General Information of the Compound
Compound ID
CP0577987
Compound Name
ethyl 11-azatetracyclo[8.7.0.02,7.013,17]heptadeca-1(10),2,4,6,8,15-hexaene-12-carboxylate
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Formula
C19H19NO2
Molecular Weight
293.366
Canonical SMILES
CCOC(=O)C1Nc2ccc3ccccc3c2C2C=CCC12
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InChI
InChI=1S/C19H19NO2/c1-2-22-19(21)18-15-9-5-8-14(15)17-13-7-4-3-6-12(13)10-11-16(17)20-18/h3-8,10-11,14-15,18,20H,2,9H2,1H3
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InChIKey
NQVUPVVWXKBKRE-UHFFFAOYSA-N
Physicochemical Property
logP
3.8567
Rotatable Bonds
2
Heavy Atom Count
22
Polar Areas
38.33
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
3
Complexity
22

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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ChEMBL ID
CHEMBL4790160
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00894, Androgen receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000141 LNCaP Homo sapiens (Human)  1
1
IC50 = 820 nM
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