General Information of the Compound
Compound ID
CP0548107
Compound Name
5-[8-oxo-5-(6-oxo-1H-pyridin-3-yl)-6-sulfanylidene-5,7-diazaspiro[3.4]octan-7-yl]-3-(trifluoromethyl)pyridine-2-carbonitrile
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Structure
Formula
C18H12F3N5O2S
Molecular Weight
419.388
Canonical SMILES
Oc1ccc(cn1)N1C(=S)N(C(=O)C11CCC1)c1cnc(C#N)c(c1)C(F)(F)F
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InChI
InChI=1S/C18H12F3N5O2S/c19-18(20,21)12-6-11(9-23-13(12)7-22)25-15(28)17(4-1-5-17)26(16(25)29)10-2-3-14(27)24-8-10/h2-3,6,8-9H,1,4-5H2,(H,24,27)
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InChIKey
BQVQKLJAAGDPIU-UHFFFAOYSA-N
Physicochemical Property
logP
3.13348
Rotatable Bonds
2
Heavy Atom Count
29
Polar Areas
93.35
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
6
Complexity
29

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 130229379
ChEMBL ID
CHEMBL4850855
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00894, Androgen receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000141 LNCaP Homo sapiens (Human)  2
1
IC50 = 1000 nM
   TI
   LI
   LO
   TS
2
IC50 = 2239 nM
   TI
   LI
   LO
   TS