotatable Bonds
4
Heavy Atom Count
29
Polar Areas
68.54
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Complexity
29

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 1222960
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00894, Androgen receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000141 LNCaP Homo sapiens (Human)  1
1
IC50 > 50000 nM
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   LI
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