General Information of the Compound
Compound ID
CP0891224
Compound Name
4-(4-((4-fluorophenoxy)methyl)-1H-1,2,3-triazol-1-yl)-2-(trifluoromethyl)benzonitrile
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Structure
Formula
C17H10F4N4O
Molecular Weight
362.286
Canonical SMILES
N#Cc1ccc(-n2cc(COc3ccc(F)cc3)nn2)cc1C(F)(F)F
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InChI
InChI=1S/C17H10F4N4O/c18-12-2-5-15(6-3-12)26-10-13-9-25(24-23-13)14-4-1-11(8-22)16(7-14)17(19,20)21/h1-7,9H,10H2
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InChIKey
RLMHOMPROCVROL-UHFFFAOYSA-N
Physicochemical Property
logP
3.87588
Rotatable Bonds
4
Heavy Atom Count
26
Polar Areas
63.73
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
5
Complexity
26

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 137631372
ChEMBL ID
CHEMBL4067253
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00894, Androgen receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000141 LNCaP Homo sapiens (Human)  1
1
GI50 = 19230 nM
   TI
   LI
   LO
   TS