General Information of the Compound
Compound ID
CP0924227
Compound Name
US9126941, RD92
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Structure
Formula
C28H22F3N5S2
Molecular Weight
549.647
Canonical SMILES
[C-]#[N+]c1ccc(N2C(=S)N(c3ccc(C)cc3)C3(CCC3)/C2=N/C(=S)Nc2ccccc2)cc1C(F)(F)F
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InChI
InChI=1S/C28H22F3N5S2/c1-18-9-11-20(12-10-18)36-26(38)35(21-13-14-23(32-2)22(17-21)28(29,30)31)24(27(36)15-6-16-27)34-25(37)33-19-7-4-3-5-8-19/h3-5,7-14,17H,6,15-16H2,1H3,(H,33,37)/b34-24-
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InChIKey
ZVDSLFFXKSQESW-BCJTWVECSA-N
Physicochemical Property
logP
7.89431
Rotatable Bonds
3
Heavy Atom Count
38
Polar Areas
35.23
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
2
Complexity
38

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 137662370
ChEMBL ID
CHEMBL4115695
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00894, Androgen receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000141 LNCaP Homo sapiens (Human)  1
1
IC50 = 176 nM
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