Brief Information of the Compound and Protein
Compound Name
 Compound Info 
(2R)-N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorobenzene)sulfonyl]-2-hydroxy-2-methylpropanamide
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 PubChem ID
CID: 56069
SID: 14783081
Canonical SMILES
C[C@](O)(CS(=O)(=O)c1ccc(F)cc1)C(=O)Nc1ccc(C#N)c(c1)C(F)(F)F
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Compound Formula C18H14F4N2O4S
Compound Structure
Protein Name
 Protein Info 
Androgen receptor
Protein Classification
Transcription factor
>
Nuclear receptor
>
Nuclear hormone receptor subfamily 3
>
Nuclear hormone receptor subfamily 3 group C
>
Nuclear hormone receptor subfamily 3 group C member 4
Uniprot ID
P10275
Gene Name
AR
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000109 COS-1
 Cell Line Info 
Chlorocebus aethiops (Green monkey)  1
1
IC50 = 120.23 nM
   TI
   LI
   LO
   TS
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  2
1
IC50 = 248 nM
   TI
   LI
   LO
   TS
2
IC50 = 350 nM
   TI
   LI
   LO
   TS
CL000141 LNCaP
 Cell Line Info 
Homo sapiens (Human)  4
1
GI50 = 1800 nM
   TI
   LI
   LO
   TS
2
IC50 = 850 nM
   TI
   LI
   LO
   TS
3
IC50 = 27710 nM
   TI
   LI
   LO
   TS
4
Ki = 10 nM
   TI
   LI
   LO
   TS
CL000370 SC-3
 Cell Line Info 
Mus musculus (Mouse)  1
1
IC50 = 270 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 11 nM
2 Ki = 70 nM
3 Ki = 151 nM
4 Ki = 509 nM
5 Ki = 3700 nM